Heterocephalus glaber (naked mole rat): 101704230 Help Entry 101704230         CDS       T02812                                  Gene name Tgfb1 Definition (RefSeq) transforming growth factor beta 1   KO K13375   transforming growth factor beta-1 Organism hgl  Heterocephalus glaber (naked mole rat) Pathway hgl04010   MAPK signaling pathway hgl04060   Cytokine-cytokine receptor interaction hgl04068   FoxO signaling pathway hgl04110   Cell cycle hgl04218   Cellular senescence hgl04350   TGF-beta signaling pathway hgl04380   Osteoclast differentiation hgl04390   Hippo signaling pathway hgl04659   Th17 cell differentiation hgl04672   Intestinal immune network for IgA production hgl04926   Relaxin signaling pathway hgl04932   Non-alcoholic fatty liver disease hgl04933   AGE-RAGE signaling pathway in diabetic complications hgl05140   Leishmaniasis hgl05142   Chagas disease hgl05144   Malaria hgl05145   Toxoplasmosis hgl05146   Amoebiasis hgl05152   Tuberculosis hgl05161   Hepatitis B hgl05166   Human T-cell leukemia virus 1 infection hgl05200   Pathways in cancer hgl05205   Proteoglycans in cancer hgl05210   Colorectal cancer hgl05211   Renal cell carcinoma hgl05212   Pancreatic cancer hgl05220   Chronic myeloid leukemia hgl05225   Hepatocellular carcinoma hgl05226   Gastric cancer hgl05321   Inflammatory bowel disease hgl05323   Rheumatoid arthritis hgl05410   Hypertrophic cardiomyopathy hgl05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     101704230 (Tgfb1)    04350 TGF-beta signaling pathway     101704230 (Tgfb1)    04390 Hippo signaling pathway     101704230 (Tgfb1)    04068 FoxO signaling pathway     101704230 (Tgfb1)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     101704230 (Tgfb1)  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     101704230 (Tgfb1)    04218 Cellular senescence     101704230 (Tgfb1)  09150 Organismal Systems   09151 Immune system    04659 Th17 cell differentiation     101704230 (Tgfb1)    04672 Intestinal immune network for IgA production     101704230 (Tgfb1)   09152 Endocrine system    04926 Relaxin signaling pathway     101704230 (Tgfb1)   09158 Development and regeneration    04380 Osteoclast differentiation     101704230 (Tgfb1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101704230 (Tgfb1)    05205 Proteoglycans in cancer     101704230 (Tgfb1)   09162 Cancer: specific types    05210 Colorectal cancer     101704230 (Tgfb1)    05212 Pancreatic cancer     101704230 (Tgfb1)    05225 Hepatocellular carcinoma     101704230 (Tgfb1)    05226 Gastric cancer     101704230 (Tgfb1)    05220 Chronic myeloid leukemia     101704230 (Tgfb1)    05211 Renal cell carcinoma     101704230 (Tgfb1)   09163 Immune disease    05323 Rheumatoid arthritis     101704230 (Tgfb1)    05321 Inflammatory bowel disease     101704230 (Tgfb1)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     101704230 (Tgfb1)    05414 Dilated cardiomyopathy     101704230 (Tgfb1)   09167 Endocrine and metabolic disease    04932 Non-alcoholic fatty liver disease     101704230 (Tgfb1)    04933 AGE-RAGE signaling pathway in diabetic complications     101704230 (Tgfb1)   09171 Infectious disease: bacterial    05152 Tuberculosis     101704230 (Tgfb1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101704230 (Tgfb1)    05161 Hepatitis B     101704230 (Tgfb1)   09174 Infectious disease: parasitic    05146 Amoebiasis     101704230 (Tgfb1)    05144 Malaria     101704230 (Tgfb1)    05145 Toxoplasmosis     101704230 (Tgfb1)    05140 Leishmaniasis     101704230 (Tgfb1)    05142 Chagas disease     101704230 (Tgfb1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03110 Chaperones and folding catalysts [BR:hgl03110]     101704230 (Tgfb1)   09183 Protein families: signaling and cellular processes    04052 Cytokines and growth factors [BR:hgl04052]     101704230 (Tgfb1)    00536 Glycosaminoglycan binding proteins [BR:hgl00536]     101704230 (Tgfb1) Chaperones and folding catalysts [BR:hgl03110]  Intramolecular chaperones   Others    101704230 (Tgfb1) Cytokines and growth factors [BR:hgl04052]  Cytokines   Transforming growth factors (RSTK binding)    101704230 (Tgfb1) Glycosaminoglycan binding proteins [BR:hgl00536]  Heparan sulfate / Heparin   Growth factors/receptors    101704230 (Tgfb1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  TGFb_propeptide TGF_beta Motif Other DBs NCBI-GeneID:  101704230 NCBI-ProteinID:  XP_004873050 UniProt:  A0A0P6K6G7 LinkDB All DBs Position Un AA seq 390 aa AA seqDB search MPPFRLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAESEPEPEPDYYAKEVTRVLMVENNHNI YKSIETVAHSVYMFFNTSEIREAVPDPLLLSRAELRMQRLKLSVEQHVELYQKYSNNSWR YLSNRLLTPSDTPEWLSFDVTGVVRQWLIQREELQGFRFSAHCSCDSKDNTLRVDINGIG PKRRGDLGAIHGMNRPFLLLMATPLERAQHLHSSRHRRALDTNYCFSSTEKNCCVRQLYI DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA LEPLPIVYYVGRKAKVEQLSNMIVRSCKCS NT seq 1173 nt NT seq  +upstreamnt  +downstreamnt atgccgcccttccggctgcggctgctgccgcttctgctaccgctactgtggctactggtg ctgacgcctggccggccagctgcgggtctgtccacctgcaagaccatcgatatggagctg gtgaagcggaagcgcatcgaggccatccgcggccagatcctgtccaaattacggctcgcc agcccccccagccagggggaggtaccgcccggcccgctgcccgaggccgtgctcgccctg tacaacagcacccgcgaccgggtggccggggagagcgccgagtcggaacccgagcccgag ccggactactatgccaaggaggtcacccgcgtgctaatggtggagaacaaccacaatatc tataaaagcatcgagactgttgcacacagtgtatatatgttcttcaacacatcagagatc cgggaagctgtgcctgaccctctgttgttgtcgcgggcagagctgcgtatgcagagactc aagttaagtgtggagcaacacgtggaactgtaccaaaaatacagcaacaattcctggcgc tacctcagcaaccggctcctgacccccagtgatacaccggagtggctgtcctttgatgtc actggagttgttcggcagtggctgatccaaagagaggaattacagggctttcgcttcagt gctcactgctcctgtgacagcaaagataacacactccgagtggacatcaacgggatcggt cctaaacgccggggtgacctgggggccattcatggaatgaaccgccccttcctgctcctc atggccaccccactggagagggcccagcacctgcacagctcccgacaccgccgagccctg gacacaaactactgcttcagctccacggagaagaactgctgtgttcggcagctctacatt gacttccgcaaggacctgggatggaagtggatccacgagcccaagggctaccacgccaac ttctgcctagggccctgtccctacatttggagcctggacacacagtacagcaaggtcctg gccctgtacaaccagcacaacccgggggcgtcggcggcgccctgctgcgtgccgcaggca ctggagccgctgcccatcgtgtactacgtgggccgcaaagccaaggtggagcagctgtcc aacatgatcgtgcgctcctgcaaatgcagctga

Heterocephalus glaber (naked mole rat): 101707457 Help Entry 101707457         CDS       T02812                                  Gene name Tgfb2 Definition (RefSeq) transforming growth factor beta 2   KO K13376   transforming growth factor beta-2 Organism hgl  Heterocephalus glaber (naked mole rat) Pathway hgl04010   MAPK signaling pathway hgl04060   Cytokine-cytokine receptor interaction hgl04068   FoxO signaling pathway hgl04110   Cell cycle hgl04218   Cellular senescence hgl04350   TGF-beta signaling pathway hgl04380   