KEGG   PATHWAY: hai05164
hai05164                    Pathway                                

Influenza A - Hipposideros armiger (great roundleaf bat)
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Human Diseases; Infectious disease: viral
Pathway map
hai05164  Influenza A

Hipposideros armiger (great roundleaf bat) [GN:hai]
109376384  anionic trypsin [KO:K01312] [EC:]
109395584  trypsin [KO:K01312] [EC:]
109372657  TMPRSS2; transmembrane protease, serine 2 [KO:K09633] [EC:3.4.21.-]
109385279  TMPRSS4; transmembrane protease, serine 4 [KO:K09635] [EC:3.4.21.-]
109375904  TMPRSS11D; transmembrane protease, serine 11D [KO:K09641] [EC:3.4.21.-]
109386578  PRKCB; protein kinase C beta [KO:K19662] [EC:]
109382229  2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:]
109382257  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:]
109379163  RNASEL; ribonuclease L [KO:K01165]
109394265  DNAJB1; DnaJ heat shock protein family (Hsp40) member B1 [KO:K09507]
109394075  DNAJC3; DnaJ heat shock protein family (Hsp40) member C3 [KO:K09523]
109385455  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:]
109382061  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
109379737  TRIM25; tripartite motif containing 25 [KO:K10652] [EC:]
109371521  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:]
109379834  IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:]
109393900  NLRX1; NLR family member X1 [KO:K12653]
109383826  MAVS; mitochondrial antiviral signaling protein [KO:K12648]
109379632  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:]
109386279  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:]
109377344  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
109395326  NFKBIB; NFKB inhibitor beta [KO:K02581]
109383860  NFKBIA; NFKB inhibitor alpha [KO:K04734]
109372541  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
109384322  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
109380813  CALCOCO2; calcium binding and coiled-coil domain 2 [KO:K21348]
109395856  TLR3; toll like receptor 3 [KO:K05401]
109388568  TICAM1; toll like receptor adaptor molecule 1 [KO:K05842]
109381072  TRAF3; TNF receptor associated factor 3 [KO:K03174]
109381695  TBK1; TANK binding kinase 1 [KO:K05410] [EC:]
109386512  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:]
109391076  IRF3; interferon regulatory factor 3 [KO:K05411]
109392135  CREBBP; CREB binding protein [KO:K04498] [EC:]
109392262  EP300; E1A binding protein p300 [KO:K04498] [EC:]
109385740  TLR4; toll like receptor 4 [KO:K10160]
109387359  TLR7; toll like receptor 7 [KO:K05404]
109393491  MYD88; myeloid differentiation primary response 88 [KO:K04729]
109388403  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:]
109375630  IRF7; interferon regulatory factor 7 [KO:K09447]
109393526  IL1A; interleukin 1 alpha [KO:K04383]
109393524  IL1B; interleukin 1 beta [KO:K04519]
109387871  IL6; interleukin 6 [KO:K05405]
109373148  IL12A; interleukin 12A [KO:K05406]
109388897  IL12B; interleukin 12B [KO:K05425]
109373073  TNF; tumor necrosis factor [KO:K03156]
109394819  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
109373168  CCL5; C-C motif chemokine ligand 5 [KO:K12499]
109371167  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
109391654  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
109374670  interferon alpha-4-like [KO:K05414]
109396418  IFNB1; interferon beta 1 [KO:K05415]
109373231  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
109373246  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
109384938  JAK1; Janus kinase 1 [KO:K11217] [EC:]
109391605  TYK2; tyrosine kinase 2 [KO:K11219] [EC:]
109383617  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
109393276  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
109396910  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
109393688  IRF9; interferon regulatory factor 9 [KO:K04693]
109372656  interferon-induced GTP-binding protein Mx1-like [KO:K14754]
109372655  MX2; MX dynamin like GTPase 2 [KO:K14754]
109396273  PML; promyelocytic leukemia [KO:K10054]
109381671  IFNG; interferon gamma [KO:K04687]
109385640  IFNGR1; interferon gamma receptor 1 [KO:K05132]
109376141  interferon gamma receptor 1-like [KO:K05132]
109373230  IFNGR2; interferon gamma receptor 2 [KO:K05133]
109384506  JAK2; Janus kinase 2 [KO:K04447] [EC:]
109387149  CIITA; class II major histocompatibility complex transactivator [KO:K08060] [EC:]
109373047  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109392411  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
109392415  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
109378577  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
109373106  DRB; H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
109373108  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109373109  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
109377860  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
109377861  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
109377862  H-2 class II histocompatibility antigen, A-F alpha chain-like [KO:K06752]
