| Entry |
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| Name |
aldose 1-epimerase;
mutarotase;
aldose mutarotase;
galactose mutarotase;
galactose 1-epimerase;
D-galactose 1-epimerase
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| Class |
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
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| Sysname |
aldose 1-epimerase
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| Reaction(IUBMB) |
alpha-D-glucose = beta-D-glucose [RN: R01602]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. This enzyme catalyses the first step in galactose metabolism by converting beta-D-galactose into alpha-D-galactose, which is the substrate for EC 2.7.1.6, galactokinase [5,6].
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| History |
EC 5.1.3.3 created 1961
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| Pathway |
| ec00010 | Glycolysis / Gluconeogenesis |
| ec01110 | Biosynthesis of secondary metabolites |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
BENTLEY R, BHATE DS. |
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| Title |
Mutarotase from Penicillium notatum. I. Purification, assay, and general properties of the enzyme. |
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| Journal |
J Biol Chem 235:1219-24 (1960) |
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| Reference |
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| Authors |
BENTLEY R, BHATE DS. |
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| Title |
Mutarotase from Penicillium notatum. II. The mechanism of the mutarotation reaction. |
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| Journal |
J Biol Chem 235:1225-33 (1960) |
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| Reference |
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| Authors |
KEILIN D, HARTREE EF. |
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| Title |
Biological catalysis of mutarotation of glucose. |
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| Journal |
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| Reference |
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| Authors |
LEVY GB, COOK ES. |
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| Title |
A rotographic study of mutarotase. |
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| Journal |
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| Reference |
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| Authors |
Beebe JA, Frey PA. |
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| Title |
Galactose mutarotase: purification, characterization, and investigations of two important histidine residues. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Thoden JB, Timson DJ, Reece RJ, Holden HM |
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| Title |
Molecular structure of human galactose mutarotase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Thoden JB, Kim J, Raushel FM, Holden HM. |
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| Title |
The catalytic mechanism of galactose mutarotase. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.1.3.3 |
| ExPASy - ENZYME nomenclature database: | 5.1.3.3 |
| BRENDA, the Enzyme Database: | 5.1.3.3 |
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| LinkDB |
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