KEGG   Homo sapiens (human): 107987478
Entry
107987478         CDS       T01001                                 

Definition
(RefSeq) cytochrome P450 2D6-like
  KO
K17712  cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01522  Endocrine resistance
hsa04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    107987478
   00982 Drug metabolism - cytochrome P450
    107987478
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    107987478
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    107987478
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    107987478
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     107987478
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   107987478
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 107987478
NCBI-ProteinID: XP_016885819
UniProt: Q38LG2
LinkDB
Position
22
AA seq 497 aa
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYSPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQPRPSHSRV
VSFLVTPSPYELCAVPR
NT seq 1494 nt   +upstreamnt  +downstreamnt
atggggctagaagcactggtgcccctggccgtgatagtggccatcttcctgctcctggtg
gacctgatgcaccggcgccaacgctgggctgcacgctactcaccaggccccctgccactg
cccgggctgggcaacctgctgcatgtggacttccagaacacaccatactgcttcgaccag
ttgcggcgccgcttcggggacgtgttcagcctgcagctggcctggacgccggtggtcgtg
ctcaatgggctggcggccgtgcgcgaggcgctggtgacccacggcgaggacaccgccgac
cgcccgcctgtgcccatcacccagatcctgggttttgggccgcgttcccaaggggtgttc
ctggcgcgctatgggcccgcgtggcgcgagcagaggcgcttctccgtctccaccttgcgc
aacttgggcctgggcaagaagtcgctggagcagtgggtgaccgaggaggccgcctgcctt
tgtgccgccttcgccaaccactccggacgcccctttcgccccaacggtctcttggacaaa
gccgtgagcaacgtgatcgcctccctcacctgcgggcgccgcttcgagtacgacgaccct
cgcttcctcaggctgctggacctagctcaggagggactgaaggaggagtcgggctttctg
cgcgaggtgctgaatgctgtccccgtcctcctgcatatcccagcgctggctggcaaggtc
ctacgcttccaaaaggctttcctgacccagctggatgagctgctaactgagcacaggatg
acctgggacccagcccagcccccccgagacctgactgaggccttcctggcagagatggag
aaggccaaggggaaccctgagagcagcttcaatgatgagaacctgcgcatagtggtggct
gacctgttctctgccgggatggtgaccacctcgaccacgctggcctggggcctcctgctc
atgatcctacatccggatgtgcagcgccgtgtccaacaggagatcgacgacgtgataggg
caggtgcggcgaccagagatgggtgaccaggctcacatgccctacaccactgccgtgatt
catgaggtgcagcgctttggggacatcgtccccctgggtgtgacccatatgacatcccgt
gacatcgaagtacagggcttccgcatccctaagggaacgacactcatcaccaacctgtca
tcggtgctgaaggatgaggccgtctgggagaagcccttccgcttccaccccgaacacttc
ctggatgcccagggccactttgtgaagccggaggccttcctgcctttctcagcaggccgc
cgtgcatgcctcggggagcccctggcccgcatggagctcttcctcttcttcacctccctg
ctgcagcacttcagcttctccgtggccgccggacagccccggcccagccactctcgtgtc
gtcagctttctggtgaccccatccccctatgagctttgtgctgtgccccgctag

