Equus caballus (horse): 100051110
Help
Entry
100051110 CDS
T01058
Gene name
RAF1
Definition
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ecb
Equus caballus (horse)
Pathway
ecb01521
EGFR tyrosine kinase inhibitor resistance
ecb01522
Endocrine resistance
ecb04010
MAPK signaling pathway
ecb04012
ErbB signaling pathway
ecb04014
Ras signaling pathway
ecb04015
Rap1 signaling pathway
ecb04022
cGMP-PKG signaling pathway
ecb04024
cAMP signaling pathway
ecb04062
Chemokine signaling pathway
ecb04068
FoxO signaling pathway
ecb04071
Sphingolipid signaling pathway
ecb04072
Phospholipase D signaling pathway
ecb04140
Autophagy - animal
ecb04150
mTOR signaling pathway
ecb04151
PI3K-Akt signaling pathway
ecb04210
Apoptosis
ecb04218
Cellular senescence
ecb04270
Vascular smooth muscle contraction
ecb04360
Axon guidance
ecb04370
VEGF signaling pathway
ecb04371
Apelin signaling pathway
ecb04510
Focal adhesion
ecb04540
Gap junction
ecb04550
Signaling pathways regulating pluripotency of stem cells
ecb04613
Neutrophil extracellular trap formation
ecb04625
C-type lectin receptor signaling pathway
ecb04630
JAK-STAT signaling pathway
ecb04650
Natural killer cell mediated cytotoxicity
ecb04660
T cell receptor signaling pathway
ecb04662
B cell receptor signaling pathway
ecb04664
Fc epsilon RI signaling pathway
ecb04666
Fc gamma R-mediated phagocytosis
ecb04720
Long-term potentiation
ecb04722
Neurotrophin signaling pathway
ecb04726
Serotonergic synapse
ecb04730
Long-term depression
ecb04810
Regulation of actin cytoskeleton
ecb04910
Insulin signaling pathway
ecb04912
GnRH signaling pathway
ecb04914
Progesterone-mediated oocyte maturation
ecb04915
Estrogen signaling pathway
ecb04916
Melanogenesis
ecb04917
Prolactin signaling pathway
ecb04919
Thyroid hormone signaling pathway
ecb04921
Oxytocin signaling pathway
ecb04926
Relaxin signaling pathway
ecb04928
Parathyroid hormone synthesis, secretion and action
ecb04929
GnRH secretion
ecb04935
Growth hormone synthesis, secretion and action
ecb05010
Alzheimer disease
ecb05022
Pathways of neurodegeneration - multiple diseases
ecb05034
Alcoholism
ecb05132
Salmonella infection
ecb05152
Tuberculosis
ecb05160
Hepatitis C
ecb05161
Hepatitis B
ecb05163
Human cytomegalovirus infection
ecb05164
Influenza A
ecb05165
Human papillomavirus infection
ecb05167
Kaposi sarcoma-associated herpesvirus infection
ecb05170
Human immunodeficiency virus 1 infection
ecb05200
Pathways in cancer
ecb05205
Proteoglycans in cancer
ecb05206
MicroRNAs in cancer
ecb05210
Colorectal cancer
ecb05211
Renal cell carcinoma
ecb05212
Pancreatic cancer
ecb05213
Endometrial cancer
ecb05214
Glioma
ecb05215
Prostate cancer
ecb05218
Melanoma
ecb05219
Bladder cancer
ecb05220
Chronic myeloid leukemia
ecb05221
Acute myeloid leukemia
ecb05223
Non-small cell lung cancer
ecb05224
Breast cancer
ecb05225
Hepatocellular carcinoma
ecb05226
Gastric cancer
ecb05230
Central carbon metabolism in cancer
ecb05231
Choline metabolism in cancer
ecb05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ecb00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100051110 (RAF1)
04012 ErbB signaling pathway
100051110 (RAF1)
04014 Ras signaling pathway
100051110 (RAF1)
04015 Rap1 signaling pathway
100051110 (RAF1)
04370 VEGF signaling pathway
100051110 (RAF1)
04371 Apelin signaling pathway
100051110 (RAF1)
04630 JAK-STAT signaling pathway
100051110 (RAF1)
04068 FoxO signaling pathway
100051110 (RAF1)
04072 Phospholipase D signaling pathway
100051110 (RAF1)
04071 Sphingolipid signaling pathway
100051110 (RAF1)
04024 cAMP signaling pathway
100051110 (RAF1)
04022 cGMP-PKG signaling pathway
100051110 (RAF1)
04151 PI3K-Akt signaling pathway
100051110 (RAF1)
04150 mTOR signaling pathway
100051110 (RAF1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100051110 (RAF1)
09143 Cell growth and death
04210 Apoptosis
100051110 (RAF1)
04218 Cellular senescence
