KEGG   Homo sapiens (human): 10242
Entry
10242             CDS       T01001                                 

Gene name
KCNMB2
Definition
(RefSeq) potassium calcium-activated channel subfamily M regulatory beta subunit 2
  KO
K04938  potassium large conductance calcium-activated channel subfamily M beta member 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04911  Insulin secretion
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    10242 (KCNMB2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    10242 (KCNMB2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    10242 (KCNMB2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    10242 (KCNMB2)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   10242 (KCNMB2)
SSDB
Motif
Pfam: CaKB KcnmB2_inactiv AAA_8 tRNA-synt_1g
Other DBs
NCBI-GeneID: 10242
NCBI-ProteinID: NP_001265840
OMIM: 605214
HGNC: 6286
Ensembl: ENSG00000197584
Vega: OTTHUMG00000157264
Pharos: Q9Y691(Tbio)
UniProt: Q9Y691 B5BNW5
LinkDB
Position
3q26.32
AA seq 235 aa
MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIM
MYFLLGITLLRSYMQSVWTEESQCTLLNASITETFNCSFSCGPDCWKLSQYPCLQVYVNL
TSSGEKLLLYHTEETIKINQKCSYIPKCGKNFEESMSLVNVVMENFRKYQHFSCYSDPEG
NQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR
NT seq 708 nt   +upstreamnt  +downstreamnt
atgtttatatggaccagtggccggacctcttcatcttatagacatgatgaaaaaagaaat
atttaccagaaaatcagggaccatgacctcctggacaaaaggaaaacagtcacagcactg
aaggcaggagaggaccgagctattctcctgggactggctatgatggtgtgctccatcatg
atgtattttctgctgggaatcacactcctgcgctcatacatgcagagcgtgtggaccgaa
gagtctcaatgcaccttgctgaatgcgtccatcacggaaacatttaattgctccttcagc
tgtggtccagactgctggaaactttctcagtacccctgcctccaggtgtacgttaacctg
acttcttccggggaaaagctcctcctctaccacacagaagagacaataaaaatcaatcag
aagtgctcctatatacctaaatgtggaaaaaattttgaagaatccatgtccctggtgaat
gttgtcatggaaaacttcaggaagtatcaacacttctcctgctattctgacccagaagga
aaccagaagagtgttatcctaacaaaactctacagttccaacgtgctgttccattcactc
ttctggccaacctgtatgatggctgggggtgtggcaattgttgccatggtgaaacttaca
cagtacctctccctactatgtgagaggatccaacggatcaatagataa

KEGG   Homo sapiens (human): 157855
Entry
157855            CDS       T01001                                 

Gene name
KCNU1, KCNMC1, KCa5, KCa5.1, Kcnma3, Slo3
Definition
(RefSeq) potassium calcium-activated channel subfamily U member 1
  KO
K05274  potassium large conductance calcium-activated channel subfamily M alpha member 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04911  Insulin secretion
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    157855 (KCNU1)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    157855 (KCNU1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    157855 (KCNU1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    157855 (KCNU1)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   157855 (KCNU1)
SSDB
Motif
Pfam: BK_channel_a Ion_trans Ion_trans_2
Other DBs
NCBI-GeneID: 157855
NCBI-ProteinID: NP_001027006
OMIM: 615215
HGNC: 18867
Ensembl: ENSG00000215262
Vega: OTTHUMG00000163981
Pharos: A8MYU2(Tbio)
UniProt: A8MYU2
LinkDB
Structure
PDB: 
4HPF

