KEGG   Homo sapiens (human): 1017Help
Entry
1017              CDS       T01001                                 

Gene name
CDK2, CDKN2, p33(CDK2)
Definition
(RefSeq) cyclin dependent kinase 2
  KO
K02206  cyclin-dependent kinase 2 [EC:2.7.11.22]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04115  p53 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04218  Cellular senescence
hsa04914  Progesterone-mediated oocyte maturation
hsa04934  Cushing syndrome
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05215  Prostate cancer
hsa05222  Small cell lung cancer
hsa05226  Gastric cancer
Network
nt06130  Cell cycle (virus)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06230  Cell cycle G1/S
nt06261  Gastric cancer
nt06267  Small cell lung cancer
nt06272  Prostate cancer
nt06319  AHR-cell cycle regulation
nt06360  Cushing syndrome
  Element
N00091  p27-Cell cycle G1/S
N00093  Loss of CDKN1B to p27-cell cycle G1/S
N00254  CDKN1B-reduced expression to p27-cell cycle G1/S
N00255  Amplified CCNE to cell cycle G1/S
N00264  EBV EBNA3C to p27-Cell cycle G1/S
N00316  Mutation-inactivated CDKN1B to p27-cell cycle G1/S
N00359  HPV E7 to p27-cell cycle G1/S
N00360  HPV E7 to p27-cell cycle G1/S
N00482  EBV EBNA3C to p27-Cell cycle G1/S
N00496  MDM2-p21-Cell cycle G1/S
N00497  HTLV-1 Tax to p21-cell cycle G1/S
N00498  HTLV-1 Tax to p21-cell cycle G1/S
N00536  MDM2-p21-Cell cycle G1/S
N00537  HBV HBx to cell cycle G1/S
Drug target
Alvocidib (DG02041): D02880 D09868
Dinaciclib: D09604
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    1017 (CDK2)
   04151 PI3K-Akt signaling pathway
    1017 (CDK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1017 (CDK2)
   04114 Oocyte meiosis
    1017 (CDK2)
   04115 p53 signaling pathway
    1017 (CDK2)
   04218 Cellular senescence
    1017 (CDK2)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    1017 (CDK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1017 (CDK2)
   05203 Viral carcinogenesis
    1017 (CDK2)
  09162 Cancer: specific types
   05226 Gastric cancer
    1017 (CDK2)
   05215 Prostate cancer
    1017 (CDK2)
   05222 Small cell lung cancer
    1017 (CDK2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1017 (CDK2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1017 (CDK2)
   05162 Measles
    1017 (CDK2)
   05161 Hepatitis B
    1017 (CDK2)
   05160 Hepatitis C
    1017 (CDK2)
   05169 Epstein-Barr virus infection
    1017 (CDK2)
   05165 Human papillomavirus infection
    1017 (CDK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1017 (CDK2)
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    1017 (CDK2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1017 (CDK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     1017 (CDK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   1017 (CDK2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic Type
  DNA Replication Initiation Factors
   CDK (cyclin dependent kinase)
    1017 (CDK2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    1017 (CDK2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr Haspin_kinase Kinase-like APH
Motif
Other DBs
NCBI-GeneID: 1017
NCBI-ProteinID: NP_001789
OMIM: 116953
HGNC: 1771
Ensembl: ENSG00000123374
Vega: OTTHUMG00000170575
Pharos: P24941(Tchem)
UniProt: P24941 A0A024RB77
LinkDB All DBs
Structure
PDB: 
6Q4G 6Q49 6Q4H 6Q48 6Q4J 6Q4E 6Q4K 6Q4D 6Q4I 6Q3B 6Q4B 6Q4A 6Q3F 6Q4F 4FKL 4EK4 2R3I 6Q3C 6GUK 5MHQ 1GZ8 4EK3 2R3Q 4GCJ 4FKU 2R3R 6GUH 2R3F 2R3H 4FKG 4EK6 1JVP 4FKO 4FKS 2R3G 5OO0 5K4J 5ANJ 4FKI 4FKP 4FKT 4EK5 3RM6 1OIT 4RJ3 4FKJ 4ACM 2R3N 4EOJ 2R3J 2R3L 5IEY 2R3P 2VTT 5ANE 5ANO 4KD1 4FKV 4EK8 3SW4 3RAI 3R73 3QQJ 3PXZ 2R3K 2R3M 2CCH 6Q4C 5OO3 4FKQ 3S1H 3RPO 3RPR 3ROY 3RMF 3RAH 3RAK 3RAL 3R9N 3R7U 3R83 3R6X 3R71 3R28 3QZG 3QZI 3QXO 3QXP 3QX2 3QWJ 3QRT 3QQF 3PY0 5OSM 3NS9 1H01 5D1J 4FKW 3SW7 3S00 3RPV 3RK7 3R8M 3R8P 3R1S 3R1Y 3QTQ 3PXY 3PXF 3IG7 3IGG 3DDQ 2R3O 2CLX 2C6I 2EXM 1YKR 1HCL 6ATH 3QTU 5OSJ 4BZD 3TIY 5FP6 4D1Z 4NJ3 3SQQ 3RM7 3RK9 3RJC 3R8Z 3R7I 3R1Q 3QWK 3QTR 3QTW 3QQL 2XNB 2VU3 2FVD 2B54 2B55 2BTR 1H07 1E1X 3QQK 3QQH 2B52 2VTR 5ANG 5ANI 5ANK 4FKR 3UNJ 3RZB 3RPY 3R9O 3R8L 3R8V 3R7Y 3R7E 3QTS 3QQG 3QL8 3PXQ 2XMY 3FZ1 3EZR 2W05 2VV9 2VTS 2C6K 2C6M 2BHE 1H0V 1HCK 3QHW 1OIR 3QX4 5JQ5 5JQ8 4BGH 3RNI 3R9D 3R7V 3QZH 3QTX 3QU0 3QRU 2C68 2A0C 1PXI 1PW2 1E1V 3PJ8 1PXO 1JSV 6GUE 4EOP 3TI1 3EZV 2BTS 6GUC 5OO1 5CYI 5A14 4CFV 4LYN 3WBL 4EZ3 4ERW 4EOI 3ULI 3TNW 3S0O 3RK5 3RKB 3R8U 3QZF 3QTZ 3PXR 3LE6 2VTI 2VTL 2VTA 3BHT 2DS1 2B53 1Y8Y 1R78 1PYE 1H1R 1H1S 1KE6 1KE7 1KE8 1KE9 1GII 1B38 1AQ1 3TIZ 5IEV 5IEX 3LFQ 2W06 4I3Z 4BCK 4BCO 3PY1 1W8C 1CKP 2UUE 4D1X 4BCN 4EOM 4EOO 3UNK 3R9H 3MY5 3BHV 2C6O 2C69 2C5N 1H1P 1H0W 1DM2 1B39 6GVA 4II5 4EOQ 2W1H 2W17 2VTP 1Y91 1W98 5FP5 3QHR 2VTO 4CFN 4CFU 4EOR 2VTJ 2VTN 2V0D 2DUV 1WCC 1W0X 1H27 1KE5 1GIJ 1FVT 1DI8 1QMZ 1VYZ 1P5E 1H26 2VTM 2C5Y 4BCP 3LFN 5AND 3S2P 2WEV 3BHU 2R64 2UZN 2UZO 2C6L 1VYW 1PXJ 1PXP 1PKD 1FIN 1JSU 1V1K 1OIQ 5LMK 4BCQ 4EOL 4EON 3LFS 3F5X 2UZL 2UZE 2A4L 2BPM 1OKV 4CFW 4BCM 4EZ7 2WIH 2J9M 2G9X 1OKW 1PXL 1PXN 1P2A 1H1Q 1F5Q 2WPA 1PF8 6GUB 2WFY 1PXM 4EOK 4EOS 2WXV 2WMB 2V22 2BKZ 1URC 1OL2 1BUH 1JST 5IF1 2C6T 1G5S 6GUF 5UQ2 3DOG 3DDP 2UZB 2CCI 2C4G 1GY3 2UZD 4FX3 2X1N 5L2W 2WMA 2WIP 2I40 1PXK 1H28 1GIH 1FVV 4CFM 2WHB 2C5X 1OL1 5NEV 1FQ1 3EID 5UQ1 3EOC 3EJ1 4CFX 5UQ3 2VTH 2VTQ 2JGZ 2IW8 2IW9 2IW6 2CJM 2C5V 2C5O 2BHH 1URW 1OIU 1OIY 1OI9 1OGU 1H24 1H25 1H08 1H00 1E9H
Thumbnails

