KEGG   Homo sapiens (human): 1075
Entry
1075              CDS       T01001                                 

Gene name
CTSC, CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS
Definition
(RefSeq) cathepsin C
  KO
K01275  cathepsin C [EC:3.4.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04210  Apoptosis
Disease
H00274  Papillon-Lefevre syndrome
H00425  Lysosomal cysteine protease deficiencies
H00696  Haim-Munk syndrome
H02050  Prepubertal periodontitis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1075 (CTSC)
  09143 Cell growth and death
   04210 Apoptosis
    1075 (CTSC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1075 (CTSC)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1075 (CTSC)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1075 (CTSC)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.14  Dipeptidyl-peptidases and tripeptidyl-peptidases
    3.4.14.1  dipeptidyl-peptidase I
     1075 (CTSC)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1075 (CTSC)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1075 (CTSC)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   1075 (CTSC)
SSDB
Motif
Pfam: Peptidase_C1 CathepsinC_exc Peptidase_C1_2 Propeptide_C1
Other DBs
NCBI-GeneID: 1075
NCBI-ProteinID: NP_001805
OMIM: 602365
HGNC: 2528
Ensembl: ENSG00000109861
Vega: OTTHUMG00000167290
Pharos: P53634(Tchem)
UniProt: P53634
LinkDB
Structure
PDB: 

Position
11q14.2
AA seq 463 aa
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
NT seq 1392 nt   +upstreamnt  +downstreamnt
atgggtgctgggccctccttgctgctcgccgccctcctgctgcttctctccggcgacggc
gccgtgcgctgcgacacacctgccaactgcacctatcttgacctgctgggcacctgggtc
ttccaggtgggctccagcggttcccagcgcgatgtcaactgctcggttatgggaccacaa
gaaaaaaaagtagtggtgtaccttcagaagctggatacagcatatgatgaccttggcaat
tctggccatttcaccatcatttacaaccaaggctttgagattgtgttgaatgactacaag
tggtttgccttttttaagtataaagaagagggcagcaaggtgaccacttactgcaacgag
acaatgactgggtgggtgcatgatgtgttgggccggaactgggcttgtttcaccggaaag
aaggtgggaactgcctctgagaatgtgtatgtcaacatagcacaccttaagaattctcag
gaaaagtattctaataggctctacaagtatgatcacaactttgtgaaagctatcaatgcc
attcagaagtcttggactgcaactacatacatggaatatgagactcttaccctgggagat
atgattaggagaagtggtggccacagtcgaaaaatcccaaggcccaaacctgcaccactg
actgctgaaatacagcaaaagattttgcatttgccaacatcttgggactggagaaatgtt
catggtatcaattttgtcagtcctgttcgaaaccaagcatcctgtggcagctgctactca
tttgcttctatgggtatgctagaagcgagaatccgtatactaaccaacaattctcagacc
ccaatcctaagccctcaggaggttgtgtcttgtagccagtatgctcaaggctgtgaaggc
ggcttcccataccttattgcaggaaagtacgcccaagattttgggctggtggaagaagct
tgcttcccctacacaggcactgattctccatgcaaaatgaaggaagactgctttcgttat
tactcctctgagtaccactatgtaggaggtttctatggaggctgcaatgaagccctgatg
aagcttgagttggtccatcatgggcccatggcagttgcttttgaagtatatgatgacttc
ctccactacaaaaaggggatctaccaccacactggtctaagagaccctttcaaccccttt
gagctgactaatcatgctgttctgcttgtgggctatggcactgactcagcctctgggatg
gattactggattgttaaaaacagctggggcaccggctggggtgagaatggctacttccgg
atccgcagaggaactgatgagtgtgcaattgagagcatagcagtggcagccacaccaatt
cctaaattgtag

KEGG   Homo sapiens (human): 1508
Entry
1508              CDS       T01001                                 

Gene name
CTSB, APPS, CPSB, RECEUP
Definition
(RefSeq) cathepsin B
  KO
K01363  cathepsin B [EC:3.4.22.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04140  Autophagy - animal
hsa04142  Lysosome
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa04621  NOD-like receptor signaling pathway
hsa04924  Renin secretion
Disease
H00932  Tropical calcific pancreatitis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1508 (CTSB)
   04140 Autophagy - animal
    1508 (CTSB)
  09143 Cell growth and death
   04210 Apoptosis
    1508 (CTSB)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    1508 (CTSB)
   04612 Antigen processing and presentation
    1508 (CTSB)
  09152 Endocrine system
   04924 Renin secretion
    1508 (CTSB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1508 (CTSB)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1508 (CTSB)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1508 (CTSB)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    1508 (CTSB)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.1  cathepsin B
     1508 (CTSB)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1508 (CTSB)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1508 (CTSB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of microglial cells
   1508 (CTSB)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Others
   1508 (CTSB)
SSDB
Motif
Pfam: Peptidase_C1 Propeptide_C1 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1508
NCBI-ProteinID: NP_001899
OMIM: 116810
HGNC: 2527
Ensembl: ENSG00000164733
Vega: OTTHUMG00000090799
Pharos: P07858(Tchem)
UniProt: P07858 A0A024R374
LinkDB
Structure
PDB: 