Position
8p11.23
AA seq 1149 aa
MFQTKLRNETWEDLPKMSCTTEIQAAFILSSFVTFFSGLIILLIFRLIWRSVKKWQIIKG
TGIILELFTSGTIARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIY
FINSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIP
PTFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAG
FIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGS
LILFANYIPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEI
NTEIVFLGETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCS
DSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKL
GFIAQGCLVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFP
EVARLCFLKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRAL
FYCSVCHDDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSAS
TSSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACV
FGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCA
LYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVS
EETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTV
FSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNR
CKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITR
PANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHSDTNCPPTIDS
VTETLYSPVYSYQPRTNSLSFPKQIAWNQSRTNSIISSQIPLGDNAKENERKTSDEVYDE
DPFAYSEPL
NT seq 3450 nt   +upstreamnt  +downstreamnt
atgtttcagactaagctacgaaatgaaacttgggaagacttgccaaaaatgtcctgcaca
actgagatccaagcagcattcattctctcttcctttgtgaccttcttcagtggactcatc
atcctgttgatcttcaggctgatctggagatctgttaaaaaatggcaaatcatcaaggga
acaggaattatcttggaactgttcacatcaggtaccatcgctaggagccatgtaagaagc
ctccacttccagggacaatttcgtgatcatatagaaatgttgctttcagcccagaccttt
gtggggcaagtgttggtgatccttgtctttgtactaagcattgggtctcttataatctat
ttcatcaattctgctgaccctgttggaagctgttcatcatatgaagacaaaaccattcct
attgatttggttttcaatgctttctttagtttctattttggattgaggtttatggcagct
gatgacaagatcaagttctggctggagatgaattcaatcgtagacatctttaccatccca
ccaacctttatttcttattatttgaagagcaattggctaggtttaaggttcctaagagcc
ttgcgcctgctagaactccctcaaatcttgcaaattctacgagccatcaagaccagtaac
tcagtgaagttttccaaactgctgtcaataattctcagtacctggttcacagctgcggga
ttcattcacctggtggaaaattctggtgatccctggctcaaaggtagaaattcacagaat
atatcatattttgagtcaatttacctggtcatggcaacaacgtcaaccgttggatttgga
gatgtggtagccaagacatccttaggacggaccttcatcatgttcttcacactggggagt
ttgatattatttgcgaactatatacctgaaatggtggaactgtttgctaacaagaggaaa
tacaccagttcctatgaagcactcaaaggaaagaagtttattgtggtctgtggaaacatc
actgtggacagtgtgaccgctttcctgaggaatttcctccgcgacaagtcaggagagatc
aacactgaaattgttttcctgggagaaacccctccttctttggaacttgaaaccatattt
aaatgctacttggcctacacaacgttcatttctggatctgcaatgaagtgggaggatctg
aggcgagttgcggtggaatctgcagaggcatgcctgattatagccaatcctttgtgcagt
gattcccatgctgaagatatttccaacattatgagggtgctctctatcaagaactatgat
tctaccaccagaatcatcatacagatactgcaatcccataacaaggtttatctgccaaag
attcccagctggaactgggacaccggagacaacatcatctgctttgctgaattaaaactt
ggatttatcgcccaaggctgtttggtgccaggcttgtgtaccttcctaacatctctattt
gtggagcaaaacaaaaaggttatgcctaaacagacctggaagaaacacttcttgaatagc
atgaaaaacaaaattctgacccaacgtctctctgatgactttgctggaatgagctttcct
gaagttgcccggctctgctttctgaagatgcacctcctgttgatagccatcgaatacaag
tccctctttacggatggtttctgtggtctgatactaaatccacctccacaagtgaggata
cgtaagaacacattagggttctttattgctgaaactccaaaggacgtcagaagagccttg
ttttactgttcagtctgtcatgatgatgtgttcattcctgagctaattacaaactgtggc
tgcaaaagcagaagccggcagcacatcacagtgccatcggtaaagagaatgaaaaaatgt
ctgaagggaatctcctctcgtatatcagggcaggattctccgccaagggtatctgcaagc
acttcgagcatatcaaacttcaccaccaggactcttcaacatgatgtagaacaagattct
gaccagcttgatagcagtgggatgtttcactggtgcaaaccaacctctttggacaaggtg
actctgaaacgaactggcaagtcaaagtataagtttcggaaccatattgtagcatgtgta
tttggagatgcccactcagccccgatggggcttcggaactttgtaatgcccttgagagcc
agcaactataccaggaaggagctgaaggacatagtgttcattgggtctctggactatcta
cagagagaatggcgatttctctggaattttccccagatatacattctgcctggatgtgca
ctttattctggagacctccatgcggccaacatagagcaatgctccatgtgtgctgtcttg
tcccccccaccccagccatcaagcaaccagactttggtagacacagaagccatcatggca
accctcaccatcggatccttgcaaattgactcctcctctgacccgtcaccctcagtgtca
gaggagactccaggttacacaaatggacataatgagaaatcaaactgccgaaaagtccct
atccttactgaactgaaaaatccttccaacattcactttattgaacagcttggtggactg
gaagggtccctccaagaaacaaatctgcatctcagcactgccttttctacgggcactgtt
ttttccggcagcttcttggattctctgctggccacggccttctacaattatcatgtcctg
gaattgcttcagatgctggtgacaggaggagtaagttctcagctggaacaacatttagat
aaggataaagtctatggtgtggcagatagctgcacgtcgctcttgtctggaagaaaccgg
tgtaagctggggcttctgtccttacacgaaaccattttatcagacgttaatccaagaaac
acctttggacaactgttctgtggctcattagatctttttggaatcctgtgtgttggctta
taccgaataattgatgaagaggagctcaacccagaaaacaaaaggtttgtgatcacccgg
ccagccaatgagttcaagctgctgccttcagatcttgtgttttgtgccatacccttcagc
actgcttgttataaaaggaatgaagagttctcattgcaaaagtcatatgaaattgtaaat
aaagcatcacagacaacagagacacattcagacacaaattgtcctcccaccattgattca
gttactgagacattgtattcaccagtctattcttaccagccgagaactaactccctctct
tttcctaagcaaatagcatggaatcagagtagaacaaacagtattatatcatctcagata
cctttaggtgacaatgcaaaagaaaatgaaaggaaaacttcagatgaggtttatgatgag
gatccctttgcatattcagagccactatag

