KEGG   ENZYME: 4.2.1.57
Entry
EC 4.2.1.57                 Enzyme                                 
Name
isohexenylglutaconyl-CoA hydratase;
3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase;
isohexenylglutaconyl coenzyme A hydratase;
beta-isohexenylglutaconyl-CoA-hydratase;
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]
Reaction(IUBMB)
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O [RN:R03493]
Reaction(KEGG)
R03493
Substrate
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA [CPD:C04675]
Product
3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA [CPD:C01291];
H2O [CPD:C00001]
Comment
Also acts on dimethylacryloyl-CoA and farnesoyl-CoA.
History
EC 4.2.1.57 created 1972
Pathway
ec00281  Geraniol degradation
ec01110  Biosynthesis of secondary metabolites
Orthology
K13779  isohexenylglutaconyl-CoA hydratase
Genes
RGLCS053_05365
PAEPA2890(atuE)
PAEVN297_2993
PAEIN296_2993
PAUPA14_26690
PAPPSPA7_2264
PAGPLES_21741(atuE)
PAFPAM18_2073(atuE)
PNCNCGM2_4001
PAEBNCGM1900_3421
PDKPADK2_09920
PSGG655_10355
PRPM062_15480
PAEPPA1S_10960
PAERPA1R_gp0722
PAEMU769_10500
PAELT223_10970
PAESSCV20265_2216
PAEUBN889_03228(atuE)
PAEGAI22_22910
PAECM802_2990
PAEOM801_2858
PMYPmen_2693
PMKMDS_2025
PREPCA10_37640
PPSEBN5_2437
PFUWKF707C_19280
PALCA0T30_09825
PCQPcP3B5_19980(echA8_1)
PMUIG4G71_19930
PFLPFL_4198(atuE)
PPRCPFLCHA0_c42610(echA5)
PPROPPC_4295(atuE)
PFNHZ99_27645
PFOPfl01_3949
PFSPFLU_4396
PFCPflA506_3700(atuE)
PFBVO64_5140
PMANOU5_1499
PTVAA957_22840
PVRPverR02_22375
PAZOAYR47_28665
PRXHRH33_19065
PFWPF1751_v1c38910(atuE)
PFFPFLUOLIPICF716745
PFXA7318_18705
PPUUPputUW4_01474
PDRH681_15885
PSKU771_22890
PKCPKB_3705
PCHEY04_21280
PCZPCL1606_19670
PSOSPOS17_4286(atuE)
PKRAYO71_21560
PFKPFAS1_02935
PANRA7J50_4074
PSETTHL1_3722
PSILPMA3_07215
PYMAK972_1689
PKEDLD99_19840
PALLUYA_10250
PUMHGP31_23190
POJPtoMrB4_17780(atuE)
PGYAWU82_00340
PLALFXN65_18465
PSEJHNQ25_14635
PKHJLK41_10345(atuE)
PTYJWV26_20535
PMAOPMYSY11_2044
PATAJWU58_09110
PZEHU754_020990
PMOEHV782_020190
PCAMHNE05_10000
PSEPC4K39_6116
PVWHU752_023690
PTRTHU722_0020660
PSAMHU731_007040
PTZHU718_021185
PSHHHU773_010440
PHVHU739_020395
PASGKSS96_20310
PAZEKSS91_08300
PWZJ7655_12405(atuE)
PTWTUM18999_18970(atuE)
PIEHU724_019815
HPEGEAO82_15110
MAQMaqu_2806
MHCMARHY2693
MADHP15_2541
MSXAU14_06535
MARIACP86_03035
MLQASQ50_05315
MSQBKP64_01775
MARAD0851_06245
MARJMARI_02970(echA8_1)
ACBA1S_3006
ABMABSDF2869
ABYABAYE0482
ABCACICU_03205
ABNAB57_3457
ABBABBFA_00511(echA8_1)
ABXABK1_3257
ABZABZJ_03389
ABRABTJ_00493
ABDABTW07_3421
ABHM3Q_3438
ABADABD1_28950
ABJBJAB07104_03294
ABABBJAB0715_03357
ABAJBJAB0868_03250
ABAZP795_2375
ABKLX00_16130
ABAUIX87_11725
ABAAIX88_17970
ABWBL01_15700
ACCBDGL_002470(ech2)
ANORR32_02585
ALCOTEC02_02500
