Equus przewalskii (Przewalski's horse): 103540937 Help Entry 103540937         CDS       T04644                                  Symbol NOS3 Name (RefSeq) nitric oxide synthase 3   KO K13242   nitric-oxide synthase, endothelial [EC:1.14.13.39] Organism epz  Equus przewalskii (Przewalski's horse) Pathway epz00220   Arginine biosynthesis epz00330   Arginine and proline metabolism epz01100   Metabolic pathways epz04020   Calcium signaling pathway epz04022   cGMP-PKG signaling pathway epz04066   HIF-1 signaling pathway epz04071   Sphingolipid signaling pathway epz04151   PI3K-Akt signaling pathway epz04370   VEGF signaling pathway epz04371   Apelin signaling pathway epz04611   Platelet activation epz04915   Estrogen signaling pathway epz04921   Oxytocin signaling pathway epz04926   Relaxin signaling pathway epz04931   Insulin resistance epz04933   AGE-RAGE signaling pathway in diabetic complications epz05415   Diabetic cardiomyopathy epz05417   Lipid and atherosclerosis epz05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:epz00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     103540937 (NOS3)    00330 Arginine and proline metabolism     103540937 (NOS3)  09130 Environmental Information Processing   09132 Signal transduction    04370 VEGF signaling pathway     103540937 (NOS3)    04371 Apelin signaling pathway     103540937 (NOS3)    04066 HIF-1 signaling pathway     103540937 (NOS3)    04020 Calcium signaling pathway     103540937 (NOS3)    04071 Sphingolipid signaling pathway     103540937 (NOS3)    04022 cGMP-PKG signaling pathway     103540937 (NOS3)    04151 PI3K-Akt signaling pathway     103540937 (NOS3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103540937 (NOS3)   09152 Endocrine system    04915 Estrogen signaling pathway     103540937 (NOS3)    04921 Oxytocin signaling pathway     103540937 (NOS3)    04926 Relaxin signaling pathway     103540937 (NOS3)  09160 Human Diseases   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     103540937 (NOS3)    05418 Fluid shear stress and atherosclerosis     103540937 (NOS3)    05415 Diabetic cardiomyopathy     103540937 (NOS3)   09167 Endocrine and metabolic disease    04931 Insulin resistance     103540937 (NOS3)    04933 AGE-RAGE signaling pathway in diabetic complications     103540937 (NOS3) Enzymes [BR:epz01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      103540937 (NOS3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 Motif Other DBs NCBI-GeneID:  103540937 NCBI-ProteinID:  XP_008505839 LinkDB All DBs Position Un AA seq 1204 aa AA seqDB search MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPASEPSRAPVPAPAPAPLPAPDHSPPL ARPPEGPKFPRVKNWEVGSITYDTLCAQSQQDGPCTPRRCLGSLVFPRKLQSRPSQGPPP PEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWR NAPRCVGRIQWGKLQVFDARDCSSAQEMFTCICNHIKYATNRGNLRSAITVFPQRAPGRG DFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCVQHGWTPGNGRFDVLPLLLQAPDEP PELFTLPPELVLEVPLEHPTLEWFASLGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMS TEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVD HHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFRYQPDP WKGSAVKGTGLARKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQGYAQQLG RLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNS SPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPH FCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAA ARDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRATI LVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPAGEPVAVEQLEKGSPGG PPPSWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPSEQQELETLSQDPRR YEEWKWFRCPTLLEVLEQFPSVALPAALLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAV LAYRTQDGLGPLHYGVCSTWLSQLKAGDLVPCFIRGAPSFRLPPDPSLPCILVGPGTGIA PFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSR EPDSPKTYVQDILRTELAAEVHRVLCLDRGHMFVCGDVTMATSVLQTVQRILATEGDMEL DEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSLSLHERHLQGTVPWAFDPPGPD TSGR NT seq 3615 nt NT seq  +upstreamnt  +downstreamnt atgggcaacttgaagagtgtgggccaggagcctgggccaccctgcggcctggggctgggg ctgggcctcgggctgtgtggcaagcagggcccagcctcccccgcatctgagcccagccgg gcacctgtacccgcacccgcacccgcacccctgcctgcgccagaccacagccccccgctc gccaggcccccagaggggcccaagttcccgcgtgtgaagaactgggaggtggggagcatc acctacgacaccctgtgtgcccagtcccagcaggatgggccctgcaccccaagacgctgc ctcggctccctggtgtttccacggaaactgcagagccggccgtcccagggccctccgcct cctgagcagctgctgagtcaggctagggacttcatcaaccagtactacagctccatcaag aggagcggctcccaggcccacgagcagcgtcttcaggaggtggaggccgaggtggcagcc acgggcacctaccagcttcgggagagtgagctggtatttggggccaagcaggcctggcgc aacgctccccgttgtgtgggccggatccagtgggggaaactgcaggtctttgatgcgcgg gattgcagctctgcgcaggagatgttcacctgcatatgcaaccacatcaagtacgccacc aaccggggcaaccttcgctctgccatcacagtgttcccccagcgcgccccgggccgcgga gacttcagaatctggaacagccaactggtgcgctatgcaggctacagacagcaggacggc tctgtgcggggggacccagccaacgtggagatcaccgagctctgcgtccagcatggctgg actccaggaaatggccgctttgatgtgctgcccctgctgctccaggccccagatgaaccc ccggaactcttcactctgccccccgagctggtgcttgaagtgcccctggagcaccccacg ctggagtggttcgcatccctgggcctgcgctggtacgcgctcccggcagtgtccaacatg ctgctggaaatcgggggcctggagttccctgcggcccctttcagcggctggtacatgagc actgagatcggcacgcggaacctgtgtgaccctcaccgctacaacatcctggaggatgtg gccgtctgcatggacttggataccaggacaacctcgtccctgtggaaagacaaggcagcg gtggaaatcaacttggctgtgctgcacagttaccagctggccaaagtgaccattgtggac caccacgccgccacagcctccttcatgaagcacctggagaatgagcagaaggcgaggggg ggctgccctgccgactgggcctggattgtgccccccatctcgggcagcctcacccctgtc ttccatcaggagatggtcaactatgtcctgtcccctgccttccgctaccagccagacccc tggaaggggagtgcagtcaagggcaccggcctcgccaggaagaagacctttaaggaagtg gccaatgctgtgaagatctctgcctccctcatgggcaccgtgatggcaaagagagtgaag gctacaatcctgtacggctccgagaccggccgggcccagggctacgcacagcagctgggg aggctcttccggaaggctttcgacccccgggtcctgtgcatggatgagtatgatgtggtg tccctcgagcacgagacactggtgttggtggtgaccagcacattcgggaatggggatccc ccagagaatggagagagtttcgcagcagccctgatggagatgtcgggcccttacaacagc tcccctcggccagaacagcacaagagttacaaaatccgcttcaacagcgtctcctgttca gacccactggtgtcctcctggcggcggaagagaaaggaatccagtaacacagacagtgca ggggcactggggaccctcaggttctgtgtgttcgggctcggctcccgggcgtacccgcac ttctgcgcctttgctcgtgcggtggacacgcggctggaagagctgggtggcgagcggctc ctgcagctgggccagggagacgagctgtgcggccaggaggaggccttccgtggctgggcc caagccgccttccaggcctcctgtgagaccttctgcgtgggagaggatgccaaggctgct gcccgggacatattcagccccaaacggagctggaagcgccagaggtaccggctgagcacc caggctgagggcctccagttgctaccaggcctgatccatgtgcaccggagaaagatgttc caggctacagtcctttcagtggaaaatctgcaaagcagcaagtccacccgggccacgatc ctggtgcgcctggacactggaggccaggaggggctccagtaccagccaggggaccacata ggcgtctgcccacccaaccggccgggactcgtggaggcactgctcagccgtgtggaggac ccgccgccagcaggcgagcccgtggcagtggaacagctggagaagggcagccctggtggc cctcccccaagctgggtgcgggacccccggctgcccccgtgcacgctgcgccaggctctc accttcttcctggacatcacttccccgcccagccctcaactccttcgactgctcagcacc ttggcagaagaacccagtgaacagcaggagcttgagaccctcagccaggacccccggcgc tacgaagaatggaagtggttccgctgccccacgctgctggaggtgctggagcagtttcct tcggtggcactgcctgctgccctgctcctcacccagctgcccctgctccagccccggtac tactccgtcagctcagcccccagcacccacccaggagagatccacctcacagttgccgtg ctggcatacaggacccaggatgggctaggccccctgcactatggagtctgctccacatgg ctgagccaactcaaggccggagaccttgtaccctgcttcatcaggggggctccctccttc cggctgcctccggaccccagcttgccctgcatcctggtgggccccggcacgggcatcgcc cccttccggggattttggcaggagcggctgcatgacattgagagcaaagggctgcagccc gcccccatgaccttggtgttcggctgccgatgctcccagctcgatcacctctaccgcgac gaggtgcaggatgcccagcagcgcggggtatttggccgcgtcctcaccgccttctccagg gaaccggacagccctaagacctacgtacaggacatcctgcggaccgagctggctgccgag gtgcaccgcgtgctgtgcctcgatcggggccacatgtttgtctgcggtgatgtcaccatg gcaaccagcgtcttgcagacggtgcaacgcatcctggcgacagagggcgacatggaactg gacgaggccggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggacatt ttcgggctcacgctgcgcacccaggaggtgacaagccgcatacgcacccagagcctttcc ttgcacgagcggcatctgcagggcacagtgccctgggcgttcgacccgcccggcccagac acctctggtcgctga

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