Position
8p23.1
AA seq 339 aa
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
NT seq 1020 nt   +upstreamnt  +downstreamnt
atgtggcagctctgggcctccctctgctgcctgctggtgttggccaatgcccggagcagg
ccctctttccatcccctgtcggatgagctggtcaactatgtcaacaaacggaataccacg
tggcaggccgggcacaacttctacaacgtggacatgagctacttgaagaggctatgtggt
accttcctgggtgggcccaagccaccccagagagttatgtttaccgaggacctgaagctg
cctgcaagcttcgatgcacgggaacaatggccacagtgtcccaccatcaaagagatcaga
gaccagggctcctgtggctcctgctgggccttcggggctgtggaagccatctctgaccgg
atctgcatccacaccaatgcgcacgtcagcgtggaggtgtcggcggaggacctgctcaca
tgctgtggcagcatgtgtggggacggctgtaatggtggctatcctgctgaagcttggaac
ttctggacaagaaaaggcctggtttctggtggcctctatgaatcccatgtagggtgcaga
ccgtactccatccctccctgtgagcaccacgtcaacggctcccggcccccatgcacgggg
gagggagatacccccaagtgtagcaagatctgtgagcctggctacagcccgacctacaaa
caggacaagcactacggatacaattcctacagcgtctccaatagcgagaaggacatcatg
gccgagatctacaaaaacggccccgtggagggagctttctctgtgtattcggacttcctg
ctctacaagtcaggagtgtaccaacacgtcaccggagagatgatgggtggccatgccatc
cgcatcctgggctggggagtggagaatggcacaccctactggctggttgccaactcctgg
aacactgactggggtgacaatggcttctttaaaatactcagaggacaggatcactgtgga
atcgaatcagaagtggtggctggaattccacgcaccgatcagtactgggaaaagatctaa

KEGG   Homo sapiens (human): 1509
Entry
1509              CDS       T01001                                 

Gene name
CTSD, CLN10, CPSD, HEL-S-130P
Definition
(RefSeq) cathepsin D
  KO
K01379  cathepsin D [EC:3.4.23.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04071  Sphingolipid signaling pathway
hsa04140  Autophagy - animal
hsa04142  Lysosome
hsa04210  Apoptosis
hsa04915  Estrogen signaling pathway
hsa05152  Tuberculosis
Network
nt06227  Nuclear receptor signaling
nt06270  Breast cancer
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
  Element
N00286  Nuclear-initiated estrogen signaling pathway
Disease
H00149  Neuronal ceroid lipofuscinosis
H02279  Cathepsin D deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    1509 (CTSD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1509 (CTSD)
   04140 Autophagy - animal
    1509 (CTSD)
  09143 Cell growth and death
   04210 Apoptosis
    1509 (CTSD)
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    1509 (CTSD)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    1509 (CTSD)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1509 (CTSD)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1509 (CTSD)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.5  cathepsin D
     1509 (CTSD)
Peptidases and inhibitors [BR:hsa01002]
 Aspartic peptidases
  Family A1: pepsin family
   1509 (CTSD)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   1509 (CTSD)
SSDB
Motif
Pfam: Asp TAXi_N A1_Propeptide TAXi_C
Other DBs
NCBI-GeneID: 1509
NCBI-ProteinID: NP_001900
OMIM: 116840
HGNC: 2529
Ensembl: ENSG00000117984
Vega: OTTHUMG00000044760
Pharos: P07339(Tchem)
UniProt: P07339 V9HWI3
LinkDB
Structure
PDB: 

