KEGG ENZYME: 4.2.1.142

ENZYME: 4.2.1.142

Entry

EC 4.2.1.142 Enzyme

Name

5'-oxoaverantin cyclase;
OAVN cyclase;
5'-oxoaverantin hydro-lyase [(2'S,5'S)-averufin forming]

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

5'-oxoaverantin hydro-lyase [(1'S,5'S)-averufin forming]

Reaction(IUBMB)

5'-oxoaverantin = (1'S,5'S)-averufin + H2O [RN:R10475]

Reaction(KEGG)

R10475

Substrate

5'-oxoaverantin [CPD:C20502]

Product

(1'S,5'S)-averufin [CPD:C20574];
H2O [CPD:C00001]

Comment

Isolated from the aflatoxin-producing mold Aspergillus parasiticus. The enzyme also catalyses the conversion of versiconal to versicolorin B (EC 4.2.1.143, versicolorin B synthase). Involved in aflatoxin biosynthesis.

History

EC 4.2.1.142 created 2013

Pathway

ec00254

Aflatoxin biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K17646

5'-oxoaverantin cyclase / versicolorin B synthase

Genes

PAN:	PODANSg8556

ANI:

AN7812.2

AOR:	AO090026000028

AFV:	AFLA_139190

Reference

1 [PMID:14602595]

Authors

Sakuno E, Yabe K, Nakajima H

Title

Involvement of two cytosolic enzymes and a novel intermediate, 5'-oxoaverantin, in the pathway from 5'-hydroxyaverantin to averufin in aflatoxin biosynthesis.

Journal

Appl Environ Microbiol 69:6418-26 (2003)
DOI:10.1128/AEM.69.11.6418-6426.2003

Sequence

[ag:AAC49318]

Reference

2 [PMID:15932995]

Authors

Sakuno E, Wen Y, Hatabayashi H, Arai H, Aoki C, Yabe K, Nakajima H

Title

Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.

Journal

Appl Environ Microbiol 71:2999-3006 (2005)
DOI:10.1128/AEM.71.6.2999-3006.2005