KEGG   Homo sapiens (human): 27094
Entry
27094             CDS       T01001                                 

Gene name
KCNMB3, BKBETA3, HBETA3, K(VCA)BETA-3, KCNMB2, KCNMBL, SLO-BETA-3, SLOBETA3
Definition
(RefSeq) potassium calcium-activated channel subfamily M regulatory beta subunit 3
  KO
K04939  potassium large conductance calcium-activated channel subfamily M beta member 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04911  Insulin secretion
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    27094 (KCNMB3)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    27094 (KCNMB3)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    27094 (KCNMB3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    27094 (KCNMB3)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   27094 (KCNMB3)
SSDB
Motif
Pfam: CaKB tRNA-synt_1g
Other DBs
NCBI-GeneID: 27094
NCBI-ProteinID: NP_055222
OMIM: 605222
HGNC: 6287
Ensembl: ENSG00000171121
Vega: OTTHUMG00000157337
Pharos: Q9NPA1(Tbio)
UniProt: Q9NPA1
LinkDB
Position
3q26.32
AA seq 279 aa
MDFSPSSELGFHFVAFILLTRHRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVM
LGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQ
GKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDH
KNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLL
CEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS
NT seq 840 nt   +upstreamnt  +downstreamnt
atggacttttcaccaagctctgaactgggatttcattttgttgcattcatcctgctcacg
agacacaggacagcctttcctgcctcagggaagaagagagagacagactacagtgatgga
gacccactagatgtgcacaagaggctgccatccagtgctggagaggaccgagccgtgatg
ctggggtttgccatgatgggcttctcagtcctaatgttcttcttgctcggaacaaccatt
ctaaagccttttatgctcagcattcagagagaagaatcgacctgcactgccatccacaca
gatatcatggacgactggctggactgtgccttcacctgtggtgtgcactgccacggtcag
gggaagtacccgtgtcttcaggtgtttgtgaacctcagccatccaggtcagaaagctctc
ctacattataatgaagaggctgtccagataaatcccaagtgcttttacacacctaagtgc
caccaagatagaaatgatttgctcaacagtgctctggacataaaagaattcttcgatcac
aaaaatggaacccccttttcatgcttctacagtccagccagccaatctgaagatgtcatt
cttataaaaaagtatgaccaaatggctatcttccactgtttattttggccttcactgact
ctgctaggtggtgccctgattgttggcatggtgagattaacacaacacctgtccttactg
tgtgaaaaatatagcactgtagtcagagatgaggtaggtggaaaagtaccttatatagaa
cagcatcagttcaaactgtgcattatgaggaggagcaaaggaagagcagagaaatcttaa

KEGG   Homo sapiens (human): 27345
Entry
27345             CDS       T01001                                 

Gene name
KCNMB4
Definition
(RefSeq) potassium calcium-activated channel subfamily M regulatory beta subunit 4
  KO
K04941  potassium large conductance calcium-activated channel subfamily M beta member 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04911  Insulin secretion
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    27345 (KCNMB4)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    27345 (KCNMB4)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    27345 (KCNMB4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    27345 (KCNMB4)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   27345 (KCNMB4)
SSDB
Motif
Pfam: CaKB
Other DBs
NCBI-GeneID: 27345
NCBI-ProteinID: NP_055320
OMIM: 605223
HGNC: 6289
Ensembl: ENSG00000135643
Vega: OTTHUMG00000167586
Pharos: Q86W47(Tbio)
UniProt: Q86W47
LinkDB
Structure
PDB: 
5Y7L

Position
12q15
AA seq 210 aa
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQ
QIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCK
RENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVT
FVVGVLIVVLTICAKSLAVKAEAMKKRKFS
NT seq 633 nt   +upstreamnt  +downstreamnt
atggcgaagctccgggtggcttacgagtacacggaagccgaggacaagagcatccggctc
ggcttgtttctcatcatctccggcgtcgtgtcgctcttcatcttcggcttctgctggctg
agtcccgcgctgcaggatctgcaagccacggaggccaattgcacggtgctgtcggtgcag
cagatcggcgaggtgttcgagtgcaccttcacctgtggcgccgactgcaggggcacctcg
cagtacccctgcgtccaggtctacgtgaacaactctgagtccaactctagggcgctgctg
cacagcgacgagcaccagctcctgaccaaccccaagtgctcctatatccctccctgtaag
agagaaaatcagaagaatttggaaagtgtcatgaattggcaacagtactggaaagatgag
attggttcccagccatttacttgctattttaatcaacatcaaagaccagatgatgtgctt
ctgcatcgcactcatgatgagattgtcctcctgcattgcttcctctggcccctggtgaca
tttgtggtgggcgttctcattgtggtcctgaccatctgtgccaagagcttggcggtcaag
gcggaagccatgaagaagcgcaagttctcttaa

KEGG   Homo sapiens (human): 3778
Entry
3778              CDS       T01001                                 

Gene name
KCNMA1, BKTM, CADEDS, IEG16, KCa1.1, LIWAS, MaxiK, PNKD3, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, hSlo, mSLO1
Definition
(RefSeq) potassium calcium-activated channel subfamily M alpha 1
  KO
K04936  potassium large conductance calcium-activated channel subfamily M alpha member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04911  Insulin secretion
hsa04924  Renin secretion
hsa04970  Salivary secretion
hsa04972  Pancreatic secretion
Disease
H01258  Generalized epilepsy and paroxysmal dyskinesia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    3778 (KCNMA1)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    3778 (KCNMA1)
   04924 Renin secretion
    3778 (KCNMA1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    3778 (KCNMA1)
  09154 Digestive system
   04970 Salivary secretion
    3778 (KCNMA1)
   04972 Pancreatic secretion
    3778 (KCNMA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3778 (KCNMA1)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   3778 (KCNMA1)
SSDB
Motif
Pfam: BK_channel_a Ion_trans Ion_trans_2 TrkA_N Lig_chan
Other DBs
NCBI-GeneID: 3778
NCBI-ProteinID: NP_001154824
OMIM: 600150
HGNC: 6284
Ensembl: ENSG00000156113
Vega: OTTHUMG00000018543
Pharos: Q12791(Tclin)
UniProt: Q12791
LinkDB
Structure
PDB: 
3MT5 3NAF