100051110 (RAF1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100051110 (RAF1)
04540 Gap junction
100051110 (RAF1)
04550 Signaling pathways regulating pluripotency of stem cells
100051110 (RAF1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100051110 (RAF1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100051110 (RAF1)
04625 C-type lectin receptor signaling pathway
100051110 (RAF1)
04650 Natural killer cell mediated cytotoxicity
100051110 (RAF1)
04660 T cell receptor signaling pathway
100051110 (RAF1)
04662 B cell receptor signaling pathway
100051110 (RAF1)
04664 Fc epsilon RI signaling pathway
100051110 (RAF1)
04666 Fc gamma R-mediated phagocytosis
100051110 (RAF1)
04062 Chemokine signaling pathway
100051110 (RAF1)
09152 Endocrine system
04910 Insulin signaling pathway
100051110 (RAF1)
04929 GnRH secretion
100051110 (RAF1)
04912 GnRH signaling pathway
100051110 (RAF1)
04915 Estrogen signaling pathway
100051110 (RAF1)
04914 Progesterone-mediated oocyte maturation
100051110 (RAF1)
04917 Prolactin signaling pathway
100051110 (RAF1)
04921 Oxytocin signaling pathway
100051110 (RAF1)
04926 Relaxin signaling pathway
100051110 (RAF1)
04935 Growth hormone synthesis, secretion and action
100051110 (RAF1)
04919 Thyroid hormone signaling pathway
100051110 (RAF1)
04928 Parathyroid hormone synthesis, secretion and action
100051110 (RAF1)
04916 Melanogenesis
100051110 (RAF1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100051110 (RAF1)
09156 Nervous system
04726 Serotonergic synapse
100051110 (RAF1)
04720 Long-term potentiation
100051110 (RAF1)
04730 Long-term depression
100051110 (RAF1)
04722 Neurotrophin signaling pathway
100051110 (RAF1)
09158 Development and regeneration
04360 Axon guidance
100051110 (RAF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100051110 (RAF1)
05206 MicroRNAs in cancer
100051110 (RAF1)
05205 Proteoglycans in cancer
100051110 (RAF1)
05230 Central carbon metabolism in cancer
100051110 (RAF1)
05231 Choline metabolism in cancer
100051110 (RAF1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100051110 (RAF1)
09162 Cancer: specific types
05210 Colorectal cancer
100051110 (RAF1)
05212 Pancreatic cancer
100051110 (RAF1)
05225 Hepatocellular carcinoma
100051110 (RAF1)
05226 Gastric cancer
100051110 (RAF1)
05214 Glioma
100051110 (RAF1)
05221 Acute myeloid leukemia
100051110 (RAF1)
05220 Chronic myeloid leukemia
100051110 (RAF1)
05218 Melanoma
100051110 (RAF1)
05211 Renal cell carcinoma
100051110 (RAF1)
05219 Bladder cancer
100051110 (RAF1)
05215 Prostate cancer
100051110 (RAF1)
05213 Endometrial cancer
100051110 (RAF1)
05224 Breast cancer
100051110 (RAF1)
05223 Non-small cell lung cancer
100051110 (RAF1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100051110 (RAF1)
05022 Pathways of neurodegeneration - multiple diseases
100051110 (RAF1)
09165 Substance dependence
05034 Alcoholism
100051110 (RAF1)
09171 Infectious disease: bacterial
05132 Salmonella infection
100051110 (RAF1)
05152 Tuberculosis
100051110 (RAF1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
100051110 (RAF1)
05161 Hepatitis B
100051110 (RAF1)
05160 Hepatitis C
100051110 (RAF1)
05164 Influenza A
100051110 (RAF1)
05163 Human cytomegalovirus infection
100051110 (RAF1)
05167 Kaposi sarcoma-associated herpesvirus infection
100051110 (RAF1)
05165 Human papillomavirus infection
100051110 (RAF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100051110 (RAF1)
01522 Endocrine resistance
100051110 (RAF1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ecb01001
]
100051110 (RAF1)
Enzymes [BR:
ecb01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100051110 (RAF1)
Protein kinases [BR:
ecb01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100051110 (RAF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
100051110
NCBI-ProteinID:
XP_001492290
Ensembl:
ENSECAG00000011807
UniProt:
F6QHE2
LinkDB
All DBs
Position
16
AA seq
648 aa
AA seq
DB search
