EC                  Enzyme                                 

ABC-type xenobiotic transporter;
xenobiotic-transporting ATPase;
multidrug-resistance protein;
MDR protein;
pleiotropic-drug-resistance protein;
PDR protein;
steroid-transporting ATPase;
ATP phosphohydrolase (steroid-exporting)
Catalysing the translocation of other compounds;
Linked to the hydrolysis of a nucleoside triphosphate
ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
ATP + H2O + xenobiotic[side 1] = ADP + phosphate + xenobiotic[side 2]
ATP [CPD:C00002];
H2O [CPD:C00001];
xenobiotic[side 1]
ADP [CPD:C00008];
phosphate [CPD:C00009];
xenobiotic[side 2]
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them also transport glutathione---drug conjugates (see EC, ABC-type glutathione-S-conjugate transporter) while others also show some 'flippase' activity (cf. EC, P-type phospholipid transporter).
EC created 2000 as EC (EC incorporated 2006), modified 2006, transferred 2018 to EC
K05658  ATP-binding cassette, subfamily B (MDR/TAP), member 1
K05659  ATP-binding cassette, subfamily B (MDR/TAP), member 4
K18104  ATP-binding cassette, subfamily B, bacterial AbcA/BmrA
HSA: 5243(ABCB1) 5244(ABCB4)
PTR: 463516(ABCB1) 748364(ABCB4)
PPS: 100975579(ABCB1) 100976274(ABCB4)
GGO: 101140916(ABCB1) 101141298(ABCB4)
PON: 100452463(ABCB1) 100455534
NLE: 100602308(ABCB4) 100605124(ABCB1)
MCC: 574235(ABCB1) 706683(ABCB4)
MCF: 102115339(ABCB4) 102145631(ABCB1)
CSAB: 103226605(ABCB1) 103226609(ABCB4)
RRO: 104668032(ABCB4) 104668036(ABCB1)
RBB: 108515036(ABCB1) 108515081
CJC: 100398256(ABCB1) 100398854(ABCB4)
SBQ: 101051647(ABCB4) 101052405(ABCB1)
MMU: 18669(Abcb1b) 18670(Abcb4) 18671(Abcb1a)
MCAL: 110294486(Abcb4) 110295101(Abcb1)
RNO: 170913(Abcb1a) 24646(Abcb1b) 24891(Abcb4)
CGE: 100682535(Abcb4) 100682536(Abcb1) 100682537(Abcb1b)
NGI: 103725175(Abcb4) 103725176 103725178(Abcb1)
OCU: 100008914(ABCB1) 100354947(ABCB4)
TUP: 102478068(ABCB4) 102483808 102485093(ABCB1)
CFA: 403879(ABCB1) 482284(ABCB4)
VVP: 112935070(ABCB1) 112935084(ABCB4)
AML: 100475375(ABCB4) 100475940(ABCB1)
UMR: 103658684(ABCB4) 103658685(ABCB1)
UAH: 113259445(ABCB4) 113259495(ABCB1)
ORO: 101368373(ABCB4) 101368656(ABCB1)
FCA: 109497287(ABCB4) 493707(ABCB1)
PTG: 102971562(ABCB1) 102972907(ABCB4)
PPAD: 109263641(ABCB1) 109263643(ABCB4)
AJU: 106987580(ABCB4) 106987581(ABCB1)
BTA: 100296627 100336913(ABCB4) 281585(ABCB1)
