KEGG   Heterocephalus glaber (naked mole rat): 101717035
Entry
101717035         CDS       T02812                                 

Gene name
Grb2
Definition
(RefSeq) growth factor receptor bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
hgl01521  EGFR tyrosine kinase inhibitor resistance
hgl01522  Endocrine resistance
hgl04010  MAPK signaling pathway
hgl04012  ErbB signaling pathway
hgl04014  Ras signaling pathway
hgl04062  Chemokine signaling pathway
hgl04068  FoxO signaling pathway
hgl04072  Phospholipase D signaling pathway
hgl04150  mTOR signaling pathway
hgl04151  PI3K-Akt signaling pathway
hgl04380  Osteoclast differentiation
hgl04510  Focal adhesion
hgl04540  Gap junction
hgl04550  Signaling pathways regulating pluripotency of stem cells
hgl04630  JAK-STAT signaling pathway
hgl04650  Natural killer cell mediated cytotoxicity
hgl04660  T cell receptor signaling pathway
hgl04662  B cell receptor signaling pathway
hgl04664  Fc epsilon RI signaling pathway
hgl04714  Thermogenesis
hgl04722  Neurotrophin signaling pathway
hgl04910  Insulin signaling pathway
hgl04912  GnRH signaling pathway
hgl04915  Estrogen signaling pathway
hgl04917  Prolactin signaling pathway
hgl04926  Relaxin signaling pathway
hgl04935  Growth hormone synthesis, secretion and action
hgl05034  Alcoholism
hgl05160  Hepatitis C
hgl05161  Hepatitis B
hgl05163  Human cytomegalovirus infection
hgl05165  Human papillomavirus infection
hgl05200  Pathways in cancer
hgl05203  Viral carcinogenesis
hgl05205  Proteoglycans in cancer
hgl05206  MicroRNAs in cancer
hgl05210  Colorectal cancer
hgl05211  Renal cell carcinoma
hgl05213  Endometrial cancer
hgl05214  Glioma
hgl05215  Prostate cancer
hgl05220  Chronic myeloid leukemia
hgl05221  Acute myeloid leukemia
hgl05223  Non-small cell lung cancer
hgl05224  Breast cancer
hgl05225  Hepatocellular carcinoma
hgl05226  Gastric cancer
hgl05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101717035 (Grb2)
   04012 ErbB signaling pathway
    101717035 (Grb2)
   04014 Ras signaling pathway
    101717035 (Grb2)
   04630 JAK-STAT signaling pathway
    101717035 (Grb2)
   04068 FoxO signaling pathway
    101717035 (Grb2)
   04072 Phospholipase D signaling pathway
    101717035 (Grb2)
   04151 PI3K-Akt signaling pathway
    101717035 (Grb2)
   04150 mTOR signaling pathway
    101717035 (Grb2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101717035 (Grb2)
   04540 Gap junction
    101717035 (Grb2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101717035 (Grb2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101717035 (Grb2)
   04660 T cell receptor signaling pathway
    101717035 (Grb2)
   04662 B cell receptor signaling pathway
    101717035 (Grb2)
   04664 Fc epsilon RI signaling pathway
    101717035 (Grb2)
   04062 Chemokine signaling pathway
    101717035 (Grb2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101717035 (Grb2)
   04912 GnRH signaling pathway
    101717035 (Grb2)
   04915 Estrogen signaling pathway
    101717035 (Grb2)
   04917 Prolactin signaling pathway
    101717035 (Grb2)
   04926 Relaxin signaling pathway
    101717035 (Grb2)
   04935 Growth hormone synthesis, secretion and action
    101717035 (Grb2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101717035 (Grb2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101717035 (Grb2)
  09159 Environmental adaptation
   04714 Thermogenesis
    101717035 (Grb2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101717035 (Grb2)
   05206 MicroRNAs in cancer
    101717035 (Grb2)
   05205 Proteoglycans in cancer
    101717035 (Grb2)
   05203 Viral carcinogenesis
    101717035 (Grb2)
   05231 Choline metabolism in cancer
    101717035 (Grb2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101717035 (Grb2)
   05225 Hepatocellular carcinoma
    101717035 (Grb2)
   05226 Gastric cancer
    101717035 (Grb2)
   05214 Glioma
    101717035 (Grb2)
   05221 Acute myeloid leukemia
    101717035 (Grb2)
   05220 Chronic myeloid leukemia
    101717035 (Grb2)
   05211 Renal cell carcinoma
    101717035 (Grb2)
   05215 Prostate cancer
    101717035 (Grb2)
   05213 Endometrial cancer
    101717035 (Grb2)
   05224 Breast cancer
    101717035 (Grb2)
   05223 Non-small cell lung cancer
    101717035 (Grb2)
  09165 Substance dependence
   05034 Alcoholism
    101717035 (Grb2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101717035 (Grb2)
   05160 Hepatitis C
    101717035 (Grb2)
   05163 Human cytomegalovirus infection
    101717035 (Grb2)
   05165 Human papillomavirus infection
    101717035 (Grb2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101717035 (Grb2)
   01522 Endocrine resistance
    101717035 (Grb2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hgl04131]
    101717035 (Grb2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:hgl04990]
    101717035 (Grb2)
Membrane trafficking [BR:hgl04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    101717035 (Grb2)
Domain-containing proteins not elsewhere classified [BR:hgl04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   101717035 (Grb2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 101717035
NCBI-ProteinID: XP_004860721
UniProt: G5BNB5
LinkDB
Position
Un
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgcggacgatgagctgagcttcaaa
aggggggacatcctcaaggttttgaatgaagaatgtgatcagaattggtacaaggcagag
ctcaacggcaaggatggcttcatccccaagaactacatagagatgaagccacacccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcatgat
ggggcctttctaatccgggaaagtgagagcgctcctggggatttctccctctccgtcaag
tttggaaatgatgtgcagcacttcaaggtgctccgtgatggagccggaaagtatttcctc
tgggtggtgaagttcaattctttgaatgagctggtagattaccacagatcgacatccgtg
tccagaaaccagcagatattcctgcgggacatagaacaagtgccacagcagccgacatat
gtccaggccctctttgactttgacccccaggaggacggagagctgggcttccgccgggga
gacttcatccacgtcatggataactcagaccccaactggtggaagggggcttgccacggg
cagaccggcatgtttccccgcaactatgtcacccctgtgaaccggaacgtctaa

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