KEGG   ENZYME: 3.4.21.34Help
Entry
EC 3.4.21.34                Enzyme                                 

Name
plasma kallikrein;
serum kallikrein;
kininogenin;
kallikrein I;
kallikrein II;
kininogenase;
kallikrein;
callicrein;
glumorin;
padreatin;
padutin;
kallidinogenase;
bradykininogenase;
panceatic kallikrein;
onokrein P;
dilminal D;
depot-Padutin;
urokallikrein;
urinary kallikrein
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of some Arg! and Lys! bonds, including Lys!Arg and Arg!Ser in (human) kininogen to release bradykinin
Comment
Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Activates coagulation factors XII, VII and plasminogen. Selective for Arg > Lys in P1, in small molecule substrates.
History
EC 3.4.21.34 created 1965 as EC 3.4.4.21, transferred 1972 to EC 3.4.21.8, part transferred 1981 to EC 3.4.21.34
Orthology
K01324  plasma kallikrein
Genes
HSA: 3818(KLKB1)
PTR: 471375(KLKB1)
PPS: 100985593(KLKB1)
GGO: 101142617(KLKB1)
PON: 100172926(KLKB1)
NLE: 100594044(KLKB1)
MCC: 696639(KLKB1)
MCF: 102142369(KLKB1)
CSAB: 103236637(KLKB1)
RRO: 104673817(KLKB1)
RBB: 108522428(KLKB1)
CJC: 100409572(KLKB1)
SBQ: 101048983(KLKB1)
MMU: 16621(Klkb1)
RNO: 25048(Klkb1)
CGE: 100767873(Klkb1)
NGI: 103750509(Klkb1)
HGL: 101719264(Klkb1)
CCAN: 109684302(Klkb1)
OCU: 100356267(KLKB1)
TUP: 102485674(KLKB1)
CFA: 475624(KLKB1)
AML: 100468355(KLKB1)
UMR: 103680968(KLKB1)
ORO: 101379313(KLKB1)
FCA: 101094092(KLKB1)
PTG: 102971874(KLKB1)
AJU: 106982221(KLKB1)
BTA: 533547(KLKB1)
BOM: 102270694(KLKB1)
BIU: 109553560(KLKB1)
PHD: 102325610(KLKB1)
CHX: 102184030(KLKB1)
OAS: 101116376(KLKB1)
SSC: 397144(KLKB1)
CFR: 102512343(KLKB1)
CDK: 105102384(KLKB1)
ECB: 100056650(KLKB1)
EPZ: 103543059(KLKB1) 103543236
EAI: 106840366(KLKB1)
MYB: 102247445(KLKB1)
MYD: 102764838(KLKB1)
HAI: 109395838(KLKB1)
RSS: 109449674(KLKB1)
PALE: 102883484(KLKB1)
LAV: 100660779
TMU: 101358166
MDO: 100013981(KLKB1)
SHR: 100917450(KLKB1)
GGA: 422723(F11)
MGP: 100549617(KLKB1)
CJO: 107313680
APLA: 101805242(F11)
ACYG: 106035178
TGU: 100228027(F11)
FAB: 101814154(KLKB1)
PHI: 102108065(F11)
PMAJ: 107203558
CCW: 104690592(KLKB1)
FPG: 101918416(F11)
FCH: 102054661(KLKB1)
CLV: 102094577
EGZ: 104129485
AAM: 106484024
ASN: 102385242(KLKB1)
AMJ: 102566272(KLKB1)
PSS: 102455335(F11)
CPIC: 101952530(KLKB1)
ACS: 100557428(klkb1)
PVT: 110077890(KLKB1)
PBI: 103051995(KLKB1)
GJA: 107121980(KLKB1)
XLA: 446603(klkb1.L)
XTR: 100486524(klkb1)
NPR: 108784940
IPU: 108257413
LCO: 109137542
OLA: 101167304
ELS: 105027740
SFM: 108938912
LCM: 102361209(KLKB1)
CRG: 105331575
MYI: 110443096
 » show all
Taxonomy
Reference
1  [PMID:6918767]
  Authors
Heimark RL, Davie EW.
  Title
Bovine and human plasma prekallikrein.
  Journal
Methods Enzymol 80 Pt C:157-72 (1981)
Reference
2  [PMID:6976185]
  Authors
McRae BJ, Kurachi K, Heimark RL, Fujikawa K, Davie EW, Powers JC.
  Title
Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates.
  Journal
Biochemistry 20:7196-206 (1981)
Reference
3  [PMID:3237096]
  Authors
Silverberg M, Kaplan AP.
  Title
Prekallikrein.
  Journal
Methods Enzymol 163:85-95 (1988)
Reference
4  [PMID:2598771]
  Authors
Seidah NG, Ladenheim R, Mbikay M, Hamelin J, Lutfalla G, Rougeon F, Lazure C, Chretien M.
  Title
The cDNA structure of rat plasma kallikrein.
  Journal
DNA 8:563-74 (1989)
DOI:10.1089/dna.1989.8.563
  Sequence
[rno:25048]
Reference
5  [PMID:2534361]
  Authors
Tsuda Y, Teno N, Okada Y, Wanaka K, Bohgaki M, Hijikata-Okunomiya A, Okamoto U, Naito T, Okamoto S.
  Title
Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein.
  Journal
Chem Pharm Bull (Tokyo) 37:3108-11 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.34
IUBMB Enzyme Nomenclature: 3.4.21.34
ExPASy - ENZYME nomenclature database: 3.4.21.34
BRENDA, the Enzyme Database: 3.4.21.34
CAS: 410538-33-9
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