Position
12q13.2
AA seq 298 aa AA seqDB search
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
NT seq 897 nt NT seq  +upstreamnt  +downstreamnt
atggagaacttccaaaaggtggaaaagatcggagagggcacgtacggagttgtgtacaaa
gccagaaacaagttgacgggagaggtggtggcgcttaagaaaatccgcctggacactgag
actgagggtgtgcccagtactgccatccgagagatctctctgcttaaggagcttaaccat
cctaatattgtcaagctgctggatgtcattcacacagaaaataaactctacctggttttt
gaatttctgcaccaagatctcaagaaattcatggatgcctctgctctcactggcattcct
cttcccctcatcaagagctatctgttccagctgctccagggcctagctttctgccattct
catcgggtcctccaccgagaccttaaacctcagaatctgcttattaacacagagggggcc
atcaagctagcagactttggactagccagagcttttggagtccctgttcgtacttacacc
catgaggtggtgaccctgtggtaccgagctcctgaaatcctcctgggctgcaaatattat
tccacagctgtggacatctggagcctgggctgcatctttgctgagatggtgactcgccgg
gccctattccctggagattctgagattgaccagctcttccggatctttcggactctgggg
accccagatgaggtggtgtggccaggagttacttctatgcctgattacaagccaagtttc
cccaagtgggcccggcaagattttagtaaagttgtacctcccctggatgaagatggacgg
agcttgttatcgcaaatgctgcactacgaccctaacaagcggatttcggccaaggcagcc
ctggctcaccctttcttccaggatgtgaccaagccagtaccccatcttcgactctga

