KEGG   Homo sapiens (human): 112398Help
Entry
112398            CDS       T01001                                 

Gene name
EGLN2, EIT-6, EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1
Definition
(RefSeq) egl-9 family hypoxia inducible factor 2
  KO
K09592  hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04066  HIF-1 signaling pathway
hsa05200  Pathways in cancer
hsa05211  Renal cell carcinoma
Drug target
Daprodustat: D10874
Enarodustat: D11523
Molidustat sodium: D11273
Roxadustat: D10593
Vadadustat: D11078
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    112398 (EGLN2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112398 (EGLN2)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    112398 (EGLN2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.29  hypoxia-inducible factor-proline dioxygenase
     112398 (EGLN2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 2OG-FeII_Oxy_3 2OG-FeII_Oxy_4
Motif
Other DBs
NCBI-GeneID: 112398
NCBI-ProteinID: NP_444274
OMIM: 606424
HGNC: 14660
Ensembl: ENSG00000269858
Vega: OTTHUMG00000182703
Pharos: Q96KS0(Tchem)
UniProt: Q96KS0 A0A024R0R2
LinkDB All DBs
Structure
PDB: 

Position
19q13.2
AA seq 407 aa AA seqDB search
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAG
SGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRK
WAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALD
YIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQI
AWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEV
KPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
NT seq 1224 nt NT seq  +upstreamnt  +downstreamnt
atggacagcccgtgccagccgcagcccctaagtcaggctctccctcagttaccagggtct
tcgtcagagcccttggagcctgagcctggccgggccaggatgggagtggagagttacctg
ccctgtcccctgctcccctcctaccactgtccaggagtgcctagtgaggcctcggcaggg
agtgggacccccagagccacagccacctctaccactgccagccctcttcgggacggtttt
ggcgggcaggatggtggtgagctgcggccgctgcagagtgaaggcgctgcagcgctggtc
accaaggggtgccagcgattggcagcccagggcgcacggcctgaggcccccaaacggaaa
tgggccgaggatggtggggatgccccttcacccagcaaacggccctgggccaggcaagag
aaccaggaggcagagcgggagggtggcatgagctgcagctgcagcagtggcagtggtgag
gccagtgctgggctgatggaggaggcgctgccctctgcgcccgagcgcctggccctggac
tatatcgtgccctgcatgcggtactacggcatctgcgtcaaggacagcttcctgggggca
gcactgggcggtcgcgtgctggccgaggtggaggccctcaaacggggtgggcgcctgcga
gacgggcagctagtgagccagagggcgatcccgccgcgcagcatccgtggggaccagatt
gcctgggtggaaggccatgaaccaggctgtcgaagcattggtgccctcatggcccatgtg
gacgccgtcatccgccactgcgcagggcggctgggcagctatgtcatcaacgggcgcacc
aaggccatggtggcgtgttacccaggcaacgggctcgggtacgtaaggcacgttgacaat
ccccacggcgatgggcgctgcatcacctgtatctattacctgaatcagaactgggacgtt
aaggtgcatggcggcctgctgcagatcttccctgagggccggcccgtggtagccaacatc
gagccactctttgaccggttgctcattttctggtctgaccggcggaacccccacgaggtg
aagccagcctatgccaccaggtacgccatcactgtctggtattttgatgccaaggagcgg
gcagcagccaaagacaagtatcagctagcatcaggacagaaaggtgtccaagtacctgta
tcacagccgcctacgcccacctag

KEGG   Homo sapiens (human): 112399Help
Entry
112399            CDS       T01001                                 

Gene name
EGLN3, HIFP4H3, HIFPH3, PHD3
Definition
(RefSeq) egl-9 family hypoxia inducible factor 3
  KO
K09592  hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04066  HIF-1 signaling pathway
hsa05200  Pathways in cancer
hsa05211  Renal cell carcinoma
Drug target
Daprodustat: D10874
Enarodustat: D11523
Molidustat sodium: D11273
Roxadustat: D10593
Vadadustat: D11078
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    112399 (EGLN3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112399 (EGLN3)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    112399 (EGLN3)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.29  hypoxia-inducible factor-proline dioxygenase
     112399 (EGLN3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 2OG-FeII_Oxy_3 2OG-FeII_Oxy_4
Motif
Other DBs
NCBI-GeneID: 112399
NCBI-ProteinID: NP_071356
OMIM: 606426
HGNC: 14661
Ensembl: ENSG00000129521
Vega: OTTHUMG00000029498
Pharos: Q9H6Z9(Tchem)
UniProt: Q9H6Z9
LinkDB All DBs
Position
14q13.1
AA seq 239 aa AA seqDB search
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQ
LAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKA
MVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEP
IFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
NT seq 720 nt NT seq  +upstreamnt  +downstreamnt
atgcccctgggacacatcatgaggctggacctggagaaaattgccctggagtacatcgtg
ccctgtctgcacgaggtgggcttctgctacctggacaacttcctgggcgaggtggtgggc
gactgcgtcctggagcgcgtcaagcagctgcactgcaccggggccctgcgggacggccag
ctggcggggccgcgcgccggcgtctccaagcgacacctgcggggcgaccagatcacgtgg
atcgggggcaacgaggagggctgcgaggccatcagcttcctcctgtccctcatcgacagg
ctggtcctctactgcgggagccggctgggcaaatactacgtcaaggagaggtctaaggca
atggtggcttgctatccgggaaatggaacaggttatgttcgccacgtggacaaccccaac
ggtgatggtcgctgcatcacctgcatctactatctgaacaagaattgggatgccaagcta
catggtgggatcctgcggatatttccagaggggaaatcattcatagcagatgtggagccc
atttttgacagactcctgttcttctggtcagatcgtaggaacccacacgaagtgcagccc
tcttacgcaaccagatatgctatgactgtctggtactttgatgctgaagaaagggcagaa
gccaaaaagaaattcaggaatttaactaggaaaactgaatctgccctcactgaagactga

