Heterocephalus glaber (naked mole rat): 101718997 Help Entry 101718997         CDS       T02812                                  Gene name Kras Definition (RefSeq) KRAS proto-oncogene, GTPase   KO K07827   GTPase KRas Organism hgl  Heterocephalus glaber (naked mole rat) Pathway hgl01521   EGFR tyrosine kinase inhibitor resistance hgl01522   Endocrine resistance hgl04010   MAPK signaling pathway hgl04012   ErbB signaling pathway hgl04014   Ras signaling pathway hgl04015   Rap1 signaling pathway hgl04062   Chemokine signaling pathway hgl04068   FoxO signaling pathway hgl04071   Sphingolipid signaling pathway hgl04072   Phospholipase D signaling pathway hgl04137   Mitophagy - animal hgl04140   Autophagy - animal hgl04150   mTOR signaling pathway hgl04151   PI3K-Akt signaling pathway hgl04210   Apoptosis hgl04211   Longevity regulating pathway hgl04213   Longevity regulating pathway - multiple species hgl04218   Cellular senescence hgl04360   Axon guidance hgl04370   VEGF signaling pathway hgl04371   Apelin signaling pathway hgl04540   Gap junction hgl04550   Signaling pathways regulating pluripotency of stem cells hgl04625   C-type lectin receptor signaling pathway hgl04650   Natural killer cell mediated cytotoxicity hgl04660   T cell receptor signaling pathway hgl04662   B cell receptor signaling pathway hgl04664   Fc epsilon RI signaling pathway hgl04714   Thermogenesis hgl04720   Long-term potentiation hgl04722   Neurotrophin signaling pathway hgl04725   Cholinergic synapse hgl04726   Serotonergic synapse hgl04730   Long-term depression hgl04810   Regulation of actin cytoskeleton hgl04910   Insulin signaling pathway hgl04912   GnRH signaling pathway hgl04914   Progesterone-mediated oocyte maturation hgl04915   Estrogen signaling pathway hgl04916   Melanogenesis hgl04917   Prolactin signaling pathway hgl04919   Thyroid hormone signaling pathway hgl04921   Oxytocin signaling pathway hgl04926   Relaxin signaling pathway hgl04929   GnRH secretion hgl04933   AGE-RAGE signaling pathway in diabetic complications hgl04935   Growth hormone synthesis, secretion and action hgl04960   Aldosterone-regulated sodium reabsorption hgl05010   Alzheimer disease hgl05022   Pathways of neurodegeneration - multiple diseases hgl05034   Alcoholism hgl05160   Hepatitis C hgl05161   Hepatitis B hgl05163   Human cytomegalovirus infection hgl05165   Human papillomavirus infection hgl05166   Human T-cell leukemia virus 1 infection hgl05167   Kaposi sarcoma-associated herpesvirus infection hgl05170   Human immunodeficiency virus 1 infection hgl05200   Pathways in cancer hgl05203   Viral carcinogenesis hgl05205   Proteoglycans in cancer hgl05206   MicroRNAs in cancer hgl05210   Colorectal cancer hgl05211   Renal cell carcinoma hgl05212   Pancreatic cancer hgl05213   Endometrial cancer hgl05214   Glioma hgl05215   Prostate cancer hgl05216   Thyroid cancer hgl05218   Melanoma hgl05219   Bladder cancer hgl05220   Chronic myeloid leukemia hgl05221   Acute myeloid leukemia hgl05223   Non-small cell lung cancer hgl05224   Breast cancer hgl05225   Hepatocellular carcinoma hgl05226   Gastric cancer hgl05230   Central carbon metabolism in cancer hgl05231   Choline metabolism in cancer hgl05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     101718997 (Kras)    04012 ErbB signaling pathway     101718997 (Kras)    04014 Ras signaling pathway     101718997 (Kras)    04015 Rap1 signaling pathway     101718997 (Kras)    04370 VEGF signaling pathway     101718997 (Kras)    04371 Apelin signaling pathway     101718997 (Kras)    04068 FoxO signaling pathway     101718997 (Kras)    04072 Phospholipase D signaling pathway     101718997 (Kras)    04071 Sphingolipid signaling pathway     101718997 (Kras)    04151 PI3K-Akt signaling pathway     101718997 (Kras)    04150 mTOR signaling pathway     101718997 (Kras)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     101718997 (Kras)    04137 Mitophagy - animal     101718997 (Kras)   09143 Cell growth and death    04210 Apoptosis     101718997 (Kras)    04218 Cellular senescence     101718997 (Kras)   09144 Cellular community - eukaryotes    04540 Gap junction     101718997 (Kras)    04550 Signaling pathways regulating pluripotency of stem cells     101718997 (Kras)   09142 Cell motility    04810 Regulation of actin cytoskeleton     101718997 (Kras)  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     101718997 (Kras)    04650 Natural killer cell mediated cytotoxicity     101718997 (Kras)    04660 T cell receptor signaling pathway     101718997 (Kras)    04662 B cell receptor signaling pathway     101718997 (Kras)    04664 Fc epsilon RI signaling pathway     101718997 (Kras)    04062 Chemokine signaling pathway     101718997 (Kras)   09152 Endocrine system    04910 Insulin signaling pathway     101718997 (Kras)    04929 GnRH secretion     101718997 (Kras)    04912 GnRH signaling pathway     101718997 (Kras)    04915 Estrogen signaling pathway     101718997 (Kras)    04914 Progesterone-mediated oocyte maturation     101718997 (Kras)    04917 Prolactin signaling pathway     101718997 (Kras)    04921 Oxytocin signaling pathway     101718997 (Kras)    04926 Relaxin signaling pathway     101718997 (Kras)    04935 Growth hormone synthesis, secretion and action     101718997 (Kras)    04919 Thyroid hormone signaling pathway     101718997 (Kras)    04916 Melanogenesis     101718997 (Kras)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     101718997 (Kras)   09156 Nervous system    04725 Cholinergic synapse     101718997 (Kras)    04726 Serotonergic synapse     101718997 (Kras)    04720 Long-term potentiation     101718997 (Kras)    04730 Long-term depression     101718997 (Kras)    04722 Neurotrophin signaling pathway     101718997 (Kras)   09158 Development and regeneration    04360 Axon guidance     101718997 (Kras)   09149 Aging    04211 Longevity regulating pathway     101718997 (Kras)    04213 Longevity regulating pathway - multiple species     101718997 (Kras)   09159 Environmental adaptation    04714 Thermogenesis     101718997 (Kras)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101718997 (Kras)    05206 MicroRNAs in cancer     101718997 (Kras)    05205 Proteoglycans in cancer     101718997 (Kras)    05203 Viral carcinogenesis     101718997 (Kras)    05230 Central carbon metabolism in cancer     101718997 (Kras)    05231 Choline metabolism in cancer     101718997 (Kras)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101718997 (Kras)   09162 Cancer: specific types    05210 Colorectal cancer     101718997 (Kras)    05212 Pancreatic cancer     101718997 (Kras)    05225 Hepatocellular carcinoma     101718997 (Kras)    05226 Gastric cancer     101718997 (Kras)    05214 Glioma     101718997 (Kras)    05216 Thyroid cancer     101718997 (Kras)    05221 Acute myeloid leukemia     101718997 (Kras)    05220 Chronic myeloid leukemia     101718997 (Kras)    05218 Melanoma     101718997 (Kras)    05211 Renal cell carcinoma     101718997 (Kras)    05219 Bladder cancer     101718997 (Kras)    05215 Prostate cancer     101718997 (Kras)    05213 Endometrial cancer     101718997 (Kras)    05224 Breast cancer     101718997 (Kras)    05223 Non-small cell lung cancer     101718997 (Kras)   09164 Neurodegenerative disease    05010 Alzheimer disease     101718997 (Kras)    05022 Pathways of neurodegeneration - multiple diseases     101718997 (Kras)   09165 Substance dependence    05034 Alcoholism     101718997 (Kras)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     101718997 (Kras)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101718997 (Kras)    05170 Human immunodeficiency virus 1 infection     101718997 (Kras)    05161 Hepatitis B     101718997 (Kras)    05160 Hepatitis C     101718997 (Kras)    05163 Human cytomegalovirus infection     101718997 (Kras)    05167 Kaposi sarcoma-associated herpesvirus infection     101718997 (Kras)    05165 Human papillomavirus infection     101718997 (Kras)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101718997 (Kras)    01522 Endocrine resistance     101718997 (Kras) Membrane trafficking [BR:hgl04131]  Endocytosis   Macropinocytosis    Ras GTPases     101718997 (Kras) GTP-binding proteins [BR:hgl04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     101718997 (Kras) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 MeaB FeoB_N G-alpha ATP_bind_1 Septin NPR1_interact AAA_25 Motif Other DBs NCBI-GeneID:  101718997 NCBI-ProteinID:  XP_004845800 LinkDB All DBs Position Un AA seq 188 aa AA seqDB search MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKK SKTKCIIM NT seq 567 nt NT seq  +upstreamnt  +downstreamnt atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg atacagctaattcagaatcactttgtggatgaatatgatcctacaatagaggattcctac agaaaacaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt gtatttgccataaataatactaaatcttttgaagatattcaccattatagagaacaaatt aaaagagttaaagactctgaagatgtacctatggttctagtaggaaataaatgtgatttg ccttctagaacagtagacacaaaacaagctcaggacttagcaagaagttacggaattcct tttattgaaacatcagcaaagacaagacagggtgttgatgatgccttctatacgttagtt cgagaaattcgaaaacataaagaaaagatgagcaaagatggtaaaaagaagaaaaagaag tcaaagacaaagtgtataattatgtaa

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