KEGG   PATHWAY: etl04115
Entry
etl04115                    Pathway                                

Name
p53 signaling pathway - Empidonax traillii (willow flycatcher)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
etl04115  p53 signaling pathway
etl04115

Organism
Empidonax traillii (willow flycatcher) [GN:etl]
Gene
114066109  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
114061540  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
114069637  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
114064599  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
114063538  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
114062165  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114069119  MDM4; protein Mdm4 [KO:K10127]
114064409  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114067926  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
114067087  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
114071008  G1/S-specific cyclin-D3-like [KO:K10152]
114067504  G1/S-specific cyclin-D3-like isoform X1 [KO:K10152]
114062117  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114063486  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
114060091  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
114070800  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
114068068  SFN; 14-3-3 protein sigma [KO:K06644]
114073337  protein reprimo-like [KO:K10128]
114056383  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
114063899  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
114061921  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114061072  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114072120  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
114069681  GTSE1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
114055892  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
114068482  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
114066600  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
114069860  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
114055714  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
114055715  caspase-8-like [KO:K04398] [EC:3.4.22.61]
114069005  BID; BH3-interacting domain death agonist [KO:K04726]
114070069  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
114066726  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
114063044  BCL2L1; bcl-2-like protein 1 [KO:K04570]
114065315  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
114064445  TP53I3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
114064605  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
114058748  SHISA5; protein shisa-5 [KO:K10135]
114059504  p53 apoptosis effector related to PMP-22-like [KO:K10136]
114059511  p53 apoptosis effector related to PMP-22-like [KO:K10136]
114062400  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
114067411  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
114064043  LOW QUALITY PROTEIN: cytochrome c, somatic A-like [KO:K08738]
114063690  cytochrome c [KO:K08738]
114065277  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
114068717  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
114055579  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
114062209  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
114068393  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
114056148  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
114065893  ADGRB1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
114061633  CD82; CD82 antigen [KO:K06509]
114063733  THBS1; thrombospondin-1 [KO:K16857]
114065317  SERPINB5; serpin B5 [KO:K10139]
114058833  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
114058978  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
114057315  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
114067448  sestrin-3-like isoform X1 [KO:K10141]
114057246  SESN3; sestrin-3 isoform X1 [KO:K10141]
114063386  SESN1; sestrin-1 isoform X1 [KO:K10141]
114068397  SESN2; sestrin-2 [KO:K20394]
114069647  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114064312  TSC2; tuberin isoform X1 [KO:K07207]
114063086  STEAP3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
114068081  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
114067618  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
114067222  CCNG1; cyclin-G1 [KO:K10145]
114060027  CCNG2; cyclin-G2 [KO:K10146]
114068829  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
114069824  TP73; tumor protein p73 [KO:K10148]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Related
pathway
etl04110  Cell cycle
etl04210  Apoptosis
etl04218  Cellular senescence
KO pathway
ko04115   
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