Position
10q22.3
AA seq 1236 aa
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS
VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH
CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL
WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL
VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES
VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK
IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW
NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE
MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG
FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERD
CSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPN
TSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSG
HVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVS
ILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIG
VLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDD
DPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEEN
ALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRL
RDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSS
KKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL
NT seq 3711 nt   +upstreamnt  +downstreamnt
atggcaaatggtggcggcggcggcggcggcagcagcggcggcggcggcggcggcggaggc
agcagtcttagaatgagtagcaatatccacgcgaaccatctcagcctagacgcgtcctcc
tcctcctcctcctcctcttcctcttcttcttcttcctcctcctcttcctcctcgtcctcg
gtccacgagcccaagatggatgcgctcatcatcccggtgaccatggaggtgccgtgcgac
agccggggccaacgcatgtggtgggctttcctggcctcctccatggtgactttcttcggg
ggcctcttcatcatcttgctctggcggacgctcaagtacctgtggaccgtgtgctgccac
tgcgggggcaagacgaaggaggcccagaagattaacaatggctcaagccaggcggatggc
actctcaaaccagtggatgaaaaagaggaggcagtggccgccgaggtcggctggatgacc
tccgtgaaggactgggcgggggtgatgatatccgcccagacactgactggcagagtcctg
gttgtcttagtctttgctctcagcatcggtgcacttgtaatatacttcatagattcatca
aacccaatagaatcctgccagaatttctacaaagatttcacattacagatcgacatggct
ttcaacgtgttcttccttctctacttcggcttgcggtttattgcagccaacgataaattg
tggttctggctggaagtgaactctgtagtggatttcttcacggtgccccccgtgtttgtg
tctgtgtacttaaacagaagttggcttggtttgagatttttaagagctctgagactgata
cagttttcagaaattttgcagtttctgaatattcttaaaacaagtaattccatcaagctg
gtgaatctgctctccatatttatcagcacgtggctgactgcagccgggttcatccatttg
gtggagaattcaggggacccatgggaaaatttccaaaacaaccaggctctcacctactgg
gaatgtgtctatttactcatggtcacaatgtccaccgttggttatggggatgtttatgca
aaaaccacacttgggcgcctcttcatggtcttcttcatcctcgggggactggccatgttt
gccagctacgtccctgaaatcatagagttaataggaaaccgcaagaaatacgggggctcc
tatagtgcggttagtggaagaaagcacattgtggtctgcggacacatcactctggagagt
gtttccaacttcctgaaggactttctgcacaaggaccgggatgacgtcaatgtggagatc
gtttttcttcacaacatctcccccaacctggagcttgaagctctgttcaaacgacatttt
actcaggtggaattttatcagggttccgtcctcaatccacatgatcttgcaagagtcaag
atagagtcagcagatgcatgcctgatccttgccaacaagtactgcgctgacccggatgcg
gaggatgcctcgaatatcatgagagtaatctccataaagaactaccatccgaagataaga
atcatcactcaaatgctgcagtatcacaacaaggcccatctgctaaacatcccgagctgg
aattggaaagaaggtgatgacgcaatctgcctcgcagagttgaagttgggcttcatagcc
cagagctgcctggctcaaggcctctccaccatgcttgccaacctcttctccatgaggtca
ttcataaagattgaggaagacacatggcagaaatactacttggaaggagtctcaaatgaa
atgtacacagaatatctctccagtgccttcgtgggtctgtccttccctactgtttgtgag
ctgtgttttgtgaagctcaagctcctaatgatagccattgagtacaagtctgccaaccga
gagagccgtatattaattaatcctggaaaccatcttaagatccaagaaggtactttagga
tttttcatcgcaagtgatgccaaagaagttaaaagggcatttttttactgcaaggcctgt
catgatgacatcacagatcccaaaagaataaaaaaatgtggctgcaaacggcccaagatg
tccatctacaagagaatgagacgggcatgttgttttgattgcggacgttctgagcgtgac
tgctcatgcatgtcaggccgtgtgcgtggtaacgtggacacccttgagagagccttccca
ctttcttctgtctctgttaatgattgctccaccagtttccgtgcctttgaagatgagcag
ccgtcaacactatcaccaaaaaaaaagcaacggaatggaggcatgcggaactcacccaac
acctcgcctaagctgatgaggcatgaccccttgttaattcctggcaatgatcagattgac
aacatggactccaatgtgaagaagtacgactctactgggatgtttcactggtgtgcaccc
aaggagatagagaaagtcatcctgactcgaagtgaagctgccatgaccgtcctgagtggc
catgtcgtggtctgcatctttggcgacgtcagctcagccctgatcggcctccggaacctg
gtgatgccgctccgtgccagcaactttcattaccatgagctcaagcacattgtgtttgtg
ggctctattgagtacctcaagcgggaatgggagacgcttcataacttccccaaagtgtcc
atattgcctggtacgccattaagtcgggctgatttaagggctgtcaacatcaacctctgt
gacatgtgcgttatcctgtcagccaatcagaataatattgatgatacttcgctgcaggac
aaggaatgcatcttggcgtcactcaacatcaaatctatgcagtttgatgacagcatcgga
gtcttgcaggctaattcccaagggttcacacctccaggaatggatagatcctctccagat
aacagcccagtgcacgggatgttacgtcaaccatccatcacaactggggtcaacatcccc
atcatcactgaactagtgaacgatactaatgttcagtttttggaccaagacgatgatgat
gaccctgatacagaactgtacctcacgcagccctttgcctgtgggacagcatttgccgtc
agtgtcctggactcactcatgagcgcgacgtacttcaatgacaatatcctcaccctgata
cggaccctggtgaccggaggagccacgccggagctggaggctctgattgctgaggaaaac
gcccttagaggtggctacagcaccccgcagacactggccaatagggaccgctgccgcgtg
gcccagttagctctgctcgatgggccatttgcggacttaggggatggtggttgttatggt
gatctgttctgcaaagctctgaaaacatataatatgctttgttttggaatttaccggctg
agagatgctcacctcagcacccccagtcagtgcacaaagaggtatgtcatcaccaacccg
ccctatgagtttgagctcgtgccgacggacctgatcttctgcttaatgcagtttgaccac
aatgccggccagtcccgggccagcctgtcccattcctcccactcgtcgcagtcctccagc
aagaagagctcctctgttcactccatcccatccacagcaaaccgacagaaccggcccaag
tccagggagtcccgggacaaacagaagtacgtgcaggaagagcggctttga

