KEGG   ENZYME: 4.1.3.16Help
Entry
EC 4.1.3.16                 Enzyme                                 

Name
4-hydroxy-2-oxoglutarate aldolase;
2-oxo-4-hydroxyglutarate aldolase;
hydroxyketoglutaric aldolase;
4-hydroxy-2-ketoglutaric aldolase;
2-keto-4-hydroxyglutaric aldolase;
4-hydroxy-2-ketoglutarate aldolase;
2-keto-4-hydroxyglutarate aldolase;
2-oxo-4-hydroxyglutaric aldolase;
DL-4-hydroxy-2-ketoglutarate aldolase;
hydroxyketoglutarate aldolase;
2-keto-4-hydroxybutyrate aldolase;
4-hydroxy-2-oxoglutarate glyoxylate-lyase;
KHGA
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
Reaction(IUBMB)
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate [RN:R00470]
Reaction(KEGG)
Substrate
4-hydroxy-2-oxoglutarate [CPD:C01127]
Product
pyruvate [CPD:C00022];
glyoxylate [CPD:C00048]
Comment
The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC 4.1.3.42, (4S)-4-hydroxy-2-oxoglutarate aldolase.
History
EC 4.1.3.16 created 1972 (EC 4.1.2.1 created 1961, incorporated 1972, EC 4.1.2.31 created 1978, incorporated 1982)
Pathway
ec00330  Arginine and proline metabolism
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
Orthology
K18123  4-hydroxy-2-oxoglutarate aldolase
Genes
HSA: 112817(HOGA1)
PTR: 742884(HOGA1)
PPS: 103782784(HOGA1)
GGO: 101154009(HOGA1)
PON: 100171598(HOGA1)
NLE: 100589206(HOGA1)
MCC: 706661(HOGA1)
MCF: 102126728(HOGA1)
CSAB: 103216345(HOGA1)
RRO: 104682808(HOGA1)
RBB: 108534698(HOGA1)
CJC: 103796777(HOGA1)
SBQ: 104650492(HOGA1)
MMU: 67432(Hoga1)
MCAL: 110285310(Hoga1)
MPAH: 110333903(Hoga1)
RNO: 293949(Hoga1)
MUN: 110564114(Hoga1)
CGE: 100759109(Hoga1)
NGI: 103733196(Hoga1)
HGL: 101700602(Hoga1)
CCAN: 109695304(Hoga1)
OCU: 100344505(HOGA1)
TUP: 102486364(HOGA1)
CFA: 608755(HOGA1)
VVP: 112914409(HOGA1)
AML: 100478059(HOGA1)
UMR: 103674087(HOGA1)
UAH: 113251791(HOGA1)
ORO: 101385318(HOGA1)
ELK: 111145298
FCA: 101101417(HOGA1)
PTG: 102965487(HOGA1)
PPAD: 109272717(HOGA1)
AJU: 106966929(HOGA1)
BTA: 506001(HOGA1)
BOM: 102265621(HOGA1)
BIU: 109552999(HOGA1)
BBUB: 102398601(HOGA1)
CHX: 102173994(HOGA1)
OAS: 101114573(HOGA1)
SSC: 100153961(HOGA1)
CFR: 102512614(HOGA1)
CDK: 105084288(HOGA1)
BACU: 103004258(HOGA1)
LVE: 103077167 103089444(HOGA1)
OOR: 101271753(HOGA1)
DLE: 111172427(HOGA1)
PCAD: 102979032(HOGA1)
ECB: 100070689(HOGA1)
EPZ: 103558701(HOGA1)
EAI: 106844960(HOGA1)
MYB: 102246939(HOGA1)
MYD: 102768587(HOGA1)
MNA: 107542604(HOGA1)
HAI: 109379716(HOGA1)
DRO: 112307109(HOGA1)
PALE: 102884382(HOGA1)
RAY: 107520438(HOGA1)
MJV: 108399750(HOGA1)
LAV: 100670230(HOGA1)
TMU: 101355404
MDO: 100021876(HOGA1)
SHR: 100929176(HOGA1)
PCW: 110215427(HOGA1)
OAA: 100088274(HOGA1)
GGA: 770036(HOGA1)
MGP: 100548398(HOGA1)
CJO: 107316003(HOGA1)
NMEL: 110400352(HOGA1)
ACYG: 106036839(HOGA1)
TGU: 100231472(HOGA1)
LSR: 110473597(HOGA1)
SCAN: 103813888(HOGA1)
GFR: 102042170(HOGA1)
FAB: 101806953(HOGA1)
PHI: 102112987(HOGA1)
PMAJ: 107206698(HOGA1)
CCAE: 111931229(HOGA1)
CCW: 104695887(HOGA1)
ETL: 114070777(HOGA1)
FPG: 101920952(HOGA1)
FCH: 102052298(HOGA1)
CLV: 102097409(HOGA1)
EGZ: 104132255(HOGA1)
NNI: 104012772(HOGA1)
ACUN: 113481407(HOGA1)
PADL: 103916280(HOGA1)
