KEGG   ENZYME: 2.4.1.11Help
Entry
EC 2.4.1.11                 Enzyme                                 

Name
glycogen(starch) synthase;
UDP-glucose---glycogen glucosyltransferase;
glycogen (starch) synthetase;
UDP-glucose-glycogen glucosyltransferase;
UDP-glycogen synthase;
UDPG-glycogen synthetase;
UDPG-glycogen transglucosylase;
uridine diphosphoglucose-glycogen glucosyltransferase;
UDP-glucose:glycogen 4-alpha-D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:glycogen 4-alpha-D-glucosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-alpha-D-glucose + [(1->4)-alpha-D-glucosyl]n = UDP + [(1->4)-alpha-D-glucosyl]n+1 [RN:R00292 R06051]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
[(1->4)-alpha-D-glucosyl]n
Product
UDP [CPD:C00015];
[(1->4)-alpha-D-glucosyl]n+1
Comment
The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).
History
EC 2.4.1.11 created 1961
Pathway
ec00500  Starch and sucrose metabolism
ec01100  Metabolic pathways
Orthology
K00693  glycogen synthase
K16150  glycogen synthase
K16153  glycogen phosphorylase/synthase
Genes
HSA: 2997(GYS1) 2998(GYS2)
PTR: 456196(GYS1) 465336(GYS2)
PPS: 100972797(GYS2) 100990031(GYS1)
GGO: 101131537(GYS2) 101132203(GYS1)
PON: 100172871(GYS1) 100452879(GYS2)
NLE: 100579728(GYS1) 101177222(GYS2)
MCC: 574233(GYS1) 706152(GYS2)
MCF: 102134439(GYS1) 102145637(GYS2)
CSAB: 103218736(GYS2) 103235009(GYS1)
RRO: 104660892(GYS2) 104666538(GYS1)
RBB: 108523620(GYS1) 108539726(GYS2)
CJC: 100406574(GYS1)
SBQ: 101040983(GYS2) 101050509(GYS1)
MMU: 14936(Gys1) 232493(Gys2)
RNO: 25623(Gys2) 690987(Gys1)
CGE: 100769788(Gys1) 100770628(Gys2)
NGI: 103743640(Gys1) 103748807(Gys2)
HGL: 101699800(Gys2) 101712358(Gys1)
OCU: 100008660(GYS1) 100352840(GYS2)
TUP: 102469649(GYS1) 102472146(GYS2)
CFA: 403737(GYS2) 611993(GYS1)
AML: 100470220(GYS2) 100476206(GYS1)
UMR: 103657110(GYS1) 103665227(GYS2)
ORO: 101368722(GYS2) 101370584(GYS1)
FCA: 101092123(GYS2) 101100682(GYS1)
PTG: 102950123(GYS1) 102965400(GYS2)
AJU: 106967981(GYS2) 106988702(GYS1)
BTA: 537451(GYS2) 786335(GYS1)
BOM: 102272943(GYS2) 102278988(GYS1)
BIU: 109559597(GYS2) 109571966 109572216(GYS1)
PHD: 102324800(GYS1) 102332125(GYS2)
CHX: 102188970(GYS1) 102189015(GYS2)
OAS: 101108772(GYS1) 101118685(GYS2)
SSC: 100157080(GYS2) 574064(GYS1)
CFR: 102511249(GYS1) 102511313(GYS2)
CDK: 105096485(GYS2) 105102888(GYS1)
BACU: 103007749(GYS2) 103019791(GYS1)
LVE: 103074944(GYS2) 103084996(GYS1)
OOR: 101284496(GYS1) 101287552(GYS2)
ECB: 100054723(GYS1) 100064264(GYS2)
EPZ: 103553309(GYS1) 103554933(GYS2)
EAI: 106825573(GYS2) 106838266(GYS1)
MYB: 102251419(GYS2) 102262755(GYS1)
MYD: 102771674(GYS2) 102775147(GYS1)
HAI: 109375142(GYS2) 109390996(GYS1)
RSS: 109450635(GYS2) 109452589(GYS1)
PALE: 102884634(GYS1) 102890809(GYS2)
LAV: 100658178(GYS2) 100659799(GYS1)
MDO: 100010618(GYS2) 100030435(GYS1)