KEGG   Homo sapiens (human): 3779
Entry
3779              CDS       T01001                                 

Gene name
KCNMB1, BKbeta1, K(VCA)beta, SLO-BETA, hbeta1, hslo-beta, k(VCA)beta-1, slo-beta-1
Definition
(RefSeq) potassium calcium-activated channel subfamily M regulatory beta subunit 1
  KO
K04937  potassium large conductance calcium-activated channel subfamily M beta member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04911  Insulin secretion
Drug target
Flindokalner: D04192
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    3779 (KCNMB1)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    3779 (KCNMB1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    3779 (KCNMB1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3779 (KCNMB1)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   3779 (KCNMB1)
SSDB
Motif
Pfam: CaKB UL41A
Other DBs
NCBI-GeneID: 3779
NCBI-ProteinID: NP_004128
OMIM: 603951
HGNC: 6285
Ensembl: ENSG00000145936
Vega: OTTHUMG00000130439
Pharos: Q16558(Tbio)
UniProt: Q16558
LinkDB
Position
5q35.1
AA seq 191 aa
MVKKLVMAQKRGETRALCLGVTMVVCAVITYYILVTTVLPLYQKSVWTQESKCHLIETNI
RDQEELKGKKVPQYPCLWVNVSAAGRWAVLYHTEDTRDQNQQCSYIPGSVDNYQTARADV
EKVRAKFQEQQVFYCFSAPRGNETSVLFQRLYGPQALLFSLFWPTFLLTGGLLIIAMVKS
NQYLSILAAQK
NT seq 576 nt   +upstreamnt  +downstreamnt
atggtgaagaagctggtgatggcccagaagcggggagagacacgagccctttgcctgggt
gtaaccatggtggtgtgtgccgtcatcacctactacatcctggtcacgactgtgctgccc
ctctaccagaaaagcgtgtggacccaggaatccaagtgccacctgattgagaccaacatc
agggaccaggaggagctgaagggcaagaaggtgccccagtacccatgcctgtgggtcaac
gtgtcagctgccggcaggtgggctgtgctgtaccacacggaggacactcgggaccagaac
cagcagtgctcctacatcccaggcagcgtggacaattaccagacggcccgggccgacgtg
gagaaggtcagagccaaattccaagagcagcaggtcttctactgcttctccgcacctcgg
gggaacgaaaccagcgtcctattccagcgcctctacgggccccaggccctcctcttctcc
ctcttctggcccaccttcctgctgaccggtggcctcctcattatcgccatggtgaagagc
aaccagtacctgtccatcctggcggcccagaagtag

KEGG   Homo sapiens (human): 3780
Entry
3780              CDS       T01001                                 

Gene name
KCNN1, KCa2.1, SK1, SKCA1, hSK1
Definition
(RefSeq) potassium calcium-activated channel subfamily N member 1
  KO
K04942  potassium intermediate/small conductance calcium-activated channel subfamily N member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04911  Insulin secretion
hsa04929  GnRH secretion
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    3780 (KCNN1)
   04929 GnRH secretion
    3780 (KCNN1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3780 (KCNN1)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   3780 (KCNN1)
SSDB
Motif
Pfam: SK_channel CaMBD Ion_trans_2 Seryl_tRNA_N DALR_1 Laminin_II IRK
Other DBs
NCBI-GeneID: 3780
NCBI-ProteinID: NP_002239
OMIM: 602982
HGNC: 6290
Ensembl: ENSG00000105642
Vega: OTTHUMG00000183482
Pharos: Q92952(Tchem)
UniProt: Q92952
LinkDB
Position
19p13.11
AA seq 543 aa
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPR
GQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVV
MVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIA
MTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYL
LGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWT
VRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTAL
VVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARV
RKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEA
RLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPS
DCG
NT seq 1632 nt   +upstreamnt  +downstreamnt
atgaacagccacagctacaatggcagcgtggggcggccgctgggcagcgggccgggcgcc
ctgggacgagaccctccggaccctgaggccggccaccccccacaacccccgcacagcccg
ggcctccaggtggtagtggccaagagtgagccagcccggccctcacccggcagcccccgg
gggcagccccaggaccaggacgatgacgaggatgatgaggaagatgaggccggcaggcag
agagcctcggggaaaccctcaaatgtgggccaccgcctgggccaccggcgggcgctcttc
gagaagcggaagcgcctcagcgactatgccctcattttcggcatgtttggcatcgtcgtc
atggtgacggagaccgagctgtcctggggggtgtacaccaaggagtctctgtactcattc
gcactcaaatgcctcatcagcctctccacggccatcctgctgggtctcgttgtcctctac
catgcccgggagatccagctgttcatggtggacaacggggctgatgactggcgcatcgcc
atgacctgcgagcgcgtgttcctcatctcgctagagctggcagtgtgcgccattcacccg
gtgcccggccactaccgcttcacgtggacggcgcggctggccttcacgtacgcgccctcg
gtggccgaggccgacgtggacgtgctgctgtccatccccatgttcctgcgcctctacctg
ctgggccgggtgatgctactgcacagcaaaatcttcacggacgcctcgagccgcagcatc
ggggccctcaacaagatcaccttcaacacgcgcttcgtcatgaagacactcatgaccatc
tgccccggcaccgtgctgctggtcttcagcatctcctcctggatcatcgcagcctggacc
gtgcgcgtctgcgagaggtaccacgacaagcaggaagtgaccagcaacttcctgggggcc
atgtggctgatttccatcaccttcctctccattggctacggcgacatggtgccccacacc
tactgcgggaagggtgtgtgcctgctcactggcatcatgggagctggctgtaccgcgctc
gtggtggctgtggtggctcggaagctggagctcaccaaggctgagaagcacgtgcacaac
ttcatgatggacactcagctcaccaagcgggtaaaaaacgccgctgctaacgttctcagg
gagacgtggctcatctacaaacataccaggctggtgaagaagccagaccaagcccgggtt
cggaaacaccagcgtaagttcctccaagccatccatcaggctcagaagctccggagtgtg
aagatcgagcaagggaagctgaacgaccaggctaacacgcttaccgacctagccaagacc
cagaccgtcatgtacgaccttgtatcggagctgcacgctcagcacgaggagctggaggcc
cgcctggccaccctggaaagccgcttggatgcgctgggtgcctctctacaggccctgcct
ggcctcatcgcccaagccatacgcccacccccgcctcccctgcctcccaggcccggcccc
ggcccccaagaccaggcagcccggagctccccctgccggtggacgcccgtggccccctcg
gactgcgggtga