KEGG   Homo sapiens (human): 107987479
Entry
107987479         CDS       T01001                                 

Gene name
CYP2D6
Definition
(RefSeq) cytochrome P450 2D6
  KO
K17712  cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01522  Endocrine resistance
hsa04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    107987479 (CYP2D6)
   00982 Drug metabolism - cytochrome P450
    107987479 (CYP2D6)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    107987479 (CYP2D6)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    107987479 (CYP2D6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    107987479 (CYP2D6)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     107987479 (CYP2D6)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   107987479 (CYP2D6)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 107987479
NCBI-ProteinID: XP_016885820
UniProt: Q38LG2
LinkDB
Position
22
AA seq 497 aa
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYSPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQPRPSHSRV
VSFLVTPSPYELCAVPR
NT seq 1494 nt   +upstreamnt  +downstreamnt
atggggctagaagcactggtgcccctggccgtgatagtggccatcttcctgctcctggtg
gacctgatgcaccggcgccaacgctgggctgcacgctactcaccaggccccctgccactg
cccgggctgggcaacctgctgcatgtggacttccagaacacaccatactgcttcgaccag
ttgcggcgccgcttcggggacgtgttcagcctgcagctggcctggacgccggtggtcgtg
ctcaatgggctggcggccgtgcgcgaggcgctggtgacccacggcgaggacaccgccgac
cgcccgcctgtgcccatcacccagatcctgggttttgggccgcgttcccaaggggtgttc
ctggcgcgctatgggcccgcgtggcgcgagcagaggcgcttctccgtctccaccttgcgc
aacttgggcctgggcaagaagtcgctggagcagtgggtgaccgaggaggccgcctgcctt
tgtgccgccttcgccaaccactccggacgcccctttcgccccaacggtctcttggacaaa
gccgtgagcaacgtgatcgcctccctcacctgcgggcgccgcttcgagtacgacgaccct
cgcttcctcaggctgctggacctagctcaggagggactgaaggaggagtcgggctttctg
cgcgaggtgctgaatgctgtccccgtcctcctgcatatcccagcgctggctggcaaggtc
ctacgcttccaaaaggctttcctgacccagctggatgagctgctaactgagcacaggatg
acctgggacccagcccagcccccccgagacctgactgaggccttcctggcagagatggag
aaggccaaggggaaccctgagagcagcttcaatgatgagaacctgcgcatagtggtggct
gacctgttctctgccgggatggtgaccacctcgaccacgctggcctggggcctcctgctc
atgatcctacatccggatgtgcagcgccgtgtccaacaggagatcgacgacgtgataggg
caggtgcggcgaccagagatgggtgaccaggctcacatgccctacaccactgccgtgatt
catgaggtgcagcgctttggggacatcgtccccctgggtgtgacccatatgacatcccgt
gacatcgaagtacagggcttccgcatccctaagggaacgacactcatcaccaacctgtca
tcggtgctgaaggatgaggccgtctgggagaagcccttccgcttccaccccgaacacttc
ctggatgcccagggccactttgtgaagccggaggccttcctgcctttctcagcaggccgc
cgtgcatgcctcggggagcccctggcccgcatggagctcttcctcttcttcacctccctg
ctgcagcacttcagcttctccgtggccgccggacagccccggcccagccactctcgtgtc
gtcagctttctggtgaccccatccccctatgagctttgtgctgtgccccgctag

KEGG   Homo sapiens (human): 1557
Entry
1557              CDS       T01001                                 

Gene name
CYP2C19, CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19
Definition
(RefSeq) cytochrome P450 family 2 subfamily C member 19
  KO
K17721  cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
hsa05204  Chemical carcinogenesis
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    1557 (CYP2C19)
   00591 Linoleic acid metabolism
    1557 (CYP2C19)
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    1557 (CYP2C19)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1557 (CYP2C19)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    1557 (CYP2C19)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1557 (CYP2C19)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     1557 (CYP2C19)
    1.14.14.52  (S)-limonene 7-monooxygenase
     1557 (CYP2C19)
    1.14.14.53  (R)-limonene 6-monooxygenase
     1557 (CYP2C19)
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     1557 (CYP2C19)
    1.14.14.-  
     1557 (CYP2C19)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1557 (CYP2C19)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1557
NCBI-ProteinID: NP_000760
OMIM: 124020
HGNC: 2621
Ensembl: ENSG00000165841
Vega: OTTHUMG00000018799
Pharos: P33261(Tchem)
UniProt: P33261
LinkDB
Structure
PDB: 
4GQS

