KEGG   Homo sapiens (human): 11238Help
Entry
11238             CDS       T01001                                 

Gene name
CA5B, CA-VB, CAVB
Definition
(RefSeq) carbonic anhydrase 5B
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    11238 (CA5B)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     11238 (CA5B)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase Tudor_3
Motif
Other DBs
NCBI-GeneID: 11238
NCBI-ProteinID: NP_009151
OMIM: 300230
HGNC: 1378
Ensembl: ENSG00000169239
Vega: OTTHUMG00000021183
Pharos: Q9Y2D0(Tclin)
UniProt: Q9Y2D0 A0A024RBW9
LinkDB All DBs
Position
Xp22.2
AA seq 317 aa AA seqDB search
MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPG
GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPL
EHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVI
GVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLS
ESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDY
VLNVQAKPKPATSQATP
NT seq 954 nt NT seq  +upstreamnt  +downstreamnt
atggtggtgatgaacagcctgagggtcattcttcaagcctctccaggcaaattgctgtgg
agaaagttccagattccgagattcatgccagcgaggccctgcagcctctatacttgtact
tacaaaacccggaaccgagccttgcatccactctgggagagcgtggacctggttcctggg
ggcgatcgccagtcacccatcaacattcggtggagggacagtgtttatgatcccggctta
aaaccactgaccatctcttatgacccagccacctgcctccacgtctggaataatgggtac
tctttcctcgtggaatttgaagattctacagataaatcagtgatcaagggaggacccctg
gaacacaactaccgattgaagcagttccattttcactggggggccatcgatgcctggggt
tctgagcacaccgtggacagcaaatgcttcccagcagagctgcacttagtgcattggaac
gcagtcagatttgaaaactttgaggatgcagcactggaagaaaatggtttggctgtgata
ggagtatttttaaagctaggcaaacatcataaggagctacagaaattagtggatactttg
ccgtcaattaagcataaggacgcccttgtggaatttgggtcatttgacccttcctgcctg
atgcctacctgcccagattactggacctactcagggtctctgactaccccacccctctcc
gagtctgtcacctggatcattaagaagcaaccagtagaggttgatcatgatcagcttgag
caatttcggaccctgcttttcacttccgaaggggagaaagagaaaagaatggtggacaac
ttccgcccccttcagccactgatgaatcgcactgttcgttcatccttccggcatgattat
gtgctgaatgtacaagcgaaacccaagccggccaccagccaagcaaccccctaa

KEGG   Homo sapiens (human): 23632Help
Entry
23632             CDS       T01001                                 

Gene name
CA14, CAXiV
Definition
(RefSeq) carbonic anhydrase 14
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    23632 (CA14)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     23632 (CA14)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase NicO
Motif
Other DBs
NCBI-GeneID: 23632
NCBI-ProteinID: NP_036245
OMIM: 604832
HGNC: 1372
Ensembl: ENSG00000118298
Vega: OTTHUMG00000012549
Pharos: Q9ULX7(Tclin)
UniProt: Q9ULX7 A8K3J4
LinkDB All DBs
Structure
PDB: 

Position
1q21.2
AA seq 337 aa AA seqDB search
MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPD
LPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGG
SEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSH
LHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQ
LEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVG
CLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
NT seq 1014 nt NT seq  +upstreamnt  +downstreamnt
atgttgttctccgccctcctgctggaggtgatttggatcctggctgcagatgggggtcaa
cactggacgtatgagggcccacatggtcaggaccattggccagcctcttaccctgagtgt
ggaaacaatgcccagtcgcccatcgatattcagacagacagtgtgacatttgaccctgat
ttgcctgctctgcagccccacggatatgaccagcctggcaccgagcctttggacctgcac
aacaatggccacacagtgcaactctctctgccctctaccctgtatctgggtggacttccc
cgaaaatatgtagctgcccagctccacctgcactggggtcagaaaggatccccagggggg
tcagaacaccagatcaacagtgaagccacatttgcagagctccacattgtacattatgac
tctgattcctatgacagcttgagtgaggctgctgagaggcctcagggcctggctgtcctg
ggcatcctaattgaggtgggtgagactaagaatatagcttatgaacacattctgagtcac
ttgcatgaagtcaggcataaagatcagaagacctcagtgcctcccttcaacctaagagag
ctgctccccaaacagctggggcagtacttccgctacaatggctcgctcacaactccccct
tgctaccagagtgtgctctggacagttttttatagaaggtcccagatttcaatggaacag
ctggaaaagcttcaggggacattgttctccacagaagaggagccctctaagcttctggta
cagaactaccgagcccttcagcctctcaatcagcgcatggtctttgcttctttcatccaa
gcaggatcctcgtataccacaggtgaaatgctgagtctaggtgtaggaatcttggttggc
tgtctctgccttctcctggctgtttatttcattgctagaaagattcggaagaagaggctg
gaaaaccgaaagagtgtggtcttcacctcagcacaagccacgactgaggcataa

KEGG   Homo sapiens (human): 377677Help
Entry
377677            CDS       T01001                                 

Gene name
CA13, CAXIII
Definition
(RefSeq) carbonic anhydrase 13
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    377677 (CA13)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     377677 (CA13)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase
Motif
Other DBs
NCBI-GeneID: 377677
NCBI-ProteinID: NP_940986
OMIM: 611436
HGNC: 14914
Ensembl: ENSG00000185015
Vega: OTTHUMG00000164940
Pharos: Q8N1Q1(Tclin)
UniProt: Q8N1Q1
LinkDB All DBs
Structure
PDB: 

