KEGG   Heterocephalus glaber (naked mole rat): 101710283
Entry
101710283         CDS       T02812                                 

Gene name
Jak1
Definition
(RefSeq) Janus kinase 1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
hgl01521  EGFR tyrosine kinase inhibitor resistance
hgl04151  PI3K-Akt signaling pathway
hgl04217  Necroptosis
hgl04380  Osteoclast differentiation
hgl04550  Signaling pathways regulating pluripotency of stem cells
hgl04621  NOD-like receptor signaling pathway
hgl04630  JAK-STAT signaling pathway
hgl04658  Th1 and Th2 cell differentiation
hgl04659  Th17 cell differentiation
hgl05140  Leishmaniasis
hgl05145  Toxoplasmosis
hgl05152  Tuberculosis
hgl05160  Hepatitis C
hgl05161  Hepatitis B
hgl05162  Measles
hgl05163  Human cytomegalovirus infection
hgl05164  Influenza A
hgl05165  Human papillomavirus infection
hgl05166  Human T-cell leukemia virus 1 infection
hgl05167  Kaposi sarcoma-associated herpesvirus infection
hgl05168  Herpes simplex virus 1 infection
hgl05169  Epstein-Barr virus infection
hgl05171  Coronavirus disease - COVID-19
hgl05200  Pathways in cancer
hgl05203  Viral carcinogenesis
hgl05212  Pancreatic cancer
hgl05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    101710283 (Jak1)
   04151 PI3K-Akt signaling pathway
    101710283 (Jak1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    101710283 (Jak1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    101710283 (Jak1)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    101710283 (Jak1)
   04658 Th1 and Th2 cell differentiation
    101710283 (Jak1)
   04659 Th17 cell differentiation
    101710283 (Jak1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101710283 (Jak1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101710283 (Jak1)
   05203 Viral carcinogenesis
    101710283 (Jak1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101710283 (Jak1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    101710283 (Jak1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    101710283 (Jak1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101710283 (Jak1)
   05161 Hepatitis B
    101710283 (Jak1)
   05160 Hepatitis C
    101710283 (Jak1)
   05171 Coronavirus disease - COVID-19
    101710283 (Jak1)
   05164 Influenza A
    101710283 (Jak1)
   05162 Measles
    101710283 (Jak1)
   05168 Herpes simplex virus 1 infection
    101710283 (Jak1)
   05163 Human cytomegalovirus infection
    101710283 (Jak1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101710283 (Jak1)
   05169 Epstein-Barr virus infection
    101710283 (Jak1)
   05165 Human papillomavirus infection
    101710283 (Jak1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101710283 (Jak1)
   05140 Leishmaniasis
    101710283 (Jak1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101710283 (Jak1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hgl01001]
    101710283 (Jak1)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     101710283 (Jak1)
Protein kinases [BR:hgl01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   101710283 (Jak1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 Kinase-like RIO1 SH2
Other DBs
NCBI-GeneID: 101710283
NCBI-ProteinID: XP_004841577
LinkDB
Position
Un
AA seq 1154 aa
MQYLNIKEDCSAMAFCAKMRSSKKAEVNQVAPKPGVEVTFYLPDRGPLRLGTGEYTAEEL
CIQAAQECCISPLCHNLFALYDENTKLWYAPNRVITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKSSYEKRKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKVQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNTTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLRISSENEMN
WFHSSEGASTLCYEVMVTGNLGIQWRQKPNAVPAEKEKNKLKRKKLENKHKKDEEKNKVR
EEWSNFSYFPEITHIVIKESLVSINKQDNKNMELQLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVLGGQKQFKNFQIEVQKGRYSLHGSDRGFPSLEELMSHLKKQILRTDNISFVL
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIMQGEHLGRGTRTHIYSG
TLVDYRDDEGTAEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGVDSEIGPFIKLSDPGIPVTVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCLNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKTPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMEYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNALKEGKRLPCPPNCPDEVYQLMRKCWEFQPSSRT
TFQSLIEGFEALLK
NT seq 3465 nt   +upstreamnt  +downstreamnt
atgcagtatctaaatataaaagaggactgcagtgccatggcgttctgtgctaaaatgagg
agctccaagaaggccgaggtgaaccaggtggcgcccaagccaggggtggaggtgaccttc
tacctgccggaccggggccccctccggctgggcacaggagagtacacagcggaggagctg
tgcatccaggcggcgcaggagtgctgtatctctcctctgtgtcacaacctcttcgccctg
tacgatgagaacaccaagctctggtacgcacccaaccgtgtcatcaccgtcgacgacaag
atgtctctccggctccactaccgcatgaggttctacttcaccaactggcatgggaccaac
gacaacgagcagtcagtgtggcgacactcgccaaagaagcagaagagcagctatgagaag
aggaaggttcccgacgcaaccccgctcctggacgccagctccctggagtacctgttcgcg
cagggacagtacgatctggtcaagtgcctggcgcccatccgggaccccaagacggagcag
gacggacatgacattgagaacgagtgcctgggcatggccgtgctggccatctcgcactac
gccatgatgaagaaggtgcagctgccagagctgcccaaggacatcagctacaagcggtat
attccagaaacgttgaataagtccatcagacagaggaacctcctcacccggatgcggata
aataatgttttcaaggatttcctaaaggagtttaacaacacgaccatctgcgacagcagc
gtgtccacacacgatctcaaggtgaagtacctggccaccttggaaaccttgaccaaacat
tacggggctgaaatattcgagacttccatgttgcggatttcatcagaaaatgagatgaat
tggtttcactcgtctgagggtgcaagcacgctctgctacgaagtgatggtgaccggaaat
ctcgggatccagtggcggcagaaaccaaacgctgttcctgctgaaaaggagaaaaacaaa
ctgaagcggaaaaaactggaaaacaaacacaagaaggatgaggagaaaaacaaagtccgc
gaagagtggagcaacttctcgtacttccccgagatcactcacatcgtcataaaggagtcc
ttggtcagcattaacaagcaggacaacaagaacatggaactgcagctctcttcgcacgaa
gaggccttgtccttcgtgtccctggtggacgggtacttccggctcacggcagacgcccac
cactacctctgcactgatgtggctcctccgctgatcgtccacaacatacagaacggctgc
cacggcccaatctgcacggagtacgccatcaacaagctgcgccaggagggcagcgaggag
ggcatgtatgtgctgaggtggagctgcacggactttgacaacatcctcatgacggtcacc
tgcttcgagaagtccgagcaggtgctgggtggccagaagcagttcaagaacttccagatc
gaggtgcagaagggccgctacagcttgcatggctcggaccgtggcttccccagcctggag
gagctcatgagccacctcaagaagcagatcctgcgcacggacaacatcagcttcgtgctg
aagcgctgctgccagcccaagccccgggaaatctccaacctgctggtggccaccaagaaa
gcccaggagtggcagcccgtctaccccatgagccagctgagcttcgatcggatcctcaag
aaagatatcatgcaaggcgagcacctcggcaggggcacaaggacgcacatctactctggg
acgctggtggactacagggacgacgaggggactgcggaggagaagaggataaaagtgatc
ctgaaagtgctggaccccagccacagggacatctctctggccttcttcgaagcagccagc
atgatgaggcaggtgtcgcacaagcacatcgtgtacctgtacggcgtgtgcgtgcgggat
gtggagaacatcatggtggaggagtttgtcgagggcggccccctggacctcttcatgcac
cgcaagagcgacgtcctcaccacaccctggaagttcaaggttgccaagcagctggccagc
gccctgagttacttggaggacaaagacctggtccatggaaacgtgtgcaccaagaacctc
ctgctggcccgagaaggcgtagacagtgagatcggcccgttcatcaagctcagcgaccca
ggcatccctgtcaccgtgctgtccaggcaagagtgcatcgagcggatcccctggatcgcc
cccgagtgcgtggaggactccaagaacctgagcgtggccgctgacaagtggagctttggc
accaccctctgggagatctgctacaatggcgagatcccgctgaaggacaagacactgatc
gagaaggagaggttctacgagagccgctgccggccggtgacgccatcctgcaaggagctg
gccgacctgatgacccgctgcctgaactatgaccccaaccagaggcccttcttccgtgcc
atcatgagggacatcaacaagctggaggagcagaatccagacatcgtttcagaaaaaaca
ccagccaccgaggtggatcccacgcattttgagaagcgcttcctgaagaggatccgtgac
ctgggagagggccactttggcaaggtggagctctgcaggtacgaccccgagggggacaac
accggggagcaggtggccgtcaagtccctcaagcccgagagcggaggcaatcacatagcc
gacctgaagaaggagatcgagatcctgaggaacctctaccacgagaacattgtcaagtac
