| Entry |
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| Name |
isopentenyl-diphosphate Delta-isomerase;
isopentenylpyrophosphate Delta-isomerase;
methylbutenylpyrophosphate isomerase;
isopentenylpyrophosphate isomerase
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
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| Sysname |
isopentenyl-diphosphate Delta3-Delta2-isomerase
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| Reaction(IUBMB) |
isopentenyl diphosphate = dimethylallyl diphosphate [RN: R01123]
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| Reaction(KEGG) |
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| Substrate |
isopentenyl diphosphate [CPD: C00129]
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| Product |
dimethylallyl diphosphate [CPD: C00235]
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| Comment |
The enzyme from Streptomyces sp. strain CL190 requires FMN and NAD(P)H as cofactors. Activity is reduced if FMN is replaced by FAD, but the enzyme becomes inactive when NAD(P)H is replaced by NAD+ or NADP+. That enzyme also requires Mg2+, Mn2+ or Ca2+ for activity.
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| History |
EC 5.3.3.2 created 1961, modified 2002
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| Pathway |
| ec00900 | Terpenoid backbone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K01823 | isopentenyl-diphosphate Delta-isomerase |
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| Genes |
» show all
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| Reference |
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| Authors |
Kaneda K, Kuzuyama T, Takagi M, Hayakawa Y, Seto H |
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| Title |
An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Bishop JM. |
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| Title |
Cellular oncogenes and retroviruses. |
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| Journal |
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| Reference |
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| Authors |
AGRANOFF BW, EGGERER H, HENNING U, LYNEN F. |
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| Title |
Biosynthesis of terpenes. VII. Isopentenyl pyrophosphate isomerase. |
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| Journal |
J Biol Chem 235:326-32 (1960) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.3.2 |
| ExPASy - ENZYME nomenclature database: | 5.3.3.2 |
| BRENDA, the Enzyme Database: | 5.3.3.2 |
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| LinkDB |
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