Position
8q21.2
AA seq 262 aa AA seqDB search
MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKII
SNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELH
VVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNF
DLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAA
FLVSNHRPPQPLKGRKVRASFH
NT seq 789 nt NT seq  +upstreamnt  +downstreamnt
atgtcgaggctcagctggggataccgcgagcacaacggtcctattcactggaaggaattt
ttccctattgctgatggtgatcagcaatctccaattgagattaaaaccaaagaagtgaaa
tatgactcttccctccgaccacttagtatcaagtatgacccaagctcagctaaaatcatc
agcaacagcggccattccttcaatgttgactttgatgacacagagaacaaatcagttctg
cgtggtggtcctctcactggaagctacaggttacggcaggttcaccttcactgggggtcc
gctgatgaccacggctccgagcacatagtagatggagtgagctatgctgcagagctccat
gttgttcactggaattcagacaaataccccagctttgttgaggcagctcatgaaccagat
ggactggctgtcttgggagtgtttttacagattggtgaacctaattcccaactgcaaaag
attactgacactttggattccattaaagaaaagggtaaacaaactcgattcacaaatttt
gacctattgtctctgcttccaccatcctgggactactggacatatcctggttctcttaca
gttccacctcttcttgagagtgtcacatggattgttttaaagcaacctataaacatcagc
tctcaacagctggccaaatttcgcagtctcctgtgcacagcggagggtgaagcagcagct
tttctggtgagcaatcaccgcccaccacagcctctaaagggccgcaaagtgagagcctct
ttccattaa

KEGG   Homo sapiens (human): 759Help
Entry
759               CDS       T01001                                 

Gene name
CA1, CA-I, CAB, Car1, HEL-S-11
Definition
(RefSeq) carbonic anhydrase 1
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    759 (CA1)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     759 (CA1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase
Motif
Other DBs
NCBI-GeneID: 759
NCBI-ProteinID: NP_001122301
OMIM: 114800
HGNC: 1368
Ensembl: ENSG00000133742
Vega: OTTHUMG00000164941
Pharos: P00915(Tclin)
UniProt: P00915 V9HWE3
LinkDB All DBs
Structure
PDB: 

Position
8q21.2
AA seq 261 aa AA seqDB search
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
NT seq 786 nt NT seq  +upstreamnt  +downstreamnt
atggcaagtccagactggggatatgatgacaaaaatggtcctgaacaatggagcaagctg
tatcccattgccaatggaaataaccagtcccctgttgatattaaaaccagtgaaaccaaa
catgacacctctctgaaacctattagtgtctcctacaacccagccacagccaaagaaatt
atcaatgtggggcattccttccatgtaaattttgaggacaacgataaccgatcagtgctg
aaaggtggtcctttctctgacagctacaggctctttcagttccattttcactggggcagt
acaaatgagcatggttcagaacatacagtggatggagtcaaatattctgccgagcttcac
gtagctcactggaattctgcaaagtactccagccttgctgaagctgcctcaaaggctgat
ggtttggcagttattggtgttttgatgaaggttggtgaggccaacccaaagctgcagaaa
gtacttgatgccctccaagcaattaaaaccaagggcaaacgagccccattcacaaatttt
gacccctctactctccttccttcatccctggatttctggacctaccctggctctctgact
catcctcctctttatgagagtgtaacttggatcatctgtaaggagagcatcagtgtcagc
tcagagcagctggcacaattccgcagccttctatcaaatgttgaaggtgataacgctgtc
cccatgcagcacaacaaccgcccaacccaacctctgaagggcagaacagtgagagcttca
ttttga

