KEGG   PATHWAY: hsa00830
Entry
hsa00830                    Pathway                                

Name
Retinol metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
hsa00830  Retinol metabolism
hsa00830

Disease
H00527  Retinitis pigmentosa
H00825  Familial flecked retina syndrome
H00837  Leber congenital amaurosis
H01266  Hypercarotenemia and vitamin A deficiency
H02292  Retinal dystrophy, juvenile cataracts, and short stature syndrome
Drug
D09385  Talarozole (USAN/INN)
D10657  Pradigastat sodium (USAN)
D10664  Pradigastat (USAN)
D11008  Voretigene neparvovec (USAN/INN)
Other DBs
GO: 0006776
Organism
Homo sapiens (human) [GN:hsa]
Gene
53630  BCO1; beta-carotene oxygenase 1 [KO:K00515] [EC:1.13.11.63]
124  ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]
125  ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]
126  ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]
131  ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]
127  ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
128  ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]
130  ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]
9249  DHRS3; dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
10901  DHRS4; dehydrogenase/reductase 4 [KO:K11147] [EC:1.1.-.-]
728635  DHRS4L1; dehydrogenase/reductase 4 like 1 [KO:K11147] [EC:1.1.-.-]
317749  DHRS4L2; dehydrogenase/reductase 4 like 2 [KO:K11148] [EC:1.1.-.-]
10170  DHRS9; dehydrogenase/reductase 9 [KO:K11149] [EC:1.1.-.-]
50700  RDH8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
157506  RDH10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
51109  RDH11; retinol dehydrogenase 11 [KO:K11152] [EC:1.1.1.300]
145226  RDH12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
8608  RDH16; retinol dehydrogenase 16 [KO:K11154] [EC:1.1.1.-]
195814  SDR16C5; short chain dehydrogenase/reductase family 16C member 5 [KO:K15734] [EC:1.1.1.105]
8630  HSD17B6; hydroxysteroid 17-beta dehydrogenase 6 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
9227  LRAT; lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
8694  DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
158835  AWAT2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
8228  PNPLA4; patatin like phospholipase domain containing 4 [KO:K11157] [EC:3.1.1.-]
6121  RPE65; retinoid isomerohydrolase RPE65 [KO:K11158] [EC:3.1.1.64 5.3.3.22]
5959  RDH5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
316  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
8854  ALDH1A2; aldehyde dehydrogenase 1 family member A2 [KO:K07249] [EC:1.2.1.36]
216  ALDH1A1; aldehyde dehydrogenase 1 family member A1 [KO:K07249] [EC:1.2.1.36]
220  ALDH1A3; aldehyde dehydrogenase 1 family member A3 [KO:K07249] [EC:1.2.1.36]
1592  CYP26A1; cytochrome P450 family 26 subfamily A member 1 [KO:K07437]
56603  CYP26B1; cytochrome P450 family 26 subfamily B member 1 [KO:K12664]
340665  CYP26C1; cytochrome P450 family 26 subfamily C member 1 [KO:K12665]
1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1 [KO:K07408] [EC:1.14.14.1]
1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
1548  CYP2A6; cytochrome P450 family 2 subfamily A member 6 [KO:K17683] [EC:1.14.13.-]
1555  CYP2B6; cytochrome P450 family 2 subfamily B member 6 [KO:K17709] [EC:1.14.13.-]
1558  CYP2C8; cytochrome P450 family 2 subfamily C member 8 [KO:K17718] [EC:1.14.14.1]
1559  CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
1562  CYP2C18; cytochrome P450 family 2 subfamily C member 18 [KO:K17720] [EC:1.14.14.1]
29785  CYP2S1; cytochrome P450 family 2 subfamily S member 1 [KO:K07420] [EC:1.14.14.1]
1576  CYP3A4; cytochrome P450 family 3 subfamily A member 4 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.13.-]
1577  CYP3A5; cytochrome P450 family 3 subfamily A member 5 [KO:K17690] [EC:1.14.14.1]
1551  CYP3A7; cytochrome P450 family 3 subfamily A member 7 [KO:K17691] [EC:1.14.14.1]
100861540  CYP3A7-CYP3A51P; CYP3A7-CYP3A51P readthrough [KO:K17691] [EC:1.14.14.1]
1579  CYP4A11; cytochrome P450 family 4 subfamily A member 11 [KO:K07425] [EC:1.14.14.80]
284541  CYP4A22; cytochrome P450 family 4 subfamily A member 22 [KO:K07425] [EC:1.14.14.80]
10941  UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
79799  UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
7367  UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
10720  UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
54490  UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
54578  UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
54657  UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
54658  UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
54659  UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
7365  UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
54600  UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
7364  UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
54575  UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
54576  UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
54579  UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
7366  UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
54577  UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
7363  UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
574537  UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
54884  RETSAT; retinol saturase [KO:K09516] [EC:1.3.99.23]
339761  CYP27C1; cytochrome P450 family 27 subfamily C member 1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
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