KEGG   Homo sapiens (human): 1019Help
Entry
1019              CDS       T01001                                 

Gene name
CDK4, CMM3, PSK-J3
Definition
(RefSeq) cyclin dependent kinase 4
  KO
K02089  cyclin-dependent kinase 4 [EC:2.7.11.22]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04110  Cell cycle
hsa04115  p53 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04218  Cellular senescence
hsa04530  Tight junction
hsa04660  T cell receptor signaling pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04934  Cushing syndrome
hsa05160  Hepatitis C
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05212  Pancreatic cancer
hsa05214  Glioma
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
Network
nt06130  Cell cycle (virus)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06230  Cell cycle G1/S
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia
  Element
N00066  MDM2-p21-Cell cycle G1/S
N00067  Deleted p14(ARF) to p21-cell cycle G1/S
N00068  Amplified MDM2 to p21-cell cycle G1/S
N00069  p16-Cell cycle G1/S
N00070  Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
N00071  Deleted p16(INK4a) to p16-cell cycle G1/S
N00072  Amplified CDK4 to cell cycle G1/S
N00073  Mutation-activated CDK4 to cell cycle G1/S
N00076  Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00088  Amplified MYC to p15-cell cycle G1/S
N00089  Amplified MYC to cell cycle G1/S
N00090  p15-Cell cycle G1/S
N00167  KSHV vIRF1/3 to p21-cell cycle G1/S
N00168  KSHV vCyclin to cell cycle G1/S
N00169  KSHV LANA to p21-cell cycle G1/S
N00275  Amplified CCND1 to cell cycle G1/S
N00347  p300-p21-Cell cycle G1/S
N00348  HPV E6 to p300-p21-Cell cycle G1/S
N00349  HPV E6 to p300-p21-Cell cycle G1/S
N00358  HPV E6 to p21-cell cycle G1/S
N00362  HPV E5 to p21-cell cycle G1/S
N00420  HCMV IE2-86 to p21-cell cycle G1/S
N00421  HCMV IE2-86 to p21-cell cycle G1/S
N00483  EBV EBNA3C to cell cycle G1/S
N00494  HTLV-1 Tax to p16-cell cycle G1/S
N00495  HTLV-1 Tax to p15-cell cycle G1/S
N00521  HCV Core to p21-cell cycle G1/S
N00529  HCV core to RXRA/PPARA-mediated transcription
N00530  HCV core to RXRA/LXRA-mediated transcription
Disease
H00030  Cervical cancer
H00038  Melanoma
H00042  Glioma
Drug target
Abemaciclib: D10688
Alvocidib (DG02041): D02880 D09868
Lerociclib: D11455
Palbociclib (DG01831): D10372 D10652
Ribociclib (DG02084): D10883 D10979
Trilaciclib: D11130
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    1019 (CDK4)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1019 (CDK4)
   04115 p53 signaling pathway
    1019 (CDK4)
   04218 Cellular senescence
    1019 (CDK4)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    1019 (CDK4)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    1019 (CDK4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1019 (CDK4)
   05203 Viral carcinogenesis
    1019 (CDK4)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    1019 (CDK4)
   05225 Hepatocellular carcinoma
    1019 (CDK4)
   05214 Glioma
    1019 (CDK4)
   05220 Chronic myeloid leukemia
    1019 (CDK4)
   05218 Melanoma
    1019 (CDK4)
   05219 Bladder cancer
    1019 (CDK4)
   05224 Breast cancer
    1019 (CDK4)
   05222 Small cell lung cancer
    1019 (CDK4)
   05223 Non-small cell lung cancer
    1019 (CDK4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    1019 (CDK4)
   04934 Cushing syndrome
    1019 (CDK4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1019 (CDK4)
   05162 Measles
    1019 (CDK4)
   05164 Influenza A
    1019 (CDK4)
   05160 Hepatitis C
    1019 (CDK4)
   05163 Human cytomegalovirus infection
    1019 (CDK4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1019 (CDK4)
   05169 Epstein-Barr virus infection
    1019 (CDK4)
   05165 Human papillomavirus infection
    1019 (CDK4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    1019 (CDK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1019 (CDK4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     1019 (CDK4)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   1019 (CDK4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr APH Kdo Haspin_kinase Kinase-like
Motif
Other DBs
NCBI-GeneID: 1019
NCBI-ProteinID: NP_000066
OMIM: 123829
HGNC: 1773
Ensembl: ENSG00000135446
Vega: OTTHUMG00000170382
Pharos: P11802(Tclin)
UniProt: P11802 A0A024RBB6
LinkDB All DBs
Structure
PDB: 