KEGG   Homo sapiens (human): 3781
Entry
3781              CDS       T01001                                 

Gene name
KCNN2, KCa2.2, SK2, SKCA2, SKCa_2, hSK2
Definition
(RefSeq) potassium calcium-activated channel subfamily N member 2
  KO
K04943  potassium intermediate/small conductance calcium-activated channel subfamily N member 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04726  Serotonergic synapse
hsa04911  Insulin secretion
hsa04929  GnRH secretion
hsa04976  Bile secretion
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    3781 (KCNN2)
   04929 GnRH secretion
    3781 (KCNN2)
  09154 Digestive system
   04976 Bile secretion
    3781 (KCNN2)
  09156 Nervous system
   04726 Serotonergic synapse
    3781 (KCNN2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3781 (KCNN2)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   3781 (KCNN2)
SSDB
Motif
Pfam: SK_channel CaMBD Ion_trans_2 Med9 YvrJ IRK
Other DBs
NCBI-GeneID: 3781
NCBI-ProteinID: NP_067627
OMIM: 605879
HGNC: 6291
Ensembl: ENSG00000080709
Vega: OTTHUMG00000128836
Pharos: Q9H2S1(Tchem)
UniProt: Q9H2S1
LinkDB
Structure
PDB: 
5V03 5V02 5WBX 5WC5 6ALE

Position
5q22.3
AA seq 791 aa
METPLQFQRGFFPEQPPPPPRSSHLHCQQQQQSQDKPCPPFAPLPHPHHHPHLAHQQPAS
GGSSPCLRCNSCASSGAPAAGAGDNLSLLLRTSSPGGAFRTRTSSPLSGSSCCCCCCSSR
RGSQLNVSELTPSSHASALRQQYAQQSAQQSASASQYHQCHSLQPAASPTGSLGSLGSGP
PLSHHHHHPHPAHHQHHQPQARRESNPFTEIAMSSCRYNGGVMRPLSNLSASRRNLHEMD
SEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGG
STGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVV
MVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIA
MTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYL
IARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWT
VRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTAL
VVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKV
RKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIV
TLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSS
STAPPTSSESS
NT seq 2376 nt   +upstreamnt  +downstreamnt
atggaaaccccattgcagttccagcgcggcttcttcccagagcagccgccgccgccgccg
cgctcctcacacctgcattgccagcagcagcaacagagccaggacaagccgtgcccgccc
ttcgcgcccctcccgcaccctcaccaccacccgcacctcgcgcaccagcagccggccagc
ggcggcagcagcccatgcctccggtgcaacagctgcgcctcctccggtgccccggcggcg
ggggcgggagataacctgtccctgctgctccgcacctcctcgcccggcggcgccttccgg
acccgcacctcctcgccgctgtcgggctcgtcctgctgctgctgctgctgctcgtcgcgc
cggggcagccagctcaatgtgagcgagctgacgccgtccagccatgccagtgcgctccgg
cagcagtacgcgcagcagtccgcgcagcagtcggcgtccgcctcccagtaccaccagtgc
cacagcctgcagcccgccgccagccccacgggcagcctcggcagtctgggctccgggccc
ccgctctcgcaccaccaccaccacccgcacccggcgcaccaccagcaccaccagccccag
gcgcgccgcgagagcaaccccttcaccgaaatagccatgagcagctgcaggtacaacggg
ggcgtcatgcggccgctcagcaacttgagcgcgtcccgccggaacctgcacgagatggac
tcagaggcgcagcccctgcagccccccgcgtctgtcggaggaggtggcggcgcgtcctcc
ccgtctgcagccgctgccgccgccgccgctgtttcgtcctcagcccccgagatcgtggtg
tctaagcccgagcacaacaactccaacaacctggcgctctatggaaccggcggcggaggc
agcactggaggaggcggcggcggtggcgggagcgggcacggcagcagcagtggcaccaag
tccagcaaaaagaaaaaccagaacatcggctacaagctgggccaccggcgcgccctgttc
gaaaagcgcaagcggctcagcgactacgcgctcatcttcggcatgttcggcatcgtggtc
atggtcatcgagaccgagctgtcgtggggcgcctacgacaaggcgtcgctgtattcctta
gctctgaaatgccttatcagtctctccacgatcatcctgctcggtctgatcatcgtgtac
cacgccagggaaatacagttgttcatggtggacaatggagcagatgactggagaatagcc
atgacttatgagcgtattttcttcatctgcttggaaatactggtgtgtgctattcatccc
atacctgggaattatacattcacatggacggcccggcttgccttctcctatgccccatcc
acaaccaccgctgatgtggatattattttatctataccaatgttcttaagactctatctg
attgccagagtcatgcttttacatagcaaacttttcactgatgcctcctctagaagcatt
ggagcacttaataagataaacttcaatacacgttttgttatgaagactttaatgactata
tgcccaggaactgtactcttggtttttagtatctcattatggataattgccgcatggact
gtccgagcttgtgaaaggtaccatgatcaacaggatgttactagcaacttccttggagcg
atgtggttgatatcaataacttttctctccattggttatggtgacatggtacctaacaca
tactgtggaaaaggagtctgcttacttactggaattatgggtgctggttgcacagccctg
gtggtagctgtagtggcaaggaagctagaacttaccaaagcagaaaaacacgtgcacaat
ttcatgatggatactcagctgactaaaagagtaaaaaatgcagctgccaatgtactcagg
gaaacatggctaatttacaaaaatacaaagctagtgaaaaagatagatcatgcaaaagta
agaaaacatcaacgaaaattcctgcaagctattcatcaattaagaagtgtaaaaatggag
cagaggaaactgaatgaccaagcaaacactttggtggacttggcaaagacccagaacatc
atgtatgatatgatttctgacttaaacgaaaggagtgaagacttcgagaagaggattgtt
accctggaaacaaaactagagactttgattggtagcatccacgccctccctgggctcata
agccagaccatcaggcagcagcagagagatttcattgaggctcagatggagagctacgac
aagcacgtcacttacaatgctgagcggtcccggtcctcgtccaggaggcggcggtcctct
tccacagcaccaccaacttcatcagagagtagctag