Position
11p15.5
AA seq 412 aa
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
NT seq 1239 nt   +upstreamnt  +downstreamnt
atgcagccctccagccttctgccgctcgccctctgcctgctggctgcacccgcctccgcg
ctcgtcaggatcccgctgcacaagttcacgtccatccgccggaccatgtcggaggttggg
ggctctgtggaggacctgattgccaaaggccccgtctcaaagtactcccaggcggtgcca
gccgtgaccgaggggcccattcccgaggtgctcaagaactacatggacgcccagtactac
ggggagattggcatcgggacgcccccccagtgcttcacagtcgtcttcgacacgggctcc
tccaacctgtgggtcccctccatccactgcaaactgctggacatcgcttgctggatccac
cacaagtacaacagcgacaagtccagcacctacgtgaagaatggtacctcgtttgacatc
cactatggctcgggcagcctctccgggtacctgagccaggacactgtgtcggtgccctgc
cagtcagcgtcgtcagcctctgccctgggcggtgtcaaagtggagaggcaggtctttggg
gaggccaccaagcagccaggcatcaccttcatcgcagccaagttcgatggcatcctgggc
atggcctacccccgcatctccgtcaacaacgtgctgcccgtcttcgacaacctgatgcag
cagaagctggtggaccagaacatcttctccttctacctgagcagggacccagatgcgcag
cctgggggtgagctgatgctgggtggcacagactccaagtattacaagggttctctgtcc
tacctgaatgtcacccgcaaggcctactggcaggtccacctggaccaggtggaggtggcc
agcgggctgaccctgtgcaaggagggctgtgaggccattgtggacacaggcacttccctc
atggtgggcccggtggatgaggtgcgcgagctgcagaaggccatcggggccgtgccgctg
attcagggcgagtacatgatcccctgtgagaaggtgtccaccctgcccgcgatcacactg
aagctgggaggcaaaggctacaagctgtccccagaggactacacgctcaaggtgtcgcag
gccgggaagaccctctgcctgagcggcttcatgggcatggacatcccgccacccagcggg
ccactctggatcctgggcgacgtcttcatcggccgctactacactgtgtttgaccgtgac
aacaacagggtgggcttcgccgaggctgcccgcctctag

KEGG   Homo sapiens (human): 1512
Entry
1512              CDS       T01001                                 

Gene name
CTSH, ACC-4, ACC-5, ACC4, ACC5, CPSB
Definition
(RefSeq) cathepsin H
  KO
K01366  cathepsin H [EC:3.4.22.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04210  Apoptosis
Disease
H00408  Type 1 diabetes mellitus
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1512 (CTSH)
  09143 Cell growth and death
   04210 Apoptosis
    1512 (CTSH)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1512 (CTSH)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.16  cathepsin H
     1512 (CTSH)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1512 (CTSH)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1512
NCBI-ProteinID: NP_004381
OMIM: 116820
HGNC: 2535
Ensembl: ENSG00000103811
Vega: OTTHUMG00000144171
Pharos: P09668(Tchem)
UniProt: P09668
LinkDB
Structure
PDB: 
6CZS 6CZK

Position
15q25.1
AA seq 335 aa
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
NWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSV
DWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHG
CQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMV
EAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVK
NSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
NT seq 1008 nt   +upstreamnt  +downstreamnt
atgtgggccacgctgccgctgctctgcgccggggcctggctcctgggagtccccgtctgc
ggtgccgccgaactgtgcgtgaactccttagagaagtttcacttcaagtcatggatgtct
aagcaccgtaagacctacagtacggaggagtaccaccacaggctgcagacgtttgccagc
aactggaggaagataaacgcccacaacaatgggaaccacacatttaaaatggcactgaac
caattttcagacatgagctttgctgaaataaaacacaagtatctctggtcagagcctcag
aattgctcagccaccaaaagtaactaccttcgaggtactggtccctacccaccttccgtg
gactggcggaaaaaaggaaattttgtctcacctgtgaaaaatcagggtgcctgcggcagt
tgctggactttctccaccactggggccctggagtctgcgatcgccatcgcaaccggaaag
atgctgtccttggcggaacagcagctggtggactgcgcccaggacttcaataatcacggc
tgccaagggggtctccccagccaggctttcgagtatatcctgtacaacaaggggatcatg
ggtgaagacacctacccctaccagggcaaggatggttattgcaagttccaacctggaaag
gccatcggctttgtcaaggatgtagccaacatcacaatctatgacgaggaagcgatggtg
gaggctgtggccctctacaaccctgtgagctttgcctttgaggtgactcaggacttcatg
atgtatagaaccggcatctactccagtacttcctgccataaaactccagataaagtaaac
catgcagtactggctgttgggtatggagaaaaaaatgggatcccttactggatcgtgaaa
aactcttggggtccccagtggggaatgaacgggtacttcctcatcgagcgcggaaagaac
atgtgtggcctggctgcctgcgcctcctaccccatccctctggtgtga

