| Entry |
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| Name |
staphyloferrin A synthase;
sfnaB (gene name)
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| Class |
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
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| Sysname |
N5-[(S)-citryl]-D-ornithine:citrate ligase (staphyloferrin A-forming)
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| Reaction(IUBMB) |
ATP + N5-[(S)-citryl]-D-ornithine + citrate = AMP + diphosphate + staphyloferrin A [RN: R12354]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation.
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| History |
EC 6.3.2.57 created 2019
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| Pathway |
| ec00997 | Biosynthesis of various secondary metabolites - part 3 |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K23447 | staphyloferrin A synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Cotton JL, Tao J, Balibar CJ |
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| Title |
Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.3.2.57 |
| ExPASy - ENZYME nomenclature database: | 6.3.2.57 |
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| LinkDB |
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