KEGG   Homo sapiens (human): 3782
Entry
3782              CDS       T01001                                 

Gene name
KCNN3, KCa2.3, SK3, SKCA3, ZLS3, hSK3
Definition
(RefSeq) potassium calcium-activated channel subfamily N member 3
  KO
K04944  potassium intermediate/small conductance calcium-activated channel subfamily N member 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04911  Insulin secretion
hsa04929  GnRH secretion
Disease
H01573  Zimmermann-Laband syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    3782 (KCNN3)
   04929 GnRH secretion
    3782 (KCNN3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3782 (KCNN3)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   3782 (KCNN3)
SSDB
Motif
Pfam: SK_channel CaMBD Ion_trans_2 IRK
Other DBs
NCBI-GeneID: 3782
NCBI-ProteinID: NP_002240
OMIM: 602983
HGNC: 6292
Ensembl: ENSG00000143603
Vega: OTTHUMG00000037260
Pharos: Q9UGI6(Tchem)
UniProt: Q9UGI6
LinkDB
Position
1q21.3
AA seq 731 aa
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQ
PQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAIL
HPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKY
SGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNAT
HNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVI
ETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTY
ERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIAR
VMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRV
CERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVA
VVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKH
QRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLE
SKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTS
FPTPYTSSSSC
NT seq 2196 nt   +upstreamnt  +downstreamnt
atggacacttctgggcacttccatgactcgggggtgggggacttggatgaagaccccaag
tgcccctgtccatcctctggggatgagcagcagcagcagcagcagcagcaacagcagcag
cagccaccaccgccagcgccaccagcagccccccagcagcccctgggaccctcgctgcag
cctcagcctccgcagcttcagcagcagcagcagcagcagcagcagcagcagcagcagcag
ccaccgcatcccctgtctcagctcgcccaactccagagccagcccgtccaccctggcctg
ctgcactcctctcccaccgctttcagggcccccccttcgtccaactccaccgccatcctc
cacccttcctccaggcaaggcagccagctcaatctcaatgaccacttgcttggccactct
ccaagttccacagctacaagtgggcctggcggaggcagccggcaccgacaggccagcccc
ctggtgcaccggcgggacagcaaccccttcacggagatcgccatgagctcctgcaagtat
agcggtggggtcatgaagcccctcagccgcctcagcgcctcccggaggaacctcatcgag
gccgagactgagggccaacccctccagcttttcagccctagcaaccccccggagatcgtc
atctcctcccgggaggacaaccatgcccaccagaccctgctccatcaccctaatgccacc
cacaaccaccagcatgccggcaccaccgccagcagcaccaccttccccaaagccaacaag
cggaaaaaccaaaacattggctataagctgggacacaggagggccctgtttgaaaagaga
aagcgactgagtgactatgctctgatttttgggatgtttggaattgttgttatggtgata
gagaccgagctctcttggggtttgtactcaaaggactccatgttttcgttggccctgaaa
tgccttatcagtctgtccaccatcatccttttgggcttgatcatcgcctaccacacacgt
gaagtccagctcttcgtgatcgacaatggcgcggatgactggcggatagccatgacctac
gagcgcatcctgtacatcagcctggagatgctggtgtgcgccatccaccccattcctggc
gagtacaagttcttctggacggcacgcctggccttctcctacacaccctcccgggcggag
gccgatgtggacatcatcctgtctatccccatgttcctgcgcctgtacctgatcgcccga
gtcatgctgctgcacagcaagctcttcaccgatgcctcgtcccgcagcatcggggccctc
aacaagatcaacttcaacacccgctttgtcatgaagacgctcatgaccatctgccctggc
actgtgctgctcgtgttcagcatctctctgtggatcattgctgcctggaccgtccgtgtc
tgtgaaaggtaccatgaccagcaggacgtaactagtaactttctgggtgccatgtggctc
atctccatcacattcctttccattggttatggggacatggtgccccacacatactgtggg
aaaggtgtctgtctcctcactggcatcatgggtgcaggctgcactgcccttgtggtggcc
gtggtggcccgaaagctggaactcaccaaagcggagaagcacgttcataacttcatgatg
gacactcagctcaccaagcggatcaagaatgctgcagccaatgtccttcgggaaacatgg
ttaatctataaacacacaaagctgctaaagaagattgaccatgccaaagtgaggaaacac
cagaggaagttcctccaagctatccaccagttgaggagcgtcaagatggaacagaggaag
ctgagtgaccaagccaacactctggtggacctttccaagatgcagaatgtcatgtatgac
ttaatcacagaactcaatgaccggagcgaagacctggagaagcagattggcagcctggag
tcgaagctggagcatctcaccgccagcttcaactccctgccgctgctcatcgccgacacc
ctgcgccagcagcagcagcagctcctgtctgccatcatcgaggcccggggtgtcagcgtg
gcagtgggcaccacccacaccccaatctccgatagccccattggggtcagctccacctcc
ttcccgaccccgtacacaagttcaagcagttgctaa

