KEGG   Hipposideros armiger (great roundleaf bat): 109390613Help
Entry
109390613         CDS       T04661                                 

Gene name
DOT1L
Definition
(RefSeq) DOT1 like histone lysine methyltransferase
  KO
K11427  histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
Organism
hai  Hipposideros armiger (great roundleaf bat)
Pathway
hai00310  Lysine degradation
hai05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:hai00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    109390613 (DOT1L)
 09160 Human Diseases
  09161 Cancers: Overview
   05202 Transcriptional misregulation in cancer
    109390613 (DOT1L)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hai03036]
    109390613 (DOT1L)
Enzymes [BR:hai01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     109390613 (DOT1L)
Chromosome and associated proteins [BR:hai03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     109390613 (DOT1L)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: DOT1 HALZ
Motif
Other DBs
NCBI-GeneID: 109390613
NCBI-ProteinID: XP_019512829
LinkDB All DBs
Position
Un
AA seq 1724 aa AA seqDB search
MRHSVLILSDPWKMTGRGNLQRRLVSWDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAAPADTPVDSGAEEEKVGTTAIKKPSPSKARKKKLNKKGRKLAGRKRGRPKKMSTA
NPERKPKKSPTALDLLHSQTMSQTAAASPQDAYKSPHSPFYQLPPTVQRQPPDQLLLAPI
PPALQKLLESFKIQYLQFLAYTKTPQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYSDLIQAQKEISAHNQQLREQTEQLDKDNRELRTQSLQLL
KARCEELKLDWSTLSLENLLKEKQALRSQISEKQRRCLELQISIVELEKSQRQQELLQLK
SCVPPDDAVPGHLRGKSGLGRELEAEPGRLHLELDCSKLSLPHFSSMSPELSMNGHVSGY
ELCSALSRPSSKQNTPQYLASPLDQEVVPCTPGHSSRPRLERLSGLALPDYTRLSPAKLV
LRRHLSQDHAANSKAAAGELHPRAEHTKENSLPYHSPGLTNGIKLSPQYPRSSSPMSLQM
TGEKGSEKGLKERTYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRST
PSPVPQARESSSTLEKQMGANAHGAGSKGLALAPAGFSYTGSVAISGALAGSPAPLVSGA
EPPAFDESSSSGSLFATMGSRSSTPQHPPLLVQPRNSGPASPAHQLCASPRLGTAQGPLP
DASKGDLPSEAGFSDPESEAKRRTIFTISAGTSSTKQSPSNKHSPLPASIRGDSSQSHGQ
DSRKRGRRKRASAGTPSLSSGVSPKRRALPSVASLFTQSSGSPLNLNSMVNNINQPLEIT
AISSPESSLKSSPVPYQDNDQPPVLKKEKPLNQTNGAQYSPLTSDEEPGSEDEPGSARIE
RKIATISLESKSPPKTLENGGGLAGRKPVPASEPVNSSKWKATFSPISDLSLAKATDSPL
QASSTLGQNSLFAFRPTLEEPSSVDAKLASHPRKSFPSALSAAGGLSPNSNPPNGFAFSG
GLATDLSLHSFNDGASLSHKAPEVASLGTPLSFPALRGKEGSTESGPFVNKRQLDGLNSL
KGEGGKGREAELGLPSCTPSDKASLAHGKAGKGRDREPDFKNGHNLFISAAAVPPGGLLS
GPGLATAASSAGNMASSAQTHRPFLGTFAPSPQFSLGPMSLQANLGSSVLQSLFSSVPAA
AGLVHVSSAATRLTNSHAMGSFSSGVAGGAVGGVFNHAVPSASSHPFGASFGSGAACRSA
TLSLTPLQAVASTPASSFQAPPSLEPRQPPPQPLGRPPAGPPTLHVPLPPNAALPPAHAL
LPANSEPALLQNLAPLPANQAFLPVSSAASLPPANASLSIKLASLPHKASRPSFTVHHQP
LPGLALAQAAPVIPQASSTGPSAVWVSLGMPPPCAARLAGVKPR
NT seq 5175 nt NT seq  +upstreamnt  +downstreamnt