Position
10q23.33
AA seq 490 aa
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
NT seq 1473 nt   +upstreamnt  +downstreamnt
atggatccttttgtggtccttgtgctctgtctctcatgtttgcttctcctttcaatctgg
agacagagctctgggagaggaaaactccctcctggccccactcctctcccagtgattgga
aatatcctacagatagatattaaggatgtcagcaaatccttaaccaatctctcaaaaatc
tatggccctgtgttcactctgtattttggcctggaacgcatggtggtgctgcatggatat
gaagtggtgaaggaagccctgattgatcttggagaggagttttctggaagaggccatttc
ccactggctgaaagagctaacagaggatttggaatcgttttcagcaatggaaagagatgg
aaggagatccggcgtttctccctcatgacgctgcggaattttgggatggggaagaggagc
attgaggaccgtgttcaagaggaagcccgctgccttgtggaggagttgagaaaaaccaag
gcttcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctcc
attattttccagaaacgtttcgattataaagatcagcaatttcttaacttgatggaaaaa
ttgaatgaaaacatcaggattgtaagcaccccctggatccagatatgcaataattttccc
actatcattgattatttcccgggaacccataacaaattacttaaaaaccttgcttttatg
gaaagtgatattttggagaaagtaaaagaacaccaagaatcgatggacatcaacaaccct
cgggactttattgattgcttcctgatcaaaatggagaaggaaaagcaaaaccaacagtct
gaattcactattgaaaacttggtaatcactgcagctgacttacttggagctgggacagag
acaacaagcacaaccctgagatatgctctccttctcctgctgaagcacccagaggtcaca
gctaaagtccaggaagagattgaacgtgtcattggcagaaaccggagcccctgcatgcag
gacaggggccacatgccctacacagatgctgtggtgcacgaggtccagagatacatcgac
ctcatccccaccagcctgccccatgcagtgacctgtgacgttaaattcagaaactacctc
attcccaagggcacaaccatattaacttccctcacttctgtgctacatgacaacaaagaa
tttcccaacccagagatgtttgaccctcgtcactttctggatgaaggtggaaattttaag
aaaagtaactacttcatgcctttctcagcaggaaaacggatttgtgtgggagagggcctg
gcccgcatggagctgtttttattcctgaccttcattttacagaactttaacctgaaatct
ctgattgacccaaaggaccttgacacaactcctgttgtcaatggatttgcttctgtcccg
cccttctatcagctgtgcttcattcctgtctga

KEGG   Homo sapiens (human): 1558
Entry
1558              CDS       T01001                                 

Gene name
CYP2C8, CPC8, CYP2C8DM, CYPIIC8, MP-12/MP-20
Definition
(RefSeq) cytochrome P450 family 2 subfamily C member 8
  KO
K17718  cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa00830  Retinol metabolism
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
hsa05204  Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    1558 (CYP2C8)
   00591 Linoleic acid metabolism
    1558 (CYP2C8)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1558 (CYP2C8)
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    1558 (CYP2C8)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1558 (CYP2C8)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    1558 (CYP2C8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1558 (CYP2C8)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1558 (CYP2C8)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1558 (CYP2C8)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1558
NCBI-ProteinID: NP_000761
OMIM: 601129
HGNC: 2622
Ensembl: ENSG00000138115
Vega: OTTHUMG00000018804
Pharos: P10632(Tbio)
UniProt: P10632
LinkDB
Structure
PDB: 
2NNJ 2NNH 2VN0 1PQ2 2NNI

Position
10q23.33
AA seq 490 aa
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
NT seq 1473 nt   +upstreamnt  +downstreamnt
atggaaccttttgtggtcctggtgctgtgtctctcttttatgcttctcttttcactctgg
agacagagctgtaggagaaggaagctccctcctggccccactcctcttcctattattgga
aatatgctacagatagatgttaaggacatctgcaaatctttcaccaatttctcaaaagtc
tatggtcctgtgttcaccgtgtattttggcatgaatcccatagtggtgtttcatggatat
gaggcagtgaaggaagccctgattgataatggagaggagttttctggaagaggcaattcc
ccaatatctcaaagaattactaaaggacttggaatcatttccagcaatggaaagagatgg
aaggagatccggcgtttctccctcacaaccttgcggaattttgggatggggaagaggagc
attgaggaccgtgttcaagaggaagctcactgccttgtggaggagttgagaaaaaccaag
gcttcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctcc
gttgttttccagaaacgatttgattataaagatcagaattttctcaccctgatgaaaaga
ttcaatgaaaacttcaggattctgaactccccatggatccaggtctgcaataatttccct
ctactcattgattgtttcccaggaactcacaacaaagtgcttaaaaatgttgctcttaca
cgaagttacattagggagaaagtaaaagaacaccaagcatcactggatgttaacaatcct
cgggactttatcgattgcttcctgatcaaaatggagcaggaaaaggacaaccaaaagtca
gaattcaatattgaaaacttggttggcactgtagctgatctatttgttgctggaacagag
acaacaagcaccactctgagatatggactcctgctcctgctgaagcacccagaggtcaca
gctaaagtccaggaagagattgatcatgtaattggcagacacaggagcccctgcatgcag
gataggagccacatgccttacactgatgctgtagtgcacgagatccagagatacagtgac
cttgtccccaccggtgtgccccatgcagtgaccactgatactaagttcagaaactacctc
atccccaagggcacaaccataatggcattactgacttccgtgctacatgatgacaaagaa
tttcctaatccaaatatctttgaccctggccactttctagataagaatggcaactttaag
aaaagtgactacttcatgcctttctcagcaggaaaacgaatttgtgcaggagaaggactt
gcccgcatggagctatttttatttctaaccacaattttacagaactttaacctgaaatct
gttgatgatttaaagaacctcaatactactgcagttaccaaagggattgtttctctgcca
ccctcataccagatctgcttcatccctgtctga