BOM: 102267113 102280988(ABCB4)
BIU: 109557314(ABCB1) 109557315
OAS: 101112460 101121256 101122517(ABCB4) 443367(ABCB1)
SSC: 100144586(ABCB4) 100522267 100522455 396910(ABCB1)
CFR: 102511767(ABCB1) 102513941
CDK: 105087357(ABCB4) 105087358(ABCB1)
BACU: 103002339(ABCB4) 103005128(ABCB1)
LVE: 103088229(ABCB4) 103091243(ABCB1)
OOR: 101279182(ABCB4) 101279434(ABCB1)
DLE: 111182162(ABCB1) 111182170(ABCB4)
PCAD: 102983270(ABCB1) 102983763(ABCB4)
ECB: 100034074(ABCB1) 100147513(ABCB4)
EPZ: 103567918(ABCB1)
EAI: 106844768(ABCB1)
MYB: 102245646(ABCB1) 102246156(ABCB4)
MYD: 102755637(ABCB4) 102756283(ABCB1)
MNA: 107541721(ABCB4) 107541752(ABCB1)
HAI: 109371291(ABCB1) 109371296(ABCB4)
DRO: 112302075(ABCB4) 112302615(ABCB1)
PALE: 102879811(ABCB1) 102880063
RAY: 107512456(ABCB4) 107512458(ABCB1)
MJV: 108400662(ABCB1) 108409276(ABCB4)
LAV: 100662269(ABCB4) 100673458(ABCB1)
MDO: 100027271 100027288(ABCB1) 100462975(ABCB4)
PCW: 110209187(ABCB1) 110209191
OAA: 100077786(ABCB4) 100077826(ABCB1)
GGA: 395712(ABCB1) 420534(ABCB1LA)
MGP: 100303709 100548646(ABCB1)
CJO: 107309017
APLA: 110352387
ACYG: 106039633(ABCB4)
TGU: 100221908(ABCB1)
LSR: 110482426(ABCB1)
SCAN: 103812800(ABCB1)
GFR: 102036795(ABCB1)
FAB: 101820267(ABCB1)
PHI: 102110628(ABCB1)
PMAJ: 107198574(ABCB1)
CCAE: 111924185(ABCB1)
CCW: 104689196(ABCB1)
ETL: 114065100(ABCB1)
FPG: 101922679
FCH: 102049734(ABCB1)
EGZ: 104128773
ACUN: 113476636(ABCB1)
PADL: 103922399(ABCB1)
AAM: 106483501 106483502(ABCB1)
ASN: 102375248(ABCB1) 102387370
AMJ: 102558575(ABCB4) 106737547
PSS: 102454707(ABCB1)
CMY: 102941294(ABCB1)
CPIC: 101943333(ABCB1)
ACS: 100555474(abcb1)
PVT: 110070296
PBI: 103065154(ABCB1)
PMUR: 107283317(ABCB1)
TSR: 106537911(ABCB1)
PMUA: 114607873
GJA: 107107578
XLA: 108718488 397812(abcb1.L)
XTR: 100496268
SRX: 107738866
SANH: 107689873
SGH: 107549227
CCAR: 109106455
IPU: 108256530(abcb1)
PHYP: 113532684
AMEX: 103043081
EEE: 113577076(abcb1)
LCO: 104923078(abcb1)
NCC: 104959183
MZE: 101470858(abcb1)
OLA: 101171435(abcb1)
XMA: 102224768(abcb1)
XCO: 114141597
PRET: 103478129(abcb1)
NFU: 107379650(abcb1)
KMR: 108241145(abcb4)
AOCE: 111581710
CSEM: 103388176
POV: 109633038(abcb1)
LCF: 108889588(abcb1)
SDU: 111237185(abcb1)
SLAL: 111650836(abcb1)
HCQ: 109528973
BPEC: 110163198
MALB: 109964166
OTW: 112222699
ELS: 105029249
SFM: 108940694(abcb1)
PKI: 111860651(abcb1)
LCM: 102358502(ABCB1)
CMK: 103181561(abcb1)
