KEGG   ENZYME: 6.3.2.60
Entry
EC 6.3.2.60                 Enzyme                                 
Name
glutamate---[amino group carrier protein] ligase;
argX (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
L-glutamate:an [amino-group carrier protein]-C-terminal-L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + L-glutamate + an [amino-group carrier protein]-C-terminal-L-glutamate = ADP + phosphate + an [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate [RN:R10929]
Reaction(KEGG)
R10929
Substrate
ATP [CPD:C00002];
L-glutamate [CPD:C00025];
[amino-group carrier protein]-C-terminal-L-glutamate
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate
Comment
The enzyme, originally characterized from the archaeon Sulfolobus acidocaldarius, is involved in L-arginine biosynthesis. The enzyme from the archaeon Thermococcus kodakarensis is bifunctional and also catalyses the activity of EC 6.3.2.43, [amino-group carrier protein]---L-2-aminoadipate ligase.
History
EC 6.3.2.60 created 2021
Pathway
ec00220  Arginine biosynthesis
ec01100  Metabolic pathways
Orthology
K19412  glutamate---[amino group carrier protein] ligase
K25032  alpha-aminoadipate-LysW ligase/glutamate-LysW ligase
Genes
TFRIThiofri_01654
MIGMetig_0633
MVNMevan_0912
MOKMetok_1139
METFCFE53_00515
PFUPF1682
PFIPFC_10195
PHOPH1721(PH1721)
PABPAB0290(rimK)
PYNPNA2_0329 PNA2_0499
PYSPy04_1636
TKOTK0278
THSTES1_0507
THVADU37_CDS10050
TCHCHITON_1979
THEIK1720_00615(lysX)
HDLHALDL1_01655
HHBHhub_3648(argX)
HNOLT974_00080(lysX)
HLULT972_14180(lysX)
HALHHTSR_2057(lysX)
HHSRHSR6_2133(lysX)
HSUHLASF_2137(argA)
HSFHLASA_2171(argA)
HAHSHSRCO_2859(rimK3)
SALRFQU85_04735(lysX)
HALREFA46_004295(lysX) EFA46_005465(lysX)
HJEHacjB3_00990
HDOMUK72_02365(lysX)
HALXM0R89_05925(lysX)
HAXZM0R88_06110(lysX)
HAYCNGM10_09020(lysX)
HAXYNGM07_11160(lysX)
SALIL593_07885
SAIMK0C01_05795(lysX)
HARAAArcS_3061(rimK3)
HMArrnAC2679(rimK)
HHIHAH_3083(argX)
HHNHISP_15695
HABSG26_07790
HTABVU17_15005
HALJG9465_02505(lysX)
HSINKDQ40_13795
NPHNP_5258A(argX)
NMONmlp_1243(argX)
NHOHWV23_08510(lysX)
NSALHWV07_10855(lysX)
HUTHuta_1502
HTIHTIA_1539
HALAHrd1104_12295(lysX)
HASVSVXHr_0124(lysX)
HABNHBNXHr_0121(lysX)
HMUHmuk_0772
HALZE5139_07045
HALLLC1Hm_3288(lysX)
HAZPGBQ70_07040
HALIBV210_07075
HSNDV733_03395(lysX)
HDSHSR122_1705(rimK2)
HRRHZS55_04375(lysX)
HPELHZS54_04325(lysX)
HLTI7X12_08365(lysX)
HARCHARCEL1_01525(lysX)
SSAIN0B31_18450(lysX)
HAADMW046_06605(lysX)
HWAHQ_3714A(argX)
HWCHqrw_4129(argX)
HVOHVO_0046(argX)
HMEHFX_0047(argX)
HGIABY42_00220
HALEG3A49_00610(lysX)
HLSKU306_04870(lysX)
HLNSVXHx_0044(lysx)
HBOHbor_01730
HAQDU484_03085(lysX)
HAJDU500_03525(lysX)
HAERDU502_01270(lysX)
HRAEI982_12725(lysX)
HLMDV707_00740(lysX)
