KEGG   PATHWAY: hcq04115
hcq04115                    Pathway                                

p53 signaling pathway - Hippocampus comes (tiger tail seahorse)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Cellular Processes; Cell growth and death
Pathway map
hcq04115  p53 signaling pathway

Hippocampus comes (tiger tail seahorse) [GN:hcq]
109512895  atm; serine-protein kinase ATM [KO:K04728] [EC:]
109525295  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:]
109517427  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:]
109517900  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:]
109523465  gorab; RAB6-interacting golgin isoform X1 [KO:K19748]
109532684  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:]
109522483  mdm4; protein Mdm4 [KO:K10127]
109528457  cellular tumor antigen p53-like isoform X1 [KO:K04451]
109522206  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
109508904  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
109527710  G1/S-specific cyclin-D2-like [KO:K10151]
109530113  G1/S-specific cyclin-D2-like [KO:K10151]
109526797  ccnd2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
109522291  G1/S-specific cyclin-D3-like isoform X1 [KO:K10152]
109522590  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:]
109527671  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:]
109532677  cyclin-dependent kinase 6-like [KO:K02091] [EC:]
109520991  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
109524515  G1/S-specific cyclin-E1-like [KO:K06626]
109524571  G1/S-specific cyclin-E1-like [KO:K06626]
109522438  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:]
109519470  protein reprimo A-like [KO:K10128]
109527096  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
109514392  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
109523199  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:]
109517452  growth arrest and DNA damage-inducible protein GADD45 beta-like isoform X1 [KO:K04402]
109523932  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109523962  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109517509  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109524174  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
109522935  G2 and S phase-expressed protein 1-like [KO:K10129]
109528779  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
109507545  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
109525037  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
109526039  uncharacterized protein LOC109526039 [KO:K04722]
109520533  caspase-8-like isoform X1 [KO:K04398] [EC:]
109530353  bid; BH3-interacting domain death agonist [KO:K04726]
109519324  bax; apoptosis regulator BAX [KO:K02159]
109508060  apoptosis regulator BAX-like [KO:K02159]
109508612  apoptosis regulator BAX-like isoform X1 [KO:K02159]
109516043  siva1; apoptosis regulatory protein Siva [KO:K22744]
109513829  bcl2l1; bcl-2-like protein 1 [KO:K04570]
109521170  apoptosis regulator Bcl-2-like [KO:K02161]
109531144  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
109522562  protein shisa-5-like [KO:K10135]
109522563  protein shisa-5-like [KO:K10135]
109510030  perp; p53 apoptosis effector related to PMP-22 isoform X1 [KO:K10136]
109525384  zmat3; zinc finger matrin-type protein 3 [KO:K10137]
109526770  siah1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:]
109510161  cytochrome c [KO:K08738]
109522106  cytochrome c iso-1/iso-2-like [KO:K08738]
109531259  cytochrome c-like [KO:K08738]
109523695  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
109511699  casp9; caspase-9 [KO:K04399] [EC:]
109515795  caspase-3-like [KO:K02187] [EC:]
109511417  caspase-3-like [KO:K02187] [EC:]
109524696  insulin-like growth factor-binding protein 3 [KO:K10138]
109521219  insulin-like growth factor-binding protein 3 [KO:K10138]
109530129  igf1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
109528351  insulin-like growth factor I [KO:K05459]
109520372  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
109521931  brain-specific angiogenesis inhibitor 1-like isoform X1 [KO:K04596]
109507632  cd82; CD82 antigen [KO:K06509]
109514393  CD82 antigen-like [KO:K06509]
109516072  thrombospondin-1-like [KO:K16857]
109523753  thbs1; thrombospondin-1 [KO:K16857]
109519449  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
109527996  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:]
109531761  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:]
109531764  ribonucleoside-diphosphate reductase subunit M2-like isoform X1 [KO:K10808] [EC:]
109516662  sestrin-3-like [KO:K10141]
109530993  sesn1; sestrin-1 isoform X1 [KO:K10141]
109509805  sestrin-2-like isoform X1 [KO:K20394]
109526518  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:]
109528785  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:]
109527351  tsc2; tuberin isoform X1 [KO:K07207]
109518172  steap3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
109515520  rfwd2; E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:]
109525003  rchy1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:]
109515756  ccng1; cyclin-G1 [KO:K10145]
109511561  cyclin-G1-like [KO:K10145]
109527070  cyclin-G2-like [KO:K10146]
109525202  cyclin-G2-like isoform X1 [KO:K10146]
109508962  ppm1d; protein phosphatase 1D [KO:K10147] [EC:]
109526640  tp73; tumor protein p73 isoform X1 [KO:K10148]
Levine AJ, Hu W, Feng Z.
The P53 pathway: what questions remain to be explored?
Cell Death Differ 13:1027-36 (2006)
Harris SL, Levine AJ.
The p53 pathway: positive and negative feedback loops.
Oncogene 24:2899-908 (2005)
Balint E E, Vousden KH.
Activation and activities of the p53 tumour suppressor protein.
Br J Cancer 85:1813-23 (2001)
Taylor WR, Stark GR.
Regulation of the G2/M transition by p53.
Oncogene 20:1803-15 (2001)
Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci 25:177-81 (2004)
Pietenpol JA, Stewart ZA.
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology 181-182:475-81 (2002)
Tokino T, Nakamura Y.
The role of p53-target genes in human cancer.
Crit Rev Oncol Hematol 33:1-6 (2000)
Hermeking H, Benzinger A.
14-3-3 proteins in cell cycle regulation.
Semin Cancer Biol 16:183-92 (2006)
Sherr CJ.
Divorcing ARF and p53: an unsettled case.
Nat Rev Cancer 6:663-73 (2006)
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer Res 67:3043-53 (2007)
Resnick-Silverman L, Manfredi JJ
Two Faces of SIVA.
Cancer Discov 5:581-3 (2015)
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
J Cell Sci 122:2651-61 (2009)
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
J Carcinog 8:2 (2009)
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett 524:163-71 (2002)
hcq04110  Cell cycle
hcq04210  Apoptosis
hcq04218  Cellular senescence
KO pathway

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