KEGG   Homo sapiens (human): 3783
Entry
3783              CDS       T01001                                 

Gene name
KCNN4, DHS2, IK, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4
Definition
(RefSeq) potassium calcium-activated channel subfamily N member 4
  KO
K04945  potassium intermediate/small conductance calcium-activated channel subfamily N member 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04911  Insulin secretion
hsa04929  GnRH secretion
hsa04970  Salivary secretion
hsa04974  Protein digestion and absorption
Disease
H00232  Hereditary stomatocytosis
H01978  Dehydrated hereditary stomatocytosis
Drug target
Senicapoc: D06640
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    3783 (KCNN4)
   04929 GnRH secretion
    3783 (KCNN4)
  09154 Digestive system
   04970 Salivary secretion
    3783 (KCNN4)
   04974 Protein digestion and absorption
    3783 (KCNN4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    3783 (KCNN4)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Potassium channel, calcium- and sodium-activated (KCa/KNa)
   3783 (KCNN4)
SSDB
Motif
Pfam: SK_channel CaMBD Ion_trans_2 Ion_trans
Other DBs
NCBI-GeneID: 3783
NCBI-ProteinID: NP_002241
OMIM: 602754
HGNC: 6293
Ensembl: ENSG00000104783
Vega: OTTHUMG00000182779
Pharos: O15554(Tchem)
UniProt: O15554
LinkDB
Structure
PDB: 
6D42 6CNM 6CNN 6CNO

Position
19q13.31
AA seq 427 aa
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgggcggggatctggtgcttggcctgggggccttgagacgccgaaagcgcttgctggag
caggagaagtctctggccggctgggcactggtgctggcaggaactggcattggactcatg
gtgctgcatgcagagatgctgtggttcggggggtgctcgtgggcgctctacctgttcctg
gttaaatgcacgatcagcatttccaccttcttactcctctgcctcatcgtggcctttcat
gccaaagaggtccagctgttcatgaccgacaacgggctgcgggactggcgcgtggcgctg
accgggcggcaggcggcgcagatcgtgctggagctggtggtgtgtgggctgcacccggcg
cccgtgcggggcccgccgtgcgtgcaggatttaggggcgccgctgacctccccgcagccc
tggccgggattcctgggccaaggggaagcgctgctgtccctggccatgctgctgcgtctc
tacctggtgccccgcgccgtgctcctgcgcagcggcgtcctgctcaacgcttcctaccgc
agcatcggcgctctcaatcaagtccgcttccgccactggttcgtggccaagctttacatg
aacacgcaccctggccgcctgctgctcggcctcacgcttggcctctggctgaccaccgcc
tgggtgctgtccgtggccgagaggcaggctgttaatgccactgggcacctttcagacaca
ctttggctgatccccatcacattcctgaccatcggctatggtgacgtggtgccgggcacc
atgtggggcaagatcgtctgcctgtgcactggagtcatgggtgtctgctgcacagccctg
ctggtggccgtggtggcccggaagctggagtttaacaaggcagagaagcacgtgcacaac
ttcatgatggatatccagtataccaaagagatgaaggagtccgctgcccgagtgctacaa
gaagcctggatgttctacaaacatactcgcaggaaggagtctcatgctgcccgcaggcat
cagcgcaagctgctggccgccatcaacgcgttccgccaggtgcggctgaaacaccggaag
ctccgggaacaagtgaactccatggtggacatctccaagatgcacatgatcctgtatgac
ctgcagcagaatctgagcagctcacaccgggccctggagaaacagattgacacgctggcg
gggaagctggatgccctgactgagctgcttagcactgccctggggccgaggcagcttcca
gaacccagccagcagtccaagtag

DBGET integrated database retrieval system