109377863  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109376897  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109376898  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109378434  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
109378436  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
109376891  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
109376893  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752]
109377864  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109378145  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
109377395  NLRP3; NLR family pyrin domain containing 3 [KO:K12800]
109374176  PYCARD; PYD and CARD domain containing [KO:K12799]
109377701  CASP1; caspase 1 [KO:K01370] [EC:]
109388707  IL18; interleukin 18 [KO:K05482]
109394554  IL33; interleukin 33 [KO:K12967]
109382484  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
109395865  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
109373811  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
109381238  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:]
109394108  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:]
109372681  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:]
109381083  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:]
109385878  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:]
109374859  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:]
109385353  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:]
109382891  CCND3; cyclin D3 [KO:K10152]
109390747  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:]
109373596  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:]
109371673  TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
109372325  TNFRSF10A; TNF receptor superfamily member 10a [KO:K04722]
109389286  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
109385146  FASLG; Fas ligand [KO:K04389]
109377126  FAS; Fas cell surface death receptor [KO:K04390]
109373644  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
109390108  TRADD; TNFRSF1A associated via death domain [KO:K03171]
109389315  FADD; Fas associated via death domain [KO:K02373]
109379228  CASP8; caspase 8 [KO:K04398] [EC:]
109373303  BID; BH3 interacting domain death agonist [KO:K04726]
109391068  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
109392454  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
109382625  VDAC1; voltage dependent anion channel 1 [KO:K05862]
109394950  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
109375563  SLC25A6; solute carrier family 25 member 6 [KO:K05863]
109390884  ADP/ATP translocase 3-like [KO:K05863]
109395862  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
109374086  ADP/ATP translocase 2 [KO:K05863]
109393551  cytochrome c [KO:K08738]
109381354  cytochrome c [KO:K08738]
109382336  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
109381302  CASP9; caspase 9 [KO:K04399] [EC:]
109395706  CASP3; caspase 3 [KO:K02187] [EC:]
109379054  CPSF4; cleavage and polyadenylation specific factor 4 [KO:K14404]
109387207  CPSF4L; cleavage and polyadenylation specific factor 4 like [KO:K14404]
109393643  PABPN1; poly(A) binding protein nuclear 1 [KO:K14396]
109389177  PABPN1L; poly(A) binding protein nuclear 1 like, cytoplasmic [KO:K14396]
109389566  NXF5; nuclear RNA export factor 5 [KO:K14284]
109384235  NXF1; nuclear RNA export factor 1 [KO:K14284]
109376052  NXF3; nuclear RNA export factor 3 [KO:K14284]
109377472  nuclear RNA export factor 2-like [KO:K14284]
109376728  NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
109377530  NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
109376589  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U like 1 [KO:K15047]
109380123  RAE1; ribonucleic acid export 1 [KO:K14298]
109372426  NUP98; nucleoporin 98 [KO:K14297]
109384704  RSAD2; radical S-adenosyl methionine domain containing 2 [KO:K15045]
109393390  FDPS; farnesyl diphosphate synthase [KO:K00787] [EC:]
109380289  PRKCA; protein kinase C alpha [KO:K02677] [EC:]
109384548  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:]
109385252  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:]
109388626  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:]
109385803  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:]
109394900  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:]
109393048  ACTG1; actin gamma 1 [KO:K05692]
109380220  ACTB; actin beta [KO:K05692]
109385259  RAB11A; RAB11A, member RAS oncogene family [KO:K07904]
109396105  RAB11B; RAB11B, member RAS oncogene family [KO:K07905]
109377392  XPO1; exportin 1 [KO:K14290]
109388210  KPNA1; karyopherin subunit alpha 1 [KO:K23940]
109380254  KPNA2; karyopherin subunit alpha 2 [KO:K15043]
109389758  KPNA7; karyopherin subunit alpha 7 [KO:K15043]
109391789  KPNA6; karyopherin subunit alpha 6 [KO:K15042]
109396460  KPNA5; karyopherin subunit alpha 5 [KO:K15042]
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Edinger TO, Pohl MO, Stertz S
Entry of influenza A virus: host factors and antiviral targets.
