Entry |
|
Symbol |
MASP2, MAP-2, MAP19, MASP-2, MASP1P1, sMAP
|
Name |
(RefSeq) MBL associated serine protease 2
|
KO |
|
Organism |
|
Pathway |
hsa04610 | Complement and coagulation cascades |
hsa05150 | Staphylococcus aureus infection |
|
Network |
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nt06513 Complement cascade nt06514 Coagulation cascade |
Element |
N01312 | SARS-CoV-2 S to lectin pathway of complement cascade |
N01315 | Lectin pathway of coagulation cascade, prothrombin to thrombin |
N01491 | Lectin pathway of complement cascade, C4/C2 to C3 convertase formation |
N01520 | Regulation of fibrinolytic system, C1INH |
|
Disease |
H00105 | Mannose-binding lectin pathway component defects |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
09151 Immune system
04610 Complement and coagulation cascades
10747 (MASP2)
09160 Human Diseases
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
10747 (MASP2)
09171 Infectious disease: bacterial
05150 Staphylococcus aureus infection
10747 (MASP2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:hsa01002]
10747 (MASP2)
Enzymes [BR:hsa01000]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.104 mannan-binding lectin-associated serine protease-2
10747 (MASP2)
Peptidases and inhibitors [BR:hsa01002]
Serine peptidases
Family S1: chymotrypsin family
10747 (MASP2)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
LinkDB |
|
Position |
1:complement(11026523..11047239)
|
AA seq |
686 aa
MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY
FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD
YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC
SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL
CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC
PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA
CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS
SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT
AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN
KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA
AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC
GEAGQYGVYTKVINYIPWIENIISDF |
NT seq |
2061 nt +upstreamnt +downstreamnt
atgaggctgctgaccctcctgggccttctgtgtggctcggtggccacccccttgggcccg
aagtggcctgaacctgtgttcgggcgcctggcatcccccggctttccaggggagtatgcc
aatgaccaggagcggcgctggaccctgactgcaccccccggctaccgcctgcgcctctac
ttcacccacttcgacctggagctctcccacctctgcgagtacgacttcgtcaagctgagc
tcgggggccaaggtgctggccacgctgtgcgggcaggagagcacagacacggagcgggcc
cctggcaaggacactttctactcgctgggctccagcctggacattaccttccgctccgac
tactccaacgagaagccgttcacggggttcgaggccttctatgcagccgaggacattgac
gagtgccaggtggccccgggagaggcgcccacctgcgaccaccactgccacaaccacctg
ggcggtttctactgctcctgccgcgcaggctacgtcctgcaccgtaacaagcgcacctgc
tcagccctgtgctccggccaggtcttcacccagaggtctggggagctcagcagccctgaa
tacccacggccgtatcccaaactctccagttgcacttacagcatcagcctggaggagggg
ttcagtgtcattctggactttgtggagtccttcgatgtggagacacaccctgaaaccctg
tgtccctacgactttctcaagattcaaacagacagagaagaacatggcccattctgtggg
aagacattgccccacaggattgaaacaaaaagcaacacggtgaccatcacctttgtcaca
gatgaatcaggagaccacacaggctggaagatccactacacgagcacagcgcagccttgc
ccttatccgatggcgccacctaatggccacgtttcacctgtgcaagccaaatacatcctg
aaagacagcttctccatcttttgcgagactggctatgagcttctgcaaggtcacttgccc
ctgaaatcctttactgcagtttgtcagaaagatggatcttgggaccggccaatgcccgcg
tgcagcattgttgactgtggccctcctgatgatctacccagtggccgagtggagtacatc
acaggtcctggagtgaccacctacaaagctgtgattcagtacagctgtgaagagaccttc
tacacaatgaaagtgaatgatggtaaatatgtgtgtgaggctgatggattctggacgagc
tccaaaggagaaaaatcactcccagtctgtgagcctgtttgtggactatcagcccgcaca
acaggagggcgtatatatggagggcaaaaggcaaaacctggtgattttccttggcaagtc
ctgatattaggtggaaccacagcagcaggtgcacttttatatgacaactgggtcctaaca
gctgctcatgccgtctatgagcaaaaacatgatgcatccgccctggacattcgaatgggc
accctgaaaagactatcacctcattatacacaagcctggtctgaagctgtttttatacat
gaaggttatactcatgatgctggctttgacaatgacatagcactgattaaattgaataac
aaagttgtaatcaatagcaacatcacgcctatttgtctgccaagaaaagaagctgaatcc
tttatgaggacagatgacattggaactgcatctggatggggattaacccaaaggggtttt
cttgctagaaatctaatgtatgtcgacataccgattgttgaccatcaaaaatgtactgct
gcatatgaaaagccaccctatccaaggggaagtgtaactgctaacatgctttgtgctggc
ttagaaagtgggggcaaggacagctgcagaggtgacagcggaggggcactggtgtttcta
gatagtgaaacagagaggtggtttgtgggaggaatagtgtcctggggttccatgaattgt
ggggaagcaggtcagtatggagtctacacaaaagttattaactatattccctggatcgag
aacataattagtgatttttaa |