KEGG   Homo sapiens (human): 1559
Entry
1559              CDS       T01001                                 

Gene name
CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9
Definition
(RefSeq) cytochrome P450 family 2 subfamily C member 9
  KO
K17719  cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
hsa05204  Chemical carcinogenesis
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    1559 (CYP2C9)
   00591 Linoleic acid metabolism
    1559 (CYP2C9)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1559 (CYP2C9)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1559 (CYP2C9)
   00982 Drug metabolism - cytochrome P450
    1559 (CYP2C9)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1559 (CYP2C9)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    1559 (CYP2C9)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1559 (CYP2C9)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     1559 (CYP2C9)
    1.14.14.52  (S)-limonene 7-monooxygenase
     1559 (CYP2C9)
    1.14.14.53  (R)-limonene 6-monooxygenase
     1559 (CYP2C9)
    1.14.14.-  
     1559 (CYP2C9)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1559 (CYP2C9)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1559
NCBI-ProteinID: NP_000762
OMIM: 601130
HGNC: 2623
Ensembl: ENSG00000138109
Vega: OTTHUMG00000018805
Pharos: P11712(Tchem)
UniProt: P11712 S5RV20
LinkDB
Structure
PDB: 

Position
10q23.33
AA seq 490 aa
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
NT seq 1473 nt   +upstreamnt  +downstreamnt
atggattctcttgtggtccttgtgctctgtctctcatgtttgcttctcctttcactctgg
agacagagctctgggagaggaaaactccctcctggccccactcctctcccagtgattgga
aatatcctacagataggtattaaggacatcagcaaatccttaaccaatctctcaaaggtc
tatggccctgtgttcactctgtattttggcctgaaacccatagtggtgctgcatggatat
gaagcagtgaaggaagccctgattgatcttggagaggagttttctggaagaggcattttc
ccactggctgaaagagctaacagaggatttggaattgttttcagcaatggaaagaaatgg
aaggagatccggcgtttctccctcatgacgctgcggaattttgggatggggaagaggagc
attgaggaccgtgttcaagaggaagcccgctgccttgtggaggagttgagaaaaaccaag
gcctcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctcc
attattttccataaacgttttgattataaagatcagcaatttcttaacttaatggaaaag
ttgaatgaaaacatcaagattttgagcagcccctggatccagatctgcaataatttttct
cctatcattgattacttcccgggaactcacaacaaattacttaaaaacgttgcttttatg
aaaagttatattttggaaaaagtaaaagaacaccaagaatcaatggacatgaacaaccct
caggactttattgattgcttcctgatgaaaatggagaaggaaaagcacaaccaaccatct
gaatttactattgaaagcttggaaaacactgcagttgacttgtttggagctgggacagag
acgacaagcacaaccctgagatatgctctccttctcctgctgaagcacccagaggtcaca
gctaaagtccaggaagagattgaacgtgtgattggcagaaaccggagcccctgcatgcaa
gacaggagccacatgccctacacagatgctgtggtgcacgaggtccagagatacattgac
cttctccccaccagcctgccccatgcagtgacctgtgacattaaattcagaaactatctc
attcccaagggcacaaccatattaatttccctgacttctgtgctacatgacaacaaagaa
tttcccaacccagagatgtttgaccctcatcactttctggatgaaggtggcaattttaag
aaaagtaaatacttcatgcctttctcagcaggaaaacggatttgtgtgggagaagccctg
gccggcatggagctgtttttattcctgacctccattttacagaactttaacctgaaatct
ctggttgacccaaagaaccttgacaccactccagttgtcaatggatttgcctctgtgccg
cccttctaccagctgtgcttcattcctgtctga