Position
12q14.1
AA seq 303 aa AA seqDB search
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
NT seq 912 nt NT seq  +upstreamnt  +downstreamnt
atggctacctctcgatatgagccagtggctgaaattggtgtcggtgcctatgggacagtg
tacaaggcccgtgatccccacagtggccactttgtggccctcaagagtgtgagagtcccc
aatggaggaggaggtggaggaggccttcccatcagcacagttcgtgaggtggctttactg
aggcgactggaggcttttgagcatcccaatgttgtccggctgatggacgtctgtgccaca
tcccgaactgaccgggagatcaaggtaaccctggtgtttgagcatgtagaccaggaccta
aggacatatctggacaaggcacccccaccaggcttgccagccgaaacgatcaaggatctg
atgcgccagtttctaagaggcctagatttccttcatgccaattgcatcgttcaccgagat
ctgaagccagagaacattctggtgacaagtggtggaacagtcaagctggctgactttggc
ctggccagaatctacagctaccagatggcacttacacccgtggttgttacactctggtac
cgagctcccgaagttcttctgcagtccacatatgcaacacctgtggacatgtggagtgtt
ggctgtatctttgcagagatgtttcgtcgaaagcctctcttctgtggaaactctgaagcc
gaccagttgggcaaaatctttgacctgattgggctgcctccagaggatgactggcctcga
gatgtatccctgccccgtggagcctttccccccagagggccccgcccagtgcagtcggtg
gtacctgagatggaggagtcgggagcacagctgctgctggaaatgctgacttttaaccca
cacaagcgaatctctgcctttcgagctctgcagcactcttatctacataaggatgaaggt
aatccggagtga