aagggcatctgcacggaggatggaggaaacggcatcaagctcatcatggagttcctgccc
tcgggaagcctgaaggagtaccttcctaagaacaagaacaaaattaacctcaagcagcag
ctcaagtacgccgtgcagatctgtaagggcatggagtacctgggctcccggcagtacgtt
caccgcgacctggcagccagaaacgtcctggttgaaagtgagcaccaggtgaagatcggg
gactttgggctcaccaaggccatcgagaccgacaaggagtactacacggtcaaggacgac
cgcgacagccccgtattctggtacgcgccggagtgcctcatccagtgtaagttttacatt
gcctcagacgtctggtctttcggagtgaccctgcacgagctgctcacgtactgcgactcg
gactccagccccatggccttgttcctgaaaatgataggcccgacccatggccagatgaca
gtaaccagacttgtgaacgccctgaaggaaggaaaacgcttgccttgtccgcctaactgc
ccagatgaggtttatcagcttatgagaaaatgctgggaattccagccatccagccggaca
accttccagagccttattgaaggatttgaagcacttttaaaataa

KEGG   Heterocephalus glaber (naked mole rat): 101715472
Entry
101715472         CDS       T02812                                 

Gene name
Jak3
Definition
(RefSeq) Janus kinase 3
  KO
K11218  Janus kinase 3 [EC:2.7.10.2]
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
hgl04062  Chemokine signaling pathway
hgl04151  PI3K-Akt signaling pathway
hgl04217  Necroptosis
hgl04550  Signaling pathways regulating pluripotency of stem cells
hgl04630  JAK-STAT signaling pathway
hgl04658  Th1 and Th2 cell differentiation
hgl04659  Th17 cell differentiation
hgl05161  Hepatitis B
hgl05162  Measles
hgl05166  Human T-cell leukemia virus 1 infection
hgl05169  Epstein-Barr virus infection
hgl05200  Pathways in cancer
hgl05203  Viral carcinogenesis
hgl05223  Non-small cell lung cancer
hgl05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    101715472 (Jak3)
   04151 PI3K-Akt signaling pathway
    101715472 (Jak3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    101715472 (Jak3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    101715472 (Jak3)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    101715472 (Jak3)
   04659 Th17 cell differentiation
    101715472 (Jak3)
   04062 Chemokine signaling pathway
    101715472 (Jak3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101715472 (Jak3)
   05203 Viral carcinogenesis
    101715472 (Jak3)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    101715472 (Jak3)
  09163 Immune disease
   05340 Primary immunodeficiency
    101715472 (Jak3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101715472 (Jak3)
   05161 Hepatitis B
    101715472 (Jak3)
   05162 Measles
    101715472 (Jak3)
   05169 Epstein-Barr virus infection
    101715472 (Jak3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hgl01001]
    101715472 (Jak3)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     101715472 (Jak3)
Protein kinases [BR:hgl01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   101715472 (Jak3)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl APH
Other DBs
NCBI-GeneID: 101715472
NCBI-ProteinID: XP_004873384
LinkDB
Position
Un
AA seq 1101 aa
MVPPSEETPLISQRSCSLSSSEAGALHVLLPPRGPGPTQRLSFSYGDHLAEELCVRAAKA
SGILPVYHSLFALASEDLSCWFPPSHIFSVEDLGTQILVYRLRFYFPSWFGLEKCHRFGL
RKDLASAIVDLPVLEHLFFQHRSDLVSGRLAVGLGLKEQGECLSLAVLDLARMAREQGRT
PQEVLRTVSYKSCLPRGLRDLIQGLSFLTRKRIRRTVRRALHRVAACQADRHSLMAKYIL
DLERLDPAQATETFCVGLPWTASGQDARGLLQVAGGSGIAWSPREHEPFQQFCDFPEIVD
VSVKQAPRAGPAGEHRLVTVTRADNQILEAEFPALPAALSFVALVDGYFRLTCDPRHFFC
KEVAPPRLLEEVAEHCHGPITLDFAIHKLKARGSVPGTYVLRRSPQDFDSFLLTACVQTP
MGPDYKGCLIRRDPTGSFCLVGLSQPHGSLRELLSACREGGLHVDGAALSLTTCCAPTPK
EKSNLIVVRRGCGPATTAHAQLPVLSQLTFHKIPPPSLQRHENLGHGSFTKIYRGCRHEC
VDGEALETEVLLKVLDVEHRSFVESFLEAASLMSQVSYPHLVLLHGVCMAGDSIIVQELV
ALGAIDTYLLKRGHLVPASWKLQVTKQLACALNYLEDKGLPHGNVSARKVLLAREGADGS
PPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLDEARMLGLEADKWGFGATVWEVFSGAP
