KEGG   ENZYME: 5.3.3.1Help
Entry
EC 5.3.3.1                  Enzyme                                 

Name
steroid Delta-isomerase;
hydroxysteroid isomerase;
steroid isomerase;
Delta5-ketosteroid isomerase;
Delta5(or Delta4)-3-keto steroid isomerase;
Delta5-steroid isomerase;
3-oxosteroid isomerase;
Delta5-3-keto steroid isomerase;
Delta5-3-oxosteroid isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
3-oxosteroid Delta5-Delta4-isomerase
Reaction(IUBMB)
a 3-oxo-Delta5-steroid = a 3-oxo-Delta4-steroid [RN:R02644]
Reaction(KEGG)
Substrate
3-oxo-Delta5-steroid [CPD:C01034]
Product
3-oxo-Delta4-steroid [CPD:C00619]
Comment
This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase).
History
EC 5.3.3.1 created 1961
Pathway
ec00140  Steroid hormone biosynthesis
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
K01822  steroid Delta-isomerase
K16045  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase
Genes
HSA: 3283(HSD3B1) 3284(HSD3B2)
PTR: 457165 469446
PPS: 100982464(HSD3B2) 100983009 100990187
GGO: 101141801 101146563(HSD3B2)
PON: 100451655 100452394
NLE: 100596087 100605995(HSD3B2) 100606563(HSD3B1) 100607955
MCC: 712686(HSD3B2) 713091(HSD3B1)
MCF: 102129497 102133592(HSD3B1) 102134747 102135110
CSAB: 103224100(HSD3B1) 103224104 103224107 103224109(HSD3B2)
RRO: 104654599 104654605
RBB: 108528160 108528161 108528164
CJC: 100387484 100389654(HSD3B1) 100400416 100405879
SBQ: 101042680 101051416
MMU: 100043456(Gm10681) 15492(Hsd3b1) 15493(Hsd3b2) 15495(Hsd3b4) 15496(Hsd3b5) 15497(Hsd3b6)
RNO: 108348086 24470(Hsd3b5) 29632(Hsd3b2) 360348(Hsd3b1) 682974(Hsd3b3)
CGE: 100770922 100772588 103163008
NGI: 103728305 103732007 103738837
HGL: 101707488(Hsd3b1) 101707858
CCAN: 109702728 109702729
OCU: 100346986 100347914
TUP: 102470981 102471410
CFA: 483146(HSD3B2)
AML: 100464280(HSD3B1)
UMR: 103677123
ORO: 101378904
FCA: 100616070(HSD3B2)
PTG: 102957262
AJU: 106978496
BTA: 281824(HSD3B1)
BOM: 102274088
BIU: 109555859
PHD: 102328070
CHX: 100860869(3BHSD)
OAS: 100190978(HSD3B1)
SSC: 445539(HSD3B1)
CFR: 102512447
CDK: 105089475
BACU: 103015346
LVE: 103083046
OOR: 101284283
ECB: 100034078(HSD3B2)
EPZ: 103548379
EAI: 106832920(HSD3B2)
MYB: 106723550(HSD3B2)
HAI: 109389868(HSD3B2)
RSS: 109446820(HAO2)
PALE: 102891879
LAV: 100659049(HSD3B2)
TMU: 101358325
MDO: 100012668
SHR: 100913530(HSD3B2)
OAA: 100080135
GGA: 396015(HSD3B1)
MGP: 104915630
CJO: 107319373(3beta-HSD)
APLA: 101793560 101803865
ACYG: 106045741
TGU: 751770(HSD3B1)
GFR: 102039409
FAB: 101817697
PHI: 102101526
PMAJ: 107211459
CCAE: 111938581
CCW: 104687106
FPG: 101921564
FCH: 102052697
CLV: 102087460
