KEGG   PATHWAY: fch04520
Entry
fch04520                    Pathway                                

Name
Adherens junction - Falco cherrug (Saker falcon)
Description
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
fch04520  Adherens junction
fch04520

Other DBs
GO: 0005912
Organism
Falco cherrug (Saker falcon) [GN:fch]
Gene
102058210  NECTIN1; nectin-1 [KO:K06081]
102056494  NECTIN3; nectin-3 isoform X1 [KO:K06592]
102059980  NECTIN4; nectin-4 [KO:K06593]
102059808  PARD3; partitioning defective 3 homolog [KO:K04237]
102052372  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
102049811  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X3 [KO:K06082]
102055425  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102049998  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102059263  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102054322  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102048671  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
102054787  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
102056089  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
102058978  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
102052077  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
102050638  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
102056861  WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
102058790  AFDN; afadin [KO:K05702]
102046077  LMO7; LOW QUALITY PROTEIN: LIM domain only protein 7 [KO:K06084]
102053375  SSX2IP; afadin- and alpha-actinin-binding protein isoform X1 [KO:K06085]
102048522  SORBS1; sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
102048669  ACTN1; alpha-actinin-1 [KO:K05699]
102059725  alpha-actinin-4-like [KO:K05699]
102057999  VCL; vinculin isoform X3 [KO:K05700]
102053227  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
102055639  cadherin-1 [KO:K05689]
102055294  B-cadherin-like [KO:K05689]
102057595  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
102053189  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
102057954  CTNNA3; catenin alpha-3 isoform X1 [KO:K05691]
102056079  catenin alpha-1 [KO:K05691]
102051829  CTNNA2; catenin alpha-2 isoform X2 [KO:K05691]
102056825  actin, cytoplasmic type 5 [KO:K05692]
102050787  ACTB; actin, cytoplasmic 1 [KO:K05692]
102049160  RHOA; transforming protein RhoA [KO:K04513]
102057401  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
102056950  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
102052074  PTPRB; receptor-type tyrosine-protein phosphatase beta [KO:K05694] [EC:3.1.3.48]
102055022  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
102055390  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
102049222  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
102058601  LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
102047766  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
102045929  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
102057085  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
102058554  TCF7; transcription factor 7 [KO:K02620]
102051021  TCF7L1; transcription factor 7-like 1 [KO:K04490]
102053252  TCF7L2; transcription factor 7-like 2 isoform X5 [KO:K04491]
102050307  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
102046128  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102056291  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102046148  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102058683  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102057575  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102055369  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102057970  FER; tyrosine-protein kinase Fer [KO:K08889] [EC:2.7.10.2]
102057542  FYN; tyrosine-protein kinase Fyn isoform X2 [KO:K05703] [EC:2.7.10.2]
102051957  YES1; tyrosine-protein kinase Yes [KO:K05705] [EC:2.7.10.2]
102048221  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102059954  SNAI2; zinc finger protein SNAI2 [KO:K05706]
102048568  protein snail homolog Sna [KO:K05707]
102055038  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
102048632  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
102053489  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102053568  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
102057734  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
102048236  mothers against decapentaplegic homolog 4-like [KO:K04501]
102056653  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102045802  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
102058816  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102053931  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
Reference
  Authors
Nelson WJ, Nusse R.
  Title
Convergence of Wnt, beta-catenin, and cadherin pathways.
  Journal
Science 303:1483-7 (2004)
DOI:10.1126/science.1094291
Reference
  Authors
Potter E, Bergwitz C, Brabant G.
  Title
The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.
  Journal
Endocr Rev 20:207-39 (1999)
DOI:10.1210/edrv.20.2.0362
Reference
  Authors
Beavon IR.
  Title
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
  Journal
Eur J Cancer 36:1607-20 (2000)
DOI:10.1016/S0959-8049(00)00158-1
Reference
  Authors
Reynolds AB, Roczniak-Ferguson A.
  Title
Emerging roles for p120-catenin in cell adhesion and cancer.
  Journal
Oncogene 23:7947-56 (2004)
DOI:10.1038/sj.onc.1208161
Reference
  Authors
Angst BD, Marcozzi C, Magee AI.
  Title
The cadherin superfamily: diversity in form and function.
  Journal
J Cell Sci 114:629-41 (2001)
Reference
  Authors
Lilien J, Balsamo J, Arregui C, Xu G.
  Title
Turn-off, drop-out: functional state switching of cadherins.
  Journal
Dev Dyn 224:18-29 (2002)
DOI:10.1002/dvdy.10087
Reference
  Authors
Piedra J, Miravet S, Castano J, Palmer HG, Heisterkamp N, Garcia de Herreros A, Dunach M.
  Title
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
  Journal
Mol Cell Biol 23:2287-97 (2003)
DOI:10.1128/MCB.23.7.2287-2297.2003
Reference
  Authors
Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A.
  Title
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
  Journal
J Cell Biol 163:847-57 (2003)
DOI:10.1083/jcb.200308162
Reference
  Authors
Ciruna B, Rossant J.
  Title
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
  Journal
Dev Cell 1:37-49 (2001)
DOI:10.1016/S1534-5807(01)00017-X
Reference
  Authors
Peinado H, Quintanilla M, Cano A.
  Title
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
  Journal
J Biol Chem 278:21113-23 (2003)
DOI:10.1074/jbc.M211304200
Reference
  Authors
Labbe E, Letamendia A, Attisano L.
  Title
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.
  Journal
Proc Natl Acad Sci U S A 97:8358-63 (2000)
DOI:10.1073/pnas.150152697
Reference
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Related
pathway
fch04010  MAPK signaling pathway
fch04060  Cytokine-cytokine receptor interaction
fch04310  Wnt signaling pathway
fch04350  TGF-beta signaling pathway
fch04530  Tight junction
fch04810  Regulation of actin cytoskeleton
KO pathway
ko04520   
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