HALMFCF25_06925(lysX)
HLAHlac_2616
HALPDOS48_13135(lysX)
HALBEKH57_10855
HEZZEO776_15095(lysX)
HALQHrr1229_007375(lysX)
HSSJ7656_01825(lysX)
HSAIHPS36_07360(lysX)
HAZZKI388_13080(lysX)
SRUBC2R22_20780(lysX)
HAEhalTADL_1873
HALNB4589_001575(lysX)
HALGHUG10_12795
HALUHUG12_02040(lysX)
HMPK6T50_10115(lysX)
HREK6T36_09880(lysX)
HRMK6T25_06300(lysX)
HACBHbl1158_01725(lysX)
HDFAArcSl_0043(lysX)
HAAAAArcCO_0045(rimK)
HAHHalar_1202
HTUHtur_0328
HSALJMJ58_07535(lysX)
HAKZJ0X25_08135(lysX)
NMGNmag_1761(argX)
HXAHalxa_1378
NATNJ7G_0263(argX)
NPENatpe_3686
NVRFEJ81_17605(lysX)
NPLFGF80_16430(lysX)
NAYHYG81_11420(lysX)
HALYHYG82_14935(lysX)
HJTDVR14_08510(lysX)
HLOJ0X27_11130(lysX)
NGENatgr_1612
HRUHalru_0399
SAWLNGM29_05185(lysX)
HALVNGM15_14810(lysX)
NOUNatoc_0148
HLRHALLA_05490
HLCCHINAEXTREME04215
NAJB1756_08250
NAGAArcMg_3554
NANAArc1_3498
NARAQQ977_06795(lysX)
NBGDV706_07690(lysX)
NASGCU68_05005(lysX)
HDABB347_12550
FAIFAD_1383
IHOIgni_1403
IISEYM_00645
IPCIPA_04145
PFMPyrfu_0756
PDLPyrde_0370
PABIPABY_00970(lysX_1)
PAREPYJP_02380(lysX_1)
STOSTK_15050(argE)
SOHD1869_08455(lysX)
SSOSSO0645(rimK-2)
SOLSsol_1704
SSOASULA_1732(lysX)
SSOLSULB_1733(lysX)
SSOFSULC_1731(lysX)
SSHIJ5U23_02762
SCASSACC_03370
SAISaci_1621
SACNSacN8_07870
SACRSacRon12I_07880
SACSSUSAZ_07680
SISLS215_1600
SIAM1425_1492
SIMM1627_1607
SIDM164_1489
SIYYG5714_1496
SINYN1551_1340
SIILD85_1699
SIHSiH_1458
SIRSiRe_1368
SICSiL_1371
SULABFU36_02820
SULEGFS03_08525(lysX)
SULOGFS33_00300(lysX)
SULLEWF20_09625(lysX)
MSEMsed_1991
MEMJMJ1HA_2259
MCNMcup_0295
MHKDFR87_08550(lysX)
MPRUDFR88_08220(lysX)
MTENGWK48_03775(lysX)
MJNMjAS7_0291
AHOAhos_1105
AMANB6F84_09595
ABRIDFR85_09220(lysX)
ASULDFR86_08280(lysX)
AAMBD1866_00395(lysX)
ACIHHS5_25000
SACDHS1genome_0140
SAZOD1868_05495(lysX)
CSTYKN1_27050
STEPIC006_1362
SMETRQ359_000549(lysX)
PYRP186_2397
TNETneu_0136
PYWPYWP30_00148
TUZTUZN_1890
VDIVdis_0196
VMOVMUT_1535
CSUCSUB_C0076
NAANps_00535
 » show all
Reference
1  [PMID:23434852]
  Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
  Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
  Journal
Nat Chem Biol 9:277-83 (2013)
DOI:10.1038/nchembio.1200
  Sequence
[sai:Saci_1621]
Reference
2  [PMID:27566549]
  Authors
Yoshida A, Tomita T, Atomi H, Kuzuyama T, Nishiyama M
  Title
Lysine Biosynthesis of Thermococcus kodakarensis with the Capacity to Function as an Ornithine Biosynthetic System.
  Journal
J Biol Chem 291:21630-21643 (2016)
DOI:10.1074/jbc.M116.743021
  Sequence
[tko:TK0278]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.60
IUBMB Enzyme Nomenclature: 6.3.2.60
ExPASy - ENZYME nomenclature database: 6.3.2.60
BRENDA, the Enzyme Database: 6.3.2.60
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