KEGG   Heterocephalus glaber (naked mole rat): 101718997
Entry
101718997         CDS       T02812                                 

Gene name
Kras
Definition
(RefSeq) KRAS proto-oncogene, GTPase
  KO
K07827  GTPase KRas
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
hgl01521  EGFR tyrosine kinase inhibitor resistance
hgl01522  Endocrine resistance
hgl04010  MAPK signaling pathway
hgl04012  ErbB signaling pathway
hgl04014  Ras signaling pathway
hgl04015  Rap1 signaling pathway
hgl04062  Chemokine signaling pathway
hgl04068  FoxO signaling pathway
hgl04071  Sphingolipid signaling pathway
hgl04072  Phospholipase D signaling pathway
hgl04137  Mitophagy - animal
hgl04140  Autophagy - animal
hgl04150  mTOR signaling pathway
hgl04151  PI3K-Akt signaling pathway
hgl04210  Apoptosis
hgl04211  Longevity regulating pathway
hgl04213  Longevity regulating pathway - multiple species
hgl04218  Cellular senescence
hgl04360  Axon guidance
hgl04370  VEGF signaling pathway
hgl04371  Apelin signaling pathway
hgl04540  Gap junction
hgl04550  Signaling pathways regulating pluripotency of stem cells
hgl04625  C-type lectin receptor signaling pathway
hgl04650  Natural killer cell mediated cytotoxicity
hgl04660  T cell receptor signaling pathway
hgl04662  B cell receptor signaling pathway
hgl04664  Fc epsilon RI signaling pathway
hgl04714  Thermogenesis
hgl04720  Long-term potentiation
hgl04722  Neurotrophin signaling pathway
hgl04725  Cholinergic synapse
hgl04726  Serotonergic synapse
hgl04730  Long-term depression
hgl04810  Regulation of actin cytoskeleton
hgl04910  Insulin signaling pathway
hgl04912  GnRH signaling pathway
hgl04914  Progesterone-mediated oocyte maturation
hgl04915  Estrogen signaling pathway
hgl04916  Melanogenesis
hgl04917  Prolactin signaling pathway
hgl04919  Thyroid hormone signaling pathway
hgl04921  Oxytocin signaling pathway
hgl04926  Relaxin signaling pathway
hgl04929  GnRH secretion
hgl04933  AGE-RAGE signaling pathway in diabetic complications
hgl04935  Growth hormone synthesis, secretion and action
hgl04960  Aldosterone-regulated sodium reabsorption
hgl05010  Alzheimer disease
hgl05022  Pathways of neurodegeneration - multiple diseases
hgl05034  Alcoholism
hgl05160  Hepatitis C
hgl05161  Hepatitis B
hgl05163  Human cytomegalovirus infection
hgl05165  Human papillomavirus infection
hgl05166  Human T-cell leukemia virus 1 infection
hgl05167  Kaposi sarcoma-associated herpesvirus infection
hgl05170  Human immunodeficiency virus 1 infection
hgl05200  Pathways in cancer
hgl05203  Viral carcinogenesis
hgl05205  Proteoglycans in cancer
hgl05206  MicroRNAs in cancer
hgl05210  Colorectal cancer
hgl05211  Renal cell carcinoma
hgl05212  Pancreatic cancer
hgl05213  Endometrial cancer
hgl05214  Glioma
hgl05215  Prostate cancer
hgl05216  Thyroid cancer
hgl05218  Melanoma
hgl05219  Bladder cancer
hgl05220  Chronic myeloid leukemia
hgl05221  Acute myeloid leukemia
hgl05223  Non-small cell lung cancer
hgl05224  Breast cancer
hgl05225  Hepatocellular carcinoma
hgl05226  Gastric cancer
hgl05230  Central carbon metabolism in cancer
hgl05231  Choline metabolism in cancer
hgl05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101718997 (Kras)
   04012 ErbB signaling pathway
    101718997 (Kras)
   04014 Ras signaling pathway
    101718997 (Kras)
   04015 Rap1 signaling pathway
    101718997 (Kras)
   04370 VEGF signaling pathway
    101718997 (Kras)
   04371 Apelin signaling pathway
    101718997 (Kras)
   04068 FoxO signaling pathway
    101718997 (Kras)
   04072 Phospholipase D signaling pathway
    101718997 (Kras)
   04071 Sphingolipid signaling pathway
    101718997 (Kras)
   04151 PI3K-Akt signaling pathway
    101718997 (Kras)
   04150 mTOR signaling pathway
    101718997 (Kras)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101718997 (Kras)
   04137 Mitophagy - animal
    101718997 (Kras)
  09143 Cell growth and death
   04210 Apoptosis
    101718997 (Kras)
   04218 Cellular senescence
    101718997 (Kras)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101718997 (Kras)
   04550 Signaling pathways regulating pluripotency of stem cells
    101718997 (Kras)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101718997 (Kras)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    101718997 (Kras)
   04650 Natural killer cell mediated cytotoxicity
    101718997 (Kras)
   04660 T cell receptor signaling pathway
    101718997 (Kras)
   04662 B cell receptor signaling pathway
    101718997 (Kras)
   04664 Fc epsilon RI signaling pathway