EGZ: 104126518
AAM: 106497227
ASN: 102367786(HSD3B1)
AMJ: 109280168(HSD3B1)
PSS: 102453952
CMY: 102934871
CPIC: 101946936
ACS: 100561899(hsd3b1)
PVT: 110076926
PBI: 103067418
GJA: 107114856
XLA: 734818(hsd3b1.L)
XTR: 100490622
NPR: 108802532
DRE: 373131(hsd3b2) 553532(hsd3b1)
SRX: 107712267
SANH: 107658243
SGH: 107569293
CCAR: 109052439
IPU: 100304475(HSD3B)
AMEX: 103027852(hsd3b1)
TRU: 101069884(hsd3b1)
TNG: GSTEN00029150G001
LCO: 104921488(hsd3b1)
MZE: 101485719
OLA: 100144358(3bhsd)
XMA: 102228303
PRET: 103477979
NFU: 107389612(hsd3b1)
KMR: 108244192(hsd3b1)
CSEM: 103391994(hsd3b1)
LCF: 108902437
SDU: 111218347
HCQ: 109522071
BPEC: 110156192(hsd3b1)
MALB: 109951646
SASA: 106586600
OTW: 112240651
ELS: 105016430
SFM: 108937872
LCM: 102345588
CMK: 103180179
BFO: BRAFLDRAFT_221648
DME: Dmel_CG7724(CG7724)
DPO: Dpse_GA20545
DAN: Dana_GF10105 Dana_GF19644
DER: 6543694
DSE: Dsec_GM25688
DSI: Dsimw501_GD14693(Dsim_GD14693)
DWI: 6645028
DYA: Dyak_GE19901
DGR: Dgri_GH16404
DMO: Dmoj_GI12485
DVI: Dvir_GJ12388
MDE: 101899660
AGA: AgaP_AGAP006654
AAG: 5566270
CQU: CpipJ_CPIJ003056
NVI: 100120136
CLEC: 106661338
ZNE: 110831195
FCD: 110862702
ISC: IscW_ISCW018715
TUT: 107363285
HRO: HELRODRAFT_89375
CRG: 105332656 105336240
MYI: 110457155
LAK: 106151343
PRE: PCA10_13780(ksi)
PVR: PverR02_11605
PPUU: PputUW4_01655
PKC: PKB_4244
PSET: THL1_1429
SPL: Spea_2174
SHL: Shal_2145
SPOI: IMCC21906_02012
ZAL: AZF00_08390
OSG: BST96_05805
HJA: BST95_12875 BST95_17215
KAK: Kalk_07505
SDF: ACG33_03815
SOK: D0B54_00185 D0B54_09480
GPB: HDN1F_02730(ksi)
REU: Reut_A1514
REH: H16_B0602(h16_B0602)
CNC: CNE_2c05470
CTI: RALTA_B0406
CBW: RR42_s2306
BFN: OI25_4583
AJS: Ajs_2963
DIA: Dtpsy_2390
CTT: CtCNB1_1323
CTES: O987_07595
CSER: CCO03_15920
AZO: azo3316
XAU: Xaut_1492
HNE: HNE_1461
NAR: Saro_3596 Saro_3765
NPP: PP1Y_Mpl2956
NOV: TQ38_027200 TQ38_027400
SWI: Swit_3295
SPHD: HY78_09075
SPHM: G432_01540 G432_04695 G432_04850
SSAN: NX02_14810
SPKC: KC8_00670 KC8_01015 KC8_01175 KC8_03160 KC8_10955 KC8_13360
SPHB: EP837_02960 EP837_03245 EP837_03374
SPHG: AZE99_02185
SFLA: SPHFLASMR4Y_01939(ksi)
SPHY: CHN51_03380
ERK: CD351_14410
PHZ: CHX26_05225
OIH: OB0288
MTU: Rv0760c Rv1106c
MTV: RVBD_0760c RVBD_1106c
MTC: MT0785 MT1137
MRA: MRA_0770 MRA_1117
MTF: TBFG_10775 TBFG_11128
MTB: TBMG_00775 TBMG_02877
MTK: TBSG_00779 TBSG_02893
MTZ: TBXG_000768 TBXG_002857
MTG: MRGA327_04735 MRGA327_06925
MTI: MRGA423_04755 MRGA423_06915
MTE: CCDC5079_0703 CCDC5079_1022
MTUR: CFBS_0799 CFBS_1174
MTL: CCDC5180_0695 CCDC5180_1014
MTO: MTCTRI2_0779 MTCTRI2_1136
MTD: UDA_0760c UDA_1106c
MTN: ERDMAN_0842 ERDMAN_1239
