Entry
Name
glutamate---[amino group carrier protein] ligase;
argX (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
L-glutamate:an [amino-group carrier protein]-C-terminal-L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + L-glutamate + an [amino-group carrier protein]-C-terminal-L-glutamate = ADP + phosphate + an [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate [RN:
R10929 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
L-glutamate [CPD:
C00025 ];
[amino-group carrier protein]-C-terminal-L-glutamate
Product
ADP [CPD:
C00008 ];
phosphate [CPD:
C00009 ];
[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate
Comment
The enzyme, originally characterized from the archaeon Sulfolobus acidocaldarius, is involved in L-arginine biosynthesis. The enzyme from the archaeon Thermococcus kodakarensis is bifunctional and also catalyses the activity of EC
6.3.2.43 , [amino-group carrier protein]---L-2-aminoadipate ligase.
History
EC 6.3.2.60 created 2021
Pathway
Orthology
K19412 glutamate---[amino group carrier protein] ligase
K25032 alpha-aminoadipate-LysW ligase/glutamate-LysW ligase
Genes
HALR : EFA46_004295(lysX) EFA46_005465(lysX)
HALA : Hrd1104_12295(lysX)
HARC : HARCEL1_01525(lysX)
HALQ : Hrr1229_007375(lysX)
HACB : Hbl1158_01725(lysX)
» show all
Taxonomy
Reference
Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
Journal
Sequence
Reference
Authors
Yoshida A, Tomita T, Atomi H, Kuzuyama T, Nishiyama M
Title
Lysine Biosynthesis of Thermococcus kodakarensis with the Capacity to Function as an Ornithine Biosynthetic System.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.60
ExPASy - ENZYME nomenclature database: 6.3.2.60
LinkDB
All DBs