KEGG   Homo sapiens (human): 1562
Entry
1562              CDS       T01001                                 

Gene name
CYP2C18, CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17
Definition
(RefSeq) cytochrome P450 family 2 subfamily C member 18
  KO
K17720  cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00830  Retinol metabolism
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
hsa05204  Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1562 (CYP2C18)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1562 (CYP2C18)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    1562 (CYP2C18)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1562 (CYP2C18)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1562 (CYP2C18)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1562 (CYP2C18)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1562
NCBI-ProteinID: NP_000763
OMIM: 601131
HGNC: 2620
Ensembl: ENSG00000108242
Vega: OTTHUMG00000018796
Pharos: P33260(Tbio)
UniProt: P33260 Q7Z348
LinkDB
Position
10q23.33
AA seq 490 aa
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW
KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS
VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI
KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE
TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID
LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK
KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP
PLYQLCFIPV
NT seq 1473 nt   +upstreamnt  +downstreamnt
atggatccagctgtggctctggtgctctgtctctcctgtttgtttctcctttcactctgg
aggcagagctctggaagagggaggctcccgtctggccccactcctctcccgattattgga
aatatcctgcagttagatgttaaggacatgagcaaatccttaaccaatttctcaaaagtc
tatggccctgtgttcactgtgtattttggcctgaagcccattgtggtgttgcatggatat
gaagcagtgaaggaggccctgattgatcatggagaggagttttctggaagaggaagtttt
ccagtggctgaaaaagttaacaaaggacttggaatccttttcagcaatggaaagagatgg
aaggagatccggcgtttctgcctcatgactctgcggaattttgggatggggaagaggagc
atcgaggaccgtgttcaagaggaagcccgctgccttgtggaggagttgagaaaaaccaat
gcctcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctct
gttattttccatgatcgatttgattataaagatcagaggtttcttaacttgatggaaaaa
ttcaatgaaaacctcaggattctgagctctccatggatccaggtctgcaataatttccct
gctctcatcgattatctcccaggaagtcataataaaatagctgaaaattttgcttacatt
aaaagttatgtattggagagaataaaagaacatcaagaatccctggacatgaacagtgct
cgggactttattgattgtttcctgatcaaaatggaacaggaaaagcacaatcaacagtct
gaatttactgttgaaagcttgatagccactgtaactgatatgtttggggctggaacagag
acaacgagcaccactctgagatatggactcctgctcctgctgaagtacccagaggtcaca
gctaaagtccaggaagagattgaatgtgtagttggcagaaaccggagcccctgtatgcag
gacaggagtcacatgccctacacagatgctgtggtgcacgagatccagagatacattgac
ctcctccccaccaacctgccccatgcagtgacctgtgatgttaaattcaaaaactacctc
atccccaagggcacgaccataataacatccctgacttctgtgctgcacaatgacaaagaa
ttccccaacccagagatgtttgaccctggccactttctggataagagtggcaactttaag
aaaagtgactacttcatgcctttctcagcaggaaaacggatgtgtatgggagagggcctg
gcccgcatggagctgtttttattcctgaccaccattttgcagaactttaacctgaaatct
caggttgacccaaaggatattgacatcacccccattgccaatgcatttggtcgtgtgcca
cccttgtaccagctctgcttcattcctgtctga