KEGG   Homo sapiens (human): 760Help
Entry
760               CDS       T01001                                 

Gene name
CA2, CA-II, CAC, CAII, Car2, HEL-76, HEL-S-282
Definition
(RefSeq) carbonic anhydrase 2
  KO
K18245  carbonic anhydrase 2 [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
hsa04964  Proximal tubule bicarbonate reclamation
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
hsa04976  Bile secretion
Disease
H00241  Combined proximal and distal renal tubular acidosis
H00436  Osteopetrosis
H02310  Renal tubular acidosis
Drug target
Acetazolamide (DG01134): D00218 D01196
Brinzolamide: D00652
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Topiramate: D00537
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    760 (CA2)
 09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    760 (CA2)
   04972 Pancreatic secretion
    760 (CA2)
   04976 Bile secretion
    760 (CA2)
  09155 Excretory system
   04964 Proximal tubule bicarbonate reclamation
    760 (CA2)
   04966 Collecting duct acid secretion
    760 (CA2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    760 (CA2)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     760 (CA2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   760 (CA2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase
Motif
Other DBs
NCBI-GeneID: 760
NCBI-ProteinID: NP_000058
OMIM: 611492
HGNC: 1373
Ensembl: ENSG00000104267
Vega: OTTHUMG00000164944
Pharos: P00918(Tclin)
UniProt: P00918 V9HW21
LinkDB All DBs
Structure
PDB: 
6B00 5Y2S 3KS3 3K34 3U7C 1LUG 4YXI 4FU5 4FRC 4FPT 5OGO 2FOU 5Y2R 5LJT 4Q78 4MTY 6NJ3 6G3Q 4YX4 2NNO 6HR3 5LL8 3V7X 2NNS 5LJQ 5DOH 4FVN 4FVO 3VBD 2ILI 1MOO 4YXO 4WW6 4PZH 4YYT 4Q08 6GDC 5M78 4YXU 6GM9 6HQX 5OGN 5OGP 5NXV 5NXW 5NY1 5NY6 5LLC 5JGT 5DRS 4YGJ 4WL4 3SAX 3HS4 2WEG 3D92 3D93 2NNV 2FOS 5JGS 6HXD 6G6T 5LLG 5LL4 4Q6D 4Q6E 5JEH 5EKJ 4RUX 4RUY 6IC2 5SZ6 5JE7 5BYI 4Q06 4Q07 4HF3 3MHO 2NXT 2FOV 2EU2 5NXI 4ITO 3RYY 5MJN 3M2Y 5JG5 5JEG 5JEP 6QFW 5YUI 6B4D 5NYA 5NXG 5NXO 5T74 4Q09 4FIK 3RYV 3RJ7 2NNG 6D1M 5U0F 5TXY 5JG3 5JES 5EHV 5EH5 3L14 4YGN 6NJ5 5YUJ 5NXM 5NXP 3S71 2FOQ 5WEX 3GZ0 5U0E 5SZ5 4Z1J 6C7W 5G0C 6ODZ 6OE0 6QL2 6NJ4 6GXE 6GCY 5NEA 5N1R 5N1S 5T71 5T72 5E28 5DSK 5DSM 5DSR 4RH2 4QIY 3S9T 3S8X 3PYK 6H3Q 3ZP9 6QFX 5ZXW 5THN 5EKM 5JDV 5EKH 4HEZ 6QL3 6GXB 5ULN 5G03 4Z1K 4QK3 4MDG 4KUV 4BF1 3MYQ 3M1K 3KNE 6PGX 5JQT 5AML 3RYZ 5EH8 3M1W 3M14 5WLU 5VGY 5EHW 3RYJ 3KIG 6D1L 5WLV 5NY3 5N25 5JQ0 5G01 5E2K 5DSO 5DSP 5BRW 4QSB 3SBI 3S74 3MWO 3M96 3M5S 3M04 2WEO 2QO8 3IBU 6QL1 5TI0 5LVS 6CEH 5EH7 6HX5 3HLJ 6OE1 6QFV 6H6S 5YUK 5WG7 5TY8 5DSL 4Z0Q 4YVY 4YWP 4Q8Y 4Q7W 4CQ0 4KAP 4HEY 4E49 4E4A 3OKU 3OKV 3OIM 2WEJ 2QP6 6H29 2GD8 2AW1 5TH4 4Z1N 4QEF 3V2M 3QYK 3PO6 3OYQ 3DD0 5WLR 4DZ7 4DZ9 3P58 3P5A 2WD2 6NJ2 6MBY 6C7X 6FJJ 5N24 5TYA 5THI 5THJ 5TFX 5T75 5EHE 5E2S 5DSQ 4ZX1 4ZWY 5AMD 4YGK 4R5B 4QY3 4QSA 4Q99 4Q8Z 4JSA 4JSS 4BCW 4GL1 4E3F 4E3H 3V5G 3TVN 3S75 3RLD 3RG4 3P5L 3P3H 3OIK 3OIL 3N3J 3N0N 3MZC 3MNA 3MMF 3MHM 3M98 3KOK 3KON 3DCW 2AX2 1OQ5 1FR7 4YGL 3RZ1 5JN1 5JN7 4QK2 4MDL 5WGP 5TY9 4RN4 5U0G 4Q90 4N16 3OYS 2CBA 6H34 6CJV 5SZ1 5G0B 5CLU 5AMG 4Q9Y 4Q8X 4Q81 4Q83 4Q87 4MDM 4KUW 4KV0 4JS6 4E3G 3U3A 3IBL 2HNC 2HL4 1ZFQ 6GOT 5C8I 3V3G 2VVA 1ZFK 5WLT 5A6H 6RVK 6H33 5U0D 5FNK 5FNL 5FNM 6NJ6 6E8X 6FJI 5W8B 5TY1 5SZ4 5JN3 5FNI 5E2R 5BRU 5BRV 4ZWI 4ZX0 4QK1 4Q7V 4LHI 4K13 4IWZ 4ILX 4IDR 4HT0 4E3D 3U47 3TVO 3S72 3S76 3RYX 3R16 3P3J 3OY0 3N4B 3M40 3DVC 3DVD 3DC9 3DCC 3DAZ 2QOA 2POU 2POV 2OSM 2OSF 2FMZ 2FMG 2EU3 1G0E 1G0F 1FR4 1CIL 6B5A 4ZWZ 6EEH 6EEA 5SZ0 5SZ2 4RUZ 4RIV 4RFD 4N0X 4L5V 3V3J 1TH9 6B59 4R5A 2X7S 3KOI 6EQU 4RIU 4RFC 4R59 4Q7P 4MLX 4KUY 3T5Z 3SBH 3RZ5 3N2P 3MNH 3M2N 3IGP 3D9Z 2NWY 1ZGE 5FNH 5FLO 4M2W 2VVB 1Z9Y 5FNJ 5FLS 5FLT 2CBB 2CBD 5FLR 3M3X 5SZ3 3M1Q 6RW1 6MBV 5NEE 5N0D 5LMD 5L6K 5J8Z 5FLQ 5DOG 4ZWX 4L5W 4K1Q 4ITP 4HEW 4E5Q 3V2J 3U45 3RZ8 3R17 3MHI 3MHC 3M5E 3M2Z 3HKQ 3DV7 3DVB 3DC3 3DBU 3D8W 3CYU 3C7P 2Q1B 2NXR 2NWO 1ZH9 1YO1 1MUA 1CAM 5FLP 2F14 6RVL 6EEO 4M2V 3V3I 5N0E 5FDC 4QJM 4PYY 3T5U 3SAP 3S73 3MNI 3MNJ 3MNK 2POW 1ZGF 1LG5 4HBA 1XQ0 6E92 5SZ7 4K0T 6QFU 6E91 6BC9 6BCC 5O07 5GMN 5EOI 4ZAO 4XE1 4QTL 4Q7S 4Q49 4PYX 4KNI 4K0S 4K0Z 3T83 3RZ0 3RZ7 3PJJ 3NB5 3MNU 3ML2 3M67 3M1J 3HKN 3HKU 2WD3 3DCS 3CAJ 2NXS 2NWP 2NWZ 2HD6 2FNK 2FNM 2FNN 1YO0 1YO2 1THK 1TG3 1I9Q 1G52 1ZSC 1CNI 1CNJ 1RZB 1RAY 1CAI 3FFP 1XEG 4BF6 2CBE 1G45 1I9M 1G4J 1G46 5FDI 4PXX 4PQ7 4MO8 4FL7 3V3H 3BET 1BV3 1H9N 3S77 1I9N 1I9O 1G54 1G48 1G3Z 3M2X 6EDA 6EBE 1CAH 2CBC 2X7T 3B4F 6E8P 5LLE 5LLH 5JMZ 4JSW 4JSZ 3RG3 3MHL 3K7K 3F4X 3BL0 2HKK 2H15 1TG9 1LGD 1F2W 2H4N 1UGE 1CNX 1CNG 1YDB 1BCD 1RZA 1RZC 1RZD 1RZE 1RAZ 1CAZ 1CRA 1CAJ 1CAK 1BIC 1CAN 1CAO 2CA2 1I9P 3IBI 1IF4 1I9L 1I8Z 6H2Z 1IF8 1G53 4QSI 3M5T 2Q38 1TTM 1YDC 1G4O 5L3O 3S78 1IF7 5EIJ 4M2R 6BBS 5BNL 4Y0J 4MLT 4M2U 4KNJ 4G0C 3V3F 3TMJ 3T82 3T84 3P4V 3P55 3NJ9 3KWA 3KKX 3IEO 3F8E 2GEH 2EZ7 2ABE 1ZE8 1TEQ 1TEU 1TE3 1TBT 1TB0 1T9N 1IF5 1IF9 1I90 1I91 1FSN 1FSQ 1FSR 1FQM 1FQN 1FQR 1FQL 1AVN 1AM6 1H4N 1UGA 1UGB 1UGC 1UGD 1UGF 1ZSB 1CNW 1HEA 1HEB 1HEC 1HED 3CA2 1CA2 4Z1E 1XPZ 1G1D 5FNG 4L5U 1CNH 6RVF 1IF6 3RGE 3NI5 3HFP 2WEH 3BL1 2O4Z 2HOC 1EOU 1BN1 1BN4 1OKL 1YDA 1YDD 1CIM 1CIN 1DCB 1CAY 4CA2 5CA2 2X7U 5UMC 4LP6 1BNT 1BNU 1CNK 5L70 3P44 3IBN 1XEV 1LG6 1BN3 1H9Q 1UGG 1OKM 1CCT 1CVD 1CNC 1DCA 1CAL 4CAC 5CAC 6ECZ 1KWR 1BNW 1A42 1CCU 1CVE 1CVF 1CVA 1LZV 1BNN 1CNY 1CVH 1CVC 1HVA 1HCA 1CA3 1CCS 1CNB 3HKT 3T85 1BNQ 1BNV 1OKN 1CVB 12CA 7CA2 8CA2 1ZSA 6CA2 1KWQ 1BNM 5L6T 6Q9T 9CA2 5L9E 6HZX 6QEB 6HD2
Thumbnails

