Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy

chorismate pyruvate-lyase (3-hydroxybenzoate-forming)

chorismate = 3-hydroxybenzoate + pyruvate [RN:R10597]

R10597
Reaction

chorismate [CPD:C00251]

The enzyme, found in several bacterial species is involved in biosynthesis of secondary products. The enzyme from the bacterium Xanthomonas campestris pv. campestris also has the activity of EC 4.1.3.40, chorismate lyase [3].

EC 4.1.3.45 created 2013

1  [PMID:21383123]

Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.

Proc Natl Acad Sci U S A 108:4776-81 (2011)
DOI:10.1073/pnas.1015773108

[src:M271_50105]

2  [PMID:23824670]

Jiang Y, Wang H, Lu C, Ding Y, Li Y, Shen Y

Identification and characterization of the cuevaene A biosynthetic gene cluster in streptomyces sp. LZ35.

Chembiochem 14:1468-75 (2013)
DOI:10.1002/cbic.201300316

[ag:AGO98693]

3  [PMID:23113660]

Zhou L, Wang JY, Wu J, Wang J, Poplawsky A, Lin S, Zhu B, Chang C, Zhou T, Zhang LH, He YW

The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways.

Mol Microbiol 87:80-93 (2013)
DOI:10.1111/mmi.12084

[xca:xcc-b100_4207]