KEGG   ENZYME: 4.1.2.59
Entry
EC 4.1.2.59                 Enzyme                                 

Name
dihydroneopterin phosphate aldolase;
H2NMP aldolase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
7,8-dihydroneopterin 3'-phosphate glycolaldehyde phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
Reaction(IUBMB)
7,8-dihydroneopterin 3'-phosphate = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde phosphate [RN:R11718]
Reaction(KEGG)
R11718
Substrate
7,8-dihydroneopterin 3'-phosphate [CPD:C05925]
Product
6-(hydroxymethyl)-7,8-dihydropterin [CPD:C01300];
glycolaldehyde phosphate [CPD:C21614]
Comment
The enzyme participates in methanopterin biosynthesis the archaeon Pyrococcus furiosus. The enzyme is specific for 7,8-dihydroneopterin 3'-phosphate. cf. EC 4.1.2.25, dihydroneopterin aldolase and EC 4.1.2.60, dihydroneopterin triphosphate aldolase.
History
EC 4.1.2.59 created 2017
Pathway
ec00790  Folate biosynthesis
Orthology
K22102  dihydroneopterin phosphate aldolase
Genes
PFU: PF1278
PFI: PFC_05605
PHO: PH0634(PH0634)
PAB: PAB1445
PYN: PNA2_1253
PYS: Py04_1120
PYC: TQ32_04640
TCH: CHITON_0626
Reference
1  [PMID:22931285]
  Authors
de Crecy-Lagard V, Phillips G, Grochowski LL, El Yacoubi B, Jenney F, Adams MW, Murzin AG, White RH
  Title
Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate.
  Journal
ACS Chem Biol 7:1807-16 (2012)
DOI:10.1021/cb300342u
  Sequence
[pfu:PF1278]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.59
IUBMB Enzyme Nomenclature: 4.1.2.59
ExPASy - ENZYME nomenclature database: 4.1.2.59
BRENDA, the Enzyme Database: 4.1.2.59
LinkDB

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