Escherichia fergusonii: EFER_0001
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Entry
EFER_0001 CDS
T00811
Symbol
thrA
Name
(GenBank) fused aspartokinase I; homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
efe
Escherichia fergusonii
Pathway
efe00260
Glycine, serine and threonine metabolism
efe00261
Monobactam biosynthesis
efe00270
Cysteine and methionine metabolism
efe00300
Lysine biosynthesis
efe01100
Metabolic pathways
efe01110
Biosynthesis of secondary metabolites
efe01120
Microbial metabolism in diverse environments
efe01230
Biosynthesis of amino acids
Module
efe_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
efe_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
efe_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
efe00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
EFER_0001 (thrA)
00270 Cysteine and methionine metabolism
EFER_0001 (thrA)
00300 Lysine biosynthesis
EFER_0001 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
EFER_0001 (thrA)
Enzymes [BR:
efe01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
EFER_0001 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
EFER_0001 (thrA)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
NAD_binding_3
ACT_7
ACT
Sacchrp_dh_NADP
DUF6247
Motif
Other DBs
NCBI-ProteinID:
CAQ87589
UniProt:
B7LWR0
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All DBs
Position
205..2667
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AA seq
820 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADILENNARQGQVATVLSAPAKITNHLVAMIEKTIGGLDA
LTNISDAERIFSELLSGLAAAQPGFPQAQLKAFVEQEFAQIKHVLHGISLLGQCPDSVNA
SIICRGEKMSIAIMAGLLEARGHKVTVIDPVEKLLAVGHYLESTVDIAESTRRIAAGRIP
SDHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDDLPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRSGISVVLITQSSSEYSISF
CVPQADCARAKRALQDEFYLELKEGLLEPLAVTERLAVISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDVTTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQSWLKSKHIDLRVCGVANSKALLTNVHGLNLENWQAELAQAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRYAAAKSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELLHFSGILSGSLSFIFGKLDEGMSFSEATTLA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELSDIVIEPVLPQGFDAEGDVPAFMA
NLSQLDDAFAARVAKARDEGKVLRYVGNIEEDGVCRVKIADVDGNDPLFKVKNGENALAF
YTHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacggtttctgcgtgtt
gccgatattctggaaaacaatgccaggcaggggcaggtagcgaccgttctttctgctccc
gcaaaaattaccaaccacctggttgcgatgatcgaaaagaccatcggcggtctggatgcc
ttaaccaatattagcgatgcagaacggatcttctctgaattgttaagtgggctggcagct
gcgcagccgggatttccgcaagcacaactgaaggcttttgttgagcaagaattcgcgcag
attaaacatgttctgcatggtatcagcctgttggggcaatgcccggacagcgttaatgct
tcaatcatttgtcgtggcgaaaagatgtccattgccatcatggcaggcctgctggaggcg
cgtgggcataaagttaccgttattgatcctgttgagaaattattggccgtcggtcactac
ctggaatcgacggttgatattgctgaatctacccgccgtatagccgctggacgtattcct
tctgaccatatggtgctgatggccggttttactgccggtaatgaaaaaggggaacttgtg
gtgctcgggcgcaacggttccgattattccgcagcggtactggcagcgtgtttacgcgcc
gattgttgcgagatctggactgatgtcgatggtgtctatacctgcgacccacgtcaggta
ccggatgcccgattacttaagtcgatgtcgtaccaggaggcgatggaactctcctatttc
ggcgccaaagtcctccatcctcgaaccatcactcccatcgcccagttccagattccctgc
ctgataaaaaataccggaaacccgcaagcaccaggaacgctgattggcgccagccgcgac
gaagatgatctgccggtgaagggcatttcaaatctcaataatatggcgatgttcagcgtc
tccgggccggggatgaagggaatggtcggcatggctgctcgcgtgtttgcggcaatgtct
cgctcaggaatttcggtagtcctgattacgcaatcctcctctgagtacagcattagcttc
tgtgtaccgcaggctgactgtgcacgtgctaagcgggcattgcaggatgagttttatctt
gaactgaaagagggcttgctggaacctctggcagtcactgagcgtctggcagtcatctcc
gtggtaggcgatggtatgcgcacattgcgtggcatctcggcaaaattctttgctgctctg
gcgcgcgccaatatcaatattgttgcgattgctcagggatcttctgagcgctccatttca
gtggtagtcaataacgatgatgtcactactggtgtgcgtgttacgcatcagatgctgttc
aatactgatcaagtgattgaagtgttcgtcattggtgtgggtggcgttggtggcgcattg
cttgagcaattaaaacgtcaacaatcctggcttaagagtaaacatatcgatttacgcgtt
tgtggtgttgccaactccaaagcgctgttgactaacgttcatggcctaaatcttgagaac
tggcaggcggaactggcccaggcgaaagagccgtttaatttagggcgcttaattcgcctg
gtgaaagaatatcatctgcttaatccggtaattgttgactgtacctccagccaggcggtt
gcggatcagtatgctgacttcctgcgcgaaggtttccatgtggtgacgccaaacaaaaag
gccaacacttcgtcgatggactactaccatcaactgcgttatgccgcagcaaaatcccga
cgtaaattcctctacgacaccaacgtaggggcaggcttacccgttatagaaaacttacaa
aacctgctgaatgcaggggatgagttactgcatttttctggcattctttccggctcactc
tctttcatattcggtaagctggatgaaggaatgagtttctctgaggcgactacactggca
cgggaaatgggctataccgagccagatccacgagacgatctttcgggtatggatgttgcg
cgtaaattgttgatcctcgctcgtgaaaccggacgtgaactggaactgtcagatatcgtg
attgagcccgtactgccacaaggtttcgatgctgaaggcgatgttcctgcatttatggcg
aatctgtcacaactcgatgacgcctttgctgctcgggtggcaaaagcccgtgatgagggc
aaagtattacgttatgttggcaatatcgaagaagacggcgtatgtcgggtgaaaattgcc
gatgttgatggcaacgatccgctgtttaaagtgaagaatggcgagaatgcgctggctttc
tatacccattattaccaaccactgccgttggtattgcgcggttacggtgcaggtaacgat
gttacagccgccggagttttcgcggacctgctgcgtaccctttcatggaagttaggagtc
tga
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