ASN: 102382587(HOGA1)
AMJ: 102563093(HOGA1)
CPIC: 103307603(HOGA1)
ACS: 100566929(hoga1)
PVT: 110089167(HOGA1)
PBI: 103053263(HOGA1)
PMUR: 107295219(HOGA1)
TSR: 106549035(HOGA1)
PMUA: 114597588(HOGA1)
GJA: 107114457(HOGA1)
XLA: 495193(hoga1.L)
XTR: 496669(hoga1)
NPR: 108792933(HOGA1)
DRE: 405806(hoga1)
SRX: 107706114
SANH: 107663482(hoga1)
SGH: 107551368 107588470(hoga1)
CCAR: 109069442
IPU: 108259603(hoga1)
PHYP: 113546731(hoga1)
AMEX: 103023796(hoga1)
EEE: 113577699(hoga1)
TRU: 101061435(hoga1)
LCO: 104930035(hoga1)
NCC: 104953008(hoga1)
MZE: 101479315(hoga1)
ONL: 100690946(hoga1)
OLA: 101161460(hoga1)
XMA: 102230783(hoga1)
XCO: 114145238(hoga1)
PRET: 103470116(hoga1)
CVG: 107081958(hoga1)
NFU: 107382406(hoga1)
KMR: 108247450(hoga1)
ALIM: 106532717 106537034(hoga1)
AOCE: 111580411(hoga1)
CSEM: 103383203(hoga1)
LCF: 108880833(hoga1)
SDU: 111235845(hoga1)
SLAL: 111665639(hoga1)
HCQ: 109511381(hoga1)
BPEC: 110155940(hoga1)
MALB: 109952000(hoga1)
SALP: 112079381(hoga1)
ELS: 105006876(hoga1)
SFM: 108924852(hoga1)
PKI: 111848362(hoga1)
LCM: 102362318(HOGA1)
CMK: 103172525(hoga1)
RTP: 109921722(hoga1)
CIN: 100181036
SPU: 579934
APLC: 110981286
SKO: 100372772
API: 100570569
DNX: 107163989
AGS: 114132054
RMD: 113549091
ZNE: 110831450
FCD: 110856855
PVM: 113818492
CSCU: 111618478
PTEP: 107438884
PCAN: 112565420
CRG: 105328725
MYI: 110455405
OBI: 106884306
LAK: 106170963
EPA: 110231654
ADF: 107337820
AMIL: 114962597
PDAM: 113686876
SPIS: 111324439
DGT: 114515751
HMG: 100199549
QSU: 111991330
NCR: NCU05977
NTE: NEUTE1DRAFT148948(NEUTE1DRAFT_148948) NEUTE1DRAFT48910(NEUTE1DRAFT_48910)
MBE: MBM_05778
ANI: AN1503.2
ANG: ANI_1_1986144(An16g07700) ANI_1_26174(An10g00330)
CNE: CNC03990
CNB: CNBC3190
ABP: AGABI1DRAFT111212(AGABI1DRAFT_111212) AGABI1DRAFT114952(AGABI1DRAFT_114952)
ABV: AGABI2DRAFT190432(AGABI2DRAFT_190432) AGABI2DRAFT191181(AGABI2DRAFT_191181)
LIR: LAW_00107(dapA_1)
ABAS: ACPOL_6664
SUS: Acid_1067
ABAC: LuPra_06084(dapA_3)
TLI: Tlie_1310
 » show all
Taxonomy
Reference
1  [PMID:14089442]
  Authors
KURATOMI K, FUKUNAGA K.
  Title
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATE.
  Journal
Biochim Biophys Acta 78:617-28 (1963)
DOI:10.1016/0006-3002(63)91027-8
Reference
2  [PMID:5780845]
  Authors
Kobes RD, Dekker EE
  Title
2-Keto-4-hydroxyglutarate aldolase of bovine liver. Purification, criteria of purity, and general properties.
  Journal
J Biol Chem 244:1919-25 (1969)
Reference
3  [PMID:5580656]
  Authors
Lane RS, Shapley A, Dekker EE.
  Title
2-keto-4-hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in the mammalian metabolism of L-homoserine.
  Journal
Biochemistry 10:1353-64 (1971)
Reference
4  [PMID:3942759]
  Authors
Scholtz JM, Schuster SM
  Title
Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase.
  Journal
Biochim Biophys Acta 869:192-6 (1986)
DOI:10.1016/0167-4838(86)90294-3
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.16
IUBMB Enzyme Nomenclature: 4.1.3.16
ExPASy - ENZYME nomenclature database: 4.1.3.16
BRENDA, the Enzyme Database: 4.1.3.16
CAS: 9030-81-3
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