KEGG   Homo sapiens (human): 1564
Entry
1564              CDS       T01001                                 

Gene name
CYP2D7, CYP2D, CYP2D6, CYP2D7AP, CYP2D7P, CYP2D7P1, CYP2D@, P450C2D, P450DB1, RNA40057
Definition
(RefSeq) cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)
  KO
K17712  cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01522  Endocrine resistance
hsa04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1564 (CYP2D7)
   00982 Drug metabolism - cytochrome P450
    1564 (CYP2D7)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1564 (CYP2D7)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    1564 (CYP2D7)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1564 (CYP2D7)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1564 (CYP2D7)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1564 (CYP2D7)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1564
NCBI-ProteinID: NP_001335315
HGNC: 2624
Ensembl: ENSG00000205702
Vega: OTTHUMG00000030222
UniProt: A0A087X1C5
LinkDB
Position
22q13.2
AA seq 516 aa
MGLEALVPLAMIVAIFLLLVDLMHRHQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPAPIYQVLGFGPRSQGVI
LSRYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFADQAGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLPHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAKKEKAKGSPESSFNDENLRIVVG
NLFLAGMVTTSTTLAWGLLLMILHLDVQRGRRVSPGCSPIVGTHVCPVRVQQEIDDVIGQ
VRRPEMGDQAHMPCTTAVIHEVQHFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS
VLKDEAVWKKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLL
QHFSFSVAAGQPRPSHSRVVSFLVTPSPYELCAVPR
NT seq 1551 nt   +upstreamnt  +downstreamnt
atggggctagaagcactggtgcccctggccatgatagtggccatcttcctgctcctggtg
gacctgatgcaccggcaccaacgctgggctgcacgctacccgccaggtcccctgccactg
cccgggctgggcaacctgctgcatgtggacttccagaacacaccatactgcttcgaccag
ttgcggcgccgcttcggggacgtgttcagcctgcagctggcctggacgccggtggtcgtg
ctcaatgggctggcggccgtgcgcgaggcgatggtgacccgcggcgaggacacggccgac
cgcccgcctgcgcccatctaccaggtcctgggcttcgggccgcgttcccaaggggtgatc
ctgtcgcgctatgggcccgcgtggcgcgagcagaggcgcttctccgtgtccaccttgcgc
aacttgggcctgggcaagaagtcgctggagcagtgggtgaccgaggaggccgcctgcctt
tgtgccgccttcgccgaccaagccggacgcccctttcgccccaacggcctcttggacaaa
gccgtgagcaacgtgatcgcctccctcacctgcgggcgccgcttcgagtacgacgaccct
cgcttcctcaggctgctggacctagctcaggagggactgaaggaggagtcgggcttcctg
cgcgaggtgctgaatgctgtccccgtcctcccgcacatcccagcgctggctggcaaggtc
ctacgcttccaaaaggctttcctgacccagctggatgagctgctaactgagcacaggatg
acctgggacccagcccagccaccccgagacctgactgaggccttcctggcaaagaaggag
aaggccaaggggagccctgagagcagcttcaatgatgagaacctgcgcatagtggtgggt
aacctgttccttgccgggatggtgaccacctcgaccacgctggcctggggcctcctgctc
atgatcctacacctggatgtgcagcgaggaaggagagtgtcccctgggtgctcacccatt
gtggggacgcatgtctgtccagtccgtgtccaacaggagatcgacgacgtgatagggcag
gtgcggcgaccagagatgggtgaccaggctcacatgccctgcaccactgccgtgattcac
gaggtgcagcactttggggacatcgtccccctgggtgtgacccatatgacatcccgtgac
atcgaagtacagggcttccgcatccctaagggaacgacactcatcaccaacctgtcatcg
gtgctgaaggatgaggccgtctggaagaagcccttccgcttccaccccgaacacttcctg
gatgcccagggccactttgtgaagccggaggccttcctgcctttctcagcaggccgccgt
gcatgcctcggggagcccctggcccgcatggagctcttcctcttcttcacctccctgctg
cagcacttcagcttctccgtggccgccggacagccccggcccagccactctcgtgtcgtc
agctttctggtgaccccatccccctacgagctttgtgctgtgccccgctag

KEGG   Homo sapiens (human): 1565
Entry
1565              CDS       T01001                                 

Gene name
CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1
Definition
(RefSeq) cytochrome P450 family 2 subfamily D member 6
  KO
K17712  cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01522  Endocrine resistance
hsa04726  Serotonergic synapse
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1565 (CYP2D6)
   00982 Drug metabolism - cytochrome P450
    1565 (CYP2D6)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1565 (CYP2D6)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    1565 (CYP2D6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1565 (CYP2D6)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1565 (CYP2D6)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1565 (CYP2D6)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1565
NCBI-ProteinID: NP_000097
OMIM: 124030
HGNC: 2625
Ensembl: ENSG00000100197
Vega: OTTHUMG00000150918
Pharos: P10635(Tclin)
UniProt: P10635 C1ID52 Q5Y7H2
LinkDB
Structure
PDB: 

