| Entry |
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| Name |
versicolorin B synthase;
versiconal cyclase;
VBS
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
versiconal hydro-lyase (versicolorin-B forming)
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| Reaction(IUBMB) |
versiconal = versicolorin B + H2O [RN: R10402]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Isolated from the aflatoxin-producing mold Aspergillus parasiticus. Involved in aflatoxin biosynthesis.
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| History |
EC 4.2.1.143 created 2013
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K17646 | 5'-oxoaverantin cyclase / versicolorin B synthase |
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| Genes |
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| Reference |
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| Authors |
Lin BK, Anderson JA |
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| Title |
Purification and properties of versiconal cyclase from Aspergillus parasiticus. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
McGuire SM, Silva JC, Casillas EG, Townsend CA |
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| Title |
Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis of the stereodifferentiating cyclization in aflatoxin biosynthesis essential to DNA interaction. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Silva JC, Minto RE, Barry CE 3rd, Holland KA, Townsend CA |
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| Title |
Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Expansion of the aflatoxin b1 biosynthetic gene cluster. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Silva JC, Townsend CA |
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| Title |
Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus parasiticus. A key enzyme in the aflatoxin B1 biosynthetic pathway. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 4.2.1.143 |
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| LinkDB |
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