KEGG   ENZYME: 4.2.1.149Help
Entry
EC 4.2.1.149                Enzyme                                 

Name
crotonobetainyl-CoA hydratase;
CaiD;
L-carnityl-CoA dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming]
Reaction(IUBMB)
L-carnitinyl-CoA = (E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O [RN:R10675]
Reaction(KEGG)
Substrate
L-carnitinyl-CoA [CPD:C20750]
Product
(E)-4-(trimethylammonio)but-2-enoyl-CoA [CPD:C20748];
H2O [CPD:C00001]
Comment
The enzyme is also able to use crotonyl-CoA as substrate, with low efficiency [2].
History
EC 4.2.1.149 created 2014
Orthology
K08299  crotonobetainyl-CoA hydratase
Genes
ECO: b0036(caiD)
ECJ: JW0035(caiD)
ECD: ECDH10B_0037(caiD)
EBW: BWG_0034(caiD)
ECOK: ECMDS42_0029(caiD)
ECE: Z0042(caiD)
ECS: ECs0039
ECF: ECH74115_0040(caiD)
ETW: ECSP_0039(caiD)
ELX: CDCO157_0038
EOJ: ECO26_0037(caiD)
EOI: ECO111_0037(caiD)
EOH: ECO103_0038(caiD)
ECOO: ECRM13514_0037(caiD)
ECOH: ECRM13516_0039(caiD)
ECG: E2348C_0037(caiD)
EOK: G2583_0038(caiD)
ESO: O3O_04020
ESM: O3M_21265
ESL: O3K_21365
ECW: EcE24377A_0038(caiD)
ELH: ETEC_0036
EUN: UMNK88_36
ECC: c0045(caiD)
ECP: ECP_0036
ECI: UTI89_C0042(caiD)
ECV: APECO1_1945(caiD)
ECX: EcHS_A0040(caiD)
ECM: EcSMS35_0037(caiD)
ECY: ECSE_0037
ECR: ECIAI1_0038(caiD)
ECQ: ECED1_0035(caiD)
ECK: EC55989_0036(caiD)
ECT: ECIAI39_0037(caiD)
EOC: CE10_0037(caiD)
EUM: ECUMN_0038(caiD)
ECZ: ECS88_0039(caiD)
ELO: EC042_0038(caiD)
ESE: ECSF_0041
EBR: ECB_00040(caiD)
EBD: ECBD_3579
EKF: KO11_00180(caiD)
EAB: ECABU_c00410(caiD)
EDJ: ECDH1ME8569_0035(caiD)
EIH: ECOK1_0035(caiD)
ENA: ECNA114_0023(caiD)
ELW: ECW_m0036(caiD)
ELL: WFL_00180(caiD)
ELC: i14_0038(caiD)
ELD: i02_0038(caiD)
ELP: P12B_c0031(caiD)
EBL: ECD_00040(caiD)
EBE: B21_00039(caiD)
ELF: LF82_0260(caiD)
ECOI: ECOPMV1_00037(caiD_1)
ECOJ: P423_00180
ECOS: EC958_0170(caiD)
EFE: EFER_0044(caiD)
EAL: EAKF1_ch1386(caiD)
STY: STY0080(caiD)
STT: t0071(caiD)
STM: STM0070(caiD)
SEO: STM14_0083(caiD)
SEY: SL1344_0071(caiD)
SEJ: STMUK_0071(caiD)
SEB: STM474_0073(caiD)
SEF: UMN798_0078(caiD)
SENR: STMDT2_00711(caiD)
SEND: DT104_00711(caiD)
SENI: CY43_00345
SPT: SPA0071(caiD)
SEK: SSPA0067
SEI: SPC_0075(caiD)
SEC: SCH_0064(caiD)
SHB: SU5_0705
SENS: Q786_00345
SED: SeD_A0076
SEG: SG0073(caiD)
SEL: SPUL_0075(caiD)
SEGA: SPUCDC_0075(caiD)
SET: SEN0071(caiD)
SENA: AU38_00345
SENO: AU37_00345
SENV: AU39_00345