Position
8q21.2
AA seq 260 aa AA seqDB search
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
NT seq 783 nt NT seq  +upstreamnt  +downstreamnt
atgtcccatcactgggggtacggcaaacacaacggacctgagcactggcataaggacttc
cccattgccaagggagagcgccagtcccctgttgacatcgacactcatacagccaagtat
gacccttccctgaagcccctgtctgtttcctatgatcaagcaacttccctgaggatcctc
aacaatggtcatgctttcaacgtggagtttgatgactctcaggacaaagcagtgctcaag
ggaggacccctggatggcacttacagattgattcagtttcactttcactggggttcactt
gatggacaaggttcagagcatactgtggataaaaagaaatatgctgcagaacttcacttg
gttcactggaacaccaaatatggggattttgggaaagctgtgcagcaacctgatggactg
gccgttctaggtatttttttgaaggttggcagcgctaaaccgggccttcagaaagttgtt
gatgtgctggattccattaaaacaaagggcaagagtgctgacttcactaacttcgatcct
cgtggcctccttcctgaatccttggattactggacctacccaggctcactgaccacccct
cctcttctggaatgtgtgacctggattgtgctcaaggaacccatcagcgtcagcagcgag
caggtgttgaaattccgtaaacttaacttcaatggggagggtgaacccgaagaactgatg
gtggacaactggcgcccagctcagccactgaagaacaggcaaatcaaagcttccttcaaa
taa