SHR: 100918400(GYS2) 100920298(GYS1)
OAA: 100074446(GYS1)
GGA: 107050456 418201(GYS2)
MGP: 100547308(GYS2)
CJO: 107316995(GYS2)
APLA: 101795011(GYS2)
ACYG: 106038297(GYS2)
TGU: 100232653(GYS2)
GFR: 102038432(GYS2)
FAB: 101821843(GYS2)
PHI: 102105522(GYS2) 102106773(GYS1)
PMAJ: 107205059(GYS2)
CCW: 104696143(GYS2)
FPG: 101918224(GYS2) 106112713(GYS1)
FCH: 102051571(GYS2)
CLV: 102095088(GYS2)
EGZ: 104135134(GYS2)
AAM: 106486701 106488410(GYS2)
ASN: 102372928(GYS1) 102375223(GYS2)
AMJ: 102573726(GYS1) 106737074(GYS2)
PSS: 102449457(GYS2) 102462946
CMY: 102943466(GYS1) 102944417(GYS2)
CPIC: 101939182(GYS2) 101947252(GYS1)
ACS: 100555409(gys2) 100563034(gys1)
PVT: 110078508(GYS1) 110083005(GYS2)
PBI: 103048016(GYS1) 103058373(GYS2)
GJA: 107116591(GYS1) 107122425
XLA: 108696758 108697802 431912(gys2.L)
XTR: 100490155(gys1) 548515(gys2)
DRE: 373082(gys2) 394155(gys1)
IPU: 108256446(gys1) 108279630(gys2)
AMEX: 103022388 103040242(gys2)
TRU: 101077099(gys1) 101079536(gys2)
LCO: 104927634(gys2) 104930340(gys1) 109142472
MZE: 101474059 101485531(gys1)
OLA: 101155437(gys1) 101163866(gys2)
XMA: 102217274 102233516(gys1)
PRET: 103459579(gys2) 103469092(gys1)
NFU: 107376658 107381436(gys2)
CSEM: 103383026(gys2) 103392977
HCQ: 109514852(gys1) 109520116(gys2)
BPEC: 110158208(gys1) 110162197 110172488(gys2)
ELS: 105007707 105020183(gys2)
LCM: 102359961(GYS2) 102360620(GYS1)
CIN: 100183713
SPU: 578305
APLC: 110975475
SKO: 100368259
DME: Dmel_CG6904(GlyS)
DSI: Dsimw501_GD20381(Dsim_GD20381)
MDE: 101890004
AAG: 5564353
AME: 552328
BIM: 100748309
BTER: 100647195
SOC: 105206087
AEC: 105155041
ACEP: 105620164
PBAR: 105432338
HST: 105182643
CFO: 105249547
LHU: 105669367
PGC: 109860044
NVI: 100119226
TCA: 662050
DPA: 109542106
NVL: 108564856
BMOR: 101736417
PMAC: 106716340
PRAP: 110996075
API: 100166026
ZNE: 110833071
FCD: 110845614
TUT: 107372104
CEL: CELE_Y46G5A.31(gsy-1)
CBR: CBG18401(Cbr-gsy-1)
TSP: Tsp_00121
CRG: 105341160
MYI: 110453713
OBI: 106882342
LAK: 106168839
SHX: MS3_08291
EGL: EGR_02939
EPA: 110233733
HMG: 100197472(gys1)
AQU: 100640802
SCE: YFR015C(GSY1) YLR258W(GSY2)
ERC: Ecym_1276
KMX: KLMA_30370(GSY2)
NCS: NCAS_0A08870(NCAS0A08870) NCAS_0D00640(NCAS0D00640)
NDI: NDAI_0G05290(NDAI0G05290) NDAI_0H03510(NDAI0H03510)
TPF: TPHA_0B03550(TPHA0B03550) TPHA_0O01130(TPHA0O01130)
TBL: TBLA_0D05020(TBLA0D05020)
TDL: TDEL_0B06310(TDEL0B06310)
KAF: KAFR_0C04470(KAFR0C04470) KAFR_0I02020(KAFR0I02020)
PIC: PICST_81231(GSY1)
CAL: CAALFM_CR00780CA(GSY1)
CAUR: QG37_03063
SLB: AWJ20_4133(GSY1)
NCR: NCU06687(gsy-1)
NTE: NEUTE1DRAFT57176(NEUTE1DRAFT_57176)
MGR: MGG_07289
SSCK: SPSK_04978
TRE: TRIREDRAFT_44529(gys1)
MAW: MAC_05928
MAJ: MAA_07866
CMT: CCM_03736
MBE: MBM_08435
ANI: AN8010.2
ANG: ANI_1_1448024(An02g10310)
ABE: ARB_06804
TVE: TRV_06758
PTE: PTT_15101
CNE: CNJ00590
CNB: CNBJ2910
ABP: AGABI1DRAFT77702(AGABI1DRAFT_77702)