ACALBUM88_16985
ASEII8T81_02655
ACDAOLE_02445
ACWA0J50_02390
ACVAMD27_02945
AHLAHTJS_02680
AJNBVL33_14910
ADVDJ533_05380
AWUBEN71_15680
AGUAS4_37350(liuC)
ADSFPL17_17120
ABERBSR55_18365
ALJG8D99_12455
ASHAG8E00_03480
MBAHHYN46_03590
PATPatl_0318
AMHI633_00605
AMBAMBAS45_14995
GAGGlaag_3942
HMIsoil367_12300
SAGAM5M_01895
SNANI6N98_02115
OSGBST96_16505
MICCAUP74_02724(caiD_2)
MIIBTJ40_09630
MICTFIU95_11175(caiD)
MICZGL2_32310(atuE)
KIMG3T16_17330
AFUSEYZ66_13125
LANTTUM19329_30250
CYQQ91_1220
CZACYCME_1208
CYYCPC19_06505
HCHHCH_05751
HAHEENC22_05160
ABOABO_0987(ech2)
ADIB5T_01798(ech2)
APACS7S_10300
ALNAS19_10500
AXEP40_08545
KAKKalk_03350
OAIOLEAN_C05750(ech)
BMARHF888_06875
OMEOLMES_1767
SOKD0B54_13390 D0B54_21520 D0B54_21680
FCEJN531_011725
GPBHDN1F_10700
RPJN234_26495
REHH16_A2138(h16_A2138)
CNCCNE_1c27020
CUHBJN34_26635
REUReut_B4461
RMERmet_1723
CBWRR42_s2503
CCUPBKK81_27005
CUPBKK80_29315
CUUBKK79_35265
COXE0W60_00885
BPSBPSS2033
BPMBURPS1710b_A1151
BPLBURPS1106A_A2776
BPDBURPS668_A2931
BPSEBDL_5456
BPSMBBQ_4088
BPSUBBN_5508
BPSDBBX_4623
BPZBP1026B_II2188
BPQBPC006_II2741
BPKBBK_4784
BPSHDR55_5688
BPSABBU_3965
BPSOX996_5493
BUTX994_5050
BTEBTH_II0287
BTQBTQ_3582
BTJBTJ_4618
BTZBTL_5405
BTDBTI_4953
BTVBTHA_4797
BTHEBTN_5076
BTHMBTRA_5344
BTHADR62_5205
BTHLBG87_5412
BOKDM82_6352
BOCBG90_4322
BUUWS70_27685
BSAVWS86_29380
BULBW21_4481
BUDAQ610_30715
BURKDM992_33055
PMEGFNZ07_28820
AXYAXYL_05147 AXYL_05905 AXYL_06695
AKATKWG_13775
RFRRfer_2816
RSBRS694_04405
RHGEXZ61_04955
ACKC380_03330
ACRABSY15_2085
ARADKI609_03520
VEIVeis_2207 Veis_4192
CTTCtCNB1_1720
CTESO987_10850
CODOLAD35_12085
ADNAlide_0006 Alide_0191
ADKAlide2_0011 Alide2_0180
LIHL63ED372_00597(paaF_2)
HYRBSY239_341
HYBQ5W_16945
HYLLPB072_13945
HPSEHPF_03620(paaF2)
HTNKI616_23290
DIHG7047_04265
SIMPC6571_17635
MELMC7H73_12860
RGERGE_32890
RBNRBXJA2T_12974
PKTAT984_14395
SHDSUTH_02875
NIYFQ775_15165
PMOBHG718_07165
RVARvan_3071
RBMTEF_02215 TEF_19345
PSFPSE_4602
PZUPHZ_p0199
HDHG5B40_00900
GAKX907_0621
SECHB18_27410
SPHGAZE99_15810
SFLASPHFLASMR4Y_02318(caiD)
SPHYCHN51_05355
PARJJ4G78_10640
PHAOHF685_10675
RCERC1_3532
TMOTMO_b0367
PMETG4Y79_18165
SCORJ3U87_30230
 » show all
Reference
1  [PMID:14339651]
  Authors
SEUBERT W, FASS E.
  Title
[STUDIES ON THE BACTERIAL DEGRADATION OF ISOPRENOIDS. IV. THE PURIFICATION AND PROPERTIES OF BETA-ISOHEXENYLGLUTACONYL-COA-HYDRATASE AND BETA-HYDROXY-BETA-ISOHEXENYLGLUTARYL-COA-LYASE.]
  Journal
Biochem Z 341:23-34 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.57
IUBMB Enzyme Nomenclature: 4.2.1.57
ExPASy - ENZYME nomenclature database: 4.2.1.57
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.57
BRENDA, the Enzyme Database: 4.2.1.57
CAS: 37290-84-9
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