KEGG   ENZYME: 5.1.1.24Help
Entry
EC 5.1.1.24                 Enzyme                                 

Name
histidine racemase;
cntK (gene name)
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
BRITE hierarchy
Sysname
histidine racemase
Reaction(IUBMB)
L-histidine = D-histidine [RN:R12313]
Reaction(KEGG)
Substrate
L-histidine [CPD:C00135]
Product
D-histidine [CPD:C06419]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.
History
EC 5.1.1.24 created 2019
Orthology
K01780  histidine racemase
Genes
DFI: AXF13_11085
DPG: DESPIGER_2298
DFL: DFE_2755
DOA: AXF15_03775
SDO: SD1155_03785
BHA: BH2071
LYB: C3943_14835
VNE: CFK40_16070
SAU: SA2258
SAV: SAV2470
SAW: SAHV_2454
SAM: MW2394
SAS: SAS2361
SAR: SAR2557
SAC: SACOL2479
SAE: NWMN_2367
SAD: SAAV_2536
SUJ: SAA6159_02367(dapF)
SUK: SAA6008_02511(dapF)
SUZ: MS7_2483
SUG: SAPIG2520
SAUA: SAAG_00296
SAUS: SA40_2218
SAUU: SA957_2302
SAUG: SA268_2375
SAUF: X998_2454
SAB: SAB2353c
SAUB: C248_2520
SAUC: CA347_2549
SAUR: SABB_02982
SAUI: AZ30_12970
SAUD: CH52_06635
SAMS: NI36_12280
SEP: SE0201
SER: SERP2375
SEPS: DP17_1263
SDT: SPSE_2401
SPAS: STP1_1306
SSCH: LH95_11160
SSCZ: RN70_11910
SAGQ: EP23_10510
PMW: B2K_11195
AIN: Acin_0749
AMI: Amir_3920
 » show all
Taxonomy
Reference
1  [PMID:27230378]
  Authors
Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P
  Title
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
  Journal
Science 352:1105-9 (2016)
DOI:10.1126/science.aaf1018
  Sequence
[sav:SAV2470]
Other DBs
ExplorEnz - The Enzyme Database: 5.1.1.24
IUBMB Enzyme Nomenclature: 5.1.1.24
ExPASy - ENZYME nomenclature database: 5.1.1.24
BRENDA, the Enzyme Database: 5.1.1.24
LinkDB All DBs

DBGET integrated database retrieval system