KEGG   Homo sapiens (human): 761Help
Entry
761               CDS       T01001                                 

Gene name
CA3, CAIII, Car3
Definition
(RefSeq) carbonic anhydrase 3
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    761 (CA3)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     761 (CA3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase
Motif
Other DBs
NCBI-GeneID: 761
NCBI-ProteinID: NP_005172
OMIM: 114750
HGNC: 1374
Ensembl: ENSG00000164879
Vega: OTTHUMG00000164942
Pharos: P07451(Tclin)
UniProt: P07451 V9HWA3
LinkDB All DBs
Structure
PDB: 

Position
8q21.2
AA seq 260 aa AA seqDB search
MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTIL
NNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHL
VHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDP
SCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPL
VSNWRPPQPINNRVVRASFK
NT seq 783 nt NT seq  +upstreamnt  +downstreamnt
atggccaaggagtggggctacgccagtcacaacggtcctgaccactggcatgaacttttc
ccaaatgccaagggggaaaaccagtcgcccgttgagctgcatactaaagacatcaggcat
gacccttctctgcagccatggtctgtgtcttatgatggtggctctgccaagaccatcctg
aataatgggaagacctgccgagttgtatttgatgatacttatgataggtcaatgctgaga
gggggtcctctccctggaccctaccgacttcgccagtttcatcttcactggggctcttcg
gatgatcatggctctgagcacaccgtggatggagtcaagtatgcagcggagcttcatttg
gttcactggaacccgaagtataacacttttaaagaagccctgaagcagcgcgatgggatc
gctgtgattggcatttttctgaagataggacatgagaatggcgagttccagattttcctt
gatgcattggacaagattaagacaaagggcaaggaggcgcccttcacaaagtttgaccca
tcctgcctgttcccggcatgccgggactactggacctaccagggctcattcaccacgccg
ccctgcgaggaatgcattgtgtggctgctgctgaaggagcccatgaccgtgagctctgac
cagatggccaagctgcggagcctcctctccagtgctgagaacgagcccccagtgcctctt
gtgagcaactggcgacctccacagcctatcaataacagggtggtgagagcttccttcaaa
tga

KEGG   Homo sapiens (human): 762Help
Entry
762               CDS       T01001                                 

Gene name
CA4, CAIV, Car4, RP17
Definition
(RefSeq) carbonic anhydrase 4
  KO
K18246  carbonic anhydrase 4 [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
hsa04964  Proximal tubule bicarbonate reclamation
Disease
H00527  Retinitis pigmentosa
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Topiramate: D00537
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    762 (CA4)
 09150 Organismal Systems
  09155 Excretory system
   04964 Proximal tubule bicarbonate reclamation
    762 (CA4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    762 (CA4)
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    762 (CA4)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     762 (CA4)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   762 (CA4)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
 Enzymes
  762 (CA4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase
Motif
Other DBs
NCBI-GeneID: 762
NCBI-ProteinID: NP_000708
OMIM: 114760
HGNC: 1375
Ensembl: ENSG00000167434
Vega: OTTHUMG00000179987
Pharos: P22748(Tclin)
UniProt: P22748
LinkDB All DBs
Structure
PDB: 

Position
17q23.1
AA seq 312 aa AA seqDB search
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
NT seq 939 nt NT seq  +upstreamnt  +downstreamnt
atgcggatgctgctggcgctcctggccctctccgcggcgcggccatcggccagtgcagag
tcacactggtgctacgaggttcaagccgagtcctccaactacccctgcttggtgccagtc
aagtggggtggaaactgccagaaggaccgccagtcccccatcaacatcgtcaccaccaag
gcaaaggtggacaaaaaactgggacgcttcttcttctctggctacgataagaagcaaacg
tggactgtccaaaataacgggcactcagtgatgatgttgctggagaacaaggccagcatt
tctggaggaggactgcctgccccataccaggccaaacagttgcacctgcactggtccgac
ttgccatataagggctcggagcacagcctcgatggggagcactttgccatggagatgcac
atagtacatgagaaagagaaggggacatcgaggaatgtgaaagaggcccaggaccctgaa
gacgaaattgcggtgctggcctttctggtggaggctggaacccaggtgaacgagggcttc
cagccactggtggaggcactgtctaatatccccaaacctgagatgagcactacgatggca
gagagcagcctgttggacctgctccccaaggaggagaaactgaggcactacttccgctac
ctgggctcactcaccacaccgacctgcgatgagaaggtcgtctggactgtgttccgggag
cccattcagcttcacagagaacagatcctggcattctctcagaagctgtactacgacaag
gaacagacagtgagcatgaaggacaatgtcaggcccctgcagcagctggggcagcgcacg
gtgataaagtccggggccccgggtcggccgctgccctgggccctgcctgccctgctgggc
cccatgctggcctgcctgctggccggcttcctgcgatga