KEGG   Homo sapiens (human): 1513
Entry
1513              CDS       T01001                                 

Gene name
CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD
Definition
(RefSeq) cathepsin K
  KO
K01371  cathepsin K [EC:3.4.22.38]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04210  Apoptosis
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa05323  Rheumatoid arthritis
Disease
H00273  Pycnodysostosis
H00425  Lysosomal cysteine protease deficiencies
Drug target
Odanacatib: D08955
Relacatib: D06634
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1513 (CTSK)
  09143 Cell growth and death
   04210 Apoptosis
    1513 (CTSK)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    1513 (CTSK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    1513 (CTSK)
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    1513 (CTSK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1513 (CTSK)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1513 (CTSK)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.38  cathepsin K
     1513 (CTSK)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1513 (CTSK)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1513 (CTSK)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1513
NCBI-ProteinID: NP_000387
OMIM: 601105
HGNC: 2536
Ensembl: ENSG00000143387
Vega: OTTHUMG00000035008
Pharos: P43235(Tchem)
UniProt: P43235
LinkDB
Structure
PDB: 

Position
1q21.3
AA seq 329 aa
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
NT seq 990 nt   +upstreamnt  +downstreamnt
atgtgggggctcaaggttctgctgctacctgtggtgagctttgctctgtaccctgaggag
atactggacacccactgggagctatggaagaagacccacaggaagcaatataacaacaag
gtggatgaaatctctcggcgtttaatttgggaaaaaaacctgaagtatatttccatccat
aaccttgaggcttctcttggtgtccatacatatgaactggctatgaaccacctgggggac
atgaccagtgaagaggtggttcagaagatgactggactcaaagtacccctgtctcattcc
cgcagtaatgacaccctttatatcccagaatgggaaggtagagccccagactctgtcgac
tatcgaaagaaaggatatgttactcctgtcaaaaatcagggtcagtgtggttcctgttgg
gcttttagctctgtgggtgccctggagggccaactcaagaagaaaactggcaaactctta
aatctgagtccccagaacctagtggattgtgtgtctgagaatgatggctgtggagggggc
tacatgaccaatgccttccaatatgtgcagaagaaccggggtattgactctgaagatgcc
tacccatatgtgggacaggaagagagttgtatgtacaacccaacaggcaaggcagctaaa
tgcagagggtacagagagatccccgaggggaatgagaaagccctgaagagggcagtggcc
cgagtgggacctgtctctgtggccattgatgcaagcctgacctccttccagttttacagc
aaaggtgtgtattatgatgaaagctgcaatagcgataatctgaaccatgcagttttggca
gtgggatatggaatccagaagggaaacaagcactggataattaaaaacagctggggagaa
aactggggaaacaaaggatatatcctcatggctcgaaataagaacaacgcctgtggcatt
gccaacctggccagcttccccaagatgtga

KEGG   Homo sapiens (human): 1514
Entry
1514              CDS       T01001                                 

Gene name
CTSL, CATL, CTSL1, MEP
Definition
(RefSeq) cathepsin L
  KO
K01365  cathepsin L [EC:3.4.22.15]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04140  Autophagy - animal
hsa04142  Lysosome
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa05205  Proteoglycans in cancer
hsa05323  Rheumatoid arthritis
hsa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    1514 (CTSL)
   04142 Lysosome
    1514 (CTSL)
   04140 Autophagy - animal
    1514 (CTSL)
  09143 Cell growth and death
   04210 Apoptosis
    1514 (CTSL)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    1514 (CTSL)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    1514 (CTSL)
  09163 Immune disease
   05323 Rheumatoid arthritis
    1514 (CTSL)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    1514 (CTSL)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1514 (CTSL)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1514 (CTSL)
  09183 Protein families: signaling and cellular processes
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    1514 (CTSL)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.15  cathepsin L
     1514 (CTSL)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1514 (CTSL)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1514 (CTSL)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
 Others
  1514 (CTSL)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2 Styelin
Other DBs
NCBI-GeneID: 1514
NCBI-ProteinID: NP_001244900
OMIM: 116880
HGNC: 2537
Ensembl: ENSG00000135047
Vega: OTTHUMG00000020149
Pharos: P07711(Tchem)
UniProt: P07711 A0A024R276
LinkDB
Structure
PDB: 

Position
9q21.33
AA seq 333 aa
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
NT seq 1002 nt   +upstreamnt  +downstreamnt
atgaatcctacactcatccttgctgccttttgcctgggaattgcctcagctactctaaca
tttgatcacagtttagaggcacagtggaccaagtggaaggcgatgcacaacagattatac
ggcatgaatgaagaaggatggaggagagcagtgtgggagaagaacatgaagatgattgaa
ctgcacaatcaggaatacagggaagggaaacacagcttcacaatggccatgaacgccttt
ggagacatgaccagtgaagaattcaggcaggtgatgaatggctttcaaaaccgtaagccc
aggaaggggaaagtgttccaggaacctctgttttatgaggcccccagatctgtggattgg
agagagaaaggctacgtgactcctgtgaagaatcagggtcagtgtggttcttgttgggct
tttagtgctactggtgctcttgaaggacagatgttccggaaaactgggaggcttatctca
ctgagtgagcagaatctggtagactgctctgggcctcaaggcaatgaaggctgcaatggt
ggcctaatggattatgctttccagtatgttcaggataatggaggcctggactctgaggaa
tcctatccatatgaggcaacagaagaatcctgtaagtacaatcccaagtattctgttgct
aatgacaccggctttgtggacatccctaagcaggagaaggccctgatgaaggcagttgca
actgtggggcccatttctgttgctattgatgcaggtcatgagtccttcctgttctataaa
gaaggcatttattttgagccagactgtagcagtgaagacatggatcatggtgtgctggtg
gttggctacggatttgaaagcacagaatcagataacaataaatattggctggtgaagaac
agctggggtgaagaatggggcatgggtggctacgtaaagatggccaaagaccggagaaac
cattgtggaattgcctcagcagccagctaccccactgtgtga