KEGG   Homo sapiens (human): 1021Help
Entry
1021              CDS       T01001                                 

Gene name
CDK6, MCPH12, PLSTIRE
Definition
(RefSeq) cyclin dependent kinase 6
  KO
K02091  cyclin-dependent kinase 6 [EC:2.7.11.22]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04115  p53 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04218  Cellular senescence
hsa04934  Cushing syndrome
hsa05160  Hepatitis C
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05206  MicroRNAs in cancer
hsa05212  Pancreatic cancer
hsa05214  Glioma
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
Network
nt06130  Cell cycle (virus)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06230  Cell cycle G1/S
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia
  Element
N00066  MDM2-p21-Cell cycle G1/S
N00067  Deleted p14(ARF) to p21-cell cycle G1/S
N00068  Amplified MDM2 to p21-cell cycle G1/S
N00069  p16-Cell cycle G1/S
N00070  Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
N00071  Deleted p16(INK4a) to p16-cell cycle G1/S
N00076  Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00088  Amplified MYC to p15-cell cycle G1/S
N00089  Amplified MYC to cell cycle G1/S
N00090  p15-Cell cycle G1/S
N00167  KSHV vIRF1/3 to p21-cell cycle G1/S
N00168  KSHV vCyclin to cell cycle G1/S
N00169  KSHV LANA to p21-cell cycle G1/S
N00347  p300-p21-Cell cycle G1/S
N00348  HPV E6 to p300-p21-Cell cycle G1/S
N00349  HPV E6 to p300-p21-Cell cycle G1/S
N00358  HPV E6 to p21-cell cycle G1/S
N00362  HPV E5 to p21-cell cycle G1/S
N00420  HCMV IE2-86 to p21-cell cycle G1/S
N00421  HCMV IE2-86 to p21-cell cycle G1/S
N00483  EBV EBNA3C to cell cycle G1/S
N00494  HTLV-1 Tax to p16-cell cycle G1/S
N00495  HTLV-1 Tax to p15-cell cycle G1/S
N00521  HCV Core to p21-cell cycle G1/S
Disease
H00269  Primary microcephaly
Drug target
Abemaciclib: D10688
Alvocidib (DG02041): D02880 D09868
Lerociclib: D11455
Palbociclib (DG01831): D10372 D10652
Ribociclib (DG02084): D10883 D10979
Trilaciclib: D11130
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    1021 (CDK6)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1021 (CDK6)
   04115 p53 signaling pathway
    1021 (CDK6)
   04218 Cellular senescence
    1021 (CDK6)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1021 (CDK6)
   05206 MicroRNAs in cancer
    1021 (CDK6)
   05203 Viral carcinogenesis
    1021 (CDK6)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    1021 (CDK6)
   05225 Hepatocellular carcinoma
    1021 (CDK6)
   05214 Glioma
    1021 (CDK6)
   05220 Chronic myeloid leukemia
    1021 (CDK6)
   05218 Melanoma
    1021 (CDK6)
   05224 Breast cancer
    1021 (CDK6)
   05222 Small cell lung cancer
    1021 (CDK6)
   05223 Non-small cell lung cancer
    1021 (CDK6)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1021 (CDK6)
  09172 Infectious disease: viral
   05162 Measles
    1021 (CDK6)
   05164 Influenza A
    1021 (CDK6)
   05160 Hepatitis C
    1021 (CDK6)
   05163 Human cytomegalovirus infection
    1021 (CDK6)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1021 (CDK6)
   05169 Epstein-Barr virus infection
    1021 (CDK6)
   05165 Human papillomavirus infection
    1021 (CDK6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1021 (CDK6)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     1021 (CDK6)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  CDK family
   1021 (CDK6)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr APH Haspin_kinase Kdo Kinase-like RIO1 FTA2
Motif
Other DBs
NCBI-GeneID: 1021
NCBI-ProteinID: NP_001138778
OMIM: 603368
HGNC: 1777
Ensembl: ENSG00000105810
Vega: OTTHUMG00000131697
Pharos: Q00534(Tclin)
UniProt: Q00534
LinkDB All DBs
Structure
PDB: 

Position
7q21.2
AA seq 326 aa AA seqDB search
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
NT seq 981 nt NT seq  +upstreamnt  +downstreamnt
atggagaaggacggcctgtgccgcgctgaccagcagtacgaatgcgtggcggagatcggg
gagggcgcctatgggaaggtgttcaaggcccgcgacttgaagaacggaggccgtttcgtg
gcgttgaagcgcgtgcgggtgcagaccggcgaggagggcatgccgctctccaccatccgc
gaggtggcggtgctgaggcacctggagaccttcgagcaccccaacgtggtcaggttgttt
gatgtgtgcacagtgtcacgaacagacagagaaaccaaactaactttagtgtttgaacat
gtcgatcaagacttgaccacttacttggataaagttccagagcctggagtgcccactgaa
accataaaggatatgatgtttcagcttctccgaggtctggactttcttcattcacaccga
gtagtgcatcgcgatctaaaaccacagaacattctggtgaccagcagcggacaaataaaa
ctcgctgacttcggccttgcccgcatctatagtttccagatggctctaacctcagtggtc
gtcacgctgtggtacagagcacccgaagtcttgctccagtccagctacgccacccccgtg
gatctctggagtgttggctgcatatttgcagaaatgtttcgtagaaagcctctttttcgt
ggaagttcagatgttgatcaactaggaaaaatcttggacgtgattggactcccaggagaa
gaagactggcctagagatgttgcccttcccaggcaggcttttcattcaaaatctgcccaa
ccaattgagaagtttgtaacagatatcgatgaactaggcaaagacctacttctgaagtgt
ttgacatttaacccagccaaaagaatatctgcctacagtgccctgtctcacccatacttc
caggacctggaaaggtgcaaagaaaacctggattcccacctgccgcccagccagaacacc
tcggagctgaatacagcctga

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