Osteoclast differentiation hgl04390   Hippo signaling pathway hgl04933   AGE-RAGE signaling pathway in diabetic complications hgl05140   Leishmaniasis hgl05142   Chagas disease hgl05144   Malaria hgl05145   Toxoplasmosis hgl05146   Amoebiasis hgl05152   Tuberculosis hgl05161   Hepatitis B hgl05166   Human T-cell leukemia virus 1 infection hgl05200   Pathways in cancer hgl05205   Proteoglycans in cancer hgl05206   MicroRNAs in cancer hgl05210   Colorectal cancer hgl05211   Renal cell carcinoma hgl05212   Pancreatic cancer hgl05220   Chronic myeloid leukemia hgl05225   Hepatocellular carcinoma hgl05226   Gastric cancer hgl05321   Inflammatory bowel disease hgl05323   Rheumatoid arthritis hgl05410   Hypertrophic cardiomyopathy hgl05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     101707457 (Tgfb2)    04350 TGF-beta signaling pathway     101707457 (Tgfb2)    04390 Hippo signaling pathway     101707457 (Tgfb2)    04068 FoxO signaling pathway     101707457 (Tgfb2)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     101707457 (Tgfb2)  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     101707457 (Tgfb2)    04218 Cellular senescence     101707457 (Tgfb2)  09150 Organismal Systems   09158 Development and regeneration    04380 Osteoclast differentiation     101707457 (Tgfb2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101707457 (Tgfb2)    05206 MicroRNAs in cancer     101707457 (Tgfb2)    05205 Proteoglycans in cancer     101707457 (Tgfb2)   09162 Cancer: specific types    05210 Colorectal cancer     101707457 (Tgfb2)    05212 Pancreatic cancer     101707457 (Tgfb2)    05225 Hepatocellular carcinoma     101707457 (Tgfb2)    05226 Gastric cancer     101707457 (Tgfb2)    05220 Chronic myeloid leukemia     101707457 (Tgfb2)    05211 Renal cell carcinoma     101707457 (Tgfb2)   09163 Immune disease    05323 Rheumatoid arthritis     101707457 (Tgfb2)    05321 Inflammatory bowel disease     101707457 (Tgfb2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     101707457 (Tgfb2)    05414 Dilated cardiomyopathy     101707457 (Tgfb2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     101707457 (Tgfb2)   09171 Infectious disease: bacterial    05152 Tuberculosis     101707457 (Tgfb2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101707457 (Tgfb2)    05161 Hepatitis B     101707457 (Tgfb2)   09174 Infectious disease: parasitic    05146 Amoebiasis     101707457 (Tgfb2)    05144 Malaria     101707457 (Tgfb2)    05145 Toxoplasmosis     101707457 (Tgfb2)    05140 Leishmaniasis     101707457 (Tgfb2)    05142 Chagas disease     101707457 (Tgfb2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and growth factors [BR:hgl04052]     101707457 (Tgfb2)    00536 Glycosaminoglycan binding proteins [BR:hgl00536]     101707457 (Tgfb2) Cytokines and growth factors [BR:hgl04052]  Cytokines   Transforming growth factors (RSTK binding)    101707457 (Tgfb2) Glycosaminoglycan binding proteins [BR:hgl00536]  Heparan sulfate / Heparin   Growth factors/receptors    101707457 (Tgfb2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  TGFb_propeptide TGF_beta SPEG_u2 Motif Other DBs NCBI-GeneID:  101707457 NCBI-ProteinID:  XP_004867449 UniProt:  A0A0P6K2D3 LinkDB All DBs Position Un AA seq 412 aa AA seqDB search MHSRVLSALLTLHLVPAALALSTCSSLDMDQFMRKRIEAIRGQILSKLKLTSPPDDFPEP DEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMRFFSENAIPPPF YRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPNQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNK SEELEARFAGIDGTSTYTSGDQKTIKSTRKTNSGKTPHLLLMLLPSYRLESPPSNRRKKR ALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSR VLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS NT seq 1239 nt NT seq  +upstreamnt  +downstreamnt atgcactcccgcgtgctgagcgcgctgctgaccctgcatctggtgcctgcggcgctcgcc ctgtctacctgcagctcgctcgacatggaccagttcatgcgcaagaggatcgaggcgatc cgcgggcagatcctcagcaagctgaagctcaccagccccccggacgacttccccgagccc gacgaggtgcccccggaggtcatctccatctacaacagcacgcgggacctgctgcaggag aaggcgagccgccgggccgccgcctgcgagcgcgagcgcagcgacgaggagtactacgcc aaggaggtctacaagatcgacatgcgcttcttctccgaaaatgccatcccgccccctttc tacagaccctacttcagaatcgtccgatttgatgtctcggcaatggagaaaaacgcttcc aatttggtgaaagcagagttcagagtctttcgtttgcagaacccaaaagccagagtgccc gagcaacggatcgagctgtaccagattctcaagtccaaagatttaacctctccaaaccag cgctacatcgacagcaaagttgtgaaaacaagagcggaaggcgagtggctgtccttcgat gtgacggatgctgtccatgagtggcttcaccataaagacaggaaccttggatttaaaata agtttacactgtccctgctgcacctttgtgccatctaataattacatcatacccaataaa agtgaagagctagaggcaagatttgcaggtattgatggcacctccacatataccagtggt gatcagaaaactataaagtccactaggaaaacaaacagtgggaagaccccacatctcctg ctaatgttattgccctcctacagacttgagtcaccaccgtctaaccggcggaagaagcgt gctttggatgcggcttattgctttagaaatgtgcaggacaattgctgcctgcgtccactt tacattgatttcaagagggatcttgggtggaaatggattcatgaacccaaaggctacaat gccaacttctgtgctggggcctgcccgtatctgtggagctccgacactcagcacagcagg gtcctcagcttgtacaacaccataaacccagaggcctctgcatctccgtgctgtgtgtcg caggacctggagccgctcaccatcctctactacatcggcaagacccccaagatcgagcag ctctccaacatgatcgtcaagtcctgcaaatgcagctaa

Heterocephalus glaber (naked mole rat): 101712904 Help Entry 101712904         CDS       T02812                                  Gene name Tgfb3 Definition (RefSeq) transforming growth factor beta 3   KO K13377   transforming growth factor beta-3 Organism hgl  Heterocephalus glaber (naked mole rat) Pathway hgl04010   MAPK signaling pathway hgl04060   Cytokine-cytokine receptor interaction hgl04068   FoxO signaling pathway hgl04110   Cell cycle hgl04218   Cellular senescence hgl04350   TGF-beta signaling pathway hgl04390   Hippo signaling pathway hgl04933   AGE-RAGE signaling pathway in diabetic complications hgl05140   Leishmaniasis hgl05142   Chagas disease hgl05144   Malaria hgl05145   Toxoplasmosis hgl05146   Amoebiasis hgl05152   Tuberculosis hgl05161   Hepatitis B hgl05166   Human T-cell leukemia virus 1 infection hgl05200   Pathways in cancer hgl05210   Colorectal cancer hgl05211   Renal cell carcinoma hgl05212   Pancreatic cancer hgl05220   Chronic myeloid leukemia hgl05225   Hepatocellular carcinoma hgl05226   Gastric cancer hgl05321   Inflammatory bowel disease hgl05323   Rheumatoid arthritis hgl05410   Hypertrophic cardiomyopathy hgl05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     101712904 (Tgfb3)    04350 TGF-beta signaling pathway     101712904 (Tgfb3)    04390 Hippo signaling pathway     101712904 (Tgfb3)    04068 FoxO signaling pathway     101712904 (Tgfb3)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     101712904 (Tgfb3)  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     101712904 (Tgfb3)    04218 Cellular senescence     101712904 (Tgfb3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101712904 (Tgfb3)   09162 Cancer: specific types    05210 Colorectal cancer     101712904 (Tgfb3)    05212 Pancreatic cancer     101712904 (Tgfb3)    05225 Hepatocellular carcinoma     101712904 (Tgfb3)    05226 Gastric cancer     101712904 (Tgfb3)    05220 Chronic myeloid leukemia     101712904 (Tgfb3)    05211 Renal cell carcinoma     101712904 (Tgfb3)   09163 Immune disease    05323 Rheumatoid arthritis     101712904 (Tgfb3)    05321 Inflammatory bowel disease     101712904 (Tgfb3)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     101712904 (Tgfb3)    05414 Dilated cardiomyopathy     101712904 (Tgfb3)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     101712904 (Tgfb3)   09171 Infectious disease: bacterial    05152 Tuberculosis     101712904 (Tgfb3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101712904 (Tgfb3)    05161 Hepatitis B     101712904 (Tgfb3)   09174 Infectious disease: parasitic    05146 Amoebiasis     101712904 (Tgfb3)    05144 Malaria     101712904 (Tgfb3)    05145 Toxoplasmosis     101712904 (Tgfb3)    05140 Leishmaniasis     101712904 (Tgfb3)    05142 Chagas disease     101712904 (Tgfb3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and growth factors [BR:hgl04052]     101712904 (Tgfb3) Cytokines and growth factors [BR:hgl04052]  Cytokines   Transforming growth factors (RSTK binding)    101712904 (Tgfb3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  TGFb_propeptide TGF_beta Motif Other DBs NCBI-GeneID:  101712904 NCBI-ProteinID:  XP_004837211 UniProt:  A0A0P6JFB7 LinkDB All DBs Position Un AA seq 412 aa AA seqDB search MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPS VMTHVPYQVLALYNSTRELLEEMQGEKEEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL AVCPKGITSKIFRFNVSSVEKNGTNLFRAEFRVLRVPNPSSKRTEQRIELFQILRPDEHI AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE NIQEVMEIKFKGMDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS NT seq 1239 nt NT seq  +upstreamnt  +downstreamnt atgaagatgcacttgcaaagggctctggtggtcctggccctgctgaactttgccacggtc agcctctctctgtccacttgcaccaccttggactttggccacatcaagaagaagagggtg gaagccattagaggacagatcttgagcaagctcaggctcaccagcccccctgagccatca gtgatgacccatgtcccctatcaagtcttggccctgtataacagcacccgggagctgctg gaagagatgcagggggagaaggaggaaggctgcactcaggaaaacaccgaatcagaatac tatgccaaagagatccataagttcgacatgatccaggggctggcagagcacaatgagctg gctgtctgccccaaaggaattacctccaagatcttccgcttcaatgtgtcctcagtggag aaaaatggaaccaacctgttccgggcagaattccgggtcttgcgggtgcccaaccccagt tccaagcgcactgagcagaggattgagctcttccagattctccggccagatgagcacatc gccaaacagcgctatatcggtggcaagaatttgcccacccggggcactgccgagtggctg tcttttgatgtcactgacactgtgcgtgagtggctgttgcgaagagagtccaacttaggt ctggaaatcagcattcattgtccatgtcacacctttcagcccaacggagatatcctggaa aacattcaagaggtgatggaaatcaaattcaaagggatggacaatgaggatgaccatggc cgtggagacctggggcgccttaagaaacagaaggatcaccacaaccctcacctaatcttg atgatgattcccccacaccggctcgacaaccctggccaaggcgggcagaggaagaagcgg gccctggacaccaactactgcttccgcaacttggaagagaactgctgcgtgcgccccctc tacattgacttcagacaggatctgggctggaagtgggtccacgaacctaaggggtactat gccaacttctgctcaggcccttgcccgtacctccgaagtgcagacacgacccacagcacg gtgctgggactatacaacaccctgaatccggaagcgtctgcctccccctgctgtgtgccc caggacttggagcccctgaccatcctgtactatgtggggaggaccccgaaggtggagcag ctctccaacatggtggtgaagtcatgtaagtgtagctga

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