MTJ: J112_04090 J112_05975
MTUB: MT7199_0781 MT7199_1133
MTUC: J113_05370 J113_07785
MTUE: J114_04060 J114_05980
MTX: M943_03980 M943_05820
MTUH: I917_05390 I917_07855
MTUL: TBHG_00752 TBHG_01091
MTUT: HKBT1_0799 HKBT1_1172
MTUU: HKBT2_0800 HKBT2_1178
MTQ: HKBS1_0799 HKBS1_1174
MBO: BQ2027_MB0783C BQ2027_MB1136C
MBB: BCG_0812c BCG_1166c
MBT: JTY_0782 JTY_1139
MBM: BCGMEX_0783c BCGMEX_1138c
MBK: K60_008130 K60_011910
MBX: BCGT_0561 BCGT_0934
MAF: MAF_07720 MAF_11210
MMIC: RN08_0849 RN08_1242
MCE: MCAN_07641 MCAN_11161
MCQ: BN44_10830 BN44_11231
MCV: BN43_20195 BN43_30163
MCX: BN42_20518 BN42_20954
MCZ: BN45_20029 BN45_30150
MLE: ML1942
MLB: MLBr01942
MPA: MAP_0594c MAP_2478 MAP_2688 MAP_2705c
MAO: MAP4_1111 MAP4_1128 MAP4_1345 MAP4_3271
MAVI: RC58_05520 RC58_05605 RC58_06655 RC58_16235
MAVU: RE97_05515 RE97_05600 RE97_06645 RE97_16265
MAV: MAV_0704 MAV_1209 MAV_1225 MAV_1444
MIT: OCO_05970 OCO_11160 OCO_11340 OCO_15430
MIA: OCU_06010 OCU_11140 OCU_11320 OCU_15870
MID: MIP_01077 MIP_01799 MIP_01824 MIP_02150
MYO: OEM_06060 OEM_11270 OEM_11450 OEM_13520
MIR: OCQ_06120 OCQ_11170 OCQ_11350 OCQ_13340
MCHI: AN480_02980 AN480_06660 AN480_06750 AN480_07710
MMAL: CKJ54_02920 CKJ54_05425 CKJ54_05520 CKJ54_06510
MLP: MLM_0827 MLM_1173 MLM_1377
MSA: Mycsm_05045 Mycsm_05075 Mycsm_05686
MUL: MUL_0172 MUL_0195 MUL_0468
MMC: Mmcs_4109 Mmcs_4139 Mmcs_4586
MKM: Mkms_4185 Mkms_4214 Mkms_4674
MJL: Mjls_4340 Mjls_4370 Mjls_4969
MMI: MMAR_4359 MMAR_4382 MMAR_4937
MMAE: MMARE11_41790 MMARE11_42020 MMARE11_47470
MMM: W7S_02930 W7S_05455 W7S_05545 W7S_06520
MLI: MULP_04570 MULP_04597 MULP_05181
MKN: MKAN_07985 MKAN_08100 MKAN_11300
MYV: G155_04240 G155_05080 G155_22700 G155_22900
MYE: AB431_06300 AB431_06460 AB431_26000
MHAD: B586_05030 B586_07090
MYN: MyAD_21005 MyAD_21100 MyAD_23425
MDX: BTO20_08205 BTO20_08365 BTO20_30850
MSM: MSMEG_5228 MSMEG_5258 MSMEG_5867
MSG: MSMEI_5091 MSMEI_5120 MSMEI_5708
MSB: LJ00_25860 LJ00_26005 LJ00_29015
MSN: LI99_25865 LI99_26010 LI99_29020
MSH: LI98_25870 LI98_26015 LI98_29025
MVA: Mvan_4635 Mvan_4664 Mvan_5165
MGI: Mflv_1592 Mflv_2053 Mflv_2075
MSP: Mspyr1_09780 Mspyr1_14770 Mspyr1_14990
MCB: Mycch_4050 Mycch_4076 Mycch_4526
MNE: D174_21420 D174_21515 D174_23880
MGO: AFA91_11385 AFA91_14335 AFA91_14490
MFT: XA26_08050 XA26_09800 XA26_46570 XA26_46970
MPHL: MPHLCCUG_00647 MPHLCCUG_04229 MPHLCCUG_04255(ksi)
MVQ: MYVA_4444 MYVA_4490 MYVA_5047
MLL: B1R94_06275 B1R94_06430 B1R94_24625
MRH: MycrhN_2406 MycrhN_3525 MycrhN_3550
MTHN: 4412656_03537 4412656_03575(ksi_2) 4412656_03992
MAB: MAB_1206
MMV: MYCMA_0644
MABB: MASS_1204
MABL: MMASJCM_1233
MCHE: BB28_05990