atgaggcattctgtcctaatcttgagtgacccttggaaaatgacaggaagaggaaattta
caaaggcgtctggtctcctgggacaaacaccatgatgctgctcatgaaatcattgagacc
atccgatgggtctgtgaggaaatcccagacctcaagctcgctatggagaattacgtccta
atcgactacgacaccaaaagctttgaaagcatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacgcaacccatgaagctgaacacg
cggccgtccaatgggctcctgcggcacatcctgcaacaggtctacaaccattcagtgacg
gaccccgagaagctcaacaactatgagcctttctcccctgaggtgtatggggagacctcc
tttgacctggtcgcacaaatgattgacgagatcaagatgaccgaggatgacctgtttgtg
gacctgggcagtggagtgggccaggtcgtgctgcaggtcgccgcggccaccaactgcaaa
catcactacggcgtcgagaaagccgacatcccagccaagtatgcggagaccatggaccga
gagttcaggaagtggatgaaatggtacggaaaaaagcatgcagaatacacactggaaaga
ggcgatttcctctcggaagagtggagagagcggatcgccaacacaagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcgatttgcaaacatg
aaggaaggtggcagaatcgtgtcctcgaagcccttcgcacctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgtgtggtggagctgtcgccgctgaaa
ggctcggtgtcatggacggggaagccagtgtcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgagaaaacaagagtaacacaaccacccccacgaaggtgccc
gagagcaaggcagctgcgcctgcggacacccctgtggattctggtgctgaggaagagaaa
gtggggacaactgccatcaagaagccatccccctccaaagcccggaagaagaagctgaac
aaaaaggggcggaagctggccggccggaagcgcgggcgccccaaaaagatgagcactgcg
aaccctgagcgtaagcccaagaagagcccgactgcactggacctgctgcattctcagacc
atgtcccagactgccgccgcctcgccgcaagatgcgtataagtcacctcacagcccgttt
tatcagctacctcccactgtgcagcggcagccacctgaccagctgctgctggcacccatc
ccgcctgcactgcagaagctgctagagtcctttaagattcagtacctgcagttcttggca
tacacgaagacccctcagtacaaggccagcctgcagcagctactggaccaggagaaggag
aagaacgcccgcttgctgggcgctgcacagcagctgtttggccactgccaggcccagaaa
gaggagatcaagaggcttttccagcagaaactagatgagttgggagtgaaggcgctgacc
tacagcgacctgatccaggcgcagaaggagatctcggctcacaaccagcagctacgggag
cagacggagcagctagacaaggataatagggagctgcgcacccagagcctgcagctgcta
aaggctcggtgtgaggaactgaagctagactggtctacgctgtccctggagaacctgctg
aaggaaaagcaggcactgaggagccagatctccgagaagcagagacgctgcctggagctg
cagatcagcattgtggagctggagaagagtcagcggcaacaggagctcctgcagctcaag
tcctgcgtgccgcctgatgacgcagtgcctggtcaccttcgcgggaagagtggcctgggc
cgtgagctggaggcagagcctggccggctgcacctggagctggactgctccaagctctca
ctgccccattttagtagcatgagcccggagctctccatgaatggccatgtgtctggctat
gagctctgcagtgcgctgagccggccctcgtccaagcagaacaccccccagtacctggcc
tcaccgctggaccaggaggttgtgccctgcacccccggccacagcagccgaccccggctc
gagaggctgtcgggcctggccctgcctgactacaccaggctctcacccgccaagctggta
ctcagacgccacctgagtcaggaccatgcggccaacagtaaggctgctgctggcgagctg
cacccacgagctgagcacactaaggagaacagccttccataccacagcccgggcctcacc
aacggcatcaaactgagccctcagtacccacggtcctcatcccccatgtccttacagatg
acaggagagaagggcagtgagaagggtctgaaggagcgcacctatgctagcagtggggag
gccattaccagcctgcctgtcagcatcccgctcagcaccgtgcagcccagcaagctgccc
