Heterocephalus glaber (naked mole rat): 101699952 Help Entry 101699952         CDS       T02812                                  Gene name Pias3 Definition (RefSeq) protein inhibitor of activated STAT 3   KO K16064   E3 SUMO-protein ligase PIAS3 [EC:2.3.2.-] Organism hgl  Heterocephalus glaber (naked mole rat) Pathway hgl04120   Ubiquitin mediated proteolysis hgl04630   JAK-STAT signaling pathway Brite KEGG Orthology (KO) [BR:hgl00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     101699952 (Pias3)  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101699952 (Pias3)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hgl04121]     101699952 (Pias3) Enzymes [BR:hgl01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.-        101699952 (Pias3) Ubiquitin system [BR:hgl04121]  Ubiquitin ligases (E3)   UBL E3 ligases    101699952 (Pias3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PINIT zf-MIZ zf-Nse Motif Other DBs NCBI-GeneID:  101699952 NCBI-ProteinID:  XP_004853964 LinkDB All DBs Position Un AA seq 625 aa AA seqDB search MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKEL YRRRFPRKSLGPSDLSMLSLPPGTSPVGSPGPLAPIPPALLAPGTLLGPKREVDMHPPLP QPVHPDVTMKPLPFYEVYGELIRPTTLASTSSHRFEEAHFTFALTPQQVQQILTSREVLP GAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSR PINITPLARLSATVPNTVVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHS RALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEK KPTWTCPVCDKKAPYESLIIDGLFMEILNSCSDCDEIQFMEDGSWCPMKPKKEASEVCPP PGYGLDGLQYSPVQEGNPSESKKKVEVIDLTIESSSDEEDLPPTKKHCPVTSAAIPALPG SKGVLTSSHQPSSVLRSPAMGTLGSDFLSSLPLHEYPPAFPLGPDIQGLDLFSFLQTESQ HYGPSVITSLDEQDALGHFFQYRGTPSHFLGPLAPTLGSSHRSSTPAPPPGRVSSIVAPG GALREGPLPSGPSLTGCRSDIISLD NT seq 1878 nt NT seq  +upstreamnt  +downstreamnt atggcggagctgggagaattaaagcacatggtgatgagtttccgggtgtctgagctccag gtgctcctcggctttgctggccggaacaagagtggacggaaacacgagctcctggccaag gctctgcatcttctcaagtccagctgtgcccccagtgtccagatgaagatcaaagagctt taccgtcggcgctttcccaggaagtccctggggccctctgatctctccatgctctctctg ccccctggcacctctcccgtaggctccccgggccccctagctcccattcccccagccctc ctggcccctggcactctgctgggccccaagcgcgaggtggacatgcaccccccactcccc cagcctgtgcaccccgatgtcaccatgaaaccattgcctttctatgaagtctacggggag ctcattcgacccaccaccctcgcatccacttctagtcatcggtttgaggaagcgcacttt actttcgccctcaccccccagcaagtgcagcagattctcacgtccagagaggttcttcca ggagccaaatgtgattataccatacaggtgcagctaaggttctgtctctgtgagaccagc tgcccccaggaggattatttcccccccaacctctttgtcaaggtcaatgggaaactgtgt cccctaccgggttaccttcccccgaccaagaatggggcggagcccaagaggcccagccgc cccatcaacatcacccccctggctagactctcggccaccgttcccaacaccgtcgtggtc aactggtcatctgagtttggacggaattactccttgtctgtgtacctggtgaggcagttg actgcagggacccttctacaaaaactcagagcaaaggggatccggaacccagaccactcc cgggcactgataaaggagaaactgaccgctgaccctgacagtgaggtggctactacgagt cttcgggtgtccctcatgtgcccgctagggaagatgcggctgactgtcccatgtcgtgcc ctcacctgtgcccacctgcagagcttcgatgctgccctttacctacagatgaatgagaag aagccgacgtggacgtgtcctgtgtgtgacaagaaggctccctacgaatctcttattatt gatggtttattcatggagattcttaattcctgttcggactgtgatgagatccagtttatg gaagatggatcctggtgcccaatgaaacccaaaaaggaggcatctgaggtttgccccccg