MIZ: BAB75_06575
MSTE: MSTE_01173
MSAO: MYCSP_05320
MJD: JDM601_1031 JDM601_1056
MTER: 4434518_01017(ksi_1) 4434518_01040
ASD: AS9A_0954
NFA: NFA_13370 NFA_22430
NFR: ERS450000_01854(ksi_1) ERS450000_02770(ksi_2)
NCY: NOCYR_1399(ksdI) NOCYR_2411
NBR: O3I_008870 O3I_012175
NNO: NONO_c36120 NONO_c59430(ksdI)
NSL: BOX37_11780
NSR: NS506_06879
RHA: RHA1_ro03609 RHA1_ro09001
RER: RER_13740(ksi) RER_59940
REY: O5Y_06470 O5Y_28730
REB: XU06_06730 XU06_08140 XU06_29060
ROP: ROP_34080(ksi)
ROA: Pd630_LPD08001
REQ: REQ_00120 REQ_46990
RPY: Y013_10750 Y013_14870 Y013_16310
RAV: AAT18_20785 AAT18_26480
RHW: BFN03_18225
RRZ: CS378_10130 CS378_15850
RQI: C1M55_06975 C1M55_30540
RHQ: IM25_02490 IM25_06195
RHOD: AOT96_10190 AOT96_17370
RRT: 4535765_04040(ksi_1) 4535765_04891(ksi_2)
GBR: Gbro_4817
GPO: GPOL_c41280(ksdI) GPOL_c49840
GOR: KTR9_4702
GOQ: ACH46_03070 ACH46_20535
GTA: BCM27_04880 BCM27_24895
GOC: CXX93_03165
GIT: C6V83_01325
DTM: BJL86_3299
DIT: C3V38_06125
DIZ: CT688_16895
DPC: A6048_17485
DLU: A6035_16835
SGR: SGR_6072
SVL: Strvi_3968
SALS: SLNWT_0271
SRC: M271_05600 M271_05605
STRC: AA958_00655
SAUO: BV401_39990
SMAL: SMALA_7276 SMALA_7277
NCA: Noca_3954
NDK: I601_0503(ksi)
PSIM: KR76_23530 KR76_27120
FAL: FRAAL4373
SEN: SACE_4441
AMYC: CU254_23470
SAQ: Sare_2441
CYN: Cyan7425_3259
MIC: Mic7113_3670
MPRO: BJP34_04745
NON: NOS3756_37870
NOE: CLI64_13960
CALO: Cal7507_5935
RIV: Riv7116_4576 Riv7116_5342
FIS: FIS3754_26380
TRS: Terro_1090
NMV: NITMOv2_2424
NGA: Ngar_c20430
 » show all
Taxonomy
Reference
1  [PMID:5867327]
  Authors
Ewald W, Werbin H, Chaikoff IL.
  Title
Evidence for the presence of 17-hydroxypregnenedione isomerase in beef adrenal cortex.
  Journal
Biochim Biophys Acta 111:306-12 (1965)
DOI:10.1016/0304-4165(65)90497-6
Reference
2  [PMID:14404954]
  Authors
KAWAHARA FS, TALALAY P.
  Title
Crystalline Delta 5-3-ketosteroid isomerase.
  Journal
J Biol Chem 235:PC1-2 (1960)
Reference
3  [PMID:13276386]
  Authors
TALALAY P, WANG VS.
  Title
Enzymic isomerization of delta5-3-ketosteroids.
  Journal
Biochim Biophys Acta 18:300-1 (1955)
Reference
4  [PMID:10822008]
  Authors
MacLachlan J, Wotherspoon AT, Ansell RO, Brooks CJ
  Title
Cholesterol oxidase: sources, physical properties and analytical applications.
  Journal
J Steroid Biochem Mol Biol 72:169-95 (2000)
DOI:10.1016/S0960-0760(00)00044-3
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.1
IUBMB Enzyme Nomenclature: 5.3.3.1
ExPASy - ENZYME nomenclature database: 5.3.3.1
BRENDA, the Enzyme Database: 5.3.3.1
CAS: 9031-36-1
LinkDB All DBs

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