KEGG T01058: 100063190

KEGG Orthology (KO) [BR:ecb00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100063190 (MAP2K2)
   04012 ErbB signaling pathway
    100063190 (MAP2K2)
   04014 Ras signaling pathway
    100063190 (MAP2K2)
   04015 Rap1 signaling pathway
    100063190 (MAP2K2)
   04370 VEGF signaling pathway
    100063190 (MAP2K2)
   04371 Apelin signaling pathway
    100063190 (MAP2K2)
   04066 HIF-1 signaling pathway
    100063190 (MAP2K2)
   04068 FoxO signaling pathway
    100063190 (MAP2K2)
   04072 Phospholipase D signaling pathway
    100063190 (MAP2K2)
   04071 Sphingolipid signaling pathway
    100063190 (MAP2K2)
   04024 cAMP signaling pathway
    100063190 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    100063190 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    100063190 (MAP2K2)
   04150 mTOR signaling pathway
    100063190 (MAP2K2)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100063190 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    100063190 (MAP2K2)
   04218 Cellular senescence
    100063190 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100063190 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100063190 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100063190 (MAP2K2)
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100063190 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    100063190 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    100063190 (MAP2K2)
   04660 T cell receptor signaling pathway
    100063190 (MAP2K2)
   04662 B cell receptor signaling pathway
    100063190 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    100063190 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100063190 (MAP2K2)
   04929 GnRH secretion
    100063190 (MAP2K2)
   04912 GnRH signaling pathway
    100063190 (MAP2K2)
   04915 Estrogen signaling pathway
    100063190 (MAP2K2)
   04917 Prolactin signaling pathway
    100063190 (MAP2K2)
   04921 Oxytocin signaling pathway
    100063190 (MAP2K2)
   04926 Relaxin signaling pathway
    100063190 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    100063190 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    100063190 (MAP2K2)
   04916 Melanogenesis
    100063190 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100063190 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    100063190 (MAP2K2)
   04730 Long-term depression
    100063190 (MAP2K2)
   04722 Neurotrophin signaling pathway
    100063190 (MAP2K2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100063190 (MAP2K2)
   05206 MicroRNAs in cancer
    100063190 (MAP2K2)
   05205 Proteoglycans in cancer
    100063190 (MAP2K2)
   05230 Central carbon metabolism in cancer
    100063190 (MAP2K2)
   05231 Choline metabolism in cancer
    100063190 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100063190 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100063190 (MAP2K2)
   05225 Hepatocellular carcinoma
    100063190 (MAP2K2)
   05226 Gastric cancer
    100063190 (MAP2K2)
   05214 Glioma
    100063190 (MAP2K2)
   05216 Thyroid cancer
    100063190 (MAP2K2)
   05221 Acute myeloid leukemia
    100063190 (MAP2K2)
   05220 Chronic myeloid leukemia
    100063190 (MAP2K2)
   05218 Melanoma
    100063190 (MAP2K2)
   05211 Renal cell carcinoma
    100063190 (MAP2K2)
   05219 Bladder cancer
    100063190 (MAP2K2)
   05215 Prostate cancer
    100063190 (MAP2K2)
   05213 Endometrial cancer
    100063190 (MAP2K2)
   05224 Breast cancer
    100063190 (MAP2K2)
   05223 Non-small cell lung cancer
    100063190 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100063190 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    100063190 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100063190 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100063190 (MAP2K2)
   05135 Yersinia infection
    100063190 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100063190 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    100063190 (MAP2K2)
   05161 Hepatitis B
    100063190 (MAP2K2)
   05160 Hepatitis C
    100063190 (MAP2K2)
   05164 Influenza A
    100063190 (MAP2K2)
   05163 Human cytomegalovirus infection
    100063190 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100063190 (MAP2K2)
   05165 Human papillomavirus infection
    100063190 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100063190 (MAP2K2)
   01522 Endocrine resistance
    100063190 (MAP2K2)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ecb01001]
    100063190 (MAP2K2)
Enzymes [BR:ecb01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100063190 (MAP2K2)
Protein kinases [BR:ecb01001]
Serine/threonine kinases: STE group
  STE7 family
   100063190 (MAP2K2)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Kinase-like APH Kdo Seadorna_VP7 CAMSAP_CC1

Other DBs

NCBI-GeneID:

100063190

NCBI-ProteinID:

XP_023500194

Ensembl:

ENSECAG00000009157

LinkDB

Position

AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERLSELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSVGRYPIPPPDAKELEAIFGRPVVDGAEDEPPSTSPRPRP
PGRAISGHGMDSRPAMAIFELLDYIVNEPPPKLPHGAFTQDFQEFVNKCLIKNPAERADL
KMLMNHAFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV

NT seq 1203 nt +upstreamnt +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcgaacctggtggacctgcagaagaag
ctcgaggagctcgagctcgacgagcagcagaagaagcggctggaagccttcctcacccag
aaggccaaggtcggggagctcaaggacgatgactttgagaggctctccgagctgggagcc
ggcaacggcggggtggtcaccaaagtccagcacaggccttcgggcctcatcatggccagg
aagctgatccacctggagatcaagccggccatccggaaccagatcatccgcgagctgcag
gtacttcacgagtgcaactcgccctacatcgtcggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggacggcggctctctggaccaggtgttgaaa
gaagccaagagaatccccgaggagattctggggaaggtcagcatcgcggtgctccggggc
ctggcgtatctccgggagaagcaccagatcatgcaccgagacgtgaagccgtccaacatc
ctggtcaactccagaggggagatcaagctgtgcgatttcggggtgagcgggcagctcatc
gactccatggccaactccttcgtggggactcgctcgtacatgtcccccgagcgcctgcag
ggcacgcactactccgtgcagtcggacatctggagcatgggcctgtccctggtggagctg
tccgtcggcaggtaccccatcccgccgcccgacgccaaggagctcgaggccatcttcggc
cggcccgtggttgacggggcggaagacgagccccccagcacctcgccgcggcccaggccc
cccggacgcgccatcagtggtcacgggatggacagccggccggccatggccatcttcgaa
ttgctggactatattgtgaatgagcctcctcccaagctgccccacggcgccttcacgcag
gacttccaggagtttgtaaataaatgcctcattaagaacccagccgagcgagcggatctg
aagatgctcatgaaccacgccttcatcaagcggtcggaggtggaagaagtggattttgcc
ggctggctgtgtaagacgctgcggctgaaccagcccagcacgcccacgcgcacggccgtg
tga

Equus caballus (horse): 100065996

Entry

100065996 CDS T01058

Gene name

MAP2K1

Definition

(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X2

K04368

mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]

Organism

ecb Equus caballus (horse)