RTP: 109914453
APLC: 110975142
DME: Dmel_CG10181(Mdr65) Dmel_CG10226(CG10226) Dmel_CG3879(Mdr49) Dmel_CG8523(Mdr50)
DSI: Dsimw501_GD11033(Dsim_GD11033) Dsimw501_GD13132(Dsim_GD13132) Dsimw501_GD13133(Dsim_GD13133) Dsimw501_GD25799(Dsim_GD25799)
AAG: 5573277
AME: 551167
BIM: 100745824
BTER: 100650108
CCAL: 108627333
OBB: 114872770
SOC: 105195263
MPHA: 105832868
AEC: 105146941
ACEP: 105627156
PBAR: 105433319
VEM: 105562134
HST: 105183497
DQU: 106744576
CFO: 105256714
LHU: 105680135
PGC: 109858738
OBO: 105284153
PCF: 106792531
NVI: 100115608
CSOL: 105359980
PVM: 113821011
TUT: 107363853
CEL: CELE_C05A9.1(pgp-5) CELE_C34G6.4(pgp-2) CELE_C47A10.1(pgp-9) CELE_DH11.3(pgp-11) CELE_F22E10.1(pgp-12) CELE_F22E10.2(pgp-13) CELE_F22E10.3(pgp-14) CELE_F42E11.1(pgp-4) CELE_K08E7.9(pgp-1) CELE_T21E8.1(pgp-6) CELE_ZK455.7(pgp-3)
CBR: CBG00078 CBG00079(Cbr-pgp-14) CBG00083 CBG00086(Cbr-pgp-12) CBG04013 CBG05664(Cbr-pgp-9) CBG12969 CBG13514(Cbr-pgp-1) CBG17356(Cbr-pgp-4) CBG17357(Cbr-pgp-3) CBG17569(Cbr-pgp-7) CBG17574 CBG24214
OBI: 106870660
HMG: 100202442(abcb1) 100213972(abcb1)
ATH: AT1G02520(ABCB11) AT1G02530(ABCB12) AT1G10680(PGP10) AT1G27940(ABCB13) AT1G28010(ABCB14) AT2G36910(ABCB1) AT2G39480(ABCB6) AT2G47000(ABCB4) AT3G28345(ABCB15) AT3G28360(ABCB16) AT3G28380(ABCB17) AT3G28390(ABCB18) AT3G28415(ABCB22) AT3G28860(ABCB19) AT3G55320(ABCB20) AT3G62150(ABCB21) AT4G01820(ABCB3) AT4G01830(ABCB5) AT4G18050(ABCB9) AT4G25960(ABCB2) AT5G46540(ABCB7)
LJA: Lj0g3v0066079.1(Lj0g3v0066079.1) Lj0g3v0066079.2(Lj0g3v0066079.2) Lj0g3v0066079.3(Lj0g3v0066079.3) Lj0g3v0285989.1(Lj0g3v0285989.1) Lj0g3v0285989.2(Lj0g3v0285989.2) Lj0g3v0304749.1(Lj0g3v0304749.1) Lj1g3v3194580.1(Lj1g3v3194580.1) Lj1g3v4591220.1(Lj1g3v4591220.1) Lj1g3v4830300.1(Lj1g3v4830300.1) Lj1g3v4830300.2(Lj1g3v4830300.2) Lj2g3v0855230.1(Lj2g3v0855230.1) Lj2g3v1022420.1(Lj2g3v1022420.1) Lj2g3v1022510.1(Lj2g3v1022510.1) Lj2g3v1022510.2(Lj2g3v1022510.2) Lj2g3v1055960.1(Lj2g3v1055960.1) Lj3g3v1011060.1(Lj3g3v1011060.1) Lj3g3v2477640.1(Lj3g3v2477640.1) Lj3g3v2576200.1(Lj3g3v2576200.1) Lj3g3v2576200.2(Lj3g3v2576200.2) Lj4g3v2227930.1(Lj4g3v2227930.1) Lj5g3v0240200.1(Lj5g3v0240200.1) Lj5g3v0240200.2(Lj5g3v0240200.2) Lj5g3v0240200.3(Lj5g3v0240200.3) Lj5g3v0240200.4(Lj5g3v0240200.4) Lj5g3v2182120.1(Lj5g3v2182120.1) Lj5g3v2288460.1(Lj5g3v2288460.1) Lj6g3v1966330.1(Lj6g3v1966330.1)