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq
1947 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggggcctggaagacgatcagcaatggttttggattcaaagacgcg
gtgtttgatggccccagctgtatctcccctacaatagttcagcagtttggctatcagcgt
cgggcgtcagatgatggcaaacttacggactcttctaagacaagcaacactatccgtgtt
ttcttgccaaataagcaaagaaccgtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccggagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgtttagattggaatactgatgctgcctca
ttgattggagaagagcttcaagtagatttcctggatcatgttcctctcacaacacacaac
tttgctcggaagacctttctgaagcttgccttttgtgacatctgtcagaagttcttgcta
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgcgtggactggagtaatatcagacaactcttattgtttccgaattccact
attggtgatagtggagtcccagcactgccttccttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacgccccacgccttcacattc
aacacctccagtccctcctctgaaggttccctctcccagaggcagagatcgacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagccacagtgaatcagcttcaccttcagccttgtccagcagccccaacaatctg
agcccaacgggctggtcacagcctaaaacccctgtgccggcacagagagagcgggcacca
ggatccgggacccaggagaaaaacaaaattagacctcgaggtcagagagattcaagctat
tactgggaaatagaagcgagtgaagtgatgctctccacccggattgggtcaggctccttt
ggaactgtgtataagggcaaatggcacggagacgttgcagtgaaaatcttaaaggttgtt
gaccccacaccagagcagttccaggcgttcaggaacgaggtggctgtcctgcgtaaaaca
cggcacgtgaacatcctgctcttcatggggtacatgacgaaggacaacctggcaattgtg
actcagtggtgtgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttc
cagatgttccagttgattgacatcgcccggcagacggctcagggaatggactatttgcat
gcaaaaaacatcatccacagagatatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagactttggtttggcaacagtcaagtcgcgctggagtggttctcag
caggttgaacaacccactggctctgtcctgtggatggccccagaggtgatccgaatgcag
gataataacccgttcagcttccagtctgatgtctactcctatggcattgtactctatgag
ctcatgacaggggaactgccttactcccacatcaacaaccgagatcagatcatcttcatg
gtgggccgagggtatgcctccccagaccttagtaagctatacaagaactgccccaaagca
atgaagaggcttgtggctgactgcgtgaagaaagttaaggaggagaggcctctttttccc
cagatcttgtcttccatcgagttgctccaacactctctaccgaaaatcaaccggagtgct
tctgagccatccctgcatcgggcggcccacaccgaggacatcaatgcctgcacgttgacc
acgtcccctagactgcctgtcttctag
Equus caballus (horse): 100061212
Help
Entry
100061212 CDS
T01058
Gene name
ARAF
Definition
(RefSeq) serine/threonine-protein kinase A-Raf isoform X2
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ecb
Equus caballus (horse)
Pathway
ecb01521
EGFR tyrosine kinase inhibitor resistance
ecb01522
Endocrine resistance
ecb04010
MAPK signaling pathway
ecb04012
ErbB signaling pathway
ecb04068
FoxO signaling pathway
ecb04270
Vascular smooth muscle contraction
ecb04650
Natural killer cell mediated cytotoxicity
ecb04720
Long-term potentiation
ecb04726
Serotonergic synapse
ecb04730
Long-term depression
ecb04810
Regulation of actin cytoskeleton
ecb04910
Insulin signaling pathway
ecb04914
Progesterone-mediated oocyte maturation
ecb04928
Parathyroid hormone synthesis, secretion and action
ecb05010
Alzheimer disease
ecb05022
Pathways of neurodegeneration - multiple diseases
ecb05034
Alcoholism
ecb05160
Hepatitis C
ecb05161
Hepatitis B
ecb05200
Pathways in cancer
ecb05205
Proteoglycans in cancer
ecb05210
Colorectal cancer
ecb05211
Renal cell carcinoma
ecb05212
Pancreatic cancer
ecb05213
Endometrial cancer
ecb05214
Glioma
ecb05215
Prostate cancer
ecb05218
Melanoma
ecb05219
Bladder cancer
ecb05220
Chronic myeloid leukemia
ecb05221
Acute myeloid leukemia
ecb05223
Non-small cell lung cancer
ecb05224
Breast cancer
ecb05225
Hepatocellular carcinoma
ecb05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
ecb00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100061212 (ARAF)
04012 ErbB signaling pathway
100061212 (ARAF)
04068 FoxO signaling pathway
100061212 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
100061212 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100061212 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
100061212 (ARAF)
04914 Progesterone-mediated oocyte maturation
100061212 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