KEGG   Homo sapiens (human): 763Help
Entry
763               CDS       T01001                                 

Gene name
CA5A, CA5, CA5AD, CAV, CAVA, GS1-21A4.1
Definition
(RefSeq) carbonic anhydrase 5A
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Disease
H01400  Secondary hyperammonemia
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    763 (CA5A)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     763 (CA5A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase
Motif
Other DBs
NCBI-GeneID: 763
NCBI-ProteinID: NP_001730
OMIM: 114761
HGNC: 1377
Ensembl: ENSG00000174990
Vega: OTTHUMG00000137677
Pharos: P35218(Tclin)
UniProt: P35218
LinkDB All DBs
Position
16q24.2
AA seq 305 aa AA seqDB search
MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPG
GTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPL
ENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVI
GVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLT
ESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATN
EGTRS
NT seq 918 nt NT seq  +upstreamnt  +downstreamnt
atgttggggaggaacacttggaagacctcagctttctccttcttggttgagcagatgtgg
gcccctctctggagtcgttcgatgaggccagggcgatggtgttctcagcgttcctgtgca
tggcaaaccagcaataacactttgcacccactctggacggtcccggtctccgtgccaggg
ggcacccggcagtctcctattaacatccagtggagggacagcgtctatgacccccagctg
aagccactcagggtctcctatgaagcggcatcctgcctgtacatctggaacactggctac
ctcttccaggtggaatttgacgatgccaccgaggcatcaggaattagtggtgggcccttg
gaaaaccactacagactgaagcaatttcacttccactggggagcagtgaacgaggggggc
tcagagcacacagtggacggccacgcgtaccccgcagagctgcatttagttcactggaat
tctgtgaaataccaaaattacaaggaagctgtcgtgggagagaatggtttggctgtgata
ggcgtgtttttaaagctcggggcccatcatcagacgctgcagaggctggtggacatcttg
ccggaaataaaacataaggacgcgcgggcggccatgcgccccttcgacccctccactctg
ctgcccacctgctgggattactggacctacgcgggctcgctcaccaccccgccgctgacc
gagtcggtcacctggatcatccagaaggagcccgttgaagtggccccaagccagctctct
gcatttcgtactctcctgttttctgcacttggtgaagaggagaagatgatggtgaacaac
tatcgcccacttcaacccttgatgaaccggaaggtctgggcgtccttccaggccactaat
gagggcacaaggtcctag

KEGG   Homo sapiens (human): 765Help
Entry
765               CDS       T01001                                 

Gene name
CA6, CA-VI, GUSTIN
Definition
(RefSeq) carbonic anhydrase 6
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    765 (CA6)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     765 (CA6)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase
Motif
Other DBs
NCBI-GeneID: 765
NCBI-ProteinID: NP_001206
OMIM: 114780
HGNC: 1380
Ensembl: ENSG00000131686
Vega: OTTHUMG00000001763
Pharos: P23280(Tclin)
UniProt: P23280 B4DUH8
LinkDB All DBs
Structure
PDB: 

Position
1p36.23
AA seq 308 aa AA seqDB search
MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYN
PSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSE
ISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNF
ISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLS
RTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEIL
DYLRRALN
NT seq 927 nt NT seq  +upstreamnt  +downstreamnt
atgagggccctggtgcttctgctgtccctgttcctgctgggtggccaggcccagcatgtg
tctgactggacctactcagaaggggcactggacgaagcgcactggccacagcactacccc
gcctgtgggggccagagacagtcgcctatcaacctacagaggacgaaggtgcggtacaac
ccctccttgaaggggctcaatatgacaggctatgagacccaggcaggggagttccccatg
gtcaacaatggccacacagtgcagatcagcctgccctccaccatgcgcatgacagtggct
gacggcactgtatacatagcccagcagatgcactttcactggggaggtgcgtcctcggag
atcagcggctctgagcacaccgtggacgggatcagacatgtgatcgagattcacattgtt
cactacaattctaaatacaagagctatgatatagcccaagatgcgccggatggtttggct
gtactggcagccttcgttgaggtgaagaattaccctgaaaacacttattacagcaacttc
atttctcatctggccaacatcaagtacccaggacaaagaacaaccctgactggccttgac
gttcaggacatgctgcccaggaacctccagcactactacacctaccatggctcactcacc
acgcctccctgcactgagaacgtccactggtttgtgctggcagattttgtcaagctctcc
aggacacaggtttggaagctggagaattccttactggatcaccgcaacaagaccatccac
aacgattaccgcaggacccagcccctgaaccacagagtggtggaatccaacttcccgaat
caggaatacactctaggctctgaattccagttttacctacataagattgaggaaattctt
gactacttaagaagagcattgaactga

KEGG   Homo sapiens (human): 766Help
Entry
766               CDS       T01001                                 

Gene name
CA7, CA-VII, CAVII
Definition
(RefSeq) carbonic anhydrase 7
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    766 (CA7)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     766 (CA7)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase
Motif
Other DBs
NCBI-GeneID: 766
NCBI-ProteinID: NP_005173
OMIM: 114770
HGNC: 1381
Ensembl: ENSG00000168748
Vega: OTTHUMG00000137524
Pharos: P43166(Tclin)
UniProt: P43166
LinkDB All DBs
Structure
PDB: 