DOSA: Os01t0533900-01(Os01g0533900) Os01t0534700-00(Os01g0534700) Os01t0695700-00(Os01g0695700) Os01t0723800-01(Os01g0723800) Os02t0189800-00(Os02g0189800) Os02t0190000-00(Os02g0190000) Os02t0190300-01(Os02g0190300) Os02t0693700-01(Os02g0693700) Os03t0181750-00(Os03g0181750) Os03t0280000-01(Os03g0280000) Os04t0459000-01(Os04g0459000) Os04t0481700-01(Os04g0481700) Os05t0548500-00(Os05g0548500) Os08t0564300-01(Os08g0564300)
APRO: F751_1263
ERC: Ecym_3612
KMX: KLMA_30034(STE6)
NCS: NCAS_0G03510(NCAS0G03510)
NDI: NDAI_0D01540(NDAI0D01540)
TPF: TPHA_0O00160(TPHA0O00160)
TBL: TBLA_0B10070(TBLA0B10070)
TDL: TDEL_0F00340(TDEL0F00340)
KAF: KAFR_0E00230(KAFR0E00230)
PIC: PICST_40758(HST6)
CDU: CD36_86480(HST6)
SLB: AWJ20_2160(STE6) AWJ20_493(STE6) AWJ20_5338(STE6)
ANG: ANI_1_1296034(An03g03620) ANI_1_1634104(An12g03150) ANI_1_1766184(An04g03690) ANI_1_1996074(An08g05360) ANI_1_2126184(An04g08340) ANI_1_244154(An17g01770) ANI_1_780074(An08g05450)
SPO: SPBC25B2.02c(mam1) SPCC663.03(pmd1)
DDI: DDB_G0291714(abcB3) DDB_G0293438(abcB2)
DFA: DFA_06954(abcB2) DFA_08677
EHI: EHI_016380(80.t00022) EHI_101230(10.t00041) EHI_114150(148.t00006) EHI_186350(405.t00006)
PCB: PCHAS_123820(PC300305.00.0)
CPV: cgd6_4700
SMIN: v1.2.000036.t1(symbB.v1.2.000036.t1) v1.2.002775.t1(symbB.v1.2.002775.t1) v1.2.012251.t1(symbB.v1.2.012251.t1) v1.2.022168.t1(symbB.v1.2.022168.t1) v1.2.022641.t1(symbB.v1.2.022641.t1) v1.2.027872.t1(symbB.v1.2.027872.t1) v1.2.029611.t1(symbB.v1.2.029611.t1) v1.2.030826.t1(symbB.v1.2.030826.t1) v1.2.030826.t2(symbB.v1.2.030826.t2)
LMA: LMJF_26_2670(ABCB2) LMJF_34_0990(MDR1)
LPAN: LPMP_262640(ABCB2)
LAB: LA76x_2690(bmrA)
LAQ: GLA29479_2958(bmrA)
LCP: LC55x_2720(bmrA)
LGU: LG3211_2478(bmrA)
LEZ: GLE_3673
PSEN: PNC201_20185(bmrA)
PBH: AAW51_3369(abcA)
BSU: BSU34820(bmrA)
BSR: I33_3609
BSL: A7A1_2702
BSH: BSU6051_34820(bmrA)
BSUT: BSUB_03712(bmrA)
BSUL: BSUA_03712(bmrA)
BSUS: Q433_01255(subT) Q433_19065
BSO: BSNT_10109(yvcC)
BSQ: B657_34820(bmrA)
BSX: C663_0485(bmrA) C663_3370(yvcC)
BSS: BSUW23_17065(bmrA)
BST: GYO_3818
BLI: BL02726(bmrA)
BLD: BLi00213(bmrA)
BLH: BaLi_c02350(bmrA)
BAQ: BACAU_3235(yvcC)
BYA: BANAU_3388(yvcC)
BAMP: B938_16470
BAML: BAM5036_3120(bmrA)
BAMA: RBAU_3343(bmrA)
BAMN: BASU_3121(bmrA)
BAMB: BAPNAU_3396(yvcC)
BAMT: AJ82_18135
BAMY: V529_34740(yvcC)
BMP: NG74_03373(bmrA)
BAO: BAMF_0777(yvcC) BAMF_3331(bmrA)
BAZ: BAMTA208_03695(yvcC) BAMTA208_17670(bmrA)
