KEGG   Homo sapiens (human): 10203
Entry
10203             CDS       T01001                                 

Gene name
CALCRL, CGRPR, CRLR, LMPHM8
Definition
(RefSeq) calcitonin receptor like receptor
  KO
K04577  calcitonin receptor-like
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Drug target
Atogepant: D11313
Davalintide (DG01352): D09600 D09601
Erenumab: D10928<US>
Rimegepant (DG01845): D10662 D10663<US>
Telcagepant (DG01353): D09391 D09392
Ubrogepant: D10673<US>
Zavegepant (DG03122): D11898 D11899
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    10203 (CALCRL)
 09150 Organismal Systems
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    10203 (CALCRL)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    10203 (CALCRL)
G protein-coupled receptors [BR:hsa04030]
 Secretin receptor family
  Calcium-regulating peptide
   Calcitonin
    10203 (CALCRL)
SSDB
Motif
Pfam: 7tm_2 HRM DUF4034
Other DBs
NCBI-GeneID: 10203
NCBI-ProteinID: NP_001258680
OMIM: 114190
HGNC: 16709
Ensembl: ENSG00000064989
Vega: OTTHUMG00000132636
Pharos: Q16602(Tchem)
UniProt: Q16602
LinkDB
Structure
PDB: 
3N7S 3AQF 3N7P 3N7R 6E3Y

Position
2q32.1
AA seq 461 aa
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
NT seq 1386 nt   +upstreamnt  +downstreamnt
atggagaaaaagtgtaccctgtattttctggttctcttgcctttttttatgattcttgtt
acagcagaattagaagagagtcctgaggactcaattcagttgggagttactagaaataaa
atcatgacagctcaatatgaatgttaccaaaagattatgcaagaccccattcaacaagca
gaaggcgtttactgcaacagaacctgggatggatggctctgctggaacgatgttgcagca
ggaactgaatcaatgcagctctgccctgattactttcaggactttgatccatcagaaaaa
gttacaaagatctgtgaccaagatggaaactggtttagacatccagcaagcaacagaaca
tggacaaattatacccagtgtaatgttaacacccacgagaaagtgaagactgcactaaat
ttgttttacctgaccataattggacacggattgtctattgcatcactgcttatctcgctt
ggcatattcttttatttcaagagcctaagttgccaaaggattaccttacacaaaaatctg
ttcttctcatttgtttgtaactctgttgtaacaatcattcacctcactgcagtggccaac
aaccaggccttagtagccacaaatcctgttagttgcaaagtgtcccagttcattcatctt
tacctgatgggctgtaattacttttggatgctctgtgaaggcatttacctacacacactc
attgtggtggccgtgtttgcagagaagcaacatttaatgtggtattattttcttggctgg
ggatttccactgattcctgcttgtatacatgccattgctagaagcttatattacaatgac
aattgctggatcagttctgatacccatctcctctacattatccatggcccaatttgtgct
gctttactggtgaatctttttttcttgttaaatattgtacgcgttctcatcaccaagtta
aaagttacacaccaagcggaatccaatctgtacatgaaagctgtgagagctactcttatc
ttggtgccattgcttggcattgaatttgtgctgattccatggcgacctgaaggaaagatt
gcagaggaggtatatgactacatcatgcacatccttatgcacttccagggtcttttggtc
tctaccattttctgcttctttaatggagaggttcaagcaattctgagaagaaactggaat
caatacaaaatccaatttggaaacagcttttccaactcagaagctcttcgtagtgcgtct
tacacagtgtcaacaatcagtgatggtccaggttatagtcatgactgtcctagtgaacac
ttaaatggaaaaagcatccatgatattgaaaatgttctcttaaaaccagaaaatttatat
aattga

KEGG   Homo sapiens (human): 799
Entry
799               CDS       T01001                                 

Gene name
CALCR, CRT, CT-R, CTR, CTR1
Definition
(RefSeq) calcitonin receptor
  KO
K04576  calcitonin receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04380  Osteoclast differentiation
Disease
H01593  Osteoporosis
Drug target
Avicatonin: D09771
Calcitonin (salmon synthetic): D00249<US>
Davalintide (DG01352): D09600 D09601
Elcatonin: D03287<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    799 (CALCR)
 09150 Organismal Systems
  09158 Development and regeneration
   04380 Osteoclast differentiation
    799 (CALCR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    799 (CALCR)
G protein-coupled receptors [BR:hsa04030]
 Secretin receptor family
  Calcium-regulating peptide
   Calcitonin
    799 (CALCR)
SSDB
Motif
Pfam: 7tm_2 HRM
Other DBs
NCBI-GeneID: 799
NCBI-ProteinID: NP_001158210
OMIM: 114131
HGNC: 1440
Ensembl: ENSG00000004948
Vega: OTTHUMG00000023599
Pharos: P30988(Tclin)
UniProt: P30988 A0A0C4DG16
LinkDB
Structure
PDB: 
5II0 6NIY 5UZ7

Position
7q21.3
AA seq 474 aa
MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQ
QLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFK
HPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLGCQR
VTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCE
GIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYI
IHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFP
WRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRR
PSNRSARAAAAAAEAGDIPIYICHQELRNEPANNQGEESAEIIPLNIIEQESSA
NT seq 1425 nt   +upstreamnt  +downstreamnt
atgaggttcacatttacaagccggtgcttggcactgtttcttcttctaaatcacccaacc
ccaattcttcctgccttttcaaatcaaacctatccaacaatagagcccaagccatttctt
tacgtcgtaggacgaaagaagatgatggatgcacagtacaaatgctatgaccgaatgcag
cagttacccgcataccaaggagaaggtccatattgcaatcgcacctgggatggatggctg
tgctgggatgacacaccggctggagtattgtcctatcagttctgcccagattattttccg
gattttgatccatcagaaaaggttacaaaatactgtgatgaaaaaggtgtttggtttaaa
catcctgaaaacaatcgaacctggtccaactatactatgtgcaatgctttcactcctgag
aaactgaagaatgcatatgttctgtactatttggctattgtgggtcattctttgtcaatt
ttcaccctagtgatttccctggggattttcgtgtttttcaggagccttggctgccaaagg
gtaaccctgcacaagaacatgtttcttacttacattctgaattctatgattatcatcatc
cacctggttgaagtagtacccaatggagagctcgtgcgaagggacccggtgagctgcaag
attttgcattttttccaccagtacatgatggcctgcaactatttctggatgctctgtgaa
gggatctatcttcatacactcattgtcgtggctgtgtttactgagaagcaacgcttgcgg
tggtattatctcttgggctgggggttcccgctggtgccaaccactatccatgctattacc
agggccgtgtacttcaatgacaactgctggctgagtgtggaaacccatttgctttacata
atccatggacctgtcatggcggcacttgtggtcaatttcttctttttgctcaacattgtc
cgggtgcttgtgaccaaaatgagggaaacccatgaggcggaatcccacatgtacctgaag
gctgtgaaggccaccatgatccttgtgcccctgctgggaatccagtttgtcgtctttccc
tggagaccttccaacaagatgcttgggaagatatatgattacgtgatgcactctctgatt
catttccagggcttctttgttgcgaccatctactgcttctgcaacaatgaggtccaaacc
accgtgaagcgccaatgggcccaattcaaaattcagtggaaccagcgttgggggaggcgc
ccctccaaccgctctgctcgcgctgcagccgctgctgcggaggctggcgacatcccaatt
tacatctgccatcaggagctgaggaatgaaccagccaacaaccaaggcgaggagagtgct
gagatcatccctttgaatatcatagagcaagagtcatctgcttga

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