100061212 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100061212 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
100061212 (ARAF)
04720 Long-term potentiation
100061212 (ARAF)
04730 Long-term depression
100061212 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100061212 (ARAF)
05205 Proteoglycans in cancer
100061212 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
100061212 (ARAF)
05212 Pancreatic cancer
100061212 (ARAF)
05225 Hepatocellular carcinoma
100061212 (ARAF)
05226 Gastric cancer
100061212 (ARAF)
05214 Glioma
100061212 (ARAF)
05221 Acute myeloid leukemia
100061212 (ARAF)
05220 Chronic myeloid leukemia
100061212 (ARAF)
05218 Melanoma
100061212 (ARAF)
05211 Renal cell carcinoma
100061212 (ARAF)
05219 Bladder cancer
100061212 (ARAF)
05215 Prostate cancer
100061212 (ARAF)
05213 Endometrial cancer
100061212 (ARAF)
05224 Breast cancer
100061212 (ARAF)
05223 Non-small cell lung cancer
100061212 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
100061212 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
100061212 (ARAF)
09165 Substance dependence
05034 Alcoholism
100061212 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
100061212 (ARAF)
05160 Hepatitis C
100061212 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100061212 (ARAF)
01522 Endocrine resistance
100061212 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ecb01001
]
100061212 (ARAF)
Enzymes [BR:
ecb01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100061212 (ARAF)
Protein kinases [BR:
ecb01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100061212 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
APH
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
100061212
NCBI-ProteinID:
XP_005614153
Ensembl:
ENSECAG00000023903
VGNC:
15438
LinkDB
All DBs
Position
X
AA seq
607 aa
AA seq
DB search
MESPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGGSRQHEAPSNRPLNEPL
TPQGPSLSPASSCTQHRDPEHFPFPASANAPLQRIRSTSTPNVHMVSTTAPMDSSLIQSF
STDAAGGRSGGDGASRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDS
GYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLR
KTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDY
LHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIR
MQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCP
KAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLL
SAARLVP
NT seq
1824 nt
NT seq
+upstream
nt +downstream
nt
atggagtcaccacggggcccccctgccaacggggccgagccatcccgggcagtggggacc
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgattctctagacaaggccctcaaggtgcgaggtctcaatcaggattgctgtgtg
gtctaccggctcatcaaggggcgaaagacagttactgcctgggacacggccattgccccc
ctggatggcgaggagctcatcgtggaggtcctcgaagacgtcccactgaccatgcacaat
tttgtacggaagacattcttcagcctggcattctgcgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccgacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaggctccctcgaaccgccccctgaatgagccgcta
acccctcagggtcccagcctttcccctgccagctcctgcacccagcaccgggaccctgag
cacttccccttccctgcctcggccaacgcccccctccagcgcatccgttccacctccacc
cccaacgtccatatggtcagcaccacagctcccatggactccagcctcatccagagtttc
agcaccgatgccgctggaggtagaagtggtggtgatggagcctcccgggggagccccagc
ccggccagcgtgtcctcggggaggaagtccccacattccaagtccccatcggagcagcgg
gagcgaaagtccttggctgacgacaagaagaaagtgaagaatctggggtaccgggactca
ggctattactgggaggtgccacccagcgaggtgcagctgctgaagaggatcgggacaggc
tcatttggcaccgtgtttcgcgggcggtggcatggtgatgtggccgtgaaggtgctcaag
gtggcgcaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcagg
aagacgcgtcatgtcaacatcttgctgttcatgggcttcatgacccggccgggctttgcc
atcatcacacagtggtgcgagggctccagcctctaccaccacctgcacgtggcggacaca
cgcttcgacatggtccagctcatcgacgtggcccggcagaccgcccagggcatggactac
cttcatgccaagaacatcatccatcgagatctcaagtctaacaacatcttcctacatgag
gggctcacggtgaagatcggtgacttcggcctggccacagtgaagacgaggtggagcggg
gcccagcccttggagcagccctcgggctctgtgctatggatggcggccgaggtgatccgt
atgcaggacccaaacccctacagcttccagtcggatgtctacgcctatggggttgtgctc
tatgagctcatgaccggctcactgccttacagccacattggcagccgtgaccagattatc
tttatggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgcccc
aaggccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggagcggcccctc
ttcccccagatcctggccacgattgagctactgcagcggtcactccccaagatcgagcgg
agtgcgtccgaaccctccttgcaccgcacccaggctgacgagttgcctgcctgcctactc
agcgcagcccgccttgtgccttag
Equus caballus (horse): 100065760
Help
Entry
100065760 CDS
T01058
Gene name
BRAF
Definition
(RefSeq) serine/threonine-protein kinase B-raf isoform X2
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ecb
Equus caballus (horse)
Pathway
ecb01521
EGFR tyrosine kinase inhibitor resistance
ecb01522
Endocrine resistance
ecb04010
MAPK signaling pathway
ecb04012
ErbB signaling pathway
ecb04015
Rap1 signaling pathway
ecb04024
cAMP signaling pathway
ecb04062
Chemokine signaling pathway
ecb04068
FoxO signaling pathway
ecb04150
mTOR signaling pathway
ecb04270
Vascular smooth muscle contraction
ecb04510
Focal adhesion
ecb04650
Natural killer cell mediated cytotoxicity
ecb04720
Long-term potentiation
ecb04722
Neurotrophin signaling pathway
ecb04726
Serotonergic synapse
ecb04730
Long-term depression
ecb04810
Regulation of actin cytoskeleton
ecb04910
Insulin signaling pathway
ecb04914
Progesterone-mediated oocyte maturation
ecb04928
Parathyroid hormone synthesis, secretion and action
ecb04934
Cushing syndrome
ecb05010
Alzheimer disease
ecb05022
Pathways of neurodegeneration - multiple diseases
ecb05034
Alcoholism
ecb05160
Hepatitis C
ecb05161
Hepatitis B
ecb05200
Pathways in cancer
ecb05205
Proteoglycans in cancer
ecb05210
Colorectal cancer
ecb05211
Renal cell carcinoma
ecb05212
Pancreatic cancer
ecb05213
Endometrial cancer
ecb05214
Glioma
ecb05215
Prostate cancer
ecb05216
Thyroid cancer
ecb05218
Melanoma
ecb05219
Bladder cancer
ecb05220
Chronic myeloid leukemia
ecb05221
Acute myeloid leukemia
ecb05223
Non-small cell lung cancer
ecb05224
Breast cancer
ecb05225
Hepatocellular carcinoma
ecb05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
ecb00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100065760 (BRAF)
04012 ErbB signaling pathway
100065760 (BRAF)
04015 Rap1 signaling pathway
100065760 (BRAF)
04068 FoxO signaling pathway
100065760 (BRAF)
04024 cAMP signaling pathway
100065760 (BRAF)
04150 mTOR signaling pathway
100065760 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
100065760 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100065760 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100065760 (BRAF)
04062 Chemokine signaling pathway
100065760 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
100065760 (BRAF)
04914 Progesterone-mediated oocyte maturation
100065760 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
100065760 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100065760 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
100065760 (BRAF)
04720 Long-term potentiation
100065760 (BRAF)
04730 Long-term depression
100065760 (BRAF)
04722 Neurotrophin signaling pathway
100065760 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100065760 (BRAF)
05205 Proteoglycans in cancer
100065760 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
100065760 (BRAF)
05212 Pancreatic cancer
100065760 (BRAF)
05225 Hepatocellular carcinoma
100065760 (BRAF)
05226 Gastric cancer
100065760 (BRAF)
05214 Glioma
100065760 (BRAF)
05216 Thyroid cancer
100065760 (BRAF)
05221 Acute myeloid leukemia
100065760 (BRAF)
05220 Chronic myeloid leukemia
100065760 (BRAF)
05218 Melanoma
100065760 (BRAF)
05211 Renal cell carcinoma
100065760 (BRAF)
05219 Bladder cancer
100065760 (BRAF)
05215 Prostate cancer
100065760 (BRAF)
05213 Endometrial cancer
100065760 (BRAF)
05224 Breast cancer
100065760 (BRAF)
05223 Non-small cell lung cancer
100065760 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
100065760 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
100065760 (BRAF)
09165 Substance dependence
05034 Alcoholism
100065760 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100065760 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