gtcagcatccccctggccagcgtggtgctgcccagccgcgccgagaaggtgagaagcacc
cccagccctgtgccacaggcacgagagtcctcatccacacttgagaagcagatgggtgct
aatgcccatggcgctggaagcaaagggcttgccctggcccccgcaggtttctcctacacc
ggctcggtggccatcagcggggccctggcaggcagcccggccccgcttgtttctggagcc
gagcccccagcctttgacgagtcctctagctcagggagcctctttgccaccatgggctcc
cgcagctctaccccgcagcatcccccactgctggtacagccccggaactctggcccggcc
tcccctgcccaccagctctgcgccagcccccggcttggcactgcccagggcccgcttcct
gacgccagcaaaggggaccttccctccgaggctggcttctcagatccagagagcgaggcc
aagaggaggaccatcttcaccatctcggctggcaccagcagcaccaagcagtcgccttcc
aacaagcacagccctctgcctgcgagtatccgcggggacagcagccagagccacgggcag
gacagccgcaagcggggcaggaggaagcgggcgtcagcaggaacccccagcctgagctcg
ggtgtgtcccccaagcgccgggccctgccatccgtcgccagcctcttcacacagtcttca
gggtcccctctcaaccttaactccatggtcaacaacatcaaccaacctttggaaatcacg
gccatctcgtcccccgagagctccctaaagagctctcctgtcccttaccaggacaacgac
cagccacccgtgctcaagaaagagaagcccctgaaccaaaccaatggggcccagtattcc
ccgctgacctcagatgaggagccgggctctgaggatgagccgggcagtgccagaatcgag
agaaaaattgcaacgatctccttagaaagcaaatctcctccaaaaaccttggaaaatggt
ggtggcctggcgggaagaaagccagtgcccgccagcgagcctgtcaacagcagcaagtgg
aaggccaccttctcgcccatctccgacctcagcctggccaaggccactgacagcccacta
caggccagctccactctgggccagaactccctgtttgctttccggcccaccctagaggag
cccagctcagttgacgccaagctggcctcccaccccaggaagagcttccccagtgccctg
tcggcggccggtgggctgagcccaaacagcaaccctcccaatggcttcgccttcagtggg
ggcctggccactgacctcagtttacacagcttcaacgatggtgcttctctctcccacaag
gcccccgaggtggccagcctgggcacccccctgagctttcccgccctgcggggcaaggag
ggcagcacagagtctggcccctttgtgaacaagaggcagctggacggactgaacagcctg
aagggcgaggggggcaagggcagggaggcagagctgggcctgccctcatgcacgccctca
gacaaggcctcactggcacatggcaaggcaggcaagggccgggaccgcgagcctgacttc
aagaacggccacaacctcttcatttctgctgccgccgtgccccccgggggcctcctcagc
ggcccgggccttgccacagcagcatcttcggcgggcaacatggcctcctctgcccaaaca
caccggcccttcctgggcaccttcgcacccagcccgcagttctccctgggccccatgtcc
ctgcaggccaacctgggatcatccgtgctgcagtccctgttcagctctgtgccggctgcc
gccggcctggtgcatgtctcgtccgctgcgaccagactgaccaactcacacgccatgggc
agtttttcatccggggtggcaggcggcgcagttggaggtgtctttaaccacgcggtgcct
tccgcctcctctcatccgtttggagccagtttcggcagcggggctgcgtgtcgcagtgcc
acgctgagcttaaccccgctgcaggcggtggccagcacccccgcctcttcctttcaggcc
ccgccctccctggagccgcggcagcccccaccccagcccctgggccggccccctgcgggg
ccgcctaccctccacgtgccccttcctcctaacgccgccttgcctcccgctcatgcgctg
ctccctgctaactctgagcccgcgctcctgcagaacctggctcccctccctgctaaccaa
gctttcttacccgtctcctctgccgcttctctgccgcctgctaacgcctctctgtccatc
aagctcgcctccctcccgcacaaggcctcccgcccctccttcacggtgcaccaccagccc
ctgcctgggctggccctggcccaggctgcgcccgtgatcccacaggccagctccacgggg
ccatccgctgtgtgggtttcccttggcatgccgcctccttgtgccgcgcgccttgcgggg
gttaagccgcgataa

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