Position
16q22.1
AA seq 264 aa AA seqDB search
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLS
ITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSEL
HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSC
FNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDER
IHMVNNFRPPQPLKGRVVKASFRA
NT seq 795 nt NT seq  +upstreamnt  +downstreamnt
atgaccggccaccacggctggggctacggccaggacgacggcccctcgcattggcacaag
ctgtatcccattgcccagggagatcgccaatcacccatcaatatcatctccagccaggct
gtgtactctcccagcctgcaaccactggagctttcctatgaggcctgcatgtccctcagc
atcaccaacaatggccactctgtccaggtagacttcaatgacagcgatgaccgaaccgtg
gtgactgggggccccctggaagggccctaccgcctcaagcagtttcacttccactggggc
aagaagcacgatgtgggttctgagcacacggtggacggcaagtccttccccagcgagctg
catctggttcactggaatgccaagaagtacagcacttttggggaggcggcctcagcacct
gatggcctggctgtggttggtgtttttttggagacaggagacgagcaccccagcatgaat
cgtctgacagatgcgctctacatggtccggttcaagggcaccaaagcccagttcagctgc
ttcaaccccaagtgcctcctgcctgccagccggcactactggacctacccgggctctctg
acgactcccccactcagtgagagtgtcacctggattgtgctccgggagcccatctgcatc
tctgaaaggcagatggggaagttccggagcctgctttttacctcggaggacgatgagagg
atccacatggtgaacaacttccggccaccacagccactgaagggccgcgtggtaaaggcc
tccttccgggcctga

KEGG   Homo sapiens (human): 767Help
Entry
767               CDS       T01001                                 

Gene name
CA8, CA-RP, CA-VIII, CALS, CAMRQ3, CARP
Definition
(RefSeq) carbonic anhydrase 8
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Disease
H01204  Cerebellar ataxia, mental retardation (MR), and dysequilibrium syndrome (CAMRQ)
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    767 (CA8)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     767 (CA8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase
Motif
Other DBs
NCBI-GeneID: 767
NCBI-ProteinID: NP_001308766
OMIM: 114815
HGNC: 1382
Ensembl: ENSG00000178538
Vega: OTTHUMG00000165325
Pharos: P35219(Tbio)
UniProt: P35219
LinkDB All DBs
Structure
PDB: 

Position
8q12.1
AA seq 290 aa AA seqDB search
MADLSFIEDTVAFPEKEEDEEEEEEGVEWGYEEGVEWGLVFPDANGEYQSPINLNSREAR
YDPSLLDVRLSPNYVVCRDCEVTNDGHTIQVILKSKSVLSGGPLPQGHEFELYEVRFHWG
RENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAVGKPHGIAIIALFVQIGKEHVGLK
AVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVYEGSLTIPPCSEGVTWILFRYPL
TISQLQIEEFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVIRAAFQ
NT seq 873 nt NT seq  +upstreamnt  +downstreamnt
atggcggacctgagcttcatcgaagataccgtcgccttccccgagaaggaagaggatgag
gaggaagaagaggagggtgtggagtggggctacgaggaaggtgttgagtggggtctggtg
tttcctgatgctaatggggaataccagtctcctattaacctaaactcaagagaggctagg
tatgacccctcgctgttggatgtccgcctctccccaaattatgtggtgtgccgagactgt
gaagtcaccaatgatggacataccattcaggttatcctgaagtcaaaatcagttctttcg
ggaggaccattgcctcaagggcatgaatttgaactgtacgaagtgagatttcactgggga
agagaaaaccagcgtggttctgagcacacggttaatttcaaagcttttcccatggagctc
catctgatccactggaactccactctgtttggcagcattgatgaggctgtggggaagccg
cacggaatcgccatcattgctctgtttgttcagataggaaaggaacatgttggcttgaag
gctgtgactgaaatcctccaagatattcagtataaggggaagtccaaaacaataccttgc
tttaatcctaacactttattaccagaccctctgctgcgggattactgggtgtatgaaggc
tctctcaccatcccaccttgcagtgaaggtgtcacctggatattattccgatacccttta
actatatcccagctacagatagaagaatttcgaaggctgaggacacatgttaagggggca
gaacttgtggaaggctgtgatgggattttgggagacaactttcggcccactcagcctctt
agtgacagagtcattagagctgcatttcagtag

KEGG   Homo sapiens (human): 768Help
Entry
768               CDS       T01001                                 

Gene name
CA9, CAIX, MN
Definition
(RefSeq) carbonic anhydrase 9
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Girentuximab: D09593
Iodine I 124 girentuximab: D09632
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    768 (CA9)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     768 (CA9)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase
Motif
Other DBs
NCBI-GeneID: 768
NCBI-ProteinID: NP_001207
OMIM: 603179
HGNC: 1383
Ensembl: ENSG00000107159
Vega: OTTHUMG00000021029
Pharos: Q16790(Tclin)
UniProt: Q16790 A0A0S2Z3D0
LinkDB All DBs
Structure
PDB: 

