| Entry |
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| Name |
JAK-STAT signaling pathway - Heterocephalus glaber (naked mole rat)
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| Description |
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
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| Class |
Environmental Information Processing; Signal transduction
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| Pathway map |
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| Other DBs |
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| Organism |
Heterocephalus glaber (naked mole rat) [GN: hgl]
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| Gene |
| 101702638 | granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066] |
| 101718902 | Stat1; signal transducer and activator of transcription 1 [KO:K11220] |
| 101707295 | Stat2; signal transducer and activator of transcription 2 [KO:K11221] |
| 101721899 | Stat3; signal transducer and activator of transcription 3 [KO:K04692] |
| 101718558 | Stat4; signal transducer and activator of transcription 4 [KO:K11222] |
| 101722721 | Stat5b; signal transducer and activator of transcription 5B [KO:K11224] |
| 101725744 | Stat6; signal transducer and activator of transcription 6 [KO:K11225] |
| 101704740 | Myc; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377] |
| 101709056 | Pias1; protein inhibitor of activated STAT 1 [KO:K04706] [EC:2.3.2.-] |
| 101709303 | Pias2; protein inhibitor of activated STAT 2 [KO:K16063] [EC:2.3.2.-] |
| 101699952 | Pias3; protein inhibitor of activated STAT 3 [KO:K16064] [EC:2.3.2.-] |
| 101707893 | Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099] |
| 101701753 | Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099] |
| 101718815 | Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649] |
| 101717096 | Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649] |
| 101703691 | Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649] |
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| Reference |
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| Authors |
Harrison DA |
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| Title |
The Jak/STAT pathway. |
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| Journal |
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| Reference |
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| Authors |
Kiu H, Nicholson SE |
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| Title |
Biology and significance of the JAK/STAT signalling pathways. |
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| Journal |
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| Reference |
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| Authors |
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I |
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| Title |
Direct effects of type I interferons on cells of the immune system. |
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| Reference |
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| Authors |
Fish EN, Platanias LC |
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| Title |
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes. |
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| Journal |
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| Reference |
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| Authors |
Ivanenkov YA, Balakin KV, Lavrovsky Y |
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| Title |
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics. |
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| Journal |
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| Reference |
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| Authors |
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A |
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| Title |
The JAK-STAT pathway: impact on human disease and therapeutic intervention. |
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| Journal |
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| Reference |
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| Authors |
Zoranovic T, Grmai L, Bach EA |
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| Title |
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway. |
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| Reference |
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| Authors |
Ungureanu D, Silvennoinen O |
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SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling. |
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| Reference |
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| Authors |
Richard AJ, Stephens JM |
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The role of JAK-STAT signaling in adipose tissue function. |
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| Journal |
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| Reference |
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| Authors |
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R |
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| Title |
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis. |
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| Reference |
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| Authors |
Hirano T, Ishihara K, Hibi M |
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| Title |
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. |
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| Journal |
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| Reference |
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| Authors |
Rane SG, Reddy EP |
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| Title |
Janus kinases: components of multiple signaling pathways. |
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| Journal |
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| Reference |
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| Authors |
Heim MH |
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| Title |
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus. |
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| Journal |
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Related
pathway |
| hgl04060 | Cytokine-cytokine receptor interaction |
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| KO pathway |
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| LinkDB |
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