100065760 (BRAF)
05160 Hepatitis C
100065760 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100065760 (BRAF)
01522 Endocrine resistance
100065760 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ecb01001
]
100065760 (BRAF)
Enzymes [BR:
ecb01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100065760 (BRAF)
Protein kinases [BR:
ecb01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100065760 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
C1_2
Pkinase_fungal
APH
Kdo
Motif
Other DBs
NCBI-GeneID:
100065760
NCBI-ProteinID:
XP_001496314
Ensembl:
ENSECAG00000002746
VGNC:
15875
LinkDB
All DBs
Position
4
AA seq
764 aa
AA seq
DB search
MAALSGGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEA
LLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTSS
SSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKK
ALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFF
TLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVSQE
EASLAETALTSGSSPSAPPSDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRS
SSAPNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQ
RERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVK
MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHI
IETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR
WSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPK
IHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq
2295 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgctgagcggcggcggcggcggcgcggagcagggccaggctctgttcaacggg
gacatggagccggaggccggcgccggcgccgcggcctcgtcggccgcggaccctgccatt
cccgaggaggtatggaatatcaaacaaatgattaaattgacacaggaacatatagaggcc
ctattggacaaatttggtggggagcataatccaccatcaatatatctggaggcctatgaa
gaatacaccagcaagctagatgccctccaacaaagagaacaacagttattggaatccctg
gggaatggaactgatttttctgtttctagttctgcatcaacggacaccgttacatcttct
tcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaatcccacagat
gtgtcacggagcaaccctaagtcaccacaaaaacctatcgttagagtcttcctgcccaac
aaacagaggacagtggtacctgcaaggtgtggcgttacagtccgggacagtctaaagaaa
gcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaattcaggatgga
gagaagaaaccaattggctgggacactgatatttcctggctcactggagaggaattgcat
gtagaagtgttggagaatgttccacttacaacacacaactttgtacggaaaacttttttc
accttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgctgtcaaaca
tgtggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaattat
gaccaacttgatttgctgtttgtctccaagttctttgaacaccacccagtatcacaggag
gaggcctccttagcagagactgcccttacatctggatcatccccttctgcacccccctcc
gattccattgggccccaaattctcaccagtccatctccttcaaaatccattccaattcca
cagcctttccgaccagcagatgaagatcatcgaaatcagtttggacaacgagaccggtcc
tcatcagctccaaatgtacatataaacacaatagaacctgtcaatattgatgacttgatt
agagaccaagggtttcgtagtgatggaggatcaaccacaggtttatctgccaccccccct
gcctcattacctggctcactcactaatgtgaaggcattacagaaatctccaggacctcaa
cgggaaaggaaatcatcttcatcctcagaagacaggaatcgaatgaaaactcttggtaga
cgggattcaagtgacgattgggagattcctgatgggcagatcacagtgggacaaagaatt
ggatctgggtcatttgggacagtctacaagggaaagtggcatggtgatgtggcagtgaaa
atgttgaatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagtagga
gtactcaggaaaactcgacatgtgaatatcctactcttcatgggctattcaacaaagcca
caactggctattgttacccagtggtgtgagggctccagcttatatcaccatctccacatc
attgagaccaaatttgagatgatcaaacttatagatattgctcggcaaactgcacagggc
atggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatattttt
cttcatgaagacctcacagtaaaaataggtgattttggtctagccacagtgaaatctcga
tggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaa
gtaatcagaatgcaagataaaaacccgtatagctttcaatcagatgtatatgcctttggg
attgttctgtatgaattgatgactggacagttaccttattcaaacatcaacaacagggac
cagataatttttatggtgggaagaggatatctatctccagatctcagtaaggtacggagt
aactgtccaaaagccatgaagagattaatggcagagtgcctaaaaaagaaaagagacgag
agaccactcttcccccaaattctcgcctctattgagctgctggcccgctcattgccaaaa
attcaccgcagtgcatcagagccctccttgaatcgggctggcttccagacagaggatttt
agtctatatgcttgtgcttctccgaaaacacccatccaggcagggggatatggagaattt
gcagccttcaagtag
DBGET
integrated database retrieval system