KEGG   Homo sapiens (human): 1515
Entry
1515              CDS       T01001                                 

Gene name
CTSV, CATL2, CTSL2, CTSU
Definition
(RefSeq) cathepsin V
  KO
K01375  cathepsin V [EC:3.4.22.43]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04210  Apoptosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1515 (CTSV)
  09143 Cell growth and death
   04210 Apoptosis
    1515 (CTSV)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1515 (CTSV)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.43  cathepsin V
     1515 (CTSV)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1515 (CTSV)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2 Styelin
Other DBs
NCBI-GeneID: 1515
NCBI-ProteinID: NP_001188504
OMIM: 603308
HGNC: 2538
Ensembl: ENSG00000136943
Vega: OTTHUMG00000020314
Pharos: O60911(Tchem)
UniProt: O60911 A0A024R141 B2R717
LinkDB
Structure
PDB: 
1FH0 3KFQ 3H6S

Position
9q22.33
AA seq 334 aa
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
NT seq 1005 nt   +upstreamnt  +downstreamnt
atgaatctttcgctcgtcctggctgccttttgcttgggaatagcctccgctgttccaaaa
tttgaccaaaatttggatacaaagtggtaccagtggaaggcaacacacagaagattatat
ggcgcgaatgaagaaggatggaggagagcagtgtgggaaaagaatatgaaaatgattgaa
ctgcacaatggggaatacagccaagggaaacatggcttcacaatggccatgaatgctttt
ggtgacatgaccaatgaagaattcaggcagatgatgggttgctttcgaaaccagaaattc
aggaaggggaaagtgttccgtgagcctctgtttcttgatcttcccaaatctgtggattgg
agaaagaaaggctacgtgacgccagtgaagaatcagaaacagtgtggttcttgttgggct
tttagtgcgactggtgctcttgaaggacagatgttccggaaaactgggaaacttgtctca
ctgagcgagcagaatctggtggactgttcgcgtcctcaaggcaatcagggctgcaatggt
ggcttcatggctagggccttccagtatgtcaaggagaacggaggcctggactctgaggaa
tcctatccatatgtagcagtggatgaaatctgtaagtacagacctgagaattctgttgct
aatgacactggcttcacagtggtcgcacctggaaaggagaaggccctgatgaaagcagtc
gcaactgtggggcccatctccgttgctatggatgcaggccattcgtccttccagttctac
aaatcaggcatttattttgaaccagactgcagcagcaaaaacctggatcatggtgttctg
gtggttggctacggctttgaaggagcaaattcgaataacagcaagtattggctcgtcaaa
aacagctggggtccagaatggggctcgaatggctatgtaaaaatagccaaagacaagaac
aaccactgtggaatcgccacagcagccagctaccccaatgtgtga