MPTRALEPAEKLRFYEERRQLPAPRWAELAALIRQCMDYEPGRRPSFRAVIRDLNSLSTS
DYELLSDPTPGALAPRDGPWSGAQQYAGQDPTIFEERHLKYISQLGKGNFGSVELCRYDP
LGDNTGALVAVKQLQHSGPDQQRDFQREVQILKALQSEFIVKYRGVSYGPGRQSLRLVME
YLPCGCLRDFLRRHRPRLDAGRLLLFATQICKGMEYLGACRCVHRDLAARNILVESETHV
KIADFGLAKLLPLDKDYYVVREPGQSPIFWFAPESLADNVFSRQSDVWSFGVVLYELFTF
GDPGCSPSAEFLRMMGCERDAPALCRLLELLAEGRRLPAPAACPAEVQELISQCWAPSPQ
DRPTFSTLGPQLEALWSGSRG
NT seq 3306 nt   +upstreamnt  +downstreamnt
atggtgcccccgagtgaggagacgcccctgatctctcagcgctcctgcagcctctcatcc
tcagaggccggggccctgcatgtgctgctgcctcctcgggggcctggccccacccagcgc
ctgtccttctcctatggggaccacttagctgaggagctgtgtgtgcgagctgccaaggcc
agtggcatcctgcctgtgtaccactctctcttcgcactggcctcggaggacctgtcttgc
tggttccccccaagccacatcttctccgtggaggacttgggcacgcaaatcttggtctac
aggctccggttttacttccccagctggtttgggctggagaaatgtcaccgcttcgggctc
cgaaaggacctggccagcgccattgttgacctgcctgtcctggaacacctcttcttccag
caccgcagcgacctggtgagcgggcgcctcgctgtgggcctcgggctcaaggagcagggc
gaatgcctcagcctggccgtcctggacctggcccggatggcccgtgagcagggccggacg
ccacaggaggtgctgcgcactgtcagctacaagtcctgcctaccccgcggcctgcgcgac
ctcatccagggcctgagcttcctgacgcgcaagcgcatccgcaggacggtgcgccgcgcc
ctgcaccgcgtggccgcctgccaggccgaccggcactcactcatggccaagtacatcttg
gacctggagcggctggacccagcccaggccacggagaccttctgcgtggggctcccgtgg
acagcgagcggccaggacgcacgcgggctgctccaagtggccgggggcagcggcatagcc
tggagccccagggagcacgagcccttccagcagttctgcgacttccccgagattgtggac
gtcagcgtcaagcaggccccacgcgcgggcccggccggcgagcaccgcctggtcaccgtc
acgcgcgccgacaaccagatcctggaggccgagttcccagcgctgcccgccgcgctgtcc
ttcgtggcgctcgtggacggctacttccgcctgacgtgcgacccgcgacacttcttctgc
aaggaggtggcgcccccgcggctgctggaggaggtggctgagcactgccacggccccatc
accctggacttcgccatccacaagttgaaggcccggggctcagtcccgggcacctacgtg
ctccgccgcagccctcaggactttgacagctttctgctcacggcctgtgtccaaacaccc
atgggccccgactacaagggctgcctcatccgccgggaccccactgggagcttctgcctg
gttggcctcagccagccgcacggcagcctcagggagctcctgtccgcctgccgcgagggc
gggctgcacgtggacggcgcggccctgagcctcaccacctgctgtgcccccacgcccaaa
gagaagtccaacctgatcgtggtgcggagaggctgcggcccggccaccacggcgcacgcg
cagctcccagtgctgagccagctgaccttccacaagatccctccgccgagcctgcagcgg
cacgagaacctgggccatggctccttcaccaagatttaccgaggctgtcgccacgagtgc
gtggacggggaggccctggagaccgaggtgctgctgaaggtgctggacgtggagcacagg
agctttgtggagtccttcctggaagcagccagtttgatgagccaggtgtcctacccgcat
ctcgtgttgctgcatggcgtgtgcatggctggagacagcatcatagtgcaggagctcgta
gccctaggcgccattgacacctacctgctcaagcgcggccacctggtgcccgccagctgg
aagctgcaggtgactaagcagctggcctgcgccctcaactatttggaggacaaaggcctc
cctcatggcaacgtctcagctcggaaggtgctgctggcccgggagggtgctgatgggagc
ccgccgtttatcaagctcagcgaccctggcgtcagccccactgtgctgagcctggagatg
ctgaccgacaggatcccctgggtggcccccgagtgtctggacgaggcccggatgcttggc
ctggaggcggacaagtggggctttggagccacggtctgggaggtcttcagcggggccccc
atgcccacccgcgcgctggagcccgccgagaaactcaggttctacgaggagcggcggcag
ctgcccgcgccccggtgggcggagctggccgcactgatccgccagtgcatggactacgag
ccgggccgcaggccgagcttccgcgcggtcatccgggacctcaacagcctcagcacctca
gattacgagcttctctccgaccccacgcccggcgccctggcgccccgggacgggccctgg
agcggcgcccagcaatacgcgggccaggaccccacgatcttcgaggagcggcacctcaag
tacatctcgcagttgggcaagggcaacttcggcagcgtggagctgtgccgctacgacccg
ctgggggacaacacgggcgccctggtggccgtgaagcagctgcagcacagcgggccggac
cagcagagggacttccagcgggaggtgcagatcctcaaggcgctgcaaagcgagttcatc
gtcaagtaccgtggcgtcagctatggccccggccggcagagcctgcgcctggtgatggag
tacctaccttgcggctgcctgcgcgacttcctgcggcgccaccgcccgcgcctggacgcg
ggccgcctgctgctcttcgccacgcagatctgcaagggcatggagtacctgggcgcctgt
cgctgtgtgcaccgggacctggccgcgcgcaacatcctggtggagagcgagacgcacgtc
aagatcgccgacttcgggcttgccaagctgctgccgctcgacaaggactactacgtggtg
cgcgagccgggccagagccccatcttctggttcgcgcccgagtccctggcggacaacgtc
ttctcgcgccagtcggacgtgtggagttttggcgtggtgctgtacgagctcttcaccttc
ggggacccgggctgcagcccctcagccgagttcctgcgcatgatgggctgtgagcgggac
