KEGG   PATHWAY: emr00010Help
Entry
emr00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Ehrlichia muris
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
emr00010  Glycolysis / Gluconeogenesis
emr00010

Ortholog table
Module
emr_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:emr00010]
Other DBs
GO: 0006096 0006094
Organism
Ehrlichia muris [GN:emr]
Gene
EMUR_03415  glpX; fructose 1,6-bisphosphatase [KO:K02446] [EC:3.1.3.11]
EMUR_00260  fructose-bisphosphate aldolase [KO:K11645] [EC:4.1.2.13]
EMUR_02135  triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
EMUR_04750  gapA; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
EMUR_00095  phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
EMUR_02745  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
EMUR_02570  eno; enolase [KO:K01689] [EC:4.2.1.11]
EMUR_03990  pyruvate dehydrogenase E1 subunit alpha [KO:K00161] [EC:1.2.4.1]
EMUR_00425  pyruvate dehydrogenase subunit beta [KO:K00162] [EC:1.2.4.1]
EMUR_00270  branched-chain alpha-keto acid dehydrogenase subunit E2 [KO:K00627] [EC:2.3.1.12]
EMUR_00665  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
EMUR_02730  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
emr00020  Citrate cycle (TCA cycle)
emr00030  Pentose phosphate pathway
emr00620  Pyruvate metabolism
emr00640  Propanoate metabolism
KO pathway
ko00010   
LinkDB All DBs

DBGET integrated database retrieval system