SENQ: AU40_00380
SENL: IY59_00360
SEEP: I137_00325
SENB: BN855_730(caiD)
SENE: IA1_00355
SBG: SBG_0055(caiD)
SBZ: A464_58
SFL: SF0033(caiD)
SFX: S0035(caiD)
SFV: SFV_0030(caiD)
SFE: SFxv_0034(caiD)
SFN: SFy_0042
SFS: SFyv_0046
SFT: NCTC1_00033(caiD)
SSN: SSON_0042(caiD)
SDY: SDY_0058(caiD)
CKO: CKO_03347
CRO: ROD_00381(caiD)
CAMA: F384_00195
EBT: EBL_c33170(caiD)
METY: MRY16398_47870(caiD)
EBF: D782_3833
PMR: PMI2658(caiD)
PMIB: BB2000_2649(caiD)
PHAU: PH4a_04765
PRG: RB151_007330(caiD)
PHEI: NCTC12003_00741(caiD)
ETR: ETAE_2660(caiD)
ETD: ETAF_2398
ETE: ETEE_0761
LRI: NCTC12151_02501(caiD)
ACI: ACIAD1571(caiD)
SLO: Shew_2672
SSE: Ssed_3225
SPL: Spea_4034
SHL: Shal_0224
SWP: swp_4934
GAI: IMCC3135_12755(caiD)
ADI: B5T_02472(fadB2)
AXE: P40_12005
BCJ: BCAM2695(caiD)
BCON: NL30_17350
BMEC: WJ16_31835
BXE: Bxe_C0322
VEI: Veis_3503
CPIN: CPIN18020_0487(caiD)
MLO: mlr5044
AMIH: CO731_02018(caiD)
PLA: Plav_2640
RBS: RHODOSMS8_01534(caiD)
SME: SMc01641
SMX: SM11_chr1006(caiD)
SMI: BN406_02077(caiD)
SMEL: SM2011_c01641(caiD)
SMER: DU99_12620
SMD: Smed_2177
SFH: SFHH103_02057(caiD)
SFD: USDA257_c45520(caiD)
SIX: BSY16_546
SAME: SAMCFNEI73_Ch2523(caiD)
EAD: OV14_3675
ARA: Arad_9264
REL: REMIM1_PB00143(caiD)
REP: IE4803_PD00564(caiD)
REI: IE4771_PE00579(caiD)
RLE: pRL100378 pRL110025(caiD)
RLG: Rleg_6427
RGA: RGR602_PC01930(caiD)
RHN: AMJ98_PB00186(caiD)
RPHA: AMC79_PA00228(caiD)
RHX: AMK02_PB00200(caiD)
RHK: Kim5_PD00537(caiD)
REZ: AMJ99_PA00186(caiD)
NEN: NCHU2750_44880(caiD)
SHZ: shn_12110
BPP: BPI_II563(caiD)
BJA: bll2946(fadB)
BRA: BRADO2574
BBT: BBta_2921
BRS: S23_50670(fadB)
AOL: S58_50380
BRAD: BF49_1747
RPA: RPA1761
RPB: RPB_3602
RPC: RPC_1675
RPD: RPD_1865
RPE: RPE_4127
RPT: Rpal_1962
OCA: OCAR_4995
OCG: OCA5_c29630(caiD)
OCO: OCA4_c29200(caiD)
MMED: Mame_04200(caiD_3)
RBM: TEF_12515
PZU: PHZ_c1108(fadB)
SIL: SPO2706(caiD-1) SPOA0285(caiD-2)
RDE: RD1_0613(caiD)
RLI: RLO149_c000760(caiD)
PGA: PGA1_c34200(caiD)
PGL: PGA2_c32410(caiD)
PGD: Gal_03487
PHP: PhaeoP97_03321(caiD)
PPIC: PhaeoP14_03227(caiD)
OAT: OAN307_c01290(caiD)
OAR: OA238_c47080(caiD)
OTM: OSB_31140(caiD)
LEJ: ETW24_19425(caiD)
LAQU: R2C4_18445(caiD)
PTP: RCA23_c04470(caiD)
MALG: MALG_01859
RMM: ROSMUCSMR3_03095(caiD)
LVS: LOKVESSMR4R_02271(caiD)
AHT: ANTHELSMS3_00030(caiD)
PSEB: EOK75_06680(caiD) EOK75_14575(caiD)
SAL: Sala_1808
SPHP: LH20_03580
