KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101133976
Entry
101133976         CDS       T02442                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo01521  EGFR tyrosine kinase inhibitor resistance
ggo01522  Endocrine resistance
ggo04010  MAPK signaling pathway
ggo04012  ErbB signaling pathway
ggo04014  Ras signaling pathway
ggo04062  Chemokine signaling pathway
ggo04068  FoxO signaling pathway
ggo04072  Phospholipase D signaling pathway
ggo04150  mTOR signaling pathway
ggo04151  PI3K-Akt signaling pathway
ggo04380  Osteoclast differentiation
ggo04510  Focal adhesion
ggo04540  Gap junction
ggo04550  Signaling pathways regulating pluripotency of stem cells
ggo04630  JAK-STAT signaling pathway
ggo04650  Natural killer cell mediated cytotoxicity
ggo04660  T cell receptor signaling pathway
ggo04662  B cell receptor signaling pathway
ggo04664  Fc epsilon RI signaling pathway
ggo04714  Thermogenesis
ggo04722  Neurotrophin signaling pathway
ggo04910  Insulin signaling pathway
ggo04912  GnRH signaling pathway
ggo04915  Estrogen signaling pathway
ggo04917  Prolactin signaling pathway
ggo04926  Relaxin signaling pathway
ggo04935  Growth hormone synthesis, secretion and action
ggo05034  Alcoholism
ggo05160  Hepatitis C
ggo05161  Hepatitis B
ggo05163  Human cytomegalovirus infection
ggo05165  Human papillomavirus infection
ggo05200  Pathways in cancer
ggo05203  Viral carcinogenesis
ggo05205  Proteoglycans in cancer
ggo05206  MicroRNAs in cancer
ggo05210  Colorectal cancer
ggo05211  Renal cell carcinoma
ggo05213  Endometrial cancer
ggo05214  Glioma
ggo05215  Prostate cancer
ggo05220  Chronic myeloid leukemia
ggo05221  Acute myeloid leukemia
ggo05223  Non-small cell lung cancer
ggo05224  Breast cancer
ggo05225  Hepatocellular carcinoma
ggo05226  Gastric cancer
ggo05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ggo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101133976 (GRB2)
   04012 ErbB signaling pathway
    101133976 (GRB2)
   04014 Ras signaling pathway
    101133976 (GRB2)
   04630 JAK-STAT signaling pathway
    101133976 (GRB2)
   04068 FoxO signaling pathway
    101133976 (GRB2)
   04072 Phospholipase D signaling pathway
    101133976 (GRB2)
   04151 PI3K-Akt signaling pathway
    101133976 (GRB2)
   04150 mTOR signaling pathway
    101133976 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101133976 (GRB2)
   04540 Gap junction
    101133976 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101133976 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101133976 (GRB2)
   04660 T cell receptor signaling pathway
    101133976 (GRB2)
   04662 B cell receptor signaling pathway
    101133976 (GRB2)
   04664 Fc epsilon RI signaling pathway
    101133976 (GRB2)
   04062 Chemokine signaling pathway
    101133976 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101133976 (GRB2)
   04912 GnRH signaling pathway
    101133976 (GRB2)
   04915 Estrogen signaling pathway
    101133976 (GRB2)
   04917 Prolactin signaling pathway
    101133976 (GRB2)
   04926 Relaxin signaling pathway
    101133976 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    101133976 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101133976 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101133976 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    101133976 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101133976 (GRB2)
   05206 MicroRNAs in cancer
    101133976 (GRB2)
   05205 Proteoglycans in cancer
    101133976 (GRB2)
   05203 Viral carcinogenesis
    101133976 (GRB2)
   05231 Choline metabolism in cancer
    101133976 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101133976 (GRB2)
   05225 Hepatocellular carcinoma
    101133976 (GRB2)
   05226 Gastric cancer
    101133976 (GRB2)
   05214 Glioma
    101133976 (GRB2)
   05221 Acute myeloid leukemia
    101133976 (GRB2)
   05220 Chronic myeloid leukemia
    101133976 (GRB2)
   05211 Renal cell carcinoma
    101133976 (GRB2)
   05215 Prostate cancer
    101133976 (GRB2)
   05213 Endometrial cancer
    101133976 (GRB2)
   05224 Breast cancer
    101133976 (GRB2)
   05223 Non-small cell lung cancer
    101133976 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    101133976 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101133976 (GRB2)
   05160 Hepatitis C
    101133976 (GRB2)
   05163 Human cytomegalovirus infection
    101133976 (GRB2)
   05165 Human papillomavirus infection
    101133976 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101133976 (GRB2)
   01522 Endocrine resistance
    101133976 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ggo04131]
    101133976 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:ggo04990]
    101133976 (GRB2)
Membrane trafficking [BR:ggo04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    101133976 (GRB2)
Domain-containing proteins not elsewhere classified [BR:ggo04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   101133976 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 101133976
NCBI-ProteinID: XP_004041047
Ensembl: ENSGGOG00000006122
UniProt: G3QTG9
LinkDB
Position
5
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaacgaagaatgtgatcagaactggtacaaggcagag
cttaatggaaaagacggcttcattcccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcacgat
ggggcctttcttatccgagagagtgagagcgctcctggggacttctccctctctgtcaag
tttggaaacgatgtgcagcacttcaaggtgctccgagatggagcagggaagtacttcctc
tgggtggtgaagttcaattctttgaatgagctggtggattatcacagatctacatctgtc
tccagaaaccagcagatattcctgcgggacatagaacaggtgccacagcagccgacatac
gtccaggccctctttgactttgatccccaggaggatggagagctgggcttccgccgggga
gattttatccatgtcatggataactcagaccccaactggtggaaaggagcttgccacggg
cagaccggcatgtttccccgcaattatgtcacccccgtgaaccggaacgtctaa

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