    101718997 (Kras)
   04062 Chemokine signaling pathway
    101718997 (Kras)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101718997 (Kras)
   04929 GnRH secretion
    101718997 (Kras)
   04912 GnRH signaling pathway
    101718997 (Kras)
   04915 Estrogen signaling pathway
    101718997 (Kras)
   04914 Progesterone-mediated oocyte maturation
    101718997 (Kras)
   04917 Prolactin signaling pathway
    101718997 (Kras)
   04921 Oxytocin signaling pathway
    101718997 (Kras)
   04926 Relaxin signaling pathway
    101718997 (Kras)
   04935 Growth hormone synthesis, secretion and action
    101718997 (Kras)
   04919 Thyroid hormone signaling pathway
    101718997 (Kras)
   04916 Melanogenesis
    101718997 (Kras)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101718997 (Kras)
  09156 Nervous system
   04725 Cholinergic synapse
    101718997 (Kras)
   04726 Serotonergic synapse
    101718997 (Kras)
   04720 Long-term potentiation
    101718997 (Kras)
   04730 Long-term depression
    101718997 (Kras)
   04722 Neurotrophin signaling pathway
    101718997 (Kras)
  09158 Development and regeneration
   04360 Axon guidance
    101718997 (Kras)
  09149 Aging
   04211 Longevity regulating pathway
    101718997 (Kras)
   04213 Longevity regulating pathway - multiple species
    101718997 (Kras)
  09159 Environmental adaptation
   04714 Thermogenesis
    101718997 (Kras)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101718997 (Kras)
   05206 MicroRNAs in cancer
    101718997 (Kras)
   05205 Proteoglycans in cancer
    101718997 (Kras)
   05203 Viral carcinogenesis
    101718997 (Kras)
   05230 Central carbon metabolism in cancer
    101718997 (Kras)
   05231 Choline metabolism in cancer
    101718997 (Kras)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101718997 (Kras)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101718997 (Kras)
   05212 Pancreatic cancer
    101718997 (Kras)
   05225 Hepatocellular carcinoma
    101718997 (Kras)
   05226 Gastric cancer
    101718997 (Kras)
   05214 Glioma
    101718997 (Kras)
   05216 Thyroid cancer
    101718997 (Kras)
   05221 Acute myeloid leukemia
    101718997 (Kras)
   05220 Chronic myeloid leukemia
    101718997 (Kras)
   05218 Melanoma
    101718997 (Kras)
   05211 Renal cell carcinoma
    101718997 (Kras)
   05219 Bladder cancer
    101718997 (Kras)
   05215 Prostate cancer
    101718997 (Kras)
   05213 Endometrial cancer
    101718997 (Kras)
   05224 Breast cancer
    101718997 (Kras)
   05223 Non-small cell lung cancer
    101718997 (Kras)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101718997 (Kras)
   05022 Pathways of neurodegeneration - multiple diseases
    101718997 (Kras)
  09165 Substance dependence
   05034 Alcoholism
    101718997 (Kras)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101718997 (Kras)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101718997 (Kras)
   05170 Human immunodeficiency virus 1 infection
    101718997 (Kras)
   05161 Hepatitis B
    101718997 (Kras)
   05160 Hepatitis C
    101718997 (Kras)
   05163 Human cytomegalovirus infection
    101718997 (Kras)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101718997 (Kras)
   05165 Human papillomavirus infection
    101718997 (Kras)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101718997 (Kras)
   01522 Endocrine resistance
    101718997 (Kras)
Membrane trafficking [BR:hgl04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    101718997 (Kras)
GTP-binding proteins [BR:hgl04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    101718997 (Kras)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 MeaB FeoB_N G-alpha ATP_bind_1 Septin NPR1_interact AAA_25
Other DBs
NCBI-GeneID: 101718997
NCBI-ProteinID: XP_004845800
LinkDB
Position
Un
AA seq 188 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKK
SKTKCIIM
NT seq 567 nt   +upstreamnt  +downstreamnt
atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg
atacagctaattcagaatcactttgtggatgaatatgatcctacaatagaggattcctac
agaaaacaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt
caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt
gtatttgccataaataatactaaatcttttgaagatattcaccattatagagaacaaatt
aaaagagttaaagactctgaagatgtacctatggttctagtaggaaataaatgtgatttg
ccttctagaacagtagacacaaaacaagctcaggacttagcaagaagttacggaattcct
tttattgaaacatcagcaaagacaagacagggtgttgatgatgccttctatacgttagtt
cgagaaattcgaaaacataaagaaaagatgagcaaagatggtaaaaagaagaaaaagaag
tcaaagacaaagtgtataattatgtaa

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