SGI: SGRAN_1077(caiD) SGRAN_3644(caiD2)
SPHU: SPPYR_0642(caiD) SPPYR_2860(caiD)
SPMI: K663_17171
SPHR: BSY17_3916
MTV: RVBD_1136
MTC: MT1169.1
MRA: MRA_1146
MTUR: CFBS_1210
MTD: UDA_1136
MTUE: J114_06130
MTUL: TBHG_01119
MTUT: HKBT1_1208
MTUU: HKBT2_1214
MAF: MAF_11530
MMIC: RN08_1276
MPA: MAP_2645c(echA1)
MAO: MAP4_1173
MAVI: RC58_05820
MAVU: RE97_05815
MID: MIP_01900
MYO: OEM_12000
MUL: MUL_0972(echA1_1)
MMC: Mmcs_4079
MKM: Mkms_4155
MJL: Mjls_4093
MMI: MMAR_4317(echA1_1)
MMAE: MMARE11_41310(echA1_1)
MMM: W7S_05790
MLI: MULP_04515(echA1_1)
MSHG: MSG_03869
MSG: MSMEI_1123(echA1) MSMEI_5063
MVA: Mvan_4588
MGI: Mflv_2117
MPHL: MPHLCCUG_04147(caiD_3)
MVQ: MYVA_4366
MTHN: 4412656_03465(caiD_7)
MHAS: MHAS_02938(caiD_1)
MJD: JDM601_1118(echA1_1) JDM601_3837(echA1_1) JDM601_3845(echA1_1)
MTER: 4434518_01077(echA1_1) 4434518_02931(caiD_3)
NFA: NFA_29420(echA13)
NFR: ERS450000_01146(caiD_2)
RHB: NY08_3982
RFA: A3L23_02151(caiD_3)
RHS: A3Q41_01227(caiD_1)
RRT: 4535765_01101(caiD_3)
GRU: GCWB2_12145(caiD8)
GOM: D7316_02167(caiD_7) D7316_02365(caiD_8) D7316_02519(dpgD_2)
SMA: SAVERM_1350(echA5)
SALS: SLNWT_0020
SLE: sle_61220(sle_61220)
ART: Arth_1079
ARX: ARZXY2_2919(caiD)
AAU: AAur_1078
ACH: Achl_3309
NOY: EXE57_03890(caiD)
SEN: SACE_2852(caiD)
AMQ: AMETH_1235(caiD)
PDX: Psed_2574
PSEE: FRP1_20970
PSEH: XF36_18565
CBAC: JI75_07120
ASC: ASAC_1433
 » show all
Taxonomy
Reference
1  [PMID:11409545]
  Authors
Engemann C, Elssner T, Kleber HP.
  Title
Biotransformation of crotonobetaine to L(-)-carnitine in Proteus sp.
  Journal
Arch Microbiol 175:353-9 (2001)
DOI:10.1007/s002030100272
  Sequence
Reference
2  [PMID:11551212]
  Authors
Elssner T, Engemann C, Baumgart K, Kleber HP
  Title
Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and  a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli.
  Journal
Biochemistry 40:11140-8 (2001)
DOI:10.1021/bi0108812
  Sequence
[eco:b0036]
Reference
3  [PMID:15731894]
  Authors
Engemann C, Elssner T, Pfeifer S, Krumbholz C, Maier T, Kleber HP
  Title
Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp.
  Journal
Arch Microbiol 183:176-89 (2005)
DOI:10.1007/s00203-005-0760-2
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.149
IUBMB Enzyme Nomenclature: 4.2.1.149
ExPASy - ENZYME nomenclature database: 4.2.1.149
BRENDA, the Enzyme Database: 4.2.1.149
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