gcccctgccctgtgccgcctgctggagctgctggccgagggtcgcaggctgcccgcacct
gctgcctgccccgcggaggtccaagagctcataagccagtgctgggcgcccagcccgcag
gaccggccgacctttagcaccctgggcccccagctggaggcgctgtggagcggaagccgg
gggtag

KEGG   Heterocephalus glaber (naked mole rat): 101715782
Entry
101715782         CDS       T02812                                 

Gene name
Tyk2
Definition
(RefSeq) tyrosine kinase 2
  KO
K11219  non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
hgl04217  Necroptosis
hgl04380  Osteoclast differentiation
hgl04621  NOD-like receptor signaling pathway
hgl04630  JAK-STAT signaling pathway
hgl04658  Th1 and Th2 cell differentiation
hgl04659  Th17 cell differentiation
hgl05145  Toxoplasmosis
hgl05160  Hepatitis C
hgl05161  Hepatitis B
hgl05162  Measles
hgl05164  Influenza A
hgl05165  Human papillomavirus infection
hgl05167  Kaposi sarcoma-associated herpesvirus infection
hgl05168  Herpes simplex virus 1 infection
hgl05169  Epstein-Barr virus infection
hgl05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    101715782 (Tyk2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    101715782 (Tyk2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    101715782 (Tyk2)
   04658 Th1 and Th2 cell differentiation
    101715782 (Tyk2)
   04659 Th17 cell differentiation
    101715782 (Tyk2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101715782 (Tyk2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    101715782 (Tyk2)
   05160 Hepatitis C
    101715782 (Tyk2)
   05171 Coronavirus disease - COVID-19
    101715782 (Tyk2)
   05164 Influenza A
    101715782 (Tyk2)
   05162 Measles
    101715782 (Tyk2)
   05168 Herpes simplex virus 1 infection
    101715782 (Tyk2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101715782 (Tyk2)
   05169 Epstein-Barr virus infection
    101715782 (Tyk2)
   05165 Human papillomavirus infection
    101715782 (Tyk2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101715782 (Tyk2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hgl01001]
    101715782 (Tyk2)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     101715782 (Tyk2)
Protein kinases [BR:hgl01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   101715782 (Tyk2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 Kinase-like Kdo APH
Other DBs
NCBI-GeneID: 101715782
NCBI-ProteinID: XP_004865547
LinkDB
Position
Un
AA seq 1184 aa
MPLCHRGGSEKGSQPARDEVQPLATTGGLQVLLHWAGSSGGQPWVTFGEVSLTAEEICIR
VAHRIGITPACFNLFALFDAEAQVWLPPNHILEVSADTRQTLYFRMRFYFRNWHGMNPQE
PPVYRCGLPGAEASSEQAEQGVQVLDPASFEYLFEQGKYEFVNDVVSLRELSSEEEIHHF
KNESLGMAFLHLCHLALCRSVPLEEVAKEISFTRCIPRSFRQQIRQYNMLTRLRLRSVFR
RFLHAFQPNHLSQQVVMVKYLATLEHLAPRFGAECIPVHHLELLFQADREPCYIRDSGQP
PEADPMSAPGPPTHEVLVTGTRGIQWRPVQPESSSANGSDSWNPKARLPGKKASAHEEAG
KQPVDKPQEPSWTYFCDFQDITHVVLKECRISIHRQDNKCLELSLSSPAAALSFAALVDG
YFRLTTDSSHYLCHEVAPPRLVLSIQDGIHGPLLEPFVRAKLQLEEGVYLIHWSTSHLER
LILTVGQRDPTPGGSGVQSVRLRKFPIERQAGGFVLEGWGRSFASVRDLRMALQGCSLRA
GDDCFSLRQCCLPQPGEISNLIIIRGPRASTRQLNLSQLSFHRVQQDDITQLSHLGQGTR
TNVYEGLLRVGTPEEDKEDSMGPVEPSGGCGQELRVVLKVLDPGHHDITLAFYETASLMS
QVSHAHLAFLHGVCVRGSENVMVTEFVEHGPLDVWLRRERGCVPLAWKLVVAQQLASALS
YLEDKNLVHGNVCGRNILLARLGLADGTSPFIKLSDPGVGLAALSREERVERIPWTAPES
LLAGASSLSTTTDKWGFGATLLEICFNGEVPLQGHTPSEKERFYQKQHQLPKPLCPELAS
ITSQCLSYEQAQRPSFRTILRDLTRLQPHSLVDVSALNPDSPASDPTVFHKRYLRKIRDL
GEGHFGKVSLYCYDPNNDGTGEMVAVKSLKAGGGPQLSSGWRREIDILRTLYHEHIVKYK
GCCEDQGEKSVQLVMEYVPLGSLRDYLPRHSVGLAQLLLFAQQICEGMAYLHGQHYIHRD
LAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLQECKFYYASD
VWSFGVTLYELLTHCDSSQSPPSKFMELIGITQGQMTVLRLTELLARGERLPWPDRCPRE