ccagggtatgggctggatggcctccagtatagcccagtccaagagggaaatccatcagag agtaagaagaaggttgaagttattgacttgacaatagaaagctcatccgatgaggaggat ctgcccccaaccaagaagcactgtcctgtcacctcagctgccatccctgccctgcctgga agcaaaggagtcctgacttctagtcaccagccatcctcggtgctgcggagccctgcaatg ggcacgctgggcagtgacttcctgtccagtctcccactacacgagtacccacctgccttc cccctggggcccgacatccaaggtttagatttattttcttttcttcagactgagagtcag cactatggtccttccgtcatcacctcgctagatgaacaggacgcccttggccacttcttc cagtaccgggggaccccttcccactttctgggccccctggcccccacgttggggagctca caccgcagctccactccagcaccccctcctggccgcgtcagcagcattgtggctcctgga ggggccttgagggagggacccctgccttctggtccttccttgactggctgtcggtcagac atcatttccctggactga

Heterocephalus glaber (naked mole rat): 101708989 Help Entry 101708989         CDS       T02812                                  Gene name Pias4 Definition (RefSeq) protein inhibitor of activated STAT 4   KO K16065   E3 SUMO-protein ligase PIAS4 [EC:2.3.2.27] Organism hgl  Heterocephalus glaber (naked mole rat) Pathway hgl04064   NF-kappa B signaling pathway hgl04120   Ubiquitin mediated proteolysis hgl04630   JAK-STAT signaling pathway hgl05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:hgl00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     101708989 (Pias4)  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101708989 (Pias4)    04064 NF-kappa B signaling pathway     101708989 (Pias4)  09160 Human Diseases   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     101708989 (Pias4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hgl04121]     101708989 (Pias4) Enzymes [BR:hgl01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      101708989 (Pias4) Ubiquitin system [BR:hgl04121]  Ubiquitin ligases (E3)   UBL E3 ligases    101708989 (Pias4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PINIT zf-MIZ zf-Nse Sporozoite_P67 SAP Motif Other DBs NCBI-GeneID:  101708989 NCBI-ProteinID:  XP_004865832 LinkDB All DBs Position Un AA seq 553 aa AA seqDB search MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKE LYETRYAKKGAEPGPQPHRPLDPLTVHSAYERASAVPRTPLSGPNIDYPVLYGKYLNGLG RLPAKTLKPEVRLVKLPFFNMLDELLKPTELVPQNNEKLQESPCIFALTPRQVELIRNSR ELQPGVKAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPC RPINLTHLMYLSSATNRITVTWGNYGKSYSAALYLVRQLTSAELLQRLETIGVKHPELCK ALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKK PTWMCPVCDKPAPYDQLIIDGLAAAPQAAFPPARSSSDSSRLPDPGQVAAAFSGPGYPGP RLLSKILSECEDADEIEFLADGSWCPIRAEKERSCSPQGPILVLGTSDTNGLVPTPNVNG SGGMALGSTGVGVGLVGSMENGKLGADVVDLTLDSSSSSEEEEEEDEEEEEEDEEGPRPK RRCPLPKGLVPAC NT seq 1662 nt NT seq  +upstreamnt  +downstreamnt atggcggcggagctggtggaggccaaaaacatggtgatgagcttccgggtctccgacctg cagatgctgctgggattcgtgggccgcagcaagagcgggctgaagcatgagctggtcacc agggcactgcagctggtgcagttcgactgcagccccgagctctttaagaagatcaaggag ctctatgagactcgctatgcgaagaagggtgccgagcccggcccgcagccacaccggccc ctggaccccctcaccgtgcactcggcttatgagcgggccagcgctgtgcccaggactccc ctgtcaggccccaatattgactaccccgtgctctacgggaagtacctgaacggactggga cgtttgcctgccaagacactcaaacccgaggtccgcctagtgaagctgcccttcttcaac atgctggacgagctgctgaagcccacggagttagtcccacagaataatgagaagctgcag