KEGG   Homo sapiens (human): 1072
Entry
1072              CDS       T01001                                 

Gene name
CFL1, CFL, HEL-S-15, cofilin
Definition
(RefSeq) cofilin 1
  KO
K05765  cofilin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
hsa04666  Fc gamma R-mediated phagocytosis
hsa04810  Regulation of actin cytoskeleton
hsa05133  Pertussis
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06124  Chemokine signaling (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
  Element
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1072 (CFL1)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    1072 (CFL1)
  09158 Development and regeneration
   04360 Axon guidance
    1072 (CFL1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    1072 (CFL1)
  09171 Infectious disease: bacterial
   05133 Pertussis
    1072 (CFL1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1072 (CFL1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    1072 (CFL1)
   04147 Exosome [BR:hsa04147]
    1072 (CFL1)
Membrane trafficking [BR:hsa04131]
 Others
  Actin-binding proteins
   Others
    1072 (CFL1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    ADF / Cofilin
     1072 (CFL1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   1072 (CFL1)
SSDB
Motif
Pfam: Cofilin_ADF
Other DBs
NCBI-GeneID: 1072
NCBI-ProteinID: NP_005498
OMIM: 601442
HGNC: 1874
Ensembl: ENSG00000172757
Vega: OTTHUMG00000166602
Pharos: P23528(Tbio)
UniProt: P23528 V9HWI5
LinkDB
Structure
PDB: 

Position
11q13.1
AA seq 166 aa
MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
NT seq 501 nt   +upstreamnt  +downstreamnt
atggcctccggtgtggctgtctctgatggtgtcatcaaggtgttcaacgacatgaaggtg
cgtaagtcttcaacgccagaggaggtgaagaagcgcaagaaggcggtgctcttctgcctg
agtgaggacaagaagaacatcatcctggaggagggcaaggagatcctggtgggcgatgtg
ggccagactgtcgacgacccctacgccacctttgtcaagatgctgccagataaggactgc
cgctatgccctctatgatgcaacctatgagaccaaggagagcaagaaggaggatctggtg
tttatcttctgggcccccgagtctgcgccccttaagagcaaaatgatttatgccagctcc
aaggacgccatcaagaagaagctgacagggatcaagcatgaattgcaagcaaactgctac
gaggaggtcaaggaccgctgcaccctggcagagaagctggggggcagtgccgtcatctcc
ctggagggcaagcctttgtga

KEGG   Homo sapiens (human): 1073
Entry
1073              CDS       T01001                                 

Gene name
CFL2, NEM7
Definition
(RefSeq) cofilin 2
  KO
K05765  cofilin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
hsa04666  Fc gamma R-mediated phagocytosis
hsa04810  Regulation of actin cytoskeleton
hsa05133  Pertussis
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06124  Chemokine signaling (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
  Element
N00433  CXCR4-GNB/G-RAC signaling pathway
N00434  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway
Disease
H00698  Nemaline myopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1073 (CFL2)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    1073 (CFL2)
  09158 Development and regeneration
   04360 Axon guidance
    1073 (CFL2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    1073 (CFL2)
  09171 Infectious disease: bacterial
   05133 Pertussis
    1073 (CFL2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1073 (CFL2)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    1073 (CFL2)
   04147 Exosome [BR:hsa04147]
    1073 (CFL2)
Membrane trafficking [BR:hsa04131]
 Others
  Actin-binding proteins
   Others
    1073 (CFL2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    ADF / Cofilin
     1073 (CFL2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   1073 (CFL2)
SSDB
Motif
Pfam: Cofilin_ADF Ribosomal_S2
Other DBs
NCBI-GeneID: 1073
NCBI-ProteinID: NP_068733
OMIM: 601443
HGNC: 1875
Ensembl: ENSG00000165410
Vega: OTTHUMG00000029536
Pharos: Q9Y281(Tbio)
UniProt: Q9Y281 Q549N0
LinkDB
Position
14q13.1
AA seq 166 aa
MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDI
GDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
KDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
NT seq 501 nt   +upstreamnt  +downstreamnt
atggcttctggagttacagtgaatgatgaagtcatcaaagtttttaatgatatgaaagta
aggaaatcttctacacaagaggagatcaaaaagagaaagaaagcagttctcttctgttta
agcgatgacaaaagacaaataattgtagaggaagcaaagcagatcttggtgggtgacatt
ggtgatactgtagaggacccctacacatcttttgtgaagttgctacctctgaatgattgc
cgatatgctttgtacgatgccacatacgaaacaaaagagtctaagaaagaagacctagta
tttatattctgggctcctgaaagtgcacctttaaaaagcaagatgatttatgctagctct
aaagatgccattaaaaagaaatttacaggtattaaacatgagtggcaagtaaatggcttg
gatgatattaaggaccgttcgacacttggagagaaattgggaggcaatgtagtagtttca
cttgaaggaaaaccattataa

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