Pathway

ecb01521

EGFR tyrosine kinase inhibitor resistance

ecb01522

Endocrine resistance

ecb04010

MAPK signaling pathway

ecb04012

ErbB signaling pathway

ecb04014

Ras signaling pathway

ecb04015

Rap1 signaling pathway

ecb04022

cGMP-PKG signaling pathway

ecb04024

cAMP signaling pathway

ecb04062

Chemokine signaling pathway

ecb04066

HIF-1 signaling pathway

ecb04068

FoxO signaling pathway

ecb04071

Sphingolipid signaling pathway

ecb04072

Phospholipase D signaling pathway

ecb04114

Oocyte meiosis

ecb04140

Autophagy - animal

ecb04150

mTOR signaling pathway

ecb04151

PI3K-Akt signaling pathway

ecb04210

Apoptosis

ecb04218

Cellular senescence

ecb04270

Vascular smooth muscle contraction

ecb04370

VEGF signaling pathway

ecb04371

Apelin signaling pathway

ecb04380

Osteoclast differentiation

ecb04510

Focal adhesion

ecb04540

Gap junction

ecb04550

Signaling pathways regulating pluripotency of stem cells

ecb04613

Neutrophil extracellular trap formation

ecb04620

Toll-like receptor signaling pathway

ecb04650

Natural killer cell mediated cytotoxicity

ecb04660

T cell receptor signaling pathway

ecb04662

B cell receptor signaling pathway

ecb04664

Fc epsilon RI signaling pathway

ecb04666

Fc gamma R-mediated phagocytosis

ecb04668

TNF signaling pathway

ecb04720

Long-term potentiation

ecb04722

Neurotrophin signaling pathway

ecb04725

Cholinergic synapse

ecb04726

Serotonergic synapse

ecb04730

Long-term depression

ecb04810

Regulation of actin cytoskeleton

ecb04910

Insulin signaling pathway

ecb04912

GnRH signaling pathway

ecb04914

Progesterone-mediated oocyte maturation

ecb04915

Estrogen signaling pathway

ecb04916

Melanogenesis

ecb04917

Prolactin signaling pathway

ecb04919

Thyroid hormone signaling pathway

ecb04921

Oxytocin signaling pathway

ecb04926

Relaxin signaling pathway

ecb04928

Parathyroid hormone synthesis, secretion and action

ecb04929

GnRH secretion

ecb04934

Cushing syndrome

ecb04935

Growth hormone synthesis, secretion and action

ecb05010

Alzheimer disease

ecb05022

Pathways of neurodegeneration - multiple diseases

ecb05034

Alcoholism

ecb05132

Salmonella infection

ecb05135

Yersinia infection

ecb05160

Hepatitis C

ecb05161

Hepatitis B

ecb05163

Human cytomegalovirus infection

ecb05164

Influenza A

ecb05165

Human papillomavirus infection

ecb05166

Human T-cell leukemia virus 1 infection

ecb05167

Kaposi sarcoma-associated herpesvirus infection

ecb05170

Human immunodeficiency virus 1 infection

ecb05200

Pathways in cancer

ecb05205

Proteoglycans in cancer

ecb05206

MicroRNAs in cancer

ecb05210

Colorectal cancer

ecb05211

Renal cell carcinoma

ecb05212

Pancreatic cancer

ecb05213

Endometrial cancer

ecb05214

Glioma

ecb05215

Prostate cancer

ecb05216

Thyroid cancer

ecb05218

Melanoma

ecb05219

Bladder cancer

ecb05220

Chronic myeloid leukemia

ecb05221

Acute myeloid leukemia

ecb05223

Non-small cell lung cancer

ecb05224

Breast cancer

ecb05225

Hepatocellular carcinoma

ecb05226

Gastric cancer

ecb05230

Central carbon metabolism in cancer

ecb05231

Choline metabolism in cancer

ecb05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Brite

KEGG Orthology (KO) [BR:ecb00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100065996 (MAP2K1)
   04012 ErbB signaling pathway
    100065996 (MAP2K1)
   04014 Ras signaling pathway
    100065996 (MAP2K1)
   04015 Rap1 signaling pathway
    100065996 (MAP2K1)
   04370 VEGF signaling pathway
    100065996 (MAP2K1)
   04371 Apelin signaling pathway
    100065996 (MAP2K1)
   04668 TNF signaling pathway
    100065996 (MAP2K1)
   04066 HIF-1 signaling pathway
    100065996 (MAP2K1)
   04068 FoxO signaling pathway
    100065996 (MAP2K1)
   04072 Phospholipase D signaling pathway
    100065996 (MAP2K1)
   04071 Sphingolipid signaling pathway
    100065996 (MAP2K1)
   04024 cAMP signaling pathway
    100065996 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    100065996 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    100065996 (MAP2K1)
   04150 mTOR signaling pathway
    100065996 (MAP2K1)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100065996 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    100065996 (MAP2K1)
   04210 Apoptosis
    100065996 (MAP2K1)
   04218 Cellular senescence
    100065996 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100065996 (MAP2K1)
   04540 Gap junction
    100065996 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100065996 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100065996 (MAP2K1)
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100065996 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    100065996 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    100065996 (MAP2K1)
   04660 T cell receptor signaling pathway
    100065996 (MAP2K1)
   04662 B cell receptor signaling pathway
    100065996 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    100065996 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    100065996 (MAP2K1)
   04062 Chemokine signaling pathway
    100065996 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100065996 (MAP2K1)
   04929 GnRH secretion
    100065996 (MAP2K1)
   04912 GnRH signaling pathway
    100065996 (MAP2K1)
   04915 Estrogen signaling pathway
    100065996 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    100065996 (MAP2K1)
   04917 Prolactin signaling pathway
    100065996 (MAP2K1)
   04921 Oxytocin signaling pathway
    100065996 (MAP2K1)
   04926 Relaxin signaling pathway
    100065996 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    100065996 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    100065996 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    100065996 (MAP2K1)
   04916 Melanogenesis
    100065996 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100065996 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    100065996 (MAP2K1)
   04726 Serotonergic synapse
    100065996 (MAP2K1)
   04720 Long-term potentiation
    100065996 (MAP2K1)
   04730 Long-term depression
    100065996 (MAP2K1)
   04722 Neurotrophin signaling pathway
    100065996 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100065996 (MAP2K1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100065996 (MAP2K1)
   05206 MicroRNAs in cancer
    100065996 (MAP2K1)
   05205 Proteoglycans in cancer
    100065996 (MAP2K1)
   05230 Central carbon metabolism in cancer
    100065996 (MAP2K1)
   05231 Choline metabolism in cancer
    100065996 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100065996 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100065996 (MAP2K1)
   05212 Pancreatic cancer
    100065996 (MAP2K1)
   05225 Hepatocellular carcinoma
    100065996 (MAP2K1)
   05226 Gastric cancer
    100065996 (MAP2K1)
   05214 Glioma
    100065996 (MAP2K1)
   05216 Thyroid cancer
    100065996 (MAP2K1)
   05221 Acute myeloid leukemia
    100065996 (MAP2K1)
   05220 Chronic myeloid leukemia
    100065996 (MAP2K1)
   05218 Melanoma
    100065996 (MAP2K1)
   05211 Renal cell carcinoma
    100065996 (MAP2K1)
   05219 Bladder cancer
    100065996 (MAP2K1)
   05215 Prostate cancer
    100065996 (MAP2K1)
   05213 Endometrial cancer
    100065996 (MAP2K1)
   05224 Breast cancer
    100065996 (MAP2K1)
   05223 Non-small cell lung cancer
    100065996 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100065996 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    100065996 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    100065996 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100065996 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100065996 (MAP2K1)
   05135 Yersinia infection
    100065996 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100065996 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    100065996 (MAP2K1)
   05161 Hepatitis B
    100065996 (MAP2K1)
   05160 Hepatitis C
    100065996 (MAP2K1)
   05164 Influenza A
    100065996 (MAP2K1)
   05163 Human cytomegalovirus infection
    100065996 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100065996 (MAP2K1)
   05165 Human papillomavirus infection
    100065996 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100065996 (MAP2K1)
   01522 Endocrine resistance
    100065996 (MAP2K1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ecb01001]
    100065996 (MAP2K1)
Enzymes [BR:ecb01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100065996 (MAP2K1)
Protein kinases [BR:ecb01001]
Serine/threonine kinases: STE group
  STE7 family
   100065996 (MAP2K1)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Kinase-like Seadorna_VP7 NAD_binding_6