KEGG   Homo sapiens (human): 1519
Entry
1519              CDS       T01001                                 

Gene name
CTSO, CTSO1
Definition
(RefSeq) cathepsin O
  KO
K01374  cathepsin O [EC:3.4.22.42]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04210  Apoptosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1519 (CTSO)
  09143 Cell growth and death
   04210 Apoptosis
    1519 (CTSO)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1519 (CTSO)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.42  cathepsin O
     1519 (CTSO)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1519 (CTSO)
SSDB
Motif
Pfam: Peptidase_C1 Peptidase_C1_2 Inhibitor_I29 Peptidase_C39_2
Other DBs
NCBI-GeneID: 1519
NCBI-ProteinID: NP_001325
OMIM: 600550
HGNC: 2542
Ensembl: ENSG00000256043
Vega: OTTHUMG00000161942
Pharos: P43234(Tdark)
UniProt: P43234
LinkDB
Position
4q32.1
AA seq 321 aa
MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPS
ENSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVV
TQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALN
WLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGP
LVVIVDAVSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGY
AHVKMGSNVCGIADSVSSIFV
NT seq 966 nt   +upstreamnt  +downstreamnt
atggacgtgcgggcgctgccgtggctgccgtggctgctgtggctgctgtgccggggcggc
ggcgatgcggactcccgcgcccccttcaccccgacctggccgcggagccgcgagcgtgaa
gccgccgccttccgggaaagtcttaatagacatcgatacttgaattctttatttcccagt
gaaaactccaccgccttctatggaataaatcagttttcctatttgtttcctgaagagttt
aaagccatttatttaagaagcaaaccttccaagtttcccagatactcagcagaagtacat
atgtccatccccaatgtgtctttgccgttaagatttgactggagggacaagcaggttgtg
acacaagtgagaaaccagcagatgtgtggaggatgctgggccttcagcgtggtgggggca
gtggaatctgcttatgcaataaaggggaagcccctggaagacctaagtgtccagcaggtc
attgactgttcgtataataattatggctgcaatggaggctctactctcaatgctttgaac
tggttaaacaagatgcaagtaaaactggtgaaagattcagaatatccttttaaagcacaa
aatggtctgtgccattacttttctggttcacattctggattttcaatcaaaggttattct
gcatatgacttcagtgaccaagaagatgaaatggcaaaagcacttcttacctttggccct
ttggtagtcatagtagatgcagtgagctggcaagattatctgggaggcattatacagcat
cactgctctagtggagaagcaaatcatgcagttctcataactgggtttgataaaacagga
agcactccatattggattgtgcggaattcctggggaagttcttggggagtagatggttat
gcccatgtcaaaatgggaagtaatgtttgtggtattgcagattccgtttcttctatattt
gtgtga

KEGG   Homo sapiens (human): 1520
Entry
1520              CDS       T01001                                 

Gene name
CTSS
Definition
(RefSeq) cathepsin S
  KO
K01368  cathepsin S [EC:3.4.22.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa05152  Tuberculosis
Drug target
Petesicatib: D11376
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    1520 (CTSS)
   04142 Lysosome
    1520 (CTSS)
  09143 Cell growth and death
   04210 Apoptosis
    1520 (CTSS)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    1520 (CTSS)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    1520 (CTSS)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1520 (CTSS)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1520 (CTSS)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.27  cathepsin S
     1520 (CTSS)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1520 (CTSS)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1520 (CTSS)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1520
NCBI-ProteinID: NP_004070
OMIM: 116845
HGNC: 2545
Ensembl: ENSG00000163131
Vega: OTTHUMG00000035010
Pharos: P25774(Tchem)
UniProt: P25774
LinkDB
Structure
PDB: 

Position
1q21.3
AA seq 331 aa
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
NT seq 996 nt   +upstreamnt  +downstreamnt
atgaaacggctggtttgtgtgctcttggtgtgctcctctgcagtggcacagttgcataaa
gatcctaccctggatcaccactggcatctctggaagaaaacctatggcaaacaatacaag
gaaaagaatgaagaagcagtacgacgtctcatctgggaaaagaatctaaagtttgtgatg
cttcacaacctggagcattcaatgggaatgcactcatacgatctgggcatgaaccacctg
ggagacatgaccagtgaagaagtgatgtctttgatgagttccctgagagttcccagccag
tggcagagaaatatcacatataagtcaaaccctaatcggatattgcctgattctgtggac
tggagagagaaagggtgtgttactgaagtgaaatatcaaggttcttgtggtgcttgctgg
gctttcagtgctgtgggggccctggaagcacagctgaagctgaaaacaggaaagctggtg
tctctcagtgcccagaacctggtggattgctcaactgaaaaatatggaaacaaaggctgc
aatggtggcttcatgacaacggctttccagtacatcattgataacaagggcatcgactca
gacgcttcctatccctacaaagccatggatcagaaatgtcaatatgactcaaaatatcgt
gctgccacatgttcaaagtacactgaacttccttatggcagagaagatgtcctgaaagaa
gctgtggccaataaaggcccagtgtctgttggtgtagatgcgcgtcatccttctttcttc
ctctacagaagtggtgtctactatgaaccatcctgtactcagaatgtgaatcatggtgta
cttgtggttggctatggtgatcttaatgggaaagaatactggcttgtgaaaaacagctgg
ggccacaactttggtgaagaaggatatattcggatggcaagaaataaaggaaatcattgt
gggattgctagctttccctcttacccagaaatctag

