KEGG   ENZYME: 6.5.1.9
Entry
EC 6.5.1.9                  Enzyme                                 

Name
cyclic 2,3-diphosphoglycerate synthase;
cpgS (gene name)
Class
Ligases;
Forming phosphoric-ester bonds;
Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
Sysname
(2R)-2,3-bisphosphoglycerate ligase (cyclizing)
Reaction(IUBMB)
ATP + 2,3-diphospho-D-glycerate = ADP + phosphate + cyclic 2,3-bisphosphoglycerate [RN:R03298]
Reaction(KEGG)
R03298
Substrate
ATP [CPD:C00002];
2,3-diphospho-D-glycerate [CPD:C01159]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
cyclic 2,3-bisphosphoglycerate [CPD:C06189]
Comment
The enzyme is present in a number of methanogenic archaeal genera that accumulate cyclic 2,3-bisphosphoglycerate as a thermoprotectant. Activity is stimulated by potassium ions.
History
EC 6.5.1.9 created 2020
Orthology
K05716  cyclic 2,3-diphosphoglycerate synthase
Genes
RXY: Rxyl_1657
RRD: RradSPS_1599
RUB: GBA63_11675
MTH: MTH_223
MMG: MTBMA_c06720
METC: MTCT_0185
MWO: MWSIV6_0635(cpgS)
METE: tca_00203(cpgS)
METZ: METMT2_0667
METK: FVF72_01190
MST: Msp_0129
MRU: mru_1017
MSI: Msm_0091
MEB: Abm4_0688
MMIL: sm9_0977(cpgS)
MEYE: TL18_05485
MOL: YLM1_0561
METH: MBMB1_1062(cpgS)
MFC: BRM9_1264
MFI: DSM1535_1947(cpgS)
MCUB: MCBB_0929(cpgS)
MFV: Mfer_0077
MKA: MK0505
PFU: PF0079
PFI: PFC_07805
PHO: PH0150(PH0150)
PAB: PAB2252
PYN: PNA2_0686
PYS: Py04_0158
TKO: TK1039
TON: TON_0743
TGA: TGAM_0725(cdpgs)
TSI: TSIB_0160
THE: GQS_01210
THA: TAM4_882
THM: CL1_1940
TLT: OCC_11502
TNU: BD01_0984
TEU: TEU_10715
PPAC: PAP_07615
 » show all
Reference
1  [PMID:2226838]
  Authors
Lehmacher A, Vogt AB, Hensel R
  Title
Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of  2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus.
  Journal
FEBS Lett 272:94-8 (1990)
DOI:10.1016/0014-5793(90)80456-s
Reference
2  [PMID:9811660]
  Authors
Matussek K, Moritz P, Brunner N, Eckerskorn C, Hensel R.
  Title
Cloning, sequencing, and expression of the gene encoding cyclic 2, 3-diphosphoglycerate synthetase, the key enzyme of cyclic 2, 3-diphosphoglycerate metabolism in Methanothermus fervidus.
  Journal
J Bacteriol 180:5997-6004 (1998)
DOI:10.1128/JB.180.22.5997-6004.1998
  Sequence
[mfv:Mfer_0077]
Other DBs
ExplorEnz - The Enzyme Database: 6.5.1.9
IUBMB Enzyme Nomenclature: 6.5.1.9
ExPASy - ENZYME nomenclature database: 6.5.1.9
BRENDA, the Enzyme Database: 6.5.1.9
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