Position
22q13.2
AA seq 497 aa
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
NT seq 1494 nt   +upstreamnt  +downstreamnt
atggggctagaagcactggtgcccctggccgtgatagtggccatcttcctgctcctggtg
gacctgatgcaccggcgccaacgctgggctgcacgctacccaccaggccccctgccactg
cccgggctgggcaacctgctgcatgtggacttccagaacacaccatactgcttcgaccag
ttgcggcgccgcttcggggacgtgttcagcctgcagctggcctggacgccggtggtcgtg
ctcaatgggctggcggccgtgcgcgaggcgctggtgacccacggcgaggacaccgccgac
cgcccgcctgtgcccatcacccagatcctgggtttcgggccgcgttcccaaggggtgttc
ctggcgcgctatgggcccgcgtggcgcgagcagaggcgcttctccgtgtccaccttgcgc
aacttgggcctgggcaagaagtcgctggagcagtgggtgaccgaggaggccgcctgcctt
tgtgccgccttcgccaaccactccggacgcccctttcgccccaacggtctcttggacaaa
gccgtgagcaacgtgatcgcctccctcacctgcgggcgccgcttcgagtacgacgaccct
cgcttcctcaggctgctggacctagctcaggagggactgaaggaggagtcgggctttctg
cgcgaggtgctgaatgctgtccccgtcctcctgcatatcccagcgctggctggcaaggtc
ctacgcttccaaaaggctttcctgacccagctggatgagctgctaactgagcacaggatg
acctgggacccagcccagcccccccgagacctgactgaggccttcctggcagagatggag
aaggccaaggggaaccctgagagcagcttcaatgatgagaacctgcgcatagtggtggct
gacctgttctctgccgggatggtgaccacctcgaccacgctggcctggggcctcctgctc
atgatcctacatccggatgtgcagcgccgtgtccaacaggagatcgacgacgtgataggg
caggtgcggcgaccagagatgggtgaccaggctcacatgccctacaccactgccgtgatt
catgaggtgcagcgctttggggacatcgtccccctgggtgtgacccatatgacatcccgt
gacatcgaagtacagggcttccgcatccctaagggaacgacactcatcaccaacctgtca
tcggtgctgaaggatgaggccgtctgggagaagcccttccgcttccaccccgaacacttc
ctggatgcccagggccactttgtgaagccggaggccttcctgcctttctcagcaggccgc
cgtgcatgcctcggggagcccctggcccgcatggagctcttcctcttcttcacctccctg
ctgcagcacttcagcttctcggtgcccactggacagccccggcccagccaccatggtgtc
tttgctttcctggtgagcccatccccctatgagctttgtgctgtgccccgctag

KEGG   Homo sapiens (human): 1573
Entry
1573              CDS       T01001                                 

Gene name
CYP2J2, CPJ2, CYPIIJ2
Definition
(RefSeq) cytochrome P450 family 2 subfamily J member 2
  KO
K07418  cytochrome P450 family 2 subfamily J [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04913  Ovarian steroidogenesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    1573 (CYP2J2)
   00591 Linoleic acid metabolism
    1573 (CYP2J2)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    1573 (CYP2J2)
  09156 Nervous system
   04726 Serotonergic synapse
    1573 (CYP2J2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    1573 (CYP2J2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1573 (CYP2J2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1573 (CYP2J2)
    1.14.14.73  albendazole monooxygenase (sulfoxide-forming)
     1573 (CYP2J2)
    1.14.14.74  albendazole monooxygenase (hydroxylating)
     1573 (CYP2J2)
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     1573 (CYP2J2)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1573 (CYP2J2)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1573
NCBI-ProteinID: NP_000766
OMIM: 601258
HGNC: 2634
Ensembl: ENSG00000134716
Vega: OTTHUMG00000008991
Pharos: P51589(Tchem)
UniProt: P51589
LinkDB
Position
1p32.1
AA seq 502 aa
MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVD
FEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHI
FKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDP
HFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL
PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEEN
LICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMP
YTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDT
FNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLS
LKFRMGITISPVSHRLCAVPQV
NT seq 1509 nt   +upstreamnt  +downstreamnt
atgctcgcggcgatgggctctctggcggctgccctctgggcagtggtccatcctcggact
ctcctactgggcactgtcgcctttctgctcgctgctgactttctcaaaagacggcgccca
aagaactacccgccggggccctggcgcctgcccttccttggcaacttcttccttgtggac
ttcgagcagtcgcacctggaggttcagctgtttgtgaagaaatatgggaacctttttagc
ttggagcttggtgacatatctgcagttcttattactggcttgcccttaatcaaagaagcc
cttatccacatggaccaaaactttgggaaccgccccgtgacccctatgcgagaacatatc
tttaagaaaaatggattgattatgtcaagtggccaggcatggaaggagcaaagaaggttc
actctgacagcactaaggaactttggtttaggaaagaagagcttagaggaacgcattcag
gaggaggcccaacacctcactgaagcaataaaagaggagaacggacagccttttgaccct
catttcaagatcaacaatgcagtttccaatatcatttgctccatcaccttcggagaacgc
tttgagtaccaggatagttggtttcagcagctgctgaagttactagatgaagtcacatac
ttggaggcttcaaagacatgccagctctacaatgtctttccatggataatgaaattcctg
cctggaccccaccaaactctcttcagcaactggaaaaaactgaaattgtttgtttctcat
atgattgacaaacacagaaaggattggaatcctgcagaaacaagagactttattgatgct
taccttaaagaaatgtcaaagcacacaggcaatcctacttcaagtttccatgaagaaaac
ctcatctgcagcaccctggacctcttctttgccggaaccgagacaacttccacaactctg
cgatgggctctgctttatatggccctctacccagaaatccaagaaaaagtacaagctgag
attgacagagtgattggccaggggcagcagccgagcacagccgcccgggagtccatgccc
tacaccaatgctgtcatccatgaggtgcagagaatgggcaacatcatccccctgaacgtt
cccagggaagtgacagttgataccactttggctgggtaccacctgcccaagggtaccatg
atcctgaccaatttgacggcgctgcacagggaccccacagagtgggccacccctgacaca
ttcaatccggaccattttctggagaatggacagtttaagaaaagggaagcctttatgcct
ttctcaataggaaagcgggcatgcctcggagaacagttggccaggactgagctgtttatt
ttcttcacttcccttatgcaaaaatttaccttcaggcccccaaacaatgagaagctgagc
ctgaagtttagaatgggtatcaccatttccccagtcagtcaccgcctctgcgctgttcct
caggtgtaa