BQL: LL3_00829(yvcC) LL3_03624(bmrA)
BQY: MUS_3824(yvcC)
BAMI: KSO_003065
BAMC: U471_33320
BAMF: U722_17205
BSON: S101395_04830(abcA)
BTEQ: G4P54_17890(bmrA)
BAT: BAS1815
BANT: A16_19930
BANR: A16R_20150
BANV: DJ46_763
BCE: BC1955
BCA: BCE_2040
BCQ: BCQ_1946
BCX: BCA_2020
BNC: BCN_1872
BCF: bcf_09630
BCER: BCK_24765
BTL: BALH_1731
BTT: HD73_2120
BTHI: BTK_10705
BTG: BTB_c20240(bmrA)
BTW: BF38_3172(bmrA)
BWW: bwei_3059(bmrA)
BMYO: BG05_4026
BPU: BPUM_2353
BJS: MY9_3525
BACP: SB24_12700
BACB: OY17_19330
BACO: OXB_0523
BACY: QF06_15795
BACL: BS34A_37920(bmrA)
BALM: BsLM_3489
BGY: BGLY_0196(bmrA)
BMQ: BMQ_2979(bmrA)
BMD: BMD_3007(bmrA)
BMEG: BG04_5510
BHA: BH0713
BKW: BkAM31D_07775(bmrA)
OIH: OB0426
LSP: Bsph_2065
VPN: A21D_00787(bmrA)
PASA: BAOM_0217(abcA)
PSYO: PB01_06100
BLEN: NCTC4824_01000(bmrA)
SAU: SA0599
SAV: SAV0643
SAW: SAHV_0640
SAM: MW0605
SAS: SAS0609
SAR: SAR0653
SAC: SACOL0700(abcA)
SAE: NWMN_0613
SAD: SAAV_0606(abcA)
SUE: SAOV_0678(abcA)
SUJ: SAA6159_00598(abcA)
SUK: SAA6008_00660(abcA)
SUC: ECTR2_595
SUZ: MS7_0694(bmrA)
SUW: SATW20_07180(abcA)
SUF: SARLGA251_05770(abcA)
SAUA: SAAG_01066
SAUS: SA40_0584(abcA)
SAUU: SA957_0599(abcA)
SAUG: SA268_0597(abcA)
SAUZ: SAZ172_0655(abcA)
SAUT: SAI1T1_2004960(abcA)
SAUJ: SAI2T2_1004980(abcA)
SAUK: SAI3T3_1004970(abcA)
SAUQ: SAI4T8_1004960(abcA)
SAUF: X998_0691
SAB: SAB0593
SUY: SA2981_0619(msbA)
SAUB: C248_0725
SAUM: BN843_6450
SAUC: CA347_657(bmrA)
SAUR: SABB_00691(bmrA)
SAUI: AZ30_03370
SAUD: CH52_02545
SAMS: NI36_03220
SER: SERP0303(abcA)
SEPP: SEB_00337
SHA: SH2253
SHH: ShL2_02102(abcA)
SSP: SSP2076
SCA: SCA_0292
SLN: SLUG_21550(abcA)
SDT: SPSE_2104
SDP: NCTC12225_02323(bmrA)
SPAS: STP1_1729
SCAP: AYP1020_0011(bmrA)
SSCH: LH95_10085
SSCZ: RN70_10820
SAGQ: EP23_11680
SPIC: SAMEA4384060_2227(bmrA)
SSH: NCTC13712_00605(bmrA)
SSIM: SAMEA4384339_0585(bmrA)
SSTE: SAMEA4384403_0323(bmrA)
LMO: lmo2745
LMOE: BN418_3250
LMOB: BN419_3267
LMOW: AX10_07900
LMOQ: LM6179_0159(bmrA)
LMR: LMR479A_2882(bmrA)
LMOM: IJ09_10980
LMOG: BN389_27200(bmrA)
LMP: MUO_13785
LMOX: AX24_11860
LMQ: LMM7_2856(msbA)
LMS: LMLG_0280
LMOK: CQ02_14045
LIN: lin2888
LWE: lwe2693
LSG: lse_2658
LIV: LIV_2698
LGZ: NCTC10812_00054(bmrA_1)
ESI: Exig_1154
EAN: Eab7_1116
BBE: BBR47_41950(yvcC)
PPY: PPE_03603
PPM: PPSC2_05730(yvcC1) PPSC2_19100(yvcC3)
PPO: PPM_1078(yvcC1) PPM_3840(yvcC3)
PPOL: X809_35175
PSAB: PSAB_22645
PRI: PRIO_6359(bmrA)
PSWU: SY83_10155
