KEGG   ENZYME: 4.1.2.62
Entry
EC 4.1.2.62                 Enzyme                                 

Name
5-deoxyribulose 1-phosphate aldolase;
5-(methylthio)ribulose-1-phosphate aldolase;
ald2 (gene name)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
5-deoxy-D-ribulose 1-phosphate acetaldehyde-lyase (glycerone-phosphate-forming)
Reaction(IUBMB)
(1) 5-deoxy-D-ribulose 1-phosphate = glycerone phosphate + acetaldehyde [RN:R12612];
(2) S-methyl-5-thio-D-ribulose 1-phosphate = glycerone phosphate + (2-methylsulfanyl)acetaldehyde [RN:R12613]
Reaction(KEGG)
R12612 R12613
Substrate
5-deoxy-D-ribulose 1-phosphate [CPD:C22280];
S-methyl-5-thio-D-ribulose 1-phosphate [CPD:C04582]
Product
glycerone phosphate [CPD:C00111];
acetaldehyde [CPD:C00084];
(2-methylsulfanyl)acetaldehyde [CPD:C22279]
Comment
The enzyme, originally characterized from the bacterium Rhodospirillum rubrum, is involved in degradation pathways for 5'-deoxyadenosine and S-methyl-5'-thioadenosine, which are formed from S-adenosyl-L-methionine (SAM, AdoMet) by radical SAM enzymes and other types of SAM-dependent enzymes, respectively. The enzyme requires a divalent metal cation, with Co2+ producing the highest activity.
History
EC 4.1.2.62 created 2020
Orthology
K24269  5-deoxyribulose 1-phosphate aldolase
Genes
BRQ: CIT40_23715
BSYM: CIT39_22685
RPA: RPA4655(fucA)
RPT: Rpal_5136
RRU: Rru_A0359
RRF: F11_01830
Reference
1  [PMID:29133429]
  Authors
North JA, Miller AR, Wildenthal JA, Young SJ, Tabita FR
  Title
Microbial pathway for anaerobic 5'-methylthioadenosine metabolism coupled to ethylene formation.
  Journal
Proc Natl Acad Sci U S A 114:E10455-E10464 (2017)
DOI:10.1073/pnas.1711625114
  Sequence
[rru:Rru_A0359] [rpa:RPA4655]
Reference
2  [PMID:31950558]
  Authors
North JA, Wildenthal JA, Erb TJ, Evans BS, Byerly KM, Gerlt JA, Tabita FR
  Title
A bifunctional salvage pathway for two distinct S-adenosylmethionine by-products  that is widespread in bacteria, including pathogenic Escherichia coli.
  Journal
Mol Microbiol 113:923-937 (2020)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.62
IUBMB Enzyme Nomenclature: 4.1.2.62
ExPASy - ENZYME nomenclature database: 4.1.2.62
BRENDA, the Enzyme Database: 4.1.2.62
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