KEGG   Homo sapiens (human): 260293
Entry
260293            CDS       T01001                                 

Gene name
CYP4X1, CYPIVX1
Definition
(RefSeq) cytochrome P450 family 4 subfamily X member 1
  KO
K07428  cytochrome P450 family 4 subfamily X [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    260293 (CYP4X1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    260293 (CYP4X1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     260293 (CYP4X1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP4 family
   260293 (CYP4X1)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 260293
NCBI-ProteinID: NP_828847
OMIM: 614999
HGNC: 20244
Ensembl: ENSG00000186377
Vega: OTTHUMG00000008017
Pharos: Q8N118(Tbio)
UniProt: Q8N118
LinkDB
Position
1p33; 1
AA seq 509 aa
MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF
IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPL
LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEV
YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL
SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS
FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ
LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW
KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD
PTRPLTFPNHFILKPKNGMYLHLKKLSEC
NT seq 1530 nt   +upstreamnt  +downstreamnt
atggaattctcctggctggagacgcgctgggcgcggcccttttacctggcgttcgtgttc
tgcctggccctggggctgctgcaggccattaagctgtacctgcggaggcagcggctgctg
cgggacctgcgccccttcccagcgccccccacccactggttccttgggcaccagaagttt
attcaggatgataacatggagaagcttgaggaaattattgaaaaataccctcgtgccttc
cctttctggattgggccctttcaggcatttttctgtatctatgacccagactatgcaaag
acacttctgagcagaacagatcccaagtcccagtacctgcagaaattctcacctccactt
cttggaaaaggactagcggctctagacggacccaagtggttccagcatcgtcgcctacta
actcctggattccattttaacatcctgaaagcatacattgaggtgatggctcattctgtg
aaaatgatgctggataagtgggagaagatttgcagcactcaggacacaagcgtggaggtc
tatgagcacatcaactcgatgtctctggatataatcatgaaatgcgctttcagcaaggag
accaactgccagacaaacagcacccatgatccttatgcaaaagccatatttgaactcagc
aaaatcatatttcaccgcttgtacagtttgttgtatcacagtgacataattttcaaactc
agccctcagggctaccgcttccagaagttaagccgagtgttgaatcagtacacagataca
ataatccaggaaagaaagaaatccctccaggctggggtaaagcaggataacactccgaag
aggaagtaccaggattttctggatattgtcctttctgccaaggatgaaagtggtagcagc
ttctcagatattgatgtacactctgaagtgagcacattcctgttggcaggacatgacacc
ttggcagcaagcatctcctggatcctttactgcctggctctgaaccctgagcatcaagag
agatgccgggaggaggtcaggggcatcctgggggatgggtcttctatcacttgggaccag
ctgggtgagatgtcgtacaccacaatgtgcatcaaggagacgtgccgattgattcctgca
gtcccgtccatttccagagatctcagcaagccacttaccttcccagatggatgcacattg
cctgcagggatcaccgtggttcttagtatttggggtcttcaccacaaccctgctgtctgg
aaaaacccaaaggtctttgaccccttgaggttctctcaggagaattctgatcagagacac
ccctatgcctacttaccattctcagctggatcaaggaactgcattgggcaggagtttgcc
atgattgagttaaaggtaaccattgccttgattctgctccacttcagagtgactccagac
cccaccaggcctcttactttccccaaccattttatcctcaagcccaagaatgggatgtat
ttgcacctgaagaaactctctgaatgttag

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