Position
9p13.3
AA seq 459 aa AA seqDB search
MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
NT seq 1380 nt NT seq  +upstreamnt  +downstreamnt
atggctcccctgtgccccagcccctggctccctctgttgatcccggcccctgctccaggc
ctcactgtgcaactgctgctgtcactgctgcttctggtgcctgtccatccccagaggttg
ccccggatgcaggaggattcccccttgggaggaggctcttctggggaagatgacccactg
ggcgaggaggatctgcccagtgaagaggattcacccagagaggaggatccacccggagag
gaggatctacctggagaggaggatctacctggagaggaggatctacctgaagttaagcct
aaatcagaagaagagggctccctgaagttagaggatctacctactgttgaggctcctgga
gatcctcaagaaccccagaataatgcccacagggacaaagaaggggatgaccagagtcat
tggcgctatggaggcgacccgccctggccccgggtgtccccagcctgcgcgggccgcttc
cagtccccggtggatatccgcccccagctcgccgccttctgcccggccctgcgccccctg
gaactcctgggcttccagctcccgccgctcccagaactgcgcctgcgcaacaatggccac
agtgtgcaactgaccctgcctcctgggctagagatggctctgggtcccgggcgggagtac
cgggctctgcagctgcatctgcactggggggctgcaggtcgtccgggctcggagcacact
gtggaaggccaccgtttccctgccgagatccacgtggttcacctcagcaccgcctttgcc
agagttgacgaggccttggggcgcccgggaggcctggccgtgttggccgcctttctggag
gagggcccggaagaaaacagtgcctatgagcagttgctgtctcgcttggaagaaatcgct
gaggaaggctcagagactcaggtcccaggactggacatatctgcactcctgccctctgac
ttcagccgctacttccaatatgaggggtctctgactacaccgccctgtgcccagggtgtc
atctggactgtgtttaaccagacagtgatgctgagtgctaagcagctccacaccctctct
gacaccctgtggggacctggtgactctcggctacagctgaacttccgagcgacgcagcct
ttgaatgggcgagtgattgaggcctccttccctgctggagtggacagcagtcctcgggct
gctgagccagtccagctgaattcctgcctggctgctggtgacatcctagccctggttttt
ggcctcctttttgctgtcaccagcgtcgcgttccttgtgcagatgagaaggcagcacaga
aggggaaccaaagggggtgtgagctaccgcccagcagaggtagccgagactggagcctag

KEGG   Homo sapiens (human): 771Help
Entry
771               CDS       T01001                                 

Gene name
CA12, CA-XII, CAXII, HsT18816, T18816
Definition
(RefSeq) carbonic anhydrase 12
  KO
K01672  carbonic anhydrase [EC:4.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
Disease
H01302  Hyperchlorhidrosis isolated (HCHLH)
Drug target
Acetazolamide (DG01134): D00218 D01196
Clofenamide: D01822
Diclofenamide: D00518
Dorzolamide (DG01135): D00653 D07871
Ethoxzolamide: D02441
Methazolamide: D00655
Sezolamide hydrochloride: D03845
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    771 (CA12)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.1  carbonic anhydrase
     771 (CA12)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Carb_anhydrase DUF4191 DUF3149
Motif
Other DBs
NCBI-GeneID: 771
NCBI-ProteinID: NP_001209
OMIM: 603263
HGNC: 1371
Ensembl: ENSG00000074410
Vega: OTTHUMG00000132881
Pharos: O43570(Tclin)
UniProt: O43570
LinkDB All DBs
Structure
PDB: 

Position
15q22.2
AA seq 354 aa AA seqDB search
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
NT seq 1065 nt NT seq  +upstreamnt  +downstreamnt
atgccccggcgcagcctgcacgcggcggccgtgctcctgctggtgatcttaaaggaacag
ccttccagcccggccccagtgaacggttccaagtggacttattttggtcctgatggggag
aatagctggtccaagaagtacccgtcgtgtgggggcctgctgcagtcccccatagacctg
cacagtgacatcctccagtatgacgccagcctcacgcccctcgagttccaaggctacaat
ctgtctgccaacaagcagtttctcctgaccaacaatggccattcagtgaagctgaacctg
ccctcggacatgcacatccagggcctccagtctcgctacagtgccacgcagctgcacctg
cactgggggaacccgaatgacccgcacggctctgagcacaccgtcagcggacagcacttc
gccgccgagctgcacattgtccattataactcagacctttatcctgacgccagcactgcc
agcaacaagtcagaaggcctcgctgtcctggctgttctcattgagatgggctccttcaat
ccgtcctatgacaagatcttcagtcaccttcaacatgtaaagtacaaaggccaggaagca
ttcgtcccgggattcaacattgaagagctgcttccggagaggaccgctgaatattaccgc
taccgggggtccctgaccacacccccttgcaaccccactgtgctctggacagttttccga
aaccccgtgcaaatttcccaggagcagctgctggctttggagacagccctgtactgcaca
cacatggacgacccttcccccagagaaatgatcaacaacttccggcaggtccagaagttc
gatgagaggctggtatacacctccttctcccaagtgcaagtctgtactgcggcaggactg
agtctgggcatcatcctctcactggccctggctggcattcttggcatctgtattgtggtg
gtggtgtccatttggcttttcagaaggaagagtatcaaaaaaggtgataacaagggagtc
atttacaagccagccaccaagatggagactgaggcccacgcttga

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