| Entry |
|
|---|
| Name |
3-hydroxybenzoate synthase;
chorismatase/3-hydroxybenzoate synthase;
hyg5 (gene name);
bra8 (gene name);
XanB2
|
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
 |
|---|
| Sysname |
chorismate pyruvate-lyase (3-hydroxybenzoate-forming)
|
|---|
| Reaction(IUBMB) |
chorismate = 3-hydroxybenzoate + pyruvate [RN: R10597]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
The enzyme, found in several bacterial species is involved in biosynthesis of secondary products. The enzyme from the bacterium Xanthomonas campestris pv. campestris also has the activity of EC 4.1.3.40, chorismate lyase [3].
|
|---|
| History |
EC 4.1.3.45 created 2013
|
|---|
| Pathway |
| ec00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
|
|---|
| Orthology |
| K18240 | chorismate lyase / 3-hydroxybenzoate synthase |
|
|---|
| Genes |
» show all
 |
|---|
| Reference |
|
|---|
| Authors |
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B |
|---|
| Title |
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Jiang Y, Wang H, Lu C, Ding Y, Li Y, Shen Y |
|---|
| Title |
Identification and characterization of the cuevaene A biosynthetic gene cluster in streptomyces sp. LZ35. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Zhou L, Wang JY, Wu J, Wang J, Poplawsky A, Lin S, Zhu B, Chang C, Zhou T, Zhang LH, He YW |
|---|
| Title |
The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.3.45 |
| ExPASy - ENZYME nomenclature database: | 4.1.3.45 |
|
|---|
| LinkDB |
 |
|---|
