Collecting duct acid secretion - Homo sapiens (human)
One of the important roles of the collecting duct segment of the kidney nephron is acid secretion. As daily food intake loads acid into the body, urinary acid excretion is essential, and urine pH can drop as low as 4.5. The alpha-intercalated cell of collecting duct is the main responsible for hydrogen secretion into the urine. The carbon dioxide, which is generated in the cells and enters from the blood, is changed to carbonic acid. This carbonic acid is divided into hydrogen ion and bicarbonate ion. Intracellular CA II catalyses the formation of these ions. The hydrogen ion is secreted into the lumen by the luminal H(+)-ATPase. The bicarbonate ion is transported to the blood side by the anion exchanger type 1. Hydrogen ion in the lumen is trapped by urinary buffers. These include ammonium and phosphate.
Organismal Systems; Excretory system
Collecting duct acid secretion
Combined proximal and distal renal tubular acidosis
Distal renal tubular acidosis (RTA type 1)
Renal tubular acidosis
Rabeprazole sodium (JP17/USP)
Omeprazole sodium (USAN)
Esomeprazole magnesium (USP)
Pantoprazole sodium (USP)
Sezolamide hydrochloride (USAN)
Esomeprazole sodium (USAN)
Omeprazole magnesium (USP)
Omeprazole sodium injection (JAN)
Esomeprazole potassium (USAN)
Penaprazole sodium hydrate (JAN)
Esomeprazole strontium (USAN)
Esomeprazole magnesium dihydrate
Homo sapiens (human) [GN:
CA2; carbonic anhydrase 2 [KO:
ATP6V1A; ATPase H+ transporting V1 subunit A [KO:
ATP6V1B1; ATPase H+ transporting V1 subunit B1 [KO:
ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:
ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:
ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:
ATP6V1G2; ATPase H+ transporting V1 subunit G2 [KO:
ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:
ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:
ATP6V1D; ATPase H+ transporting V1 subunit D [KO:
ATP6V1E2; ATPase H+ transporting V1 subunit E2 [KO:
ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:
ATP6V1F; ATPase H+ transporting V1 subunit F [KO:
ATP6V0E1; ATPase H+ transporting V0 subunit e1 [KO:
ATP6V0E2; ATPase H+ transporting V0 subunit e2 [KO:
TCIRG1; T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:
ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:
ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:
ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:
ATP6V0C; ATPase H+ transporting V0 subunit c [KO:
ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:
ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:
ATP4A; ATPase H+/K+ transporting subunit alpha [KO:
ATP4B; ATPase H+/K+ transporting subunit beta [KO:
SLC4A1; solute carrier family 4 member 1 (Diego blood group) [KO:
SLC12A7; solute carrier family 12 member 7 [KO:
CLCNKB; chloride voltage-gated channel Kb [KO:
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