IYLLMKNCWEAEASFRPTFQNLVPILKSEQEKYQGQAPSLFSVC
NT seq 3555 nt   +upstreamnt  +downstreamnt
atgcccctgtgtcatcgaggaggctctgagaagggcagccagcctgccagggatgaagtg
cagcccttggccaccacgggaggcctgcaggtccttctgcactgggctggctccagtggt
gggcagccctgggtcaccttcggtgaggtctcgctgacggctgaggagatctgcatccgg
gtcgcacacagaatcggcatcacaccagcctgctttaatctctttgctctctttgatgct
gaggcccaagtgtggctgcccccaaaccacattctggaagtttctgcagacacaagacag
acgctgtatttccgcatgaggttttacttccggaactggcatggcatgaatccgcaggag
ccacctgtgtaccgctgtggactcccaggggctgaggcatcctcagaacaagcagaacaa
ggggtacaagtcttagatccagcctcttttgagtacctctttgagcagggcaagtatgag
tttgtgaatgatgtggtgtcgctgcgggagctgtcaagtgaggaggagatccaccacttt
aagaatgagagtctaggcatggcctttctgcacctctgccacctcgctctctgccgcagt
gtccccctggaggaggtggccaaggagatcagcttcacgcgctgcatcccgcgctccttc
cggcagcagatccgccagtacaatatgctgacccggctgcgccttcggagtgtcttccga
cgcttcctgcatgccttccagccaaaccacctgtcccagcaggttgtcatggtcaagtac
cttgccaccctggagcatctggcaccccgctttggtgccgaatgcatccctgtgcatcac
ctggagctcctattccaggccgacagggagccctgctatatccgggacagtgggcagccc
ccagaagctgaccccatgtcggcccctggaccccccacccatgaggtgctggtcacgggt
accaggggcatccagtggcgcccggtacagccagagagttccagtgccaatggcagtgac
agctggaatccgaaagccaggctgcctgggaaaaaggccagtgcccatgaggaggcaggc
aagcagccagtggacaagccacaggagccctcttggacctacttctgtgacttccaggac
atcacccatgtggtcctgaaggaatgtcgcatcagcatccaccggcaggacaataagtgc
ctggagctgagcctgtcctccccggctgctgccctgtcctttgcggcgctggtggacggc
tacttccgcctgactaccgactccagccactacctgtgccatgaggtggctcctccgagg
ctggtcctgagcatccaggacggcatccacggacccctgctggagccgtttgtgcgggcc
aagctgcagctggaagagggcgtctacctcatccactggagcaccagccaccttgagcgc
ctcatcctcacggtgggccagcgtgacccgacccctggcggcagtggtgtgcagagtgtg
cgcctccgcaagttccccattgagcggcaagccgggggctttgtgctggagggctggggc
cgctccttcgccagcgtgcgggacctgcggatggccctgcagggctgctctctgcgggct
ggggacgactgcttctccctgcgccagtgctgcctgccccagccaggagagatctccaac
ctcatcatcattcgggggcctcgggccagcacccggcagctcaacctcagccagctcagc
ttccacagggtacagcaggatgacatcacccagctgtcacacttgggccagggcacaagg
accaacgtgtatgagggtctgctgcgagtggggacgcccgaggaggacaaagaggacagc
atgggccctgtggagcccagtgggggctgtgggcaggagctgcgtgtggtgctgaaggtg
ctggacccaggtcaccacgacatcacgctggccttctacgagacagccagcctcatgagc
caggtgtcccatgcacacctggccttcctgcatggcgtatgcgtgcgcggctccgagaac
gtcatggtgacggagttcgtggagcatgggcccctggacgtgtggctgcggcgggagcgg
ggctgtgtgcccctggcctggaagctggtggtggcccagcagctggccagtgccctcagc
tacctggaggacaagaacctggtgcacgggaatgtgtgtggccggaacatcctcctggcc
cggctggggctggcagatggcaccagcccattcatcaagctcagcgacccaggcgtgggg
ctggccgccctctccagggaggagcgggtggaacgcatcccctggactgcgcccgagtcc
ctgcttgctggggccagcagcctgagcacaaccacagacaagtggggcttcggtgccacc
ctgctggagatctgcttcaacggcgaggtgcccctgcagggccacaccccctccgagaaa
gagcgcttctaccagaagcagcatcagctgcccaagcctttgtgcccagagctggcctca
atcaccagccagtgcctgagctacgagcaggcccagcggccatccttccgcaccatcctg
cgcgacctcactcggctgcagccccacagtctagtagatgtctcagctctgaaccccgac
tcacctgcgtcagaccccaccgtttttcataagcgctatttgagaaagatccgagatttg
ggagagggtcactttggcaaggtcagcctgtactgctacgacccaaacaacgatggcact
ggcgagatggtggcagtgaaatccctcaaggcgggcggcgggccccagctcagctcgggc
tggaggcgggagatcgacatccttcgcactctgtaccacgagcacattgtcaagtacaag
ggctgctgtgaggaccaaggagagaagtcggtgcagctcgtcatggagtacgtgccgctg
ggcagcctccgggactacctgccccggcacagcgtcggccttgcccagctgctgctgttc
gcccagcagatctgcgagggcatggcctacctgcatgggcagcactacatccacagagac
ctggcggcgcgcaacgtgctgctggacaacgacaggctggtgaagatcggggattttggc
cttgccaaggccgtgcctgaaggccacgagtactaccgcgtgcgcgaggacggggacagt
cccgtgttctggtacgcccccgagtgcctccaggagtgtaagttttactacgcgtcggac
gtctggtccttcggggtcacactctatgagctgctgacgcactgtgactccagccagagc
cccccctcgaaattcatggagctcataggcatcacccagggccagatgactgtgctgagg
ctcacagagttgctggcgcgaggggagaggctgccgtggccagacagatgtccccgggag