ABV: AGABI2DRAFT212415(AGABI2DRAFT_212415)
DDI: DDB_G0267674(glcS)
DFA: DFA_00663(glcS)
DDS: Ddes_0468
DAS: Daes_2709
LIP: LI0332(glgP)
LIR: LAW_00344
SAT: SYN_00879
SSAN: NX02_00195
LPIL: LIP_1759
MTU: Rv3032
MTV: RVBD_3032
MTC: MT3116
MRA: MRA_3063
MTUR: CFBS_3199
MTD: UDA_3032
MTUC: J113_21130
MTUE: J114_16205
MTUL: TBHG_02961
MTUT: HKBT1_3186
MTUU: HKBT2_3191
MBB: BCG_3055
MBT: JTY_3050
MBX: BCGT_2878
MAF: MAF_30390
MMIC: RN08_3342
MLE: ML1715
MLB: MLBr01715
MPA: MAP_3064
MAO: MAP4_0736
MAVI: RC58_03590
MAVU: RE97_03595
MAV: MAV_3879
MAVD: NF84_17700
MAVR: LA63_17880
MAVA: LA64_17870
MIT: OCO_37000
MIA: OCU_37080
MID: MIP_05606
MYO: OEM_37660
MIR: OCQ_38210
MLP: MLM_3102
MUL: MUL_1919
MMC: Mmcs_1867
MKM: Mkms_1913
MJL: Mjls_1847
MMI: MMAR_1681
MMM: W7S_18520
MHAD: B586_15815
MVA: Mvan_2096
MGI: Mflv_4262
MVQ: MYVA_1984
MAB: MAB_3366
MABB: MASS_3307
MABO: NF82_16855
MCHE: BB28_16975
MSTE: MSTE_03333
ASD: AS9A_3225
NFA: NFA_42820
RER: RER_23700
REY: O5Y_11105
ROP: ROP_65120
REQ: REQ_31760
RHB: NY08_1537
GBR: Gbro_3263
GOR: KTR9_3301
TPR: Tpau_2920
SRT: Srot_1400
IDO: I598_3217
SEN: SACE_6200
AMD: AMED_1646
AMN: RAM_08365
AMM: AMES_1634
AMZ: B737_1635
AOI: AORI_6275
PDX: Psed_1742
PSEA: WY02_10525
PSEE: FRP1_03730
PSEH: XF36_19100
AMI: Amir_6058
SESP: BN6_72610(gtuS4-14)
KAL: KALB_7484
ACAD: UA74_06385
ALL: CRK58937
MIL: ML5_4113
ACTN: L083_6171
CAI: Caci_3232
SNA: Snas_2349
CWO: Cwoe_4652
GLJ: GKIL_4397
AFD: Alfi_1237
CHU: CHU_1581(glgA)
DFE: Dfer_3735
SLI: Slin_5697
LBY: Lbys_2865
FAE: FAES_1227
HSW: Hsw_2975
FLM: MY04_1504(glgA)
COC: Coch_1285
MOX: DAMO_1068
NAA: Nps_00385
 » show all
Taxonomy
Reference
1  [PMID:13682402]
  Authors
ALGRANATI ID, CABIB E.
  Title
The synthesis of glycogen in yeast.
  Journal
Biochim Biophys Acta 43:141-2 (1960)
DOI:10.1016/0006-3002(60)90422-4
Reference
2  [PMID:13687710]
  Authors
BASU DK, BACHHAWAT BK.
  Title
Purification of uridine diphosphoglucose-glycogen transglucosylase from sheep brain.
  Journal
Biochim Biophys Acta 50:123-8 (1961)
DOI:10.1016/0006-3002(61)91067-8
Reference
3
  Authors
Leloir, L.F. and Cardini, C.E.
  Title
UDPG-glycogen transglucosylase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 317-326.
Reference
4  [PMID:14415527]
  Authors
LELOIR LF, GOLDEMBERG SH.
  Title
Synthesis of glycogen from uridine diphosphate glucose in liver.
  Journal
J Biol Chem 235:919-23 (1960)
Reference
5  [PMID:2970965]
  Authors
Pitcher J, Smythe C, Cohen P.
  Title
Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.
  Journal
Eur J Biochem 176:391-5 (1988)
DOI:10.1111/j.1432-1033.1988.tb14294.x
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.11
IUBMB Enzyme Nomenclature: 2.4.1.11
ExPASy - ENZYME nomenclature database: 2.4.1.11
BRENDA, the Enzyme Database: 2.4.1.11
CAS: 9014-56-6
LinkDB All DBs

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