gagagtccctgtatcttcgcgctgacgcccaggcaggtggagctgatccggaactccaga gagctgcagccgggagtcaaggccgtgcaggttgtgctaagaatctgttactcagacacc agctgtcctcaggaggaccagtacccgcccaacatcgccgtcaaggtcaaccacagctac tgctcagtcccgggctactacccttccaacaagcccggagtggagcccaagaggccctgc cgccccatcaacctcacccacctcatgtacctgtcctcggccactaaccgaatcaccgtc acctgggggaactatggcaagagctactcagcagcgctgtacctggtgagacagctgacc tccgctgagctgttgcagaggctggaaaccatcggtgtgaagcacccggagctgtgcaaa gcgctagtcaaggagaagctgcgtctggatcctgacagcgagattgccaccactggtgtg cgggtctctctcatctgcccgctggtgaagatgcggctctcggtgccctgccgtgcggag acctgcgcacacctgcagtgcttcgatgctgtgttctacctgcagatgaacgagaagaag cctacctggatgtgcccggtgtgtgacaaaccggccccctacgaccagctcatcattgac ggcctggcagctgcgccccaagctgccttccccccagccaggagcagctcggacagctcc aggctgcctgatccaggccaggtggctgcagccttctctggccctggctacccagggccc aggctcctgtccaagatcctgagtgagtgcgaggacgccgatgagatcgagttcctggct gatgggtcgtggtgccccatccgtgctgagaaagagcggagctgcagcccccagggcccc atcctggtgcttggcacctcagacaccaatgggctggtgcccacccccaacgtcaacggc agtggtggcatggcgctgggcagcacaggtgttggggtgggcctggtgggcagcatggag aatgggaagctgggtgccgacgtggtggacctcacgctggacagctcatcatcgtcagag gaggaggaagaggaggatgaggaagaggaggaggaggacgaagaaggcccccggcccaag cgccgctgccccttgcccaagggcctggtgccggcctgctga

Heterocephalus glaber (naked mole rat): 101709056 Help Entry 101709056         CDS       T02812                                  Gene name Pias1 Definition (RefSeq) protein inhibitor of activated STAT 1   KO K04706   E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-] Organism hgl  Heterocephalus glaber (naked mole rat) Pathway hgl04120   Ubiquitin mediated proteolysis hgl04630   JAK-STAT signaling pathway hgl05160   Hepatitis C Brite KEGG Orthology (KO) [BR:hgl00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     101709056 (Pias1)  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101709056 (Pias1)  09160 Human Diseases   09172 Infectious disease: viral    05160 Hepatitis C     101709056 (Pias1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hgl04121]     101709056 (Pias1)   09183 Protein families: signaling and cellular processes    04812 Cytoskeleton proteins [BR:hgl04812]     101709056 (Pias1) Enzymes [BR:hgl01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.-        101709056 (Pias1) Ubiquitin system [BR:hgl04121]  Ubiquitin ligases (E3)   UBL E3 ligases    101709056 (Pias1) Cytoskeleton proteins [BR:hgl04812]  Eukaryotic cytoskeleton proteins   Septins    Septin associated proteins     101709056 (Pias1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PINIT zf-MIZ zf-Nse Motif Other DBs NCBI-GeneID:  101709056 NCBI-ProteinID:  NP_001290231 UniProt:  A0A0A7HV84 LinkDB All DBs Position Un AA seq 651 aa AA seqDB search MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKEL YRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHEL ELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQ ISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNG VEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRTYSMAVYLVKQLSSTVLLQRLRAK GIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDAT LYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGSWAPMRSKK EVQEVSASYNGVDGCLSSTLEHQVASHNQSSSKNKKVEVIDLTIDSSSDEEEEEPSAKRT CPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDL QGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTS LPATNGSSSGSNSSLVSSNSLRESHSHTVASRSSTDAASVFGIIPDIISLD NT seq 1956 nt NT seq  +upstreamnt  +downstreamnt atggcggacagtgcggaactaaagcaaatggttatgagccttagagtttctgaactccaa gtattgttgggctacgctgggagaaacaagcacggacgcaaacacgaacttctcacaaaa gccctgcatttactcaaggctggctgtagtcctgctgtacaaatgaaaattaaagaactc tataggcgacggttcccccagaaaatcatgacgcctgcggacttgtctatccccaatgta cattcaagtcctatgccagcaactttgtctccatctaccattccacagctcacttatgat ggtcaccctgcatcttcaccattactccccgtttctcttctgggacctaaacatgaactg gaactcccacatcttacatcagctcttcacccagtccatccggatataaaacttcaaaaa ctaccattttatgacttactggatgaactgataaagcccaccagtctagcatcagacaac agtcagcgctttcgagaaacctgttttgcatttgccttgaccccacaacaagtgcagcag atcagtagctccatggatatttccgggaccaaatgtgacttcacagtgcaggtccagtta aggttttgtttatctgaaaccagttgtccacaagaagatcacttcccacccaatctttgt gtgaaagtgaatactaaaccttgcagccttccaggttaccttccacctactaaaaatggt gtggaaccaaagcgacccagcagaccaattaatatcacctcacttgtccgattgtccaca acagtaccaaacaccattgttgtttcatggactgcggaaattggaagaacctattccatg gcagtatatcttgtaaaacagttgtcctcaacagttcttcttcagaggttacgagcaaag ggaataaggaatccggatcattctagagctttaattaaagagaaactgactgctgatcca gacagtgaaatagctacaaccagcctaagggtttctctactttgtccccttggtaaaatg cggctgacaattccatgccgagccctcacatgttctcatctgcagtgttttgatgcaact ctttatattcagatgaatgagaaaaaaccaacctgggtctgtcctgtctgtgataagaag gctccatatgaacaccttattattgatggcttgtttatggaaatcctaaagtactgtaca gactgtgatgaaatacagtttaaggaagatggctcttgggcaccaatgcgatcaaaaaag gaagtacaggaagtttctgcctcttacaatggagttgatggatgcttgagttccactttg gagcatcaggtggcttctcacaaccagtcctccagtaaaaacaagaaagtcgaggttatt gacctaaccatagacagctcatctgatgaagaggaggaagagccatctgccaagagaacc tgtccttccctttctcccacctcaccactaaacaataaaggcattttaagtcttccacac caagcatctccagtatcccgcaccccaagccttcctgctgtagacacgagctacatcaac acctctctcatccaagactacaggcatcctttccacatgacacccatgccttatgactta caaggattagatttctttccattcttgtcaggagacaatcagcattacaacacctccctc ctcgctgccgcagccgccgcagtctccgatgaccaggacctgctgcactcatcgcgcttt tttccatatacctcctcccagatgttcctcgaccagctgagtgcaggaggcagcacgtcc ctgccagccaccaatgggagcagcagtggcagcaacagcagccttgtgtcttccaacagc ctgagggagagccacagccacacagtggccagcaggagcagcacagacgcggcatccgtc ttcggcatcataccggacattatctccctggactga

Heterocephalus glaber (naked mole rat): 101709303 Help Entry 101709303         CDS       T02812                                  Gene name Pias2 Definition (RefSeq) protein inhibitor of activated STAT 2   KO K16063   E3 SUMO-protein ligase PIAS2 [EC:2.3.2.-] Organism hgl  Heterocephalus glaber (naked mole rat) Pathway hgl04120   Ubiquitin mediated proteolysis hgl04630   JAK-STAT signaling pathway Brite KEGG Orthology (KO) [BR:hgl00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     101709303 (Pias2)  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101709303 (Pias2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hgl04121]     101709303 (Pias2) Enzymes [BR:hgl01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.