atctacctcctcatgaagaactgctgggaggccgaggcctcgttccgtcccaccttccag
aaccttgtccccatcctcaagtcggagcaagagaaataccaaggccaggccccctcgttg
ttcagtgtgtgctga

KEGG   Heterocephalus glaber (naked mole rat): 101717708
Entry
101717708         CDS       T02812                                 

Gene name
Jak2
Definition
(RefSeq) Janus kinase 2
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
hgl01521  EGFR tyrosine kinase inhibitor resistance
hgl04062  Chemokine signaling pathway
hgl04151  PI3K-Akt signaling pathway
hgl04217  Necroptosis
hgl04550  Signaling pathways regulating pluripotency of stem cells
hgl04630  JAK-STAT signaling pathway
hgl04658  Th1 and Th2 cell differentiation
hgl04659  Th17 cell differentiation
hgl04725  Cholinergic synapse
hgl04917  Prolactin signaling pathway
hgl04920  Adipocytokine signaling pathway
hgl04933  AGE-RAGE signaling pathway in diabetic complications
hgl04935  Growth hormone synthesis, secretion and action
hgl05140  Leishmaniasis
hgl05145  Toxoplasmosis
hgl05152  Tuberculosis
hgl05161  Hepatitis B
hgl05164  Influenza A
hgl05167  Kaposi sarcoma-associated herpesvirus infection
hgl05168  Herpes simplex virus 1 infection
hgl05200  Pathways in cancer
hgl05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    101717708 (Jak2)
   04151 PI3K-Akt signaling pathway
    101717708 (Jak2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    101717708 (Jak2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    101717708 (Jak2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    101717708 (Jak2)
   04659 Th17 cell differentiation
    101717708 (Jak2)
   04062 Chemokine signaling pathway
    101717708 (Jak2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    101717708 (Jak2)
   04917 Prolactin signaling pathway
    101717708 (Jak2)
   04935 Growth hormone synthesis, secretion and action
    101717708 (Jak2)
  09156 Nervous system
   04725 Cholinergic synapse
    101717708 (Jak2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101717708 (Jak2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101717708 (Jak2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101717708 (Jak2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    101717708 (Jak2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101717708 (Jak2)
   05164 Influenza A
    101717708 (Jak2)
   05168 Herpes simplex virus 1 infection
    101717708 (Jak2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101717708 (Jak2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101717708 (Jak2)
   05140 Leishmaniasis
    101717708 (Jak2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101717708 (Jak2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hgl01001]
    101717708 (Jak2)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     101717708 (Jak2)
Protein kinases [BR:hgl01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   101717708 (Jak2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 RIO1 Kinase-like APH
Other DBs
NCBI-GeneID: 101717708
NCBI-ProteinID: XP_004838297
UniProt: G5B4Y4
LinkDB
Position
Un
AA seq 1132 aa
MGMACLMMTEMEATSTSPKHQNGDIPGNANSVKQLDSVLQVFLYHSLGKAEGDYLKFPTG
EYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESSRHNVLYRIRFYF
PHWYCSGSNRTYRYGISRGTEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKEKDQTPLAIYNSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFLDIIDVSIKQANQEGSNESRIVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENREYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVSTSPTLQRHNNVNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQMAWA
MHFLEEKNLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEADFRPSFRAIIRDLNSLFTPDYELLTENDMLPNLRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPVEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcttgccttatgatgacagaaatggaagcaacatccacatctcctaaacat
cagaatggtgatattcctggaaatgctaattctgtgaagcaactagattcagtccttcaa
gtgtttctttaccattcccttgggaaagctgagggagattatctgaagtttccaactgga
gagtatgttgcagaagaaatttgtgttgctgcttctaaagcgtgtggtatcacacctgtg
tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaatcat
gtcttccatatagatgagtcatccaggcataatgtactctacagaataagattttatttt
cctcactggtattgcagtggaagcaacagaacctatcggtatggaatatctcgaggcact
gaagctcctcttcttgatgattttgtcatgtcttacctttttgctcagtggcggcatgat
tttgtgcatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttgga
atggcagtgttagatatgatgagaatagccaaagaaaaagatcaaactccattggctatc
tataactcaatcagttataagacattcttaccaaaatgtgttcgagcaaagatccaagac
tatcatattttgacaaggaagagaataaggtacagatttcgcagatttattcagcagttc
agtcaatgcaaagctactgccagaaacttgaaacttaagtatcttataaatctggagacc
cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttgtattgtgatttt
cttgatattattgatgtcagtattaagcaagcaaaccaggaaggctcaaatgaaagtagg
attgtaactatccataagcaagatggtaaaaatttggaaattgaactgagctcattaagg
gaagctttgtcttttgtgtcattgattgatggatattacagactgactgcagatgctcat
cattacctctgtaaagaggtggcacccccggcagtgcttgagaacatacagagcaactgt
catggccccatttcaatggatttcgcaatcagtaaactgaaaaaagcaggtaatcagact
ggactgtatgtacttcggtgcagtcctaaggactttaataagtattttctgacttttgct
gttgagcgagaaaatgtcattgaatataaacattgtttgattacaaaaaatgagaataga
gaatacaacctcagtgggactaagaagaacttcagtaatcttaaagatcttttgaattgc
taccagatggaaaccgttcgctcagacagtataattttccagtttactaaatgctgtcct
ccgaaaccaaaagataaatcaaaccttctagtctttagaaccaatggtgtttctgatgta
tcaacttcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatatttaatgaaagccttggccaagggactttcacaaaaattttt
aaaggagtaagaagagaagtaggagactatggtcaacttcatgaaacagaagttcttttg
aaagttctggataaagcacatagaaactattcagagtctttttttgaagcagcaagcatg
atgagtcagctttctcacaagcatttggttttaaattatggtgtatgtgtctgtggagaa
gaaaatattctggttcaggagtttgtaaaatttggatcattagatacatatctgaaaaag
aataaaaattctataaatatattatggaaacttgaagtagctaaacagatggcatgggct
atgcattttctagaagaaaaaaaccttattcatggaaatgtatgtgccaaaaatattcta
cttatcagagaagaagacaggaagacaggaaatcctcctttcattaaacttagtgatcct
ggcattagtattacagttttaccaaaggacattcttcaggagagaataccgtgggtgcca
ccagaatgcattgaaaatcctaaaaatctaaatttggcaacagacaaatggagttttggt
acgactttgtgggaaatctgcagtggaggagataagcctctgagtgctctagattctcaa
agaaaactacagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta
gcaaaccttataaataattgtatggattatgaagcagattttaggccttctttcagagcc
atcatacgagatcttaacagtttatttactccagattatgaactattaacagagaatgac
atgttaccaaacctgaggataggtgccttagggttttctggtgcttttgaagacagagac
cctacacaatttgaagagagacacctaaaatttctacagcaacttggcaagggtaatttt
ggcagtgtggagatgtgccggtatgaccctctacaggataacacaggggaggtggtagct
gtgaaaaagctccagcacagtactgaagagcacctcagagactttgaaagggaaattgaa
atcttgaaatccctacagcatgacaacattgtaaaatacaaaggagtctgctacagtgct
ggccggcgtaatctaagattaattatggaatatttaccatatggaagtttacgagactat
ctccaaaaacacaaagaacggatagatcacaaaaaacttctgcagtacacatctcagata
tgcaagggtatggagtaccttgggacaaaaagatacatacacagggatctggcaacaaga
aatatattggtggagaatgagaacagagttaaaattggagattttggattaaccaaagtc
ttgccacaagacaaagaatactacaaagtgaaagaaccaggtgaaagtcccatattctgg
tatgctccagaatcgctgacagagagcaagttttctgtggcctccgatgtttggagtttt
ggagtagttctgtatgaacttttcacatatattgagaagagtaaaagtccaccagcagag
tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgttccatttgatagaa
ctcctaaagaataatggaagattaccacgaccagatggatgcccagttgagatttatatg
atcatgacagaatgctggaacaataatgtaaaccagcgcccctcctttagggacctagca
cttcgagtggatcaaataagggacaacatggctggatga

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