KEGG ENZYME: 2.7.1.145

ENZYME: 2.7.1.145

Entry

EC 2.7.1.145                Enzyme

Name

deoxynucleoside kinase;
multispecific deoxynucleoside kinase;
ms-dNK;
multisubstrate deoxyribonucleoside kinase;
multifunctional deoxynucleoside kinase;
D. melanogaster deoxynucleoside kinase;
Dm-dNK;
ATP:deoxynucleoside 5'-phosphotransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:deoxyribonucleoside 5'-phosphotransferase

Reaction(IUBMB)

ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate [RN:R05806]

Reaction(KEGG)

R05806 > R01567 R01666 R01967 R02089 R02099

Substrate

ATP [CPD:C00002];
2'-deoxyribonucleoside [CPD:C02269]

Product

ADP [CPD:C00008];
2'-deoxyribonucleoside 5'-phosphate [CPD:C00676]

Comment

The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common 2'-deoxyribonucleosides.

History

EC 2.7.1.145 created 2001

Pathway

ec00230

Purine metabolism

ec00240

Pyrimidine metabolism

ec01100

Metabolic pathways

Orthology

K05961

deoxynucleoside kinase

Genes

DME:	Dmel_CG5452(dnk)

DER:

6554072

DSE:

6620705

DSI:	Dsimw501_GD19261(Dsim_GD19261)

DYA:	Dyak_GE25572

DAN:

6505870

DSR:

110186665

DPO:

4801838

DPE:

6588091

DMN:

108156402

DWI:

6647251

DGR:

6568426

DMO:	Dmoj_GI10047

DAZ:

108620993

DNV:

108658836

DHE:

111602690

DVI:

6631195

CCAT:

101450470

BOD:

106617808

BDR:

105231069

RZE:

108355448

AOQ:

129236198

TDA:	119680404 119681378

MDE:

101896877

SCAC:

106090041

LCQ:

111680959

LSQ:

119613191

GFS:

119639424

ECOE:

129942128

CLON:

129605891 129612847

HIS:

119650996

AGA:

1281587

ACOZ:

120953957

AARA:

120898076

AMER:

121590743

ASTE:

118505597 118516567

AFUN:

125774874

AMOU:

128297035

AALI:

118461083

AAG:

5579214

AALB:

109405935 109417111 115266522

CQU:	CpipJ_CPIJ003276

CPII:

120424947

CNS:	116347604 116350021 116351806

BCOO:

119069920 119070619 119075577 119079253 119085227

AME:

552840

ACER:

107998280

ALAB:

122714892

ADR:

102672898

AFLR:

100871899

BIM:

100744576

BBIF:

117205012

BVK:

117230963

BVAN:

117153269

BTER:

100648317

BAFF:

126921834

BPYO:

122567739

BPAS:

132912725

FVI:

122537787

CCAL:

108626754

OBB:

114878736

OLG:

117602966

MGEN:

117221411

NMEA:

116423874

CGIG:

122398991

SOC:	105196060 105207545

MPHA:

105836053 105837551

AEC:	105144858 105146649

ACEP:

105623946 105626028

PBAR:

105422323 105427465

VEM:	105564478 105567866

HST:	105187065 105188611

DQU:	106741152 106749991

CFO:	105248838 105257645

FEX:	115238243 115243702

LHU:	105672005 105672239

PGC:	109856640 109858340

OBO:	105275914 105281382

PCF:

106784413

PFUC:

122519186

VPS:

122630646

VCRB:

124424167

VVE:	124950789 124950790

LHT:

122513012

LBD:

127284996

FAS:

105270889

DAM:

107041802

AGIF:

122861087

VCAN:

122412197

CCIN:

107262785

DSM:	124410894 124416581

NPT:

124215415

NFB:

124179224

NLO:

107219391

NVG:

124300585

AROA:

105684234

TCA:	659303 659935 660567

DPA:	109542197 109546462

SOY:	115876628 115880872 115880987 115883471

AGRG:

126746792 126747076 126747310

ATD:

109602144

CSET:

123319946 123321861

AGB:	108907401 108911548 108915258

LDC:	111501828 111511326

NVL:	108559729 108561321 108567605

APLN:

108736123 108740527

PPYR:

116171896 116172019 116178371 116181669 116182896

OTU:	111416219 111424509 111429051

BMOR:

101741300 692569

BMAN:

114244024 114245792

MSEX:

115448679 115450116

DPL:	KGM_201543 KGM_210835

BANY:

112044401 112051943

MJU:	123871697 123871853

NIQ:	126769380 126770645

VCD:	124529800 124532529

MCIX:

123655306 123657209

PMAC:

106707992 106716895

PPOT:

106109692 106111772

PXU:	106121104 106124000

PRAP:

111000809 111002863

PBX:	123708340 123714501

PNAP:

125049648 125059630

ZCE:	119829693 119832290

CCRC:

123694796 123695479

LSIN:

126976424 126979176

AAGE:

121730760 121732263

HAW:	110376532 110377523

HZE:	124633059 124633234

TNL:	113494794 113496714

SLIU:

111353352 111359721

OFU:	114357187 114361976

PXY:

105393061

PGW:	126369271 126372417

CFEL:

113376318 113377350

API:	100165338 100165639 100573648

DNX:	107163678 107166092

AGS:

114125562

RMD:	113555271 113560575

ACOO:

126837273 126839223

DVT:

126901113

BTAB:

109030166 109030645 109042887

NLU:	111045781 111048849

HVI:

124355318

PHU:	Phum_PHUM399920 Phum_PHUM407830

TPAL:

117642345 117644223 117644227 117644838 117645549 117646362 117646570 117647020 117647901 117648133 117650702 117650881 117652427 117652670 117653641

ZNE:	110827391 110835653

CSEC:

111866426 111875651

SGRE:

126273169

BROR:

134528510

IEL:

124165263

FCD:

110842433

DPX:	DAPPUDRAFT_305834 DAPPUDRAFT_99663

PVM:	113805250 113818333

PMOO:

119596870

HAME:

121868408

MNZ:	135206122 135213635 135213638

HAZT:

108665785

EAF:	111699873 111704998 111706452 111718376

LSM:	121121677 121122856

TCF:	131878958 131879683 131882528 131885170 131889936

PPOI:

119101655

VDE:	111249878 111253427

VJA:	111260459 111269325

DPTE:

113789910

DFR:

124499059

PMEO:

129588944 129593989

DPOL:

127865105

» show all

Reference

1 [PMID:9461577]

Authors

Munch-Petersen B, Piskur J, Sondergaard L.

Title

Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase.

Journal

J Biol Chem 273:3926-31 (1998)
DOI:10.1074/jbc.273.7.3926

Sequence

[dme:Dmel_CG5452]

Reference

2 [PMID:10692477]

Authors

Munch-Petersen B, Knecht W, Lenz C, Sondergaard L, Piskur J

Title

Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants.

Journal

J Biol Chem 275:6673-9 (2000)
DOI:10.1074/jbc.275.9.6673