KEGG   ENZYME: 6.2.1.9
Entry
EC 6.2.1.9                  Enzyme                                 

Name
malate---CoA ligase;
malyl-CoA synthetase;
malyl coenzyme A synthetase;
malate thiokinase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
malate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + malate + CoA = ADP + phosphate + malyl-CoA [RN:R01256]
Reaction(KEGG)
R01256
Substrate
ATP [CPD:C00002];
malate [CPD:C00149];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
malyl-CoA [CPD:C04348]
History
EC 6.2.1.9 created 1972
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08692  malate-CoA ligase subunit alpha
K14067  malate-CoA ligase subunit beta
Genes
MCA: MCA1740(sucC-2) MCA1741(sucD-2)
METU: GNH96_10425(sucC)
MMT: Metme_2693 Metme_2694
MDN: JT25_000145 JT25_000150(sucC)
MDH: AYM39_08395(sucC) AYM39_08400
MKO: MKLM6_1753 MKLM6_1754
METL: U737_10265 U737_10270(sucD)
MAH: MEALZ_3215(mtkB) MEALZ_3216(mtkA)
MBUR: EQU24_04635 EQU24_04640(sucD)
MPSY: CEK71_18040 CEK71_18045
MMAI: sS8_2224
MMOB: F6R98_20175(sucC)
TSN: W908_06420 W908_06425(sucC)
BPH: Bphy_5926 Bphy_5927
BCAI: K788_0001576 K788_0001577
PHS: C2L64_21715 C2L64_21720
PTER: C2L65_26275 C2L65_26280
MPT: Mpe_A3256 Mpe_A3257
METP: C1M51_05905 C1M51_05910
NEU: NE1810 NE1811
NET: Neut_0605 Neut_0606
NIT: NAL212_0421 NAL212_0422
NII: Nit79A3_0104 Nit79A3_0105
NCO: AAW31_08290(sucC) AAW31_08295
NUR: ATY38_03745 ATY38_03750(sucC)
NST: Nstercoris_01829 Nstercoris_01830
NMU: Nmul_A1079 Nmul_A1080
NLC: EBAPG3_012570 EBAPG3_012575
METR: BSY238_255(sucD) BSY238_256(sucC)
NIM: W01_13790(sucC_1)
FMY: HO273_03885 HO273_03890(sucD)
MLO: mlr1324 mlr1326
MLN: A9174_19855 A9174_19860
MOP: Mesop_3791 Mesop_3792
MAM: Mesau_03582 Mesau_03583
MAMO: A6B35_22115(sucC) A6B35_22120
MESP: C1M53_18675 C1M53_18680
MHUA: MCHK_2943 MCHK_2944(sucD)
MJR: EB229_19615(sucD) EB229_19620
MERD: EB233_16960(sucD) EB233_16965
AAK: AA2016_5787 AA2016_5788
AMIH: CO731_05426(sucC_2) CO731_05427(sucD_2)
PHT: BLM14_27155 BLM14_27160
RHI: NGR_c26240 NGR_c26250
SFH: SFHH103_02475(succ1) SFHH103_02476(sucd1)
SFD: USDA257_c22010(mtkB) USDA257_c22020(mtkA)
SAME: SAMCFNEI73_pC0657(mtkA) SAMCFNEI73_pC0658(mtkB)
SINO: SS05631_b61270 SS05631_b61280
ESJ: SJ05684_b48790 SJ05684_b48800
EAK: EKH55_4316 EKH55_4317
LNE: FZC33_08685(sucD) FZC33_08690
MEA: Mex_1p1730(mtkA) Mex_1p1731(mtkB)
MDI: METDI2482(mtkA) METDI2483(mtkB)
MEX: Mext_1799 Mext_1800
MCH: Mchl_2135 Mchl_2136
MPO: Mpop_1751 Mpop_1752
MZA: B2G69_16655 B2G69_16660
MRD: Mrad2831_3665 Mrad2831_3666
MET: M446_6556 M446_6557
MNO: Mnod_7116 Mnod_7117
MOR: MOC_4188 MOC_4189
META: Y590_08600(sucC) Y590_08605