SIV: SSIL_0331
JEO: JMA_08120
KUR: ASO14_180
KZO: NCTC404_01023(bmrA)
LLA: L116532(lmrA)
LLK: LLKF_0728(lmrA)
LLT: CVCAS_0665(lmrA)
LLS: lilo_0645(lmrA)
LLX: NCDO2118_0726(lmrA)
LLJ: LG36_0695(lmrA)
LLM: llmg_1856(lmrA)
LLR: llh_9360
LLW: kw2_0653
LGR: LCGT_0296
LGV: LCGL_0296
SSI: SSU0044
SUP: YYK_00215
SSUY: YB51_0260
SSUT: TL13_0064(msbA)
SVB: NCTC12167_01806(lmrA)
LJO: LJ_1157
LAC: LBA0597
LAD: LA14_0626
LAF: SD55_0620
LDB: Ldb0031
LBU: LBUL_0024
LCA: LSEI_2132
LCS: LCBD_2298(tagA)
LCE: LC2W_2280(tagA)
LCW: BN194_22720(lmrA)
LCB: LCABL_23130(horA_homolog)
LPJ: JDM1_2010 JDM1_2375(lmrA)
LRE: Lreu_0018
LRF: LAR_0017
LRT: LRI_0022
LSN: LSA_05020(lmrA)
LBH: Lbuc_2036
LHIL: G8J22_00395(lmrA)
LBR: LVIS_1995
PPE: PEPE_1658
PPEN: T256_08160
PCE: PECL_1953(horA)
LSA: LCA_0232(lmrA)
OOE: OEOE_1345
LCI: LCK_00921(lmrA)
WKO: WKK_06145
EFS: EFS1_2572
ENE: ENT_28870
EHR: EHR_01070
ECAS: ECBG_03129
MPS: MPTP_1913
MPX: MPD5_1706
CML: BN424_752(bmrA)
JDA: BW727_200001(bmrA)
CBL: CLK_0162
CLD: CLSPO_c07850(lmrA1)
 » show all
1  [PMID:8725386]
Bellamy WT.
P-glycoproteins and multidrug resistance.
Annu Rev Pharmacol Toxicol 36:161-83 (1996)
2  [PMID:8869755]
Frijters CM, Ottenhoff R, Van Wijland MJ, Van Nieuwkerk C, Groen AK, Oude Elferink RP.
Influence of bile salts on hepatic mdr2 P-glycoprotein expression.
Adv Enzyme Regul 36:351-63 (1996)
3  [PMID:9381978]
Keppler D, Konig J, Buchler M.
The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes.
Adv Enzyme Regul 37:321-33 (1997)
4  [PMID:9823323]
Loe DW, Deeley RG, Cole SP.
Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.
Cancer Res 58:5130-6 (1998)
5  [PMID:9693718]
van Veen HW, Konings WN.
The ABC family of multidrug transporters in microorganisms.
Biochim Biophys Acta 1365:31-6 (1998)
Griffiths, J.K. and Sansom, C.E.
The Transporter Factsbook, Academic Press, San Diego, 1998
7  [PMID:7614555]
Prasad R, De Wergifosse P, Goffeau A, Balzi E
Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals.
Curr Genet 27:320-9 (1995)
8  [PMID:7883711]
Nagao K, Taguchi Y, Arioka M, Kadokura H, Takatsuki A, Yoda K, Yamasaki M.
bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily.
J Bacteriol 177:1536-43 (1995)
9  [PMID:8810273]
Mahe Y, Lemoine Y, Kuchler K.
The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo.
J Biol Chem 271:25167-72 (1996)
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