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

Ensembl:

VGNC:

LinkDB

Position

AA seq 371 aa
MKPERTNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV
FKVAHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC
MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG
EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP
IPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPP
PKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN
QPSTPTHAAGV

NT seq 1116 nt +upstreamnt +downstreamnt
atgaagccggagaggaccaacctggaggccttgcagaagaagctggaggagctggagctc
gatgaacagcagcgaaagcgccttgaggcctttcttactcagaagcagaaggttggggaa
ctgaaggatgatgactttgagaagatcagtgagctgggtgctggcaatggtggtgtggta
ttcaaggttgcccacaaaccgtctggtttggtcatggccagaaagctaattcacctggag
atcaagcctgcaatccggaaccagatcataagggagctgcaggttctacatgagtgcaac
tccccatatattgtgggcttctatggcgcattctacagcgatggtgagatcagcatctgc
atggagcacatggatgggggttccttggatcaagtcctaaagaaagctggaagaattcct
gagcaaattttaggaaaagttagcattgctgtaataaaaggcctgacgtatctgagggag
aagcacaagattatgcacagagatgtcaagccctccaacatcctagtgaactcccgtggg
gagatcaagctgtgtgattttggggtcagcgggcagctcatcgactccatggccaactcc
ttcgtgggcacaaggtcttacatgtcgccggaaagactccaggggactcattattcagtg
cagtcggacatctggagcatggggctctctctggttgagatggcggtcgggaggtatccc
atccctcctccagatgccaaggagctggagctgatgtttgggtgccaagtggagggagat
gcggctgagactccgcctaggccaaggacccctggaagacccctcagctcttatggaatg
gacagccgacctcctatggcaatttttgagttactggattacatagtcaacgagcctcct
cccaagctgcccagtggagtattcagtctggaatttcaggattttgtgaataaatgctta
atcaaaaaccctgcagagagagcagatttgaagcaactcatggttcacgcttttatcaag
agatctgatgccgaggaagtggattttgcaggttggctctgctccaccattggccttaac
cagcccagcacaccaacccacgcggctggcgtctaa

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