MAQU: Maq22A_c19260(mtkB) Maq22A_c19265(mtkA)
MPHY: MCBMB27_03147 MCBMB27_03148
MEE: DA075_26540 DA075_26545
METD: C0214_10365 C0214_10370
METX: A3862_13155 A3862_13160
METS: DK389_15345 DK389_15350
METI: DK427_15540 DK427_15545
MMES: MMSR116_21300
MTEA: DK419_14275 DK419_14280
MSL: Msil_1716 Msil_1717
MTUN: MTUNDRAET4_3404 MTUNDRAET4_3406(mtkA)
MLG: CWB41_04705 CWB41_04710
BBAR: RHAL1_03823(sucC_2) RHAL1_03824(sucD_2)
HDN: Hden_3151 Hden_3152
HDT: HYPDE_38933 HYPDE_38938
HMC: HYPMC_4393(mtkB) HYPMC_4394(mtkA)
HNI: W911_15810(sucC) W911_15815
FIL: BN1229_v1_1241(sucC) BN1229_v1_1242(sucD) BN1229_v1_2531(mtkA)
FIY: BN1229_v1_1239(sucC) BN1229_v1_1240(sucD) BN1229_v1_3385(mtkA)
MSC: BN69_1173 BN69_1174(sucC1)
MBRY: B1812_17525 B1812_17530
MROS: EHO51_12195(sucD) EHO51_12200
MHEY: H2LOC_011815(sucD) H2LOC_011820
MPAR: F7D14_09160 F7D14_09165(sucD)
MTW: CQW49_12220 CQW49_12225
PLEO: OHA_1_00679(sucD_1) OHA_1_00680(sucC_1)
MCG: GL4_3373 GL4_3374
HDI: HDIA_2218(sucC_1) HDIA_2219(sucD_2)
NOH: G5V57_12990(sucD) G5V57_12995
METG: HT051_02830 HT051_02835(sucD)
SIL: SPO1568 SPO1569
RUA: D1823_20505 D1823_20510
RUT: FIU92_19880(sucD2) FIU92_19885(sucC2)
RDE: RD1_1162(mtkA) RD1_4246(mtkB)
RLI: RLO149_c036810(mtkB) RLO149_c036820(mtkA)
PAMI: JCM7686_2766 JCM7686_2767
PZH: CX676_04825 CX676_04830
PAMN: pAMV1p0131(mtkA) pAMV1p0132(mtkB)
DSH: Dshi_2491(sucC2) Dshi_2492(sucD2)
LMD: METH_18370 METH_18375(sucC)
LEJ: ETW24_17890(sucD) ETW24_17895
LAQU: R2C4_19805 R2C4_19810(sucD)
RED: roselon_02261 roselon_02262
CID: P73_3959 P73_3960
RMM: ROSMUCSMR3_01020(sucC) ROSMUCSMR3_03453(sucD) ROSMUCSMR3_03454(sucC)
ROK: RAK1035_2338 RAK1035_2339 RAK1035_3888
RID: RIdsm_02780(sucC_1) RIdsm_02781(sucD_1)
ROM: EI983_08260(sucD) EI983_08265
ROH: FIU89_03745(sucC1) FIU89_11590(sucC3) FIU89_11595(sucD3)
RBG: BG454_05620 BG454_05625
SAGU: CDO87_15510 CDO87_15515
GEH: HYN69_16135 HYN69_16140
TAW: EI545_00085 EI545_00090(sucD)
PAED: G5B38_01655(sucD) G5B38_01660
MALU: KU6B_14470(sucC_1) KU6B_14480 KU6B_40000 KU6B_40010(sucC_2)
GBE: GbCGDNIH1_0052 GbCGDNIH1_0053
GBH: GbCGDNIH2_0052 GbCGDNIH2_0053
GBC: GbCGDNIH3_0052 GbCGDNIH3_0053
GBS: GbCGDNIH4_0052 GbCGDNIH4_0053
 » show all
Reference
1  [PMID:14244056]
  Authors
MUE S, TUBOI S, KIKUCHI G.
  Title
ON MALYL-COENZYME A SYNTHETASE.
  Journal
J Biochem 56:545-51 (1964)
DOI:10.1093/oxfordjournals.jbchem.a128032
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.9
IUBMB Enzyme Nomenclature: 6.2.1.9
ExPASy - ENZYME nomenclature database: 6.2.1.9
BRENDA, the Enzyme Database: 6.2.1.9
CAS: 37318-58-4
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