Entry |
|
Name |
steroid Delta-isomerase;
hydroxysteroid isomerase;
steroid isomerase;
Delta5-ketosteroid isomerase;
Delta5(or Delta4)-3-keto steroid isomerase;
Delta5-steroid isomerase;
3-oxosteroid isomerase;
Delta5-3-keto steroid isomerase;
Delta5-3-oxosteroid isomerase
|
Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
|
Sysname |
3-oxosteroid Delta5-Delta4-isomerase
|
Reaction(IUBMB) |
a 3-oxo-Delta5-steroid = a 3-oxo-Delta4-steroid [RN: R02644]
|
Reaction(KEGG) |
|
Substrate |
3-oxo-Delta5-steroid [CPD: C01034]
|
Product |
3-oxo-Delta4-steroid [CPD: C00619]
|
Comment |
This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase).
|
History |
EC 5.3.3.1 created 1961
|
Pathway |
ec00140 | Steroid hormone biosynthesis |
ec01120 | Microbial metabolism in diverse environments |
|
Orthology |
K00070 | 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase |
K01822 | steroid Delta-isomerase |
K16045 | 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase |
|
Genes |
» show all
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Reference |
|
Authors |
Ewald W, Werbin H, Chaikoff IL. |
Title |
Evidence for the presence of 17-hydroxypregnenedione isomerase in beef adrenal cortex. |
Journal |
|
Reference |
|
Authors |
KAWAHARA FS, TALALAY P. |
Title |
Crystalline Delta 5-3-ketosteroid isomerase. |
Journal |
J Biol Chem 235:PC1-2 (1960) |
Reference |
|
Authors |
TALALAY P, WANG VS. |
Title |
Enzymic isomerization of delta5-3-ketosteroids. |
Journal |
|
Reference |
|
Authors |
MacLachlan J, Wotherspoon AT, Ansell RO, Brooks CJ |
Title |
Cholesterol oxidase: sources, physical properties and analytical applications. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 5.3.3.1 |
ExPASy - ENZYME nomenclature database: | 5.3.3.1 |
BRENDA, the Enzyme Database: | 5.3.3.1 |
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LinkDB |
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