-        101709303 (Pias2) Ubiquitin system [BR:hgl04121]  Ubiquitin ligases (E3)   UBL E3 ligases    101709303 (Pias2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PINIT zf-MIZ zf-Nse PHD Motif Other DBs NCBI-GeneID:  101709303 NCBI-ProteinID:  XP_004855153 UniProt:  A0A0P6J1G7 LinkDB All DBs Position Un AA seq 620 aa AA seqDB search MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIREL YRRRYPRTLEGLSDLSAIKSSVFSLDSSSSPVEPDLAVAGIHSLPSTSVTSHSPSSPVGS VLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFP LPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLT SAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLTCPLGKMRLTIPCRAV TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQE DGSWCPMRPKKEAMKVSSQPCTKIESSGVLSKPCSVTVAGEVSKKKVDVIDLTIESSSDE EEDPPAKRKCIFMSETQSSPTKGVLMYQPSIRVPSVTSVDPAAIPPSLTDYSVPFHHTPI SSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSTSVTTTSPHESSTHVSSSSSR SETGVITSSGSSIPDIISLD NT seq 1863 nt NT seq  +upstreamnt  +downstreamnt atggcggatttcgaagagttgaggaatatggtttctagttttagagtttctgaactacaa gtgttactaggctttgctggacggaataaaagtggacgcaagcatgacctcctgatgagg gccctgcatttattgaagagtggctgcagccctgcggttcagattaaaatccgagaattg tatagacgccgatatccacggactcttgaagggctttctgatttatctgcaatcaaatca tcagttttcagtttggatagtagctcatcacctgtagaacctgacctggctgtggctgga atccactcgttgccctccacttcagttacatctcactcaccgtcctctcctgttggttct gtgctacttcaagatactaagcccacttttgagatgcagcaaccatctcctccaattcct cctgtccatcctgatgtgcagttaaaaaacctgcccttttatgatgtccttgatgttctc atcaagcccacaagtttagttcaaagcagtattcaacgatttcaagagaagttttttatt tttgctttgacacctcaacaggttagagagatatgcatatcaagggactttttgccaggt ggtcggagagattatacagttcaagttcagctaagactttgcctggcagagacaagttgt cctcaagaagataactatcccaatagtctctgtataaaagtaaatgggaaactatttcct ttgcctggctatgcaccaccaccgaaaaatgggattgagcagaagcgccctggacgcccc ttgaatattacatctttagtgaggttgtcttcagctgtgccaaaccagatttctatttct tgggcatctgaaattggaaagaattattctatgtctgtatatcttgtacgacaactgaca tcagccatgttattacagagattaaaaatgaaaggtattagaaaccccgatcattccaga gcactaattaaagaaaaacttactgcagatcctgatagtgaaattgctacaactagtctc cgggtgtccttgacgtgccctctagggaaaatgaggctaacaatcccatgccgtgcagtg acatgtacacatctgcagtgtttcgatgctgccctttatctacaaatgaatgagaagaag cccacctggatttgtcctgtctgtgacaaaaaagctgcctacgaaagtctaatattagat gggctttttatggaaattctcaatgactgttctgatgtggatgagatcaaattccaagaa gatggttcttggtgtccgatgagaccgaagaaagaagctatgaaagtatccagccaacca tgtacaaaaatagaaagttcaggtgtcctcagtaagccttgttcagttactgtagccggt gaggtaagcaagaagaaagtggatgttatcgacctaacaatagaaagctcttctgatgaa gaggaagacccccctgccaaaaggaaatgcatctttatgtcagaaacacaaagcagccca accaaaggggttctcatgtatcagccatctataagggtgcctagtgtgacttcggttgat cctgctgctattccgccttcattaacagactactcagtaccattccaccacaccccaata tcaagcatgtcatcagatttgccaggtttggattttctttcccttattccagttgatccc cagtactgtcctcctatgtttttggatagtctcacctcacccttaacagcaagcagtacg tctgtcaccaccaccagcccccatgaaagcagtactcatgttagttcatccagcagcagg agtgagacaggggtcataaccagcagtggaagtagcattcctgacatcatctcattggac taa

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