KEGG   Homo sapiens (human): 54583Help
Entry
54583             CDS       T01001                                 

Gene name
EGLN1, C1orf12, ECYT3, HALAH, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6
Definition
(RefSeq) egl-9 family hypoxia inducible factor 1
  KO
K09592  hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04066  HIF-1 signaling pathway
hsa05200  Pathways in cancer
hsa05211  Renal cell carcinoma
Disease
H00236  Congenital polycythemia
Drug target
Daprodustat: D10874
Enarodustat: D11523
Molidustat sodium: D11273
Roxadustat: D10593
Vadadustat: D11078
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    54583 (EGLN1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    54583 (EGLN1)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    54583 (EGLN1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.29  hypoxia-inducible factor-proline dioxygenase
     54583 (EGLN1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 2OG-FeII_Oxy_3 zf-MYND 2OG-FeII_Oxy_4 zf-Mss51
Motif
Other DBs
NCBI-GeneID: 54583
NCBI-ProteinID: NP_071334
OMIM: 606425
HGNC: 1232
Ensembl: ENSG00000135766
Vega: OTTHUMG00000038027
Pharos: Q9GZT9(Tchem)
UniProt: Q9GZT9 R4SCQ0
LinkDB All DBs
Structure
PDB: 

Position
1q42.2
AA seq 426 aa AA seqDB search
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
NT seq 1281 nt NT seq  +upstreamnt  +downstreamnt
atggccaatgacagcggcgggcccggcgggccgagcccgagcgagcgagaccggcagtac
tgcgagctgtgcgggaagatggagaacctgctgcgctgcagccgctgccgcagctccttc
tactgctgcaaggagcaccagcgtcaggactggaagaagcacaagctcgtgtgccagggc
agcgagggcgccctcggccacggagtgggcccacaccagcattccggccccgcgccgccg
gctgcagtgccgccgcccagggccggggcccgggagcccaggaaggcagcggcgcgccgg
gacaacgcctccggggacgcggccaagggaaaagtaaaggccaagcccccggccgaccca
gcggcggccgcgtcgccgtgtcgtgcggccgccggcggccagggctcggcggtggctgcc
gaagccgagcccggcaaggaggagccgccggcccgctcatcgctgttccaggagaaggcg
aacctgtaccccccaagcaacacgcccggggatgcgctgagccccggcggcggcctgcgg
cccaacgggcagacgaagcccctgccggcgctgaagctggcgctcgagtacatcgtgccg
tgcatgaacaagcacggcatctgtgtggtggacgacttcctcggcaaggagaccggacag
cagatcggcgacgaggtgcgcgccctgcacgacaccgggaagttcacggacgggcagctg
gtcagccagaagagtgactcgtccaaggacatccgaggcgataagatcacctggatcgag
ggcaaggagcccggctgcgaaaccattgggctgctcatgagcagcatggacgacctgata
cgccactgtaacgggaagctgggcagctacaaaatcaatggccggacgaaagccatggtt
gcttgttatccgggcaatggaacgggttatgtacgtcatgttgataatccaaatggagat
ggaagatgtgtgacatgtatatattatcttaataaagactgggatgccaaggtaagtgga
ggtatacttcgaatttttccagaaggcaaagcccagtttgctgacattgaacccaaattt
gatagactgctgtttttctggtctgaccgtcgcaaccctcatgaagtacaaccagcatat
gctacaaggtacgcaataactgtttggtattttgatgcagatgagagagcacgagctaaa
gtaaaatatctaacaggtgaaaaaggtgtgagggttgaactcaataaaccttcagattcg
gtcggtaaagacgtcttctag

DBGET integrated database retrieval system