J Gen Virol 95:263-77 (2014)
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
J Mol Genet Med 3:167-75 (2008)
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
Trends Microbiol 24:933-943 (2016)
Thanh TT, van Doorn HR, de Jong MD
Human H5N1 influenza: current insight into pathogenesis.
Int J Biochem Cell Biol 40:2671-4 (2008)
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
Influenza A induced cellular signal transduction pathways.
J Thorac Dis 5 Suppl 2:S132-41 (2013)
Hale BG, Albrecht RA, Garcia-Sastre A
Innate immune evasion strategies of influenza viruses.
Future Microbiol 5:23-41 (2010)
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
PLoS One 6:e20215 (2011)
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
Interplay between influenza A virus and the innate immune signaling.
Microbes Infect 12:81-7 (2010)
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
Evasion of influenza A viruses from innate and adaptive immune responses.
Viruses 4:1438-76 (2012)
Long JS, Mistry B, Haslam SM, Barclay WS
Host and viral determinants of influenza A virus species specificity.
Nat Rev Microbiol 17:67-81 (2019)
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
Host Immune Response to Influenza A Virus Infection.
Front Immunol 9:320 (2018)
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
J Gen Virol 91:1439-49 (2010)
Ichinohe T, Iwasaki A, Hasegawa H
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
Expert Rev Vaccines 7:1435-45 (2008)
Le Sage V, Cinti A, Amorim R, Mouland AJ
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
Viruses 8:E152 (2016)
Fan Y, Sanyal S, Bruzzone R
Breaking Bad: How Viruses Subvert the Cell Cycle.
Front Cell Infect Microbiol 8:396 (2018)
Varga ZT, Palese P
The influenza A virus protein PB1-F2: killing two birds with one stone?
Virulence 2:542-6 (2011)
Atkin-Smith GK, Duan M, Chen W, Poon IKH
The induction and consequences of Influenza A virus-induced cell death.
Cell Death Dis 9:1002 (2018)
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
Viruses 10:E708 (2018)
Dai X, Zhang L, Hong T
Host cellular signaling induced by influenza virus.
Sci China Life Sci 54:68-74 (2011)
Li J, Yu M, Zheng W, Liu W
Nucleocytoplasmic shuttling of influenza A virus proteins.
Viruses 7:2668-82 (2015)
Dou D, Revol R, Ostbye H, Wang H, Daniels R
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
Front Immunol 9:1581 (2018)
Paterson D, Fodor E
Emerging roles for the influenza A virus nuclear export protein (NEP).
PLoS Pathog 8:e1003019 (2012)
hai00900  Terpenoid backbone biosynthesis
hai03013  RNA transport
hai03015  mRNA surveillance pathway
hai04010  MAPK signaling pathway
hai04110  Cell cycle
hai04144  Endocytosis
hai04210  Apoptosis
hai04620  Toll-like receptor signaling pathway
hai04621  NOD-like receptor signaling pathway
hai04622  RIG-I-like receptor signaling pathway
hai04630  JAK-STAT signaling pathway
hai05416  Viral myocarditis
KO pathway

DBGET integrated database retrieval system