KEGG   PATHWAY: gja00310Help
Entry
gja00310                    Pathway                                

Name
Lysine degradation - Gekko japonicus
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
gja00310  Lysine degradation
gja00310

Ortholog table
Module
gja_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:gja00310]
Organism
Gekko japonicus [GN:gja]
Gene
107111118  AASS; aminoadipate-semialdehyde synthase [KO:K14157] [EC:1.5.1.8 1.5.1.9]
107112391  ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
107107125  AADAT; aminoadipate aminotransferase [KO:K00825] [EC:2.6.1.7 2.6.1.39]
107107127  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial-like [KO:K00825] [EC:2.6.1.7 2.6.1.39]
107111049  DHTKD1; dehydrogenase E1 and transketolase domain containing 1 [KO:K15791] [EC:1.2.4.2]
107118322  DLST; dihydrolipoamide S-succinyltransferase [KO:K00658] [EC:2.3.1.61]
107119908  DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
107117823  GCDH; glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
107113769  HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [KO:K07515] [EC:4.2.1.17 1.1.1.211]
107123582  EHHADH; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
107106993  ECHS1; enoyl-CoA hydratase, short chain 1 [KO:K07511] [EC:4.2.1.17]
107123147  HADH; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]
107111947  ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
107113475  ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
107109147  HYKK; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
107125426  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
107112613  PHYKPL; 5-phosphohydroxy-L-lysine phospho-lyase [KO:K18202] [EC:4.2.3.134]
107119422  PIPOX; pipecolic acid and sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
107119512  calmodulin-lysine N-methyltransferase-like [KO:K18826] [EC:2.1.1.60]
107119521  calmodulin-lysine N-methyltransferase-like [KO:K18826] [EC:2.1.1.60]
107112539  KMT2A; lysine methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
107105838  KMT2D; lysine methyltransferase 2D [KO:K09187] [EC:2.1.1.354]
107123156  histone-lysine N-methyltransferase 2C-like [KO:K09188] [EC:2.1.1.354]
107123162  KMT2C; lysine methyltransferase 2C [KO:K09188] [EC:2.1.1.354]
107108169  KMT2B; lysine methyltransferase 2B [KO:K14959] [EC:2.1.1.354]
107109138  histone-lysine N-methyltransferase 2B-like [KO:K14959] [EC:2.1.1.354]
107113725  KMT2E; lysine methyltransferase 2E [KO:K09189] [EC:2.1.1.354]
107106655  SETD1A; SET domain containing 1A [KO:K11422] [EC:2.1.1.354]
107115893  SETD1B; SET domain containing 1B [KO:K11422] [EC:2.1.1.354]
107110772  SETD7; SET domain containing lysine methyltransferase 7 [KO:K11431] [EC:2.1.1.354]
107119617  ASH1L; ASH1 like histone lysine methyltransferase [KO:K06101] [EC:2.1.1.354]
107105569  SMYD1; SET and MYND domain containing 1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
107108065  SMYD3; SET and MYND domain containing 3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
107106688  histone-lysine N-methyltransferase SMYD3-like [KO:K11426] [EC:2.1.1.354 2.1.1.357]
107121665  SMYD2; SET and MYND domain containing 2 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
107112843  SUV39H1; suppressor of variegation 3-9 homolog 1 [KO:K11419] [EC:2.1.1.355]
107105480  EHMT2; euchromatic histone lysine methyltransferase 2 [KO:K11420] [EC:2.1.1.355]
107118801  EHMT1; euchromatic histone lysine methyltransferase 1 [KO:K11420] [EC:2.1.1.355]
107121584  SETDB1; SET domain bifurcated 1 [KO:K11421] [EC:2.1.1.355]
107113385  SETDB2; SET domain bifurcated 2 [KO:K18494] [EC:2.1.1.355]
107119301  histone-lysine N-methyltransferase SETDB2-like [KO:K18494] [EC:2.1.1.355]
107119302  PHD finger protein 11-like [KO:K18494] [EC:2.1.1.355]
107106223  PRDM2; PR/SET domain 2 [KO:K11432] [EC:2.1.1.355]
107123351  EZH1; enhancer of zeste 1 polycomb repressive complex 2 subunit [KO:K17451] [EC:2.1.1.356]
107119624  EZH2; enhancer of zeste 2 polycomb repressive complex 2 subunit [KO:K11430] [EC:2.1.1.356]
107111562  NSD1; nuclear receptor binding SET domain protein 1 [KO:K15588] [EC:2.1.1.357]
107121904  NSD2; nuclear receptor binding SET domain protein 2 [KO:K11424] [EC:2.1.1.357]
107112988  NSD3; nuclear receptor binding SET domain protein 3 [KO:K11425] [EC:2.1.1.357]
107121138  histone-lysine N-methyltransferase SETMAR [KO:K11433] [EC:2.1.1.357]
107120098  SETD2; SET domain containing 2 [KO:K11423] [EC:2.1.1.358]
107122041  DOT1L; DOT1 like histone lysine methyltransferase [KO:K11427] [EC:2.1.1.360]
107117211  KMT5A; lysine methyltransferase 5A [KO:K11428] [EC:2.1.1.361]
107114655  PRDM6; PR/SET domain 6 [KO:K20795] [EC:2.1.1.361]
107118429  KMT5C; lysine methyltransferase 5C [KO:K11429] [EC:2.1.1.362]
107119069  KMT5B; lysine methyltransferase 5B [KO:K11429] [EC:2.1.1.362]
107118207  TMLHE; trimethyllysine hydroxylase, epsilon [KO:K00474] [EC:1.14.11.8]
107116599  ALDH16A1; aldehyde dehydrogenase 16 family member A1 [KO:K00128] [EC:1.2.1.3]
107112148  ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
107111228  ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
107106980  4-trimethylaminobutyraldehyde dehydrogenase-like [KO:K00149] [EC:1.2.1.47 1.2.1.3]
107118664  ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
107122568  BBOX1; gamma-butyrobetaine hydroxylase 1 [KO:K00471] [EC:1.14.11.1]
107111573  PLOD1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [KO:K00473] [EC:1.14.11.4]
107112451  PLOD2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [KO:K13645] [EC:1.14.11.4]
107118151  PLOD3; procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
107114906  COLGALT1; collagen beta(1-O)galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
107117514  COLGALT2; collagen beta(1-O)galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01028  N6-Hydroxy-L-lysine
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C03955  N6-Acetyl-N6-hydroxy-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05554  Aerobactin
C05825  2-Amino-5-oxohexanoate
C12455  5-Aminopentanal
C16741  L-Hydroxylysine
C20333  N2-Citryl-N6-acetyl-N6-hydroxy-L-lysine
Reference
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
gja00020  Citrate cycle (TCA cycle)
gja00780  Biotin metabolism
KO pathway
ko00310   
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