KEGG   Homo sapiens (human): 1521
Entry
1521              CDS       T01001                                 

Gene name
CTSW, LYPN
Definition
(RefSeq) cathepsin W
  KO
K08569  cathepsin W [EC:3.4.22.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04210  Apoptosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1521 (CTSW)
  09143 Cell growth and death
   04210 Apoptosis
    1521 (CTSW)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1521 (CTSW)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.-  
     1521 (CTSW)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1521 (CTSW)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1521
NCBI-ProteinID: NP_001326
OMIM: 602364
HGNC: 2546
Ensembl: ENSG00000172543
Vega: OTTHUMG00000166663
Pharos: P56202(Tbio)
UniProt: P56202
LinkDB
Position
11q13.1
AA seq 376 aa
MALTAHPSCLLALLVAGLAQGIRGPLRAQDLGPQPLELKEAFKLFQIQFNRSYLSPEEHA
HRLDIFAHNLAQAQRLQEEDLGTAEFGVTPFSDLTEEEFGQLYGYRRAAGGVPSMGREIR
SEEPEESVPFSCDWRKVASAISPIKDQKNCNCCWAMAAAGNIETLWRISFWDFVDVSVQE
LLDCGRCGDGCHGGFVWDAFITVLNNSGLASEKDYPFQGKVRAHRCHPKKYQKVAWIQDF
IMLQNNEHRIAQYLATYGPITVTINMKPLQLYRKGVIKATPTTCDPQLVDHSVLLVGFGS
VKSEEGIWAETVSSQSQPQPPHPTPYWILKNSWGAQWGEKGYFRLHRGSNTCGITKFPLT
ARVQKPDMKPRVSCPP
NT seq 1131 nt   +upstreamnt  +downstreamnt
atggcactgactgcccacccctcctgcctcctggccctgttggtggcaggcctagcccaa
ggcatcagaggcccccttagggcccaggacctaggtccccagccgctagagctgaaagag
gccttcaagttgttccagatccagttcaaccggagttacctgagcccagaagagcatgct
caccgcctggacatctttgcccacaacctggcccaggctcagaggctgcaggaggaggac
ttgggcacagctgagtttggggtgactccattcagtgacctcacagaggaggagtttggc
cagctctatggctatcggagggcagctggaggggtccccagcatgggcagagaaataagg
tctgaagagccagaggagtcagtacctttcagctgtgactggcggaaggtggccagcgcc
atctcacccatcaaggaccagaaaaactgcaactgctgctgggccatggcagcggcaggc
aacatagagaccctgtggcgcatcagtttctgggattttgtggatgtctccgtgcaggaa
ctgctggactgtggccgctgtggggatggctgccacggtggcttcgtctgggacgcgttc
ataactgtcctcaacaacagcggcctggccagtgaaaaggactacccgttccagggcaaa
gtcagagcccacaggtgccaccccaagaagtaccagaaggtggcctggatccaggacttc
atcatgctgcagaacaacgagcacagaattgcgcagtacctggccacttatggccccatc
accgtgaccatcaacatgaagccccttcagctataccggaaaggtgtgatcaaggccaca
cccaccacctgtgacccccagcttgtggaccactctgtcctgctggtgggttttggcagc
gtcaagtcagaggaggggatatgggcagagacagtctcatcgcagtctcagcctcagcct
ccacaccccaccccatactggatcctgaagaactcctggggggcccaatggggagagaag
ggctatttccggctgcaccgagggagcaatacctgtggcatcaccaagttcccgctcact
gcccgtgtgcagaaaccggatatgaagccccgagtctcctgccctccctga

KEGG   Homo sapiens (human): 1522
Entry
1522              CDS       T01001                                 

Gene name
CTSZ, CTSX
Definition
(RefSeq) cathepsin Z
  KO
K08568  cathepsin X [EC:3.4.18.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04210  Apoptosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1522 (CTSZ)
  09143 Cell growth and death
   04210 Apoptosis
    1522 (CTSZ)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1522 (CTSZ)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.18  Cysteine-type carboxypeptidases
    3.4.18.1  cathepsin X
     1522 (CTSZ)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1522 (CTSZ)
SSDB
Motif
Pfam: Peptidase_C1 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1522
NCBI-ProteinID: NP_001327
OMIM: 603169
HGNC: 2547
Ensembl: ENSG00000101160
Vega: OTTHUMG00000032858
Pharos: Q9UBR2(Tchem)
UniProt: Q9UBR2
LinkDB
Structure
PDB: 
1DEU 1EF7

Position
20q13.32
AA seq 303 aa
MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPA
DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV
QNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECH
AIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYIN
HVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGD
PIV
NT seq 912 nt   +upstreamnt  +downstreamnt
atggcgaggcgcgggccagggtggcggccgcttctgctgctcgtgctgctggcgggcgcg
gcgcagggcggcctctacttccgccggggacagacctgctaccggcctctgcggggggac
gggctggctccgctggggcgcagcacatacccccggcctcatgagtacctgtccccagcg
gatctgcccaagagctgggactggcgcaatgtggatggtgtcaactatgccagcatcacc
cggaaccagcacatcccccaatactgcggctcctgctgggcccacgccagcaccagcgct
atggcggatcggatcaacatcaagaggaagggagcgtggccctccaccctcctgtccgtg
cagaacgtcatcgactgcggtaacgctggctcctgtgaagggggtaatgacctgtccgtg
tgggactacgcccaccagcacggcatccctgacgagacctgcaacaactaccaggccaag
gaccaggagtgtgacaagtttaaccaatgtgggacatgcaatgaattcaaagagtgccac
gccatccggaactacaccctctggagggtgggagactacggctccctctctgggagggag
aagatgatggcagaaatctatgcaaatggtcccatcagctgtggaataatggcaacagaa
agactggctaactacaccggaggcatctatgccgaataccaggacaccacatatataaac
catgtcgtttctgtggctgggtggggcatcagtgatgggactgagtactggattgtccgg
aattcatggggtgaaccatggggcgagagaggctggctgaggatcgtgaccagcacctat
aaggatgggaagggcgccagatacaaccttgccatcgaggagcactgtacatttggggac
cccatcgtttaa

KEGG   Homo sapiens (human): 8722
Entry
8722              CDS       T01001                                 

Gene name
CTSF, CATSF, CLN13
Definition
(RefSeq) cathepsin F
  KO
K01373  cathepsin F [EC:3.4.22.41]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04210  Apoptosis
Disease
H00149  Neuronal ceroid lipofuscinosis
H02276  Kufs disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    8722 (CTSF)
  09143 Cell growth and death
   04210 Apoptosis
    8722 (CTSF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    8722 (CTSF)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.41  cathepsin F
     8722 (CTSF)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   8722 (CTSF)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2
Other DBs
NCBI-GeneID: 8722
NCBI-ProteinID: NP_003784
OMIM: 603539
HGNC: 2531
Ensembl: ENSG00000174080
Vega: OTTHUMG00000167090
Pharos: Q9UBX1(Tchem)
UniProt: Q9UBX1
LinkDB
Structure
PDB: 
1M6D

Position
11q13.2
AA seq 484 aa
MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRA
VLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLL
RKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRNETFSSVISLLNEDPLSQDLP
VKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLT
EEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSV
TGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQ
GHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPL
RPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASS
AVVD
NT seq 1455 nt   +upstreamnt  +downstreamnt
atggcgccctggctgcagctcctgtcgctgctggggctgctcccgggcgcagtggccgcc
cccgcccagccccgagccgccagctttcaggcctgggggccgccgtccccggagctgctg
gcgcccacccgcttcgcgctggagatgttcaaccgcggccgggctgcggggacgcgggcc
gtgctgggccttgtgcgcggccgcgtccgccgggcgggtcaggggtcgctgtactccctg
gaggccaccctggaggagccaccctgcaacgaccccatggtgtgccggctccccgtgtcc
aagaaaaccctgctctgcagcttccaagtcctggatgagctcggaagacacgtgctgctg
cggaaggactgtggcccagtggacaccaaggttccaggtgctggggagcccaagtcagcc
ttcactcagggctcagccatgatttcttctctgtcccaaaaccatccagacaacagaaac
gagactttcagctcagtcatttccctgttgaatgaggatcccctgtcccaggacttgcct
gtgaagatggcttcaatcttcaagaactttgtcattacctataaccggacatatgagtca
aaggaagaagcccggtggcgcctgtccgtctttgtcaataacatggtgcgagcacagaag
atccaggccctggaccgtggcacagctcagtatggagtcaccaagttcagtgatctcaca
gaggaggagttccgcactatctacctgaatactctcctgaggaaagagcctggcaacaag
atgaagcaagccaagtctgtgggtgacctcgccccacctgaatgggactggaggagtaag
ggggctgtcacaaaagtcaaagaccagggcatgtgtggctcctgctgggccttctcagtc
acaggcaatgtggagggccagtggtttctcaaccaggggaccctgctctccctctctgaa
caggagctcttggactgtgacaagatggacaaggcctgcatgggcggcttgccctccaat
gcctactcggccataaagaatttgggagggctggagacagaggatgactacagctaccag
ggtcacatgcagtcctgcaacttctcagcagagaaggccaaggtctacatcaatgactcc
gtggagctgagccagaacgagcagaagctggcagcctggctggccaagagaggcccaatc
tccgtggccatcaatgcctttggcatgcagttttaccgccacgggatctcccgccctctc
cggcccctctgcagcccttggctcattgaccatgcggtgttgcttgtgggctacggcaac
cgctctgacgttcccttttgggccatcaagaacagctggggcactgactggggtgagaag
ggttactactacttgcatcgtgggtccggggcctgtggcgtgaacaccatggccagctcg
gcggtggtggactga

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