| Entry |
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| Name |
L-3-cyanoalanine synthase;
beta-cyanoalanine synthase;
beta-cyanoalanine synthetase;
beta-cyano-L-alanine synthase;
L-cysteine hydrogen-sulfide-lyase (adding HCN)
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| Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
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| Sysname |
L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)
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| Reaction(IUBMB) |
L-cysteine + hydrogen cyanide = L-3-cyanoalanine + hydrogen sulfide [RN: R03524]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
L-3-cyanoalanine [CPD: C02512];
hydrogen sulfide [CPD: C00283]
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| Comment |
Contains pyridoxal phospate.
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| History |
EC 4.4.1.9 created 1972, deleted 1976, reinstated 1978
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K13034 | L-3-cyanoalanine synthase/ cysteine synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Akopyan TN, Braunstein AE, Goryachenkova EV. |
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| Title |
Beta-cyanoalanine synthase: purification and characterization. |
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| Journal |
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| Reference |
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| Authors |
Castric PA, Conn EE. |
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| Title |
Formation of -cyanoalanine by O-acetylserine sulfhydrylase. |
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| Journal |
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| Reference |
3 |
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| Authors |
Hendrickson, H.R. |
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| Title |
The beta-cyanoalanine synthase of blue lupine. |
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| Journal |
Fed Proc 27:593 (1968) |
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| Reference |
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| Authors |
Hendrickson HR, Conn EE. |
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| Title |
Cyanide metabolism in higher plants. IV. Purification and properties of the beta-cyanolanine synthase of blue lupine. |
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| Journal |
J Biol Chem 244:2632-40 (1969) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.4.1.9 |
| ExPASy - ENZYME nomenclature database: | 4.4.1.9 |
